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  1. Article ; Online: Classical Hodgkin lymphoma.

    Brice, Pauline / de Kerviler, Eric / Friedberg, Jonathan W

    Lancet (London, England)

    2021  Volume 398, Issue 10310, Page(s) 1518–1527

    Abstract: Classical Hodgkin lymphoma is one of the more frequent lymphomas and is generally considered a highly curable disease with standard first-line chemotherapy and radiotherapy in some cases. Despite these outstanding results, major problems remain ... ...

    Abstract Classical Hodgkin lymphoma is one of the more frequent lymphomas and is generally considered a highly curable disease with standard first-line chemotherapy and radiotherapy in some cases. Despite these outstanding results, major problems remain unresolved. First, there are still patients who will not be cured with front-line regimens and, second, many patients who are cured of classical Hodgkin lymphoma continue to die prematurely due to the late toxic effects of their therapy. Because the median age of patients with classical Hodgkin lymphoma is in the mid-30s, the disease's impact on the number of years lost from productive life is remarkable. In recent years, the gold standard of chemotherapy (often combined with radiotherapy) has changed, with the approval of immunotherapy mostly in relapse settings.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Disease-Free Survival ; Hodgkin Disease/drug therapy ; Hodgkin Disease/radiotherapy ; Humans ; Immunotherapy ; Neoplasm Recurrence, Local/drug therapy
    Language English
    Publishing date 2021-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)32207-8
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  2. Article: Deep clustering for abdominal organ classification in ultrasound imaging.

    Dadoun, Hind / Delingette, Hervé / Rousseau, Anne-Laure / de Kerviler, Eric / Ayache, Nicholas

    Journal of medical imaging (Bellingham, Wash.)

    2023  Volume 10, Issue 3, Page(s) 34502

    Abstract: Purpose: The purpose of this study is to examine the utilization of unlabeled data for abdominal organ classification in multi-label (non-mutually exclusive classes) ultrasound images, as an alternative to the conventional transfer learning approach.: ...

    Abstract Purpose: The purpose of this study is to examine the utilization of unlabeled data for abdominal organ classification in multi-label (non-mutually exclusive classes) ultrasound images, as an alternative to the conventional transfer learning approach.
    Approach: We present a new method for classifying abdominal organs in ultrasound images. Unlike previous approaches that only relied on labeled data, we consider the use of both labeled and unlabeled data. To explore this approach, we first examine the application of deep clustering for pretraining a classification model. We then compare two training methods, fine-tuning with labeled data through supervised learning and fine-tuning with both labeled and unlabeled data using semisupervised learning. All experiments were conducted on a large dataset of unlabeled images (
    Results: We show that for supervised fine-tuning, deep clustering is an effective pre-training method, with performance matching that of ImageNet pre-training using five times less labeled data. For semi-supervised learning, deep clustering pre-training also yields higher performance when the amount of labeled data is limited. Best performance is obtained with deep clustering pre-training combined with semi-supervised learning and 2742 labeled example images with an
    Conclusions: This method can be used as a tool to preprocess large unprocessed databases, thus reducing the need for prior annotations of abdominal ultrasound studies for the training of image classification algorithms, which in turn could improve the clinical use of ultrasound images.
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4302
    ISSN 2329-4302
    DOI 10.1117/1.JMI.10.3.034502
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  3. Article: Imagerie dans le cancer de la prostate.

    de Kerviler, Eric

    La Revue du praticien

    2013  Volume 63, Issue 4, Page(s) 480–484

    Abstract: The management of prostate cancer has dramatically changed due to the progresses made in imaging, especially in MRI. MRI in indicated in the initial workup of a patient with a biopsy proven prostate carcinoma eligible to a curative treatment. Detection ... ...

    Title translation Imaging in prostate cancer.
    Abstract The management of prostate cancer has dramatically changed due to the progresses made in imaging, especially in MRI. MRI in indicated in the initial workup of a patient with a biopsy proven prostate carcinoma eligible to a curative treatment. Detection MRI is used in patients with increased PSA levels and negative biopsies for targeting a new series of biopsies. Lastly, MRI combined with PET allows one to schedule a salvation treatment in patients with a biological relapse of prostate cancer after treatment and a local recurrence.
    MeSH term(s) Diagnostic Imaging ; Humans ; Male ; Prostatic Neoplasms/diagnosis
    Language French
    Publishing date 2013-04
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  4. Article ; Online: Renal Function After CT-Guided Cryoablation of Small Renal Tumours in Patients with Solitary Kidney: An Analysis of European Multinational Prospective EuRECA Registry.

    Pietersen, Pia I / Stougaard, Sarah / Keeley, Francis X / Lagerveld, Brunolf / Breen, David / King, Alexander / Nielsen, Tommy K / van Strijen, Marco / Garnon, Julien / Alcorn, Des / de Kerviler, Eric / Zondervan, Patricia / Wah, Tze M / Junker, Theresa / Graumann, Ole

    Cardiovascular and interventional radiology

    2024  

    Abstract: Purpose: Treatment of renal cell carcinoma (RCC) in patients with solitary kidneys remains challenging. The purpose of this multicentre cohort study was to explore how renal function is affected by percutaneous image-guided cryoablation in patients with ...

    Abstract Purpose: Treatment of renal cell carcinoma (RCC) in patients with solitary kidneys remains challenging. The purpose of this multicentre cohort study was to explore how renal function is affected by percutaneous image-guided cryoablation in patients with solitary kidneys.
    Material and methods: Data from the European Registry for Renal Cryoablation database were extracted on patients with RCC in solitary kidneys treated with image-guided, percutaneous cryoablation. Patients were excluded if they had multiple tumours, had received previous treatment of the tumour, or were treated with more than one cryoablation procedure. Pre- and post-treatment eGFR (within 3 months of the procedure) were compared.
    Results: Of 222 patients with solitary kidneys entered into the database, a total of 70 patients met inclusion criteria. The mean baseline eGFR was 55.8 ± 16.8 mL/min/1.73 m
    Conclusion: Image-guided renal cryoablation appears to be safe and effective for renal function preservation in patients with RCC in a solitary kidney. Following cryoablation, all patients had preservation of renal function without the need for dialysis or progression in chronic kidney disease stage despite the statistically significant reduction in eGFR. LEVEL OF EVIDENCE 3: Observational study.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-023-03634-4
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  5. Article: Cryothérapie sous anesthésie locale des tumeurs rénales.

    De Kerviler, Éric / Colleter, Loïc / Masson-Lecomte, Alexandra / Desgrandchamps, François

    La Revue du praticien

    2019  Volume 68, Issue 1, Page(s) 45–47

    Abstract: Cryoablation under local anesthesia of renal tumors. The incidence of small renal tumors is increasing. These small tumors measuring less than 4 cm are typically slow-growing. The development of non-invasive percutaneous ablative techniques represents an ...

    Title translation Cryoablation under local anesthesia of renal tumors.
    Abstract Cryoablation under local anesthesia of renal tumors. The incidence of small renal tumors is increasing. These small tumors measuring less than 4 cm are typically slow-growing. The development of non-invasive percutaneous ablative techniques represents an alternative to active surveillance or surgery in at risk patients who are candidates to nephron sparing techniques. The intrinsic anesthetic properties of cryoablation make the procedure feasible under local anesthesia.
    MeSH term(s) Anesthesia, Local ; Cryosurgery ; Humans ; Incidence ; Kidney Neoplasms/therapy
    Language French
    Publishing date 2019-03-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  6. Article: Oncological and Peri-Operative Outcomes of Percutaneous Cryoablation of Renal Cell Carcinoma for Patients with Hereditary RCC Diseases-An Analysis of European Multi-Centre Prospective EuRECA Registry.

    Osman, Filzah Hanis / Chan, Vinson Wai-Shun / Breen, David J / King, Alexander / Nielsen, Tommy Kjærgaard / Garnon, Julien / Alcorn, Des / Lagerveld, Brunolf / Graumann, Ole / Keeley, Francis Xavier / Walkden, Miles / de Kerviler, Éric / Wah, Tze Min

    Cancers

    2023  Volume 15, Issue 13

    Abstract: This study aims to evaluate the safety, efficacy, and renal function preservation of percutaneous cryoablation (PCA) for small renal masses (SRMs) in inherited RCC syndromes. Patients with inherited T1N0M0 RCCs (<7 cm) undergoing PCA from 2015 to 2021 ... ...

