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  1. Artikel ; Online: Alpha-1-antitrypsin: A possible host protective factor against Covid-19.

    de Loyola, Mariana Braccialli / Dos Reis, Thaís Tereza Aguiar / de Oliveira, Guilherme Xavier Lyra Malcher / da Fonseca Palmeira, Julys / Argañaraz, Gustavo A / Argañaraz, Enrique R

    Reviews in medical virology

    2020  Band 31, Heft 2, Seite(n) e2157

    Abstract: Understanding Covid-19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha-1-antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti-inflammatory properties. A1AT ... ...

    Abstract Understanding Covid-19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha-1-antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti-inflammatory properties. A1AT inhibits SARS-CoV-2 infection and two of the most important proteases in the pathophysiology of Covid-19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflammatory molecules, such as IL-8, TNF-α, and neutrophil elastase (NE). TMPRSS2 is essential for SARS-CoV-2-S protein priming and viral infection. ADAM17 mediates ACE2, IL-6R, and TNF-α shedding. ACE2 is the SARS-CoV-2 entry receptor and a key component for the balance of the renin-angiotensin system, inflammation, vascular permeability, and pulmonary homeostasis. In addition, clinical findings indicate that A1AT levels might be important in defining Covid-19 outcomes, potentially partially explaining associations with air pollution and with diabetes. In this review, we focused on the interplay between A1AT with TMPRSS2, ADAM17 and immune molecules, and the role of A1AT in the pathophysiology of Covid-19, opening new avenues for investigating effective treatments.
    Mesh-Begriff(e) ADAM17 Protein/metabolism ; Animals ; COVID-19/metabolism ; Humans ; Protective Factors ; Serine Endopeptidases/metabolism ; alpha 1-Antitrypsin/metabolism
    Chemische Substanzen alpha 1-Antitrypsin ; Serine Endopeptidases (EC 3.4.21.-) ; ADAM17 Protein (EC 3.4.24.86)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-08-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1086043-5
    ISSN 1099-1654 ; 1052-9276
    ISSN (online) 1099-1654
    ISSN 1052-9276
    DOI 10.1002/rmv.2157
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Alpha-1-antitrypsin: A possible host protective factor against Covid-19

    de Loyola, Mariana Braccialli / Dos Reis, Thaís Tereza Aguiar / de Oliveira, Guilherme Xavier Lyra Malcher / da Fonseca Palmeira, Julys / Argañaraz, Gustavo A / Argañaraz, Enrique R

    Rev Med Virol

    Abstract: Understanding Covid-19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha-1-antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti-inflammatory properties. A1AT ... ...

    Abstract Understanding Covid-19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha-1-antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti-inflammatory properties. A1AT inhibits SARS-CoV-2 infection and two of the most important proteases in the pathophysiology of Covid-19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflammatory molecules, such as IL-8, TNF-α, and neutrophil elastase (NE). TMPRSS2 is essential for SARS-CoV-2-S protein priming and viral infection. ADAM17 mediates ACE2, IL-6R, and TNF-α shedding. ACE2 is the SARS-CoV-2 entry receptor and a key component for the balance of the renin-angiotensin system, inflammation, vascular permeability, and pulmonary homeostasis. In addition, clinical findings indicate that A1AT levels might be important in defining Covid-19 outcomes, potentially partially explaining associations with air pollution and with diabetes. In this review, we focused on the interplay between A1AT with TMPRSS2, ADAM17 and immune molecules, and the role of A1AT in the pathophysiology of Covid-19, opening new avenues for investigating effective treatments.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #731139
    Datenquelle COVID19

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