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Article: Diagnostic et traitement des viroses émergentes : comment aller de l’avant ?

de Lamballerie, Xavier

Bulletin de l'Academie nationale de medecine

2019 Volume 200, Issue 8, Page(s) 1605–1615

Abstract: Virus emergence episodes follow one another at a steady pace. The medical and scientific community responds to needs as and when they arise but finds difficult to propose a global strategy in the medium and long term. Regarding diagnosis, priority should ...

Title translation	Diagnosis and treatment of emerging viral diseases : how can we do better ?
Abstract	Virus emergence episodes follow one another at a steady pace. The medical and scientific community responds to needs as and when they arise but finds difficult to propose a global strategy in the medium and long term. Regarding diagnosis, priority should be given to anticipating the management of re-emerging pathogens, to developing capacities of real-time molecular diagnosis, and to preserving reference expertise and reference biological materials. This effort should also include sero-epidemiological studies aiming at obtaining a more accurate mapping of the circulation of potentially re-emerging pathogens. Regarding therapeutics (with the exception of vaccines which are addressed in another presentation), the expected improvements are the advance implementation of ready-to-use protocol frames for clinical trials and that of an ambitious strategy aiming at gradually covering the taxonomic spectrum of evolutionary virus groups infecting vertebrates.
Keywords	covid19
Language	French
Publishing date	2019-06-18
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	213227-8
ISSN	0001-4079
ISSN	0001-4079
DOI	10.1016/S0001-4079(19)30571-0
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Article ; Online: Of chloroquine and COVID-19.

Touret, Franck / de Lamballerie, Xavier

Antiviral research

2020 Volume 177, Page(s) 104762

Abstract: Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this ... ...

Abstract	Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
MeSH term(s)	Antiviral Agents/adverse effects ; Antiviral Agents/pharmacology ; Antiviral Agents/standards ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; China ; Chloroquine/adverse effects ; Chloroquine/pharmacology ; Chloroquine/standards ; Chloroquine/therapeutic use ; Clinical Trials as Topic/standards ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/standards ; Hydroxychloroquine/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
Keywords	covid19
Language	English
Publishing date	2020-03-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/j.antiviral.2020.104762
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Article ; Online: In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolate.

Touret, Franck / Baronti, Cécile / Bouzidi, Hawa Sophia / de Lamballerie, Xavier

Scientific reports

2022 Volume 12, Issue 1, Page(s) 4683

Abstract: The emergence and rapid spread of the Omicron variant of SARS-CoV-2, which has more than 30 substitutions in the spike glycoprotein, compromises the efficacy of currently available vaccines and therapeutic antibodies. Using a clinical strain of the ... ...

Abstract	The emergence and rapid spread of the Omicron variant of SARS-CoV-2, which has more than 30 substitutions in the spike glycoprotein, compromises the efficacy of currently available vaccines and therapeutic antibodies. Using a clinical strain of the Omicron variant, we analyzed the neutralizing power of eight currently used monoclonal antibodies compared to the ancestral B.1 BavPat1 D614G strain. We observed that six of these antibodies have lost their ability to neutralize the Omicron variant. Of the antibodies still having neutralizing activity, Sotrovimab/Vir-7831 shows the smallest reduction in activity, with a factor change of 3.1. Cilgavimab/AZD1061 alone shows a reduction in efficacy of 15.8, resulting in a significant loss of activity for the Evusheld cocktail (42.6-fold reduction) in which the other antibody, Tixagevimab, does not retain significant activity against Omicron. Our results suggest that the clinical efficacy of the initially proposed doses should be rapidly evaluated and the possible need to modify doses or propose combination therapies should be considered.
MeSH term(s)	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral/therapeutic use ; COVID-19/drug therapy ; Humans ; Membrane Glycoproteins ; Neutralization Tests ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; Membrane Glycoproteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; spike protein, SARS-CoV-2 ; tixagevimab ; cilgavimab (1KUR4BN70F) ; sotrovimab (1MTK0BPN8V)
Language	English
Publishing date	2022-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-08559-5
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Article ; Online: Emergence of Oropouche fever in Latin America: a narrative review.

Wesselmann, Konrad M / Postigo-Hidalgo, Ignacio / Pezzi, Laura / de Oliveira-Filho, Edmilson F / Fischer, Carlo / de Lamballerie, Xavier / Drexler, Jan Felix

The Lancet. Infectious diseases

2024

Abstract: Since its discovery in 1955, the incidence and geographical spread of reported Oropouche virus (OROV) infections have increased. Oropouche fever has been suggested to be one of the most important vector-borne diseases in Latin America. However, both ... ...

Abstract	Since its discovery in 1955, the incidence and geographical spread of reported Oropouche virus (OROV) infections have increased. Oropouche fever has been suggested to be one of the most important vector-borne diseases in Latin America. However, both literature on OROV and genomic sequence availability are scarce, with few contributing laboratories worldwide. Three reassortant OROV glycoprotein gene variants termed Iquitos, Madre de Dios, and Perdões virus have been described from humans and non-human primates. OROV predominantly causes acute febrile illness, but severe neurological disease such as meningoencephalitis can occur. Due to unspecific symptoms, laboratory diagnostics are crucial. Several laboratory tests have been developed but robust commercial tests are hardly available. Although OROV is mainly transmitted by biting midges, it has also been detected in several mosquito species and a wide range of vertebrate hosts, which likely facilitates its widespread emergence. However, potential non-human vertebrate reservoirs have not been systematically studied. Robust animal models to investigate pathogenesis and immune responses are not available. Epidemiology, pathogenesis, transmission cycle, cross-protection from infections with OROV reassortants, and the natural history of infection remain unclear. This Review identifies Oropouche fever as a neglected disease and offers recommendations to address existing knowledge gaps, enable risk assessments, and ensure effective public health responses.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(23)00740-5
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Article ; Online: The Authors' Reply.

Carrat, Fabrice / Desenclos, Jean-Claude / de Lamballerie, Xavier / Zins, Marie

European journal of epidemiology

2022 Volume 37, Issue 10, Page(s) 1085–1086

Language	English
Publishing date	2022-10-26
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-022-00927-9
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Article ; Online: Failure of favipiravir to treat chronic norovirus infection in a kidney-transplant patient.

Darres, Amandine / Del Bello, Arnaud / Marion, Olivier / de Lamballerie, Xavier / Malvy, Denis / Izopet, Jacques / Kamar, Nassim

Transplant infectious disease : an official journal of the Transplantation Society

2024 Volume 26, Issue 1, Page(s) e14235

MeSH term(s)	Humans ; Norovirus ; Kidney Transplantation/adverse effects ; Caliciviridae Infections/drug therapy ; Kidney ; Amides ; Pyrazines
Chemical Substances	favipiravir (EW5GL2X7E0) ; Amides ; Pyrazines
Language	English
Publishing date	2024-01-05
Publishing country	Denmark
Document type	Letter
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.14235
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Article ; Online: Exploring cell-free assays for COVID-19 serosurvey.

Inchauste, Lucia / Nurtop, Elif / Brisbarre, Nadège / Ninove, Laetitia / Gallian, Pierre / de Lamballerie, Xavier / Priet, Stéphane

Scientific reports

2024 Volume 14, Issue 1, Page(s) 6096

Abstract: Serosurveys to monitor immunity toward COVID-19 in the population are primarily performed using an ELISA to screen samples for SARS-CoV-2 antibodies, followed by confirmation by a virus neutralization test, which is considered the Gold Standard. However, ...

Abstract	Serosurveys to monitor immunity toward COVID-19 in the population are primarily performed using an ELISA to screen samples for SARS-CoV-2 antibodies, followed by confirmation by a virus neutralization test, which is considered the Gold Standard. However, virus neutralization test may not be feasible for some laboratories because of the requirement for specific facilities and trained personnel. In an attempt to address this limitation, we evaluated three cell-free methods as potential alternatives for assessing SARS-CoV-2 seroprevalence in human population from plasma. We report the establishment of two inhibition ELISAs designed to detect anti-Spike RBD IgG antibodies and a microsphere quantitative suspension array technology assay, based on the Luminex xMAP platform, to measure the presence of antibodies against various SARS-CoV-2 antigens, including anti-RBD. These methods were also compared to a commercial chemiluminescent immunoassay designed for anti-RBD antibodies detection and to the combined ELISA + virus neutralization test strategy. These cell-free assays performed equally to estimate the percentage of positive and negative samples and could be used to determine the prevalence of SARS-CoV-2 antibodies in human population, at least in cohort with high-expected prevalence, without the use of seroneutralization assay.
MeSH term(s)	Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; SARS-CoV-2 ; Seroepidemiologic Studies ; Antibodies, Viral ; Antigens, Viral ; Antibodies, Neutralizing
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55852-6
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Article ; Online: Correspondence: serum neutralization of SARS-CoV-2 Omicron sublineages BA.1, BA.2 and BA.5 in lung transplant recipients receiving prophylactic tixagevimab/cilgavimab.

Eldin, Carole / Nurtop, Elif / Coiffard, Benjamin / Colombini, Nathalie / Ninove, Laetitia / Priet, Stéphane / Barthélémy, Karine / Reynaud-Gaubert, Martine / de Lamballerie, Xavier

Infection

2024

Language	English
Publishing date	2024-04-07
Publishing country	Germany
Document type	Letter
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-024-02258-1
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Article ; Online: Crimean-Congo Hemorrhagic Fever Virus in Ticks Collected from Cattle, Corsica, France, 2023.

Kiwan, Paloma / Masse, Shirley / Piorkowski, Geraldine / Ayhan, Nazli / Gasparine, Morena / Vial, Laurence / Charrel, Remi N / de Lamballerie, Xavier / Falchi, Alessandra

Emerging infectious diseases

2024 Volume 30, Issue 5, Page(s) 1036–1039

Abstract: We report the detection of Crimean-Congo hemorrhagic fever virus (CCHFV) in Corsica, France. We identified CCHFV African genotype I in ticks collected from cattle at 2 different sites in southeastern and central-western Corsica, indicating an established ...

Abstract	We report the detection of Crimean-Congo hemorrhagic fever virus (CCHFV) in Corsica, France. We identified CCHFV African genotype I in ticks collected from cattle at 2 different sites in southeastern and central-western Corsica, indicating an established CCHFV circulation. Healthcare professionals and at-risk groups should be alerted to CCHFV circulation in Corsica.
MeSH term(s)	Animals ; Hemorrhagic Fever Virus, Crimean-Congo/genetics ; Hemorrhagic Fever Virus, Crimean-Congo/isolation & purification ; Hemorrhagic Fever Virus, Crimean-Congo/classification ; Cattle ; France/epidemiology ; Hemorrhagic Fever, Crimean/veterinary ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever, Crimean/virology ; Cattle Diseases/virology ; Cattle Diseases/epidemiology ; Cattle Diseases/parasitology ; Ticks/virology ; Phylogeny ; Genotype ; Humans
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Research Support, Non-U.S. Gov't ; Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3005.231742
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Article ; Online: Estimating SARS-CoV-2 infection probabilities with serological data and a Bayesian mixture model.

Glemain, Benjamin / de Lamballerie, Xavier / Zins, Marie / Severi, Gianluca / Touvier, Mathilde / Deleuze, Jean-François / Lapidus, Nathanaël / Carrat, Fabrice

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9503

Abstract: The individual results of SARS-CoV-2 serological tests measured after the first pandemic wave of 2020 cannot be directly interpreted as a probability of having been infected. Plus, these results are usually returned as a binary or ternary variable, ... ...

Abstract	The individual results of SARS-CoV-2 serological tests measured after the first pandemic wave of 2020 cannot be directly interpreted as a probability of having been infected. Plus, these results are usually returned as a binary or ternary variable, relying on predefined cut-offs. We propose a Bayesian mixture model to estimate individual infection probabilities, based on 81,797 continuous anti-spike IgG tests from Euroimmun collected in France after the first wave. This approach used serological results as a continuous variable, and was therefore not based on diagnostic cut-offs. Cumulative incidence, which is necessary to compute infection probabilities, was estimated according to age and administrative region. In France, we found that a "negative" or a "positive" test, as classified by the manufacturer, could correspond to a probability of infection as high as 61.8% or as low as 67.7%, respectively. "Indeterminate" tests encompassed probabilities of infection ranging from 10.8 to 96.6%. Our model estimated tailored individual probabilities of SARS-CoV-2 infection based on age, region, and serological result. It can be applied in other contexts, if estimates of cumulative incidence are available.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Bayes Theorem ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Middle Aged ; Adult ; France/epidemiology ; Aged ; Antibodies, Viral/blood ; Probability ; Immunoglobulin G/blood ; Adolescent ; Female ; COVID-19 Serological Testing/methods ; Young Adult ; Male ; Incidence ; Child ; Child, Preschool ; Infant ; Aged, 80 and over
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60060-3
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