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Article ; Online: Extrahepatic Cholangiocarcinoma: What the Surgeon Needs to Know RadioGraphics Fundamentals | Online Presentation.

Itri, Jason N / de Lange, Eduard E

Radiographics : a review publication of the Radiological Society of North America, Inc

2018 Volume 38, Issue 7, Page(s) 2019–2020

MeSH term(s)	Bile Duct Neoplasms/classification ; Bile Duct Neoplasms/diagnostic imaging ; Bile Duct Neoplasms/surgery ; Cholangiocarcinoma/classification ; Cholangiocarcinoma/diagnostic imaging ; Cholangiocarcinoma/surgery ; Humans ; Magnetic Resonance Imaging ; Prognosis
Language	English
Publishing date	2018-11-13
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.2018180067
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Article ; Online: Highly accelerated dynamic acquisition of 3D grid-tagged hyperpolarized-gas lung images using compressed sensing.

Garrison, William J / Qing, Kun / Tafti, Sina / Mugler, John P / Shim, Y Michael / Mata, Jaime F / Cates, Gordon D / de Lange, Eduard E / Meyer, Craig H / Cai, Jing / Miller, G Wilson

Magnetic resonance in medicine

2023 Volume 89, Issue 6, Page(s) 2255–2263

Abstract: Purpose: To develop and test compressed sensing-based multiframe 3D MRI of grid-tagged hyperpolarized gas in the lung.: Theory and methods: Applying grid-tagging RF pulses to inhaled hyperpolarized gas results in images in which signal intensity is ... ...

Abstract	Purpose: To develop and test compressed sensing-based multiframe 3D MRI of grid-tagged hyperpolarized gas in the lung. Theory and methods: Applying grid-tagging RF pulses to inhaled hyperpolarized gas results in images in which signal intensity is predictably and sparsely distributed. In the present work, this phenomenon was used to produce a sampling pattern in which k-space is undersampled by a factor of approximately seven, yet regions of high k-space energy remain densely sampled. Three healthy subjects received multiframe 3D Results: Tags remained clearly resolvable for 4-6 timepoints (5-8 s) in each subject. Displacement maps revealed noteworthy temporal and spatial nonlinearities in lung motion during exhalation. Compressive normal strains occurred along all three principal directions but were primarily oriented in the head-foot direction. Fractional volume changes displayed clear bilateral symmetry, but with the lower lobes displaying slightly higher change than the upper lobes in 2 of the 3 subjects. Conclusion: We developed a compressed sensing-based method for multiframe 3D MRI of grid-tagged hyperpolarized gas in the lung during exhalation. This method successfully overcomes previous challenges for 3D dynamic grid-tagging, allowing time-resolved biomechanical readouts of lung function to be generated.
MeSH term(s)	Male ; Humans ; Lung/diagnostic imaging ; Respiration ; Magnetic Resonance Imaging/methods ; Data Compression
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.29595
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Book: Essentials of body MRI

Brant, William E / De Lange, Eduard E

2012

Abstract: Essentials of Body MRI extensively covers the field, offering clear and detailed guidance on MRI as an invaluable tool for the primary diagnosis and problem solving of diseases of the body, including the abdomen, liver, pancreas, pelvis, heart, urinary ... ...

Author's details	[edited by] William E. Brant, Eduard E. de Lange
Abstract	"Essentials of Body MRI extensively covers the field, offering clear and detailed guidance on MRI as an invaluable tool for the primary diagnosis and problem solving of diseases of the body, including the abdomen, liver, pancreas, pelvis, heart, urinary tract, and great vessels. The beginning chapters focus on the physics, pulse sequences and other practical considerations related to body MR imaging to help the reader fully understand the imaging appearance of clinical disease. The remaining chapters discuss the clinical applications, with the topics spanning from the normal anatomic structures and diagnosis of abdominal, pelvic, cardiac and vascular diseases to the modality's role as a tool for solving diagnostic problems. The key points of each chapter are boxed as "Essentials to Remember" for rapid review and learning. Written in clear, accessible text, and featuring 887 figures and numerous tables, Essentials of Body MRI is a resource that the radiology resident and physician will turn to again and again"--Provided by publisher.
MeSH term(s)	Magnetic Resonance Imaging
Language	English
Size	xv, 397 p. :, ill.
Publisher	Oxford University Press
Publishing place	New York
Document type	Book
ISBN	9780199738496 ; 0199738491
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Science to practice: what is new about detecting emphysema?

de Lange, Eduard E

Radiology

2006 Volume 239, Issue 3, Page(s) 619–620

Abstract: Through the use of diffusion-weighted 3He MR imaging, Fain et al in this issue of Radiology demonstrated the potential for detection of early emphysema in the lungs of healthy smokers. The technique possibly could become an important tool for ... ...

Abstract	Through the use of diffusion-weighted 3He MR imaging, Fain et al in this issue of Radiology demonstrated the potential for detection of early emphysema in the lungs of healthy smokers. The technique possibly could become an important tool for understanding the pulmonary processes that occur with emphysema, for implementing treatment before clinical symptoms occur, and for monitoring the effect of treatment.
MeSH term(s)	Diffusion Magnetic Resonance Imaging/methods ; Early Diagnosis ; Helium ; Humans ; Isotopes ; Pulmonary Emphysema/diagnosis ; Pulmonary Emphysema/prevention & control ; Respiratory Function Tests ; Smoking ; Tomography, X-Ray Computed/methods
Chemical Substances	Isotopes ; Helium (206GF3GB41)
Language	English
Publishing date	2006-06
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2393060147
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Article ; Online: Measures of ventilation heterogeneity mapped with hyperpolarized helium-3 MRI demonstrate a T2-high phenotype in asthma.

Gerald Teague, W / Mata, Jaime / Qing, Kun / Tustison, Nicholas J / Mugler, John P / Meyer, Craig H / de Lange, Eduard E / Shim, Yun M / Wavell, Kristin / Altes, Talissa A

Pediatric pulmonology

2021 Volume 56, Issue 6, Page(s) 1440–1448

Abstract: Background: Hyperpolarized gas with helium (HHe-3) MR (magnetic resonance) is a noninvasive imaging method which maps and quantifies regions of ventilation heterogeneity (VH) in the lung. VH is an important feature of asthma, but little is known as to ... ...

Abstract	Background: Hyperpolarized gas with helium (HHe-3) MR (magnetic resonance) is a noninvasive imaging method which maps and quantifies regions of ventilation heterogeneity (VH) in the lung. VH is an important feature of asthma, but little is known as to how VH informs patient phenotypes. Purpose: To determine if VH indicators quantified by HHe-3 MR imaging (MRI) predict phenotypic characteristics and map to regions of inflammation in children with problematic wheeze or asthma. Methods: Sixty children with poorly-controlled wheeze or asthma underwent HHe-3 MRI, including 22 with bronchoalveolar lavage (BAL). The HHe-3 signal intensity defined four ventilation compartments. The non-ventilated and hypoventilated compartments divided by the total lung volume defined a VH index (VHI %). Results: Children with VHI % in the upper quartile had significantly greater airflow limitation, bronchodilator responsiveness, blood eosinophils, expired nitric oxide (FeNO), and BAL eosinophilic or neutrophilic granulocyte patterns compared to children with VHI % in the lower quartile. Lavage return from hypoventilated bronchial segments had greater eosinophil % than from ventilated segments. Conclusion: In children with asthma, greater VHI % as measured by HHe-3 MRI identifies a severe phenotype with higher type 2 inflammatory markers, and maps to regions of lung eosinophilia. Listed on ClinicalTrials. gov (NCT02577497).
MeSH term(s)	Asthma/diagnostic imaging ; Helium ; Humans ; Isotopes ; Lung/diagnostic imaging ; Magnetic Resonance Imaging ; Phenotype
Chemical Substances	Isotopes ; Helium (206GF3GB41) ; Helium-3 (I83W8ELB18)
Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.25303
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Book: Body MRI cases

Brant, William E / De Lange, Eduard E

(Cases in radiology)

2013

Author's details	William E. Brant, Eduard E. de Lange
Series title	Cases in radiology
MeSH term(s)	Magnetic Resonance Imaging ; Image Interpretation, Computer-Assisted
Language	English
Size	xiii, 299 p. :, ill.
Publisher	Oxford University Press
Publishing place	New York
Document type	Book
ISBN	9780199740710 ; 0199740712
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Emphysema Index Based on Hyperpolarized