    Abstract This study aims to evaluate the safety, efficacy, and renal function preservation of percutaneous cryoablation (PCA) for small renal masses (SRMs) in inherited RCC syndromes. Patients with inherited T1N0M0 RCCs (<7 cm) undergoing PCA from 2015 to 2021 were identified from the European Registry for Renal Cryoablation (EuRECA). The primary outcome was local recurrence-free survival (LRFS). The secondary outcomes included technical success, peri-operative outcomes, and other oncological outcomes estimated using the Kaplan-Meier method. Simple proportions, chi-squared tests, and
    Language English
    Publishing date 2023-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133322
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  7. Article ; Online: Zonal anatomy of the prostate using magnetic resonance imaging, morphometrics, and radiomic features: impact of age-related changes.

    Laschkar, Sophie / Montagne, Sarah / De Kerviler, Eric / Roupret, Morgan / Lucidarme, Olivier / Cussenot, Olivier / Renard Penna, Raphaele

    The British journal of radiology

    2021  Volume 95, Issue 1131, Page(s) 20210156

    Abstract: Objective: To evaluate the impact of age on the zonal anatomy of the prostate by MRI using morphometric and textural analysis.: Methods: A total of 154 men (mean age: 63 years) who underwent MRI due to a high prostate-specific antigen (PSA) level ... ...

    Abstract Objective: To evaluate the impact of age on the zonal anatomy of the prostate by MRI using morphometric and textural analysis.
    Methods: A total of 154 men (mean age: 63 years) who underwent MRI due to a high prostate-specific antigen (PSA) level were included retrospectively. At each MRI examination the following variables were measured: overall dimensions of the prostate (whole gland (WG), transitional zone (TZ), and peripheral zone (PZ)), and thickness of the anterior fibromuscular stroma (AFMS) and the periprostatic venous plexus (PPVP) on
    Results: Age was positively correlated with PSA level and glandular volumes (WG, TZ, and TZ/WG ratio;
    Conclusion: Gradual variations in morphologic and textural features of the prostate were observed with age, mainly due to the increase in TZ volume while PZ volume tended to decrease. These modifications resulted in textural changes mainly at the expense of entropy.
    Advances in knowledge: Entropy could be relevant for studying the process of aging of the prostate.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Diffusion Magnetic Resonance Imaging/methods ; Entropy ; Humans ; Male ; Middle Aged ; Prostate/anatomy & histology ; Prostate-Specific Antigen/blood ; Retrospective Studies
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20210156
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  8. Book ; Online: Combining Bayesian and Deep Learning Methods for the Delineation of the Fan in Ultrasound Images

    Dadoun, Hind / Delingette, Hervé / Rousseau, Anne-Laure / de Kerviler, Eric / Ayache, Nicholas

    2021  

    Abstract: Ultrasound (US) images usually contain identifying information outside the ultrasound fan area and manual annotations placed by the sonographers during exams. For those images to be exploitable in a Deep Learning framework, one needs to first delineate ... ...

    Abstract Ultrasound (US) images usually contain identifying information outside the ultrasound fan area and manual annotations placed by the sonographers during exams. For those images to be exploitable in a Deep Learning framework, one needs to first delineate the border of the fan which delimits the ultrasound fan area and then remove other annotations inside. We propose a parametric probabilistic approach for the first task. We make use of this method to generate a training data set with segmentation masks of the region of interest (ROI) and train a U-Net to perform the same task in a supervised way, thus considerably reducing computational time of the method, one hundred and sixty times faster. These images are then processed with existing inpainting methods to remove annotations present inside the fan area. To the best of our knowledge, this is the first parametric approach to quickly detect the fan in an ultrasound image without any other information than the image itself.
    Keywords Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 004
    Publishing date 2021-02-02
    Publishing country us
    Document type Book ; Online
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  9. Article ; Online: Percutaneous tumor ablation versus image guided robotic-assisted partial nephrectomy for cT1b renal cell carcinoma: a comparative matched-pair analysis (UroCCR 80).

    Klein, Clément / Cazalas, Grégoire / Margue, Gaëlle / Piana, Gilles / DE Kerviler, Eric / Gangi, Afshin / Puech, Phillipe / Nedelcu, Cosmina / Grange, Remi / Buy, Xavier / Michiels, Clément / Jegonday, Marc-Antoine / Rouviere, Olivier / Grenier, Nicolas / Marcelin, Clément / Bernhard, Jean-Christophe

    Minerva urology and nephrology

    2023  Volume 75, Issue 5, Page(s) 559–568

    Abstract: Background: Partial nephrectomy (PN) is the gold standard treatment for cT1b renal tumors. Percutaneous guided thermal ablation (TA) has proven oncologic efficacy with low morbidity for the treatment of small renal masses (<3 cm). Recently, 3D image- ... ...

    Abstract Background: Partial nephrectomy (PN) is the gold standard treatment for cT1b renal tumors. Percutaneous guided thermal ablation (TA) has proven oncologic efficacy with low morbidity for the treatment of small renal masses (<3 cm). Recently, 3D image-guided robot-assisted PN (3D-IGRAPN) has been described, and decreased perioperative morbidity compared to standard RAPN has been reported. Our objective was to compare two minimally invasive image-guided nephron-sparing procedures (TA vs. 3D-IGRAPN) for the treatment of cT1b renal cell carcinomas (4.1-7 cm).
    Methods: Patients treated with TA and 3D-IGRAPN for cT1b renal cell carcinoma, prospectively included in the UroCCR database (NCT03293563), were pair-matched for tumor size, pathology, and RENAL score. The primary endpoint was the local recurrence rate between the two groups. Secondary endpoints included metastatic evolution, perioperative complications, decrease in renal function, and length of hospitalization.
    Results: A total of 198 patients were included and matched into two groups of 72 patients. The local recurrence rate was significantly higher in the TA group than that in the 3D-IGRAPN group (4.2% vs. 15.2%, P=0.04). Metastatic evolution and perioperative outcomes such as major complications, eGFR decrease, and length of hospitalization did not differ significantly between the two groups.
    Conclusions: 3D-IGRAPN resulted in a significantly lower local recurrence rate and comparable rates of complications and metastatic evolution compared with thermal ablation.
    MeSH term(s) Humans ; Robotic Surgical Procedures/adverse effects ; Carcinoma, Renal Cell/surgery ; Matched-Pair Analysis ; Nephrectomy ; Kidney Neoplasms/surgery
    Language English
    Publishing date 2023-09-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062840-4
    ISSN 2724-6442
    ISSN (online) 2724-6442
    DOI 10.23736/S2724-6051.23.05274-6
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  10. Article ; Online: Deep Learning for the Detection, Localization, and Characterization of Focal Liver Lesions on Abdominal US Images.

    Dadoun, Hind / Rousseau, Anne-Laure / de Kerviler, Eric / Correas, Jean-Michel / Tissier, Anne-Marie / Joujou, Fanny / Bodard, Sylvain / Khezzane, Kemel / de Margerie-Mellon, Constance / Delingette, Hervé / Ayache, Nicholas

    Radiology. Artificial intelligence

    2022  Volume 4, Issue 3, Page(s) e210110

    Abstract: Purpose: To train and assess the performance of a deep learning-based network designed to detect, localize, and characterize focal liver lesions (FLLs) in the liver parenchyma on abdominal US images.: Materials and methods: In this retrospective, ... ...

    Abstract Purpose: To train and assess the performance of a deep learning-based network designed to detect, localize, and characterize focal liver lesions (FLLs) in the liver parenchyma on abdominal US images.
    Materials and methods: In this retrospective, multicenter, institutional review board-approved study, two object detectors, Faster region-based convolutional neural network (Faster R-CNN) and Detection Transformer (DETR), were fine-tuned on a dataset of 1026 patients (
    Results: DETR achieved a specificity of 90% (95% CI: 75, 100) and a sensitivity of 97% (95% CI: 97, 97) for the detection of FLLs. The performance of DETR met or exceeded that of the three caregivers for this task. DETR correctly localized 80% of the lesions, and it achieved a specificity of 81% (95% CI: 67, 91) and a sensitivity of 82% (95% CI: 62, 100) for FLL characterization (benign vs malignant) among lesions localized by all raters. The performance of DETR met or exceeded that of two experts and Faster R-CNN for these tasks.
    Conclusion: DETR demonstrated high specificity for detection, localization, and characterization of FLLs on abdominal US images.
    Language English
    Publishing date 2022-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 2638-6100
    ISSN (online) 2638-6100
    DOI 10.1148/ryai.210110
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