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Article ; Online: Similar but Not the Same?

de Medina, Fermín Sánchez

2016 Volume 22, Issue 9, Page(s) E31–2

Language	English
Publishing date	2016-08-19
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1097/MIB.0000000000000877
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Article: Corrigendum: A standardized extract of

Tena-Garitaonaindia, Mireia / Ceacero-Heras, Diego / Montoro, María Del Mar Maldonado / de Medina, Fermín Sánchez / Martínez-Augustin, Olga / Daddaoua, Abdelali

Frontiers in microbiology

2023 Volume 14, Page(s) 1183760

Abstract: This corrects the article DOI: 10.3389/fmicb.2022.814448.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmicb.2022.814448.].
Language	English
Publishing date	2023-03-28
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1183760
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Article ; Online: A perspective current and past modes of inhalation therapy.

Canto Mangana, José / Schilder, Kelsey Aguirre / Bretones-Pedrinaci, José Ignacio / Blesa, Ana Rosa Márquez / de Medina, Fermín Sánchez / Martínez-Augustin, Olga / Daddaoua, Abdelali

Microbial biotechnology

2024 Volume 17, Issue 2, Page(s) e14419

Abstract: Inhalation is the preferred route of delivery for anti-asthma and chronic obstructive pulmonary disease (COPD) drugs. The use of this route has demonstrated efficacy in these and other conditions, it offers rapid onset of action, and is associated with ... ...

Abstract	Inhalation is the preferred route of delivery for anti-asthma and chronic obstructive pulmonary disease (COPD) drugs. The use of this route has demonstrated efficacy in these and other conditions, it offers rapid onset of action, and is associated with minimal systemic exposure, thereby reducing the risk of adverse effects. Therefore, the current brief covers an interesting collection of inhaler action modes, shedding light on their molecular mechanisms and clinical applications for anti-asthma, COPD and antibacterial inhalation therapy. Hence, not only enriches our understanding of inhalation therapy molecular intricacies but also provides a comprehensive overview of the evolving landscape in clinical and antibacterial inhalation therapy. In doing so, it underscores the pivotal role of microbiology and biotechnology in advancing therapeutic approaches that harness the power of inhalation.
MeSH term(s)	Humans ; Administration, Inhalation ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Nebulizers and Vaporizers ; Pulmonary Disease, Chronic Obstructive/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2406063-X
ISSN	1751-7915 ; 1751-7915
ISSN (online)	1751-7915
ISSN	1751-7915
DOI	10.1111/1751-7915.14419
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Article: A Standardized Extract of

Tena-Garitaonaindia, Mireia / Ceacero-Heras, Diego / Montoro, María Del Mar Maldonado / de Medina, Fermín Sánchez / Martínez-Augustin, Olga / Daddaoua, Abdelali

Frontiers in microbiology

2022 Volume 13, Page(s) 814448

Abstract: The priority pathogen list of the World Health Organization ... ...

Abstract	The priority pathogen list of the World Health Organization classified
Language	English
Publishing date	2022-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.814448
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Article ; Online: Intestinal epithelial deletion of the glucocorticoid receptor NR3C1 alters expression of inflammatory mediators and barrier function.

Aranda, Carlos J / Arredondo-Amador, María / Ocón, Borja / Lavín, Jose Luis / Aransay, Ana María / Martínez-Augustin, Olga / de Medina, Fermín Sánchez

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2019 Volume 33, Issue 12, Page(s) 14067–14082

Abstract: Glucocorticoids (GCs) are important hormones involved in the regulation of multiple physiologic functions. GCs are also widely used in anti-inflammatory/immunosuppressant drugs. GCs are synthesized by the adrenal cortex as part of the hypothalamus- ... ...

Abstract	Glucocorticoids (GCs) are important hormones involved in the regulation of multiple physiologic functions. GCs are also widely used in anti-inflammatory/immunosuppressant drugs. GCs are synthesized by the adrenal cortex as part of the hypothalamus-pituitary-adrenal axis and also by intestinal epithelial cells, among other peripheral sites. GCs are one of the main therapy choices for the exacerbations of inflammatory bowel disease, but they are not useful to prolong remission, and development of tolerance with secondary treatment failure is frequent. Thus, GC actions at the intestinal epithelial level are of great importance, both physiologically and pharmacologically. We generated a tamoxifen-inducible nuclear receptor subfamily 3 group C member 1 (NR3C1)
MeSH term(s)	Animals ; Calgranulin A/genetics ; Calgranulin A/metabolism ; Calgranulin B/genetics ; Calgranulin B/metabolism ; Epithelial Cells/metabolism ; Estrogen Antagonists/toxicity ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/physiology ; Inflammation/metabolism ; Intestinal Mucosa/cytology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Tamoxifen/toxicity
Chemical Substances	Calgranulin A ; Calgranulin B ; Estrogen Antagonists ; NR3C1 protein, mouse ; Receptors, Chemokine ; Receptors, Glucocorticoid ; S100A9 protein, mouse ; S100a8 protein, mouse ; Tamoxifen (094ZI81Y45)
Language	English
Publishing date	2019-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.201900404RR
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.

Gámez-Belmonte, Reyes / Tena-Garitaonaindia, Mireia / Hernández-Chirlaque, Cristina / Córdova, Samir / Ceacero-Heras, Diego / de Medina, Fermín Sánchez / Martínez-Augustin, Olga

International journal of molecular sciences

2020 Volume 22, Issue 1

Abstract: The liver expresses tissue-nonspecific alkaline phosphatase (TNAP), which may participate in the defense against bacterial components, in cell regulation as part of the purinome or in bile secretion, among other roles. We aimed to study the role of TNAP ... ...

Abstract	The liver expresses tissue-nonspecific alkaline phosphatase (TNAP), which may participate in the defense against bacterial components, in cell regulation as part of the purinome or in bile secretion, among other roles. We aimed to study the role of TNAP in the development of hepatosteatosis. TNAP
MeSH term(s)	Alkaline Phosphatase/deficiency ; Alkaline Phosphatase/metabolism ; Alleles ; Animals ; Choline/metabolism ; Choline Deficiency ; Diet ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Enzyme Activation ; Fatty Liver/etiology ; Fatty Liver/metabolism ; Methionine/deficiency ; Methionine/metabolism ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinases/metabolism ; PPAR alpha/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	PPAR alpha ; Ppara protein, mouse ; Methionine (AE28F7PNPL) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Alkaline Phosphatase (EC 3.1.3.1) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2020-12-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22010051
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Article ; Online: Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota.

Cian, Raúl E / Drago, Silvina R / de Medina, Fermín Sánchez / Martínez-Augustin, Olga

Marine drugs

2015 Volume 13, Issue 8, Page(s) 5358–5383

Abstract: Based on their composition, marine algae, and namely red seaweeds, are good potential functional foods. Intestinal mucosal barrier function refers to the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules. ... ...

Abstract	Based on their composition, marine algae, and namely red seaweeds, are good potential functional foods. Intestinal mucosal barrier function refers to the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules. Here, we will first outline the component of seaweeds and will summarize the effects of these on the regulation of mucosal barrier function. Special attention will be paid to unique components of red seaweeds: proteins and derived peptides (e.g., phycobiliproteins, glycoproteins that contain "cellulose binding domains", phycolectins and the related mycosporine-like amino acids) together with polysaccharides (e.g., floridean starch and sulfated galactans, such as carrageenans, agarans and "dl-hybrid") and minerals. These compounds have been shown to exert prebiotic effects, to regulate intestinal epithelial cell, macrophage and lymphocyte proliferation and differentiation and to modulate the immune response. Molecular mechanisms of action of peptides and polysaccharides are starting to be elucidated, and evidence indicating the involvement of epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGFR), Toll-like receptors (TLR) and signal transduction pathways mediated by protein kinase B (PKB or AKT), nuclear factor-κB (NF-κB) and mitogen activated protein kinases (MAPK) will also be summarized. The need for further research is clear, but in vivo experiments point to an overall antiinflammatory effect of these algae, indicating that they can reinforce membrane barrier function.
MeSH term(s)	Animals ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Tract/drug effects ; Gastrointestinal Tract/microbiology ; Humans ; Peptides/pharmacology ; Polysaccharides/pharmacology ; Proteins/pharmacology ; Seaweed/metabolism
Chemical Substances	Peptides ; Polysaccharides ; Proteins
Language	English
Publishing date	2015-08-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md13085358
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Article: Fructooligosaccharides exert intestinal anti-inflammatory activity in the CD4+ CD62L+ T cell transfer model of colitis in C57BL/6J mice

Capitán-Cañadas, Fermín / Ocón, Borja / Aranda, Carlos José / Anzola, Andrea / Suárez, María Dolores / Zarzuelo, Antonio / de Medina, Fermín Sánchez / Martínez-Augustin, Olga

European journal of nutrition. 2016 June, v. 55, no. 4

2016

Abstract: PURPOSE: Fructooligosaccharides (FOS) are used as functional foods due to their prebiotic effects. Intestinal anti-inflammatory activity has been established in most, but not all, studies in animal models of colitis, using mainly chemically induced ... ...

Abstract	PURPOSE: Fructooligosaccharides (FOS) are used as functional foods due to their prebiotic effects. Intestinal anti-inflammatory activity has been established in most, but not all, studies in animal models of colitis, using mainly chemically induced inflammation. Our goal was to test the effect of FOS (degree of polymerization 2–8) in the chronic, lymphocyte-driven CD4+ CD62L+ T cell transfer model of colitis. METHODS: Colitis was induced by transfer of CD4+ CD62L+ T cells to C57BL/6J Rag1⁻/⁻ mice. FOS (75 mg day⁻¹) was administered by gavage as a post-treatment. Three groups were established: non-colitic (NC), colitic control (C, CD4+ CD62L+ transferred mice treated with vehicle) and colitic+FOS (C+FOS, similar but treated with FOS). Mice were killed after 13 days. RESULTS: Treatment of mice with FOS ameliorated colitis, as evidenced by an increase in body weight, a lesser myeloperoxidase and alkaline phosphatase activities, a lower secretion of proinflammatory cytokines by mesenteric lymph node cells ex vivo (IFN-γ, IL-17, and TNF-α), and a higher colonic expression of occludin (C+FOS vs. C, p < 0.05). Increased relative abundance of lactic acid bacteria was observed in FOS-treated mice (p < 0.05). CONCLUSIONS: FOS exert intestinal anti-inflammatory activity in T lymphocyte-dependent colitis, suggesting it may be useful in the management of inflammatory bowel disease in appropriate conditions.
Keywords	T-lymphocytes ; alkaline phosphatase ; animal models ; anti-inflammatory activity ; body weight ; colitis ; fructooligosaccharides ; functional foods ; inflammation ; interferon-gamma ; interleukin-17 ; lactic acid bacteria ; lymph nodes ; mice ; myeloperoxidase ; occludins ; polymerization ; prebiotics ; secretion ; tumor necrosis factor-alpha
Language	English
Dates of publication	2016-06
Size	p. 1445-1454.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-015-0962-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Insulin Crystals Grown in Short-Peptide Supramolecular Hydrogels Show Enhanced Thermal Stability and Slower Release Profile.

Contreras-Montoya, Rafael / Arredondo-Amador, María / Escolano-Casado, Guillermo / Mañas-Torres, Mari C / González, Mercedes / Conejero-Muriel, Mayte / Bhatia, Vaibhav / Díaz-Mochón, Juan J / Martínez-Augustin, Olga / de Medina, Fermín Sánchez / Lopez-Lopez, Modesto T / Conejero-Lara, Francisco / Gavira, José A / de Cienfuegos, Luis Álvarez

ACS applied materials & interfaces

2021 Volume 13, Issue 10, Page(s) 11672–11682

Abstract: Protein therapeutics have a major role in medicine in that they are used to treat diverse pathologies. Their three-dimensional structures not only offer higher specificity and lower toxicity than small organic compounds but also make them less stable, ... ...

Abstract	Protein therapeutics have a major role in medicine in that they are used to treat diverse pathologies. Their three-dimensional structures not only offer higher specificity and lower toxicity than small organic compounds but also make them less stable, limiting their
MeSH term(s)	Animals ; Crystallization/methods ; Drug Liberation ; Humans ; Hydrogels/chemistry ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/chemistry ; Insulin/administration & dosage ; Insulin/chemistry ; Male ; Peptides/chemistry ; Protein Stability ; Rats, Wistar ; Rats
Chemical Substances	Hydrogels ; Hypoglycemic Agents ; Insulin ; Peptides
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c00639
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Article: Host–microbe interactions: the difficult yet peaceful coexistence of the microbiota and the intestinal mucosa

de Medina, Fermín Sánchez / Ortega-González, Mercedes / González-Pérez, Raquel / Capitán-Cañadas, Fermín / Martínez-Augustin, Olga

British journal of nutrition. 2013 Jan., v. 109, no. S2

2013

Abstract: The immune system has evolved to live in a collaborative relationship with the microbiota, while still serving its seminal function to fight off invasive pathogenic bacteria. The mechanisms that rule the interactions between the intestinal microbiota and ...

Abstract	The immune system has evolved to live in a collaborative relationship with the microbiota, while still serving its seminal function to fight off invasive pathogenic bacteria. The mechanisms that rule the interactions between the intestinal microbiota and the intestinal immune system are the focus of intense research. Here, we describe how the innate immunity is, to a great extent, in charge of the control of the microbiota in the intestine and relies on non-specific receptors called pathogen-recognition receptors. While the microbiota has a well-defined effect on the host immune homoeostasis, it has become clear that the opposite is also true, i.e., the mucosal immune system has the capacity to shape the microbial population. The mechanisms that rule the reciprocal regulation between host immunity and commensal bacteria (including specific bacteria) are currently being elucidated and will be described here. A better knowledge of how the host and bacteria interact and how the intestinal microbiota and the immune system are co-regulated will provide the basis for a better understanding of intestinal and systemic immunopathologies and for the development of new therapeutic approaches.
Keywords	bacteria ; host-pathogen relationships ; immune system ; innate immunity ; intestinal microorganisms ; intestinal mucosa ; mucosal immunity ; receptors ; therapeutics ; virulent strains
Language	English
Dates of publication	2013-01
Size	p. S12-S20.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114512004035
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