Tafti, Sina / Garrison, William J / Mugler, John P / Shim, Y Michael / Altes, Talissa A / Mata, Jaime F / de Lange, Eduard E / Cates, Gordon D / Ropp, Alan M / Wang, Chengbo / Miller, G Wilson

Radiology

2020 Volume 297, Issue 1, Page(s) 201–210

Abstract: Background Apparent diffusion coefficient (ADC) maps of inhaled hyperpolarized gases have shown promise in the characterization of emphysema in patients with chronic obstructive pulmonary disease (COPD), yet an easily interpreted quantitative metric ... ...

Abstract	Background Apparent diffusion coefficient (ADC) maps of inhaled hyperpolarized gases have shown promise in the characterization of emphysema in patients with chronic obstructive pulmonary disease (COPD), yet an easily interpreted quantitative metric beyond mean and standard deviation has not been established. Purpose To introduce a quantitative framework with which to characterize emphysema burden based on hyperpolarized helium 3 (
MeSH term(s)	Case-Control Studies ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Helium ; Humans ; Male ; Middle Aged ; Pulmonary Emphysema/diagnostic imaging ; Respiratory Function Tests ; Tomography, X-Ray Computed/methods ; Xenon Isotopes
Chemical Substances	Xenon Isotopes ; Xenon-129 ; Helium (206GF3GB41)
Language	English
Publishing date	2020-08-11
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2020192804
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Article ; Online: Fluoroscopy-guided jejunal extension tube placement through existing gastrostomy tubes: analysis of 391 procedures.

Uflacker, Andre / Qiao, Yujie / Easley, Genevieve / Patrie, James / Lambert, Drew / de Lange, Eduard E

Diagnostic and interventional radiology (Ankara, Turkey)

2015 Volume 21, Issue 6, Page(s) 488–493

Abstract: Purpose: We aimed to evaluate the safety and efficacy of fluoroscopically placed jejunal extension tubes (J-arm) in patients with existing gastrostomy tubes.: Methods: We conducted a retrospective review of 391 J-arm placements performed in 174 ... ...

Abstract	Purpose: We aimed to evaluate the safety and efficacy of fluoroscopically placed jejunal extension tubes (J-arm) in patients with existing gastrostomy tubes. Methods: We conducted a retrospective review of 391 J-arm placements performed in 174 patients. Indications for jejunal nutrition were aspiration risk (35%), pancreatitis (17%), gastroparesis (13%), gastric outlet obstruction (12%), and other (23%). Technical success, complications, malfunctions, and patency were assessed. Percutaneous gastrostomy (PEG) tube location, J-arm course, and fluoroscopy time were correlated with success/failure. Failure was defined as inability to exit the stomach. Procedure-related complications were defined as adverse events related to tube placement occurring within seven days. Tube malfunctions and aspiration events were recorded and assessed. Results: Technical success was achieved in 91.9% (95% CI, 86.7%-95.2%) of new tubes versus 94.2% (95% CI, 86.7%-95.2%) of replacements (P = 0.373). Periprocedural complications occurred in three patients (0.8%). Malfunctions occurred in 197 patients (50%). Median tube patency was 103 days (95% CI, 71-134 days). No association was found between successful J-arm placement and gastric PEG tube position (P = 0.677), indication for jejunal nutrition (P = 0.349), J-arm trajectory in the stomach and incidence of malfunction (P = 0.365), risk of tube migration and PEG tube position (P = 0.173), or J-arm length (P = 0.987). A fluoroscopy time of 21.3 min was identified as a threshold for failure. Malfunctions occurred more often in tubes replaced after 90 days than in tubes replaced before 90 days (P < 0.001). A total of 42 aspiration events occurred (OR 6.4, P < 0.001, compared with nonmalfunctioning tubes). Conclusion: Fluoroscopy-guided J-arm placement is safe for patients requiring jejunal nutrition. Tubes indwelling for longer than 90 days have higher rates of malfunction and aspiration.
MeSH term(s)	Adult ; Aged ; Equipment Failure ; Female ; Fluoroscopy ; Gastrostomy/adverse effects ; Gastrostomy/instrumentation ; Gastrostomy/methods ; Humans ; Jejunum/diagnostic imaging ; Jejunum/surgery ; Male ; Middle Aged ; Retrospective Studies
Language	English
Publishing date	2015-11
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2184145-7
ISSN	1305-3612 ; 1305-3825
ISSN (online)	1305-3612
ISSN	1305-3825
DOI	10.5152/dir.2015.14524
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Article ; Online: Hyperpolarized Helium-3 Diffusion-weighted Magnetic Resonance Imaging Detects Abnormalities of Lung Structure in Children With Bronchopulmonary Dysplasia.

Flors, Lucia / Mugler, John P / Paget-Brown, Alix / Froh, Deborah K / de Lange, Eduard E / Patrie, James T / Altes, Talissa A

Journal of thoracic imaging

2017 Volume 32, Issue 5, Page(s) 323–332

Abstract: Purpose: The aim of the study was to determine whether hyperpolarized He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children.: ... ...

Abstract	Purpose: The aim of the study was to determine whether hyperpolarized He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children. Materials and methods: All experiments were compliant with Health Insurance Portability and Accountability Act (HIPAA) and performed with Food and Drug Administration approval under an IND application. The protocol was approved by our Institutional Review Board, and written informed consent was obtained. Hyperpolarized He diffusion-weighted magnetic resonance imaging was performed in 16 subjects with a history of preterm birth complicated by BPD (age range, 6.8 to 13.5 y; mean, 9.0 y) and in 29 healthy term-birth subjects (age range, 4.5-14.7 y; mean, 9.2 y) using a gradient-echo sequence with bipolar diffusion gradients and with measurements at 2 b values (0 and 1.6 s/cm). Age-related comparison of the whole-lung mean apparent diffusion coefficient (ADC), 90th percentile ADC, and percentage of whole-lung volume with ADC>0.2 cm/s between the 2 groups was examined using ordinary least-squares multiple regression. Results: The mean ADC was significantly greater in subjects with BPD (0.187 vs. 0.152 cm/s, P<0.001). The 90th percentile ADC and mean percentage lung volume with ADC>0.2 cm/s were also higher in the BPD group (0.258 vs. 0.215 cm/s, 30.3% vs. 11.9%, P<0.001 for both). The body surface area-adjusted ventilated lung volume was similar in the 2 groups (1.93 vs. 1.91 L, P=0.90). Conclusions: Children with BPD had higher ADCs and the same lung volumes when compared with age-matched healthy subjects, suggesting that children with BPD have enlarged alveoli that are reduced in number.
MeSH term(s)	Adolescent ; Bronchopulmonary Dysplasia/diagnostic imaging ; Child ; Child, Preschool ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Helium ; Humans ; Isotopes ; Lung/abnormalities ; Lung/diagnostic imaging ; Male
Chemical Substances	Isotopes ; Helium (206GF3GB41) ; Helium-3 (I83W8ELB18)
Language	English
Publishing date	2017-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/RTI.0000000000000244
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Article ; Online: Imaging of the distal airways.

Tashkin, Donald P / de Lange, Eduard E

The Journal of allergy and clinical immunology

2009 Volume 124, Issue 6 Suppl, Page(s) S78–83

Abstract: Imaging techniques of the lung continue to advance, with improving ability to image the more distal airways. Two imaging techniques are reviewed: computed tomography and magnetic resonance with hyperpolarized helium-3. ...

Abstract	Imaging techniques of the lung continue to advance, with improving ability to image the more distal airways. Two imaging techniques are reviewed: computed tomography and magnetic resonance with hyperpolarized helium-3.
MeSH term(s)	Animals ; Asthma/diagnosis ; Asthma/diagnostic imaging ; Asthma/physiopathology ; Bronchioles/pathology ; Diagnostic Imaging/methods ; Helium ; Humans ; Lung/anatomy & histology ; Lung/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Tomography, X-Ray Computed/methods
Chemical Substances	Helium (206GF3GB41)
Language	English
Publishing date	2009-12-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2009.10.002
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