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  1. Article ; Online: Is imiquimod a promising drug to treat oral mucosa diseases? A scoping review and new perspectives.

    de Mello Palma, Victor / Frank, Luiza Abrahão / Balinha, Daiana Moraes / Rados, Pantelis Varvaki / Pohlmann, Adriana Raffin / Guterres, Silvia Stanisçuaski / Visioli, Fernanda

    British journal of clinical pharmacology

    2023  Volume 90, Issue 2, Page(s) 427–439

    Abstract: Imiquimod (IMQ) is a chemotherapeutic and immunostimulant drug that is applied topically, demonstrating antitumor and antiviral activities. The objective of this review was to compile data on the off-label use of IMQ in oral mucosal diseases. IMQ has ... ...

    Abstract Imiquimod (IMQ) is a chemotherapeutic and immunostimulant drug that is applied topically, demonstrating antitumor and antiviral activities. The objective of this review was to compile data on the off-label use of IMQ in oral mucosal diseases. IMQ has exhibited effectiveness in the treatment of various oral mucosal conditions, including oral carcinogenic lesions, neoplasms, HPV-related lesions and autoimmune disorders. Although IMQ holds promise as a potential strategy for addressing oral mucosal lesions, it is important to note that significant side effects have been frequently reported. Nonetheless, it is crucial to develop and test new technological systems, such as the combination of nanotechnology with innovative drug delivery platforms. These advancements aim to minimize side effects and prolong the drug's contact time with the mucosa, preventing its removal by salivary flow.
    MeSH term(s) Humans ; Imiquimod/therapeutic use ; Pharmaceutical Preparations ; Mouth Mucosa ; Drug Delivery Systems
    Chemical Substances Imiquimod (P1QW714R7M) ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-10-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Study of Pathological Changes in the Dental Follicle of Disease-Free Impacted Third Molars.

    de Mello Palma, Victor / Danesi, Cristiane Cademartori / Arend, Cristiane Frantz / Venturini, Andressa Borin / Blaya, Diego Segatto / Neto, Marcos Martins / Flores, Jorge Abel / Ferrazzo, Kivia Linhares

    Journal of maxillofacial and oral surgery

    2018  Volume 17, Issue 4, Page(s) 611–615

    Abstract: Background: The prophylactic extraction of third molars is a common practice in dental offices, but divergent opinions are found in the literature regarding the indication of this procedure. The aim of the present study was to determine the prevalence ... ...

    Abstract Background: The prophylactic extraction of third molars is a common practice in dental offices, but divergent opinions are found in the literature regarding the indication of this procedure. The aim of the present study was to determine the prevalence of pathological changes associated with the pericoronal tissue of asymptomatic impacted third molars that could justify prophylactic extraction.
    Materials and methods: A cross-sectional observational study was conducted in which 109 pericoronal tissues with no radiographic evidence of pathology were histopathologically analyzed. The specimens were fixed in 10% formalin, embedded in paraffin, stained with hematoxylin and eosin and analyzed individually by two pathologists.
    Result: The frequency of inflammatory infiltrate in the dental follicle of patients older than 20 years of age was significantly higher than that of younger patients (
    Conclusion: Pathological changes may be present in the dental follicle of impacted third molars even in the absence of clinical or radiographic signs of disease.
    Language English
    Publishing date 2018-06-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2502352-4
    ISSN 0974-942X ; 0972-8279
    ISSN (online) 0974-942X
    ISSN 0972-8279
    DOI 10.1007/s12663-018-1131-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antimicrobial photodynamic therapy with photosensitizer in ethanol improves oxidative status and gingival collagen in a short-term in periodontitis.

    Pillusky, Fernanda Maia / Barcelos, Raquel Cristine Silva / Vey, Luciana Taschetto / Barin, Luisa Machado / de Mello Palma, Victor / Maciel, Roberto Marinho / Kantorski, Karla Zanini / Bürger, Marilise Escobar / Danesi, Cristiane Cademartori

    Photodiagnosis and photodynamic therapy

    2017  Volume 19, Page(s) 119–127

    Abstract: Background: This study evaluated the antimicrobial photodynamic therapy (aPDT) effects using the methylene blue (MB) in ethanol 20% on systemic oxidative status and collagen content from gingiva of rats with periodontitis.: Methods: Rats were divided ...

    Abstract Background: This study evaluated the antimicrobial photodynamic therapy (aPDT) effects using the methylene blue (MB) in ethanol 20% on systemic oxidative status and collagen content from gingiva of rats with periodontitis.
    Methods: Rats were divided into five experimental groups: NC (negative control; no periodontitis); PC (positive control; periodontitis without any treatment); SRP (periodontitis and scaling and root planing), aPDT I (periodontitis and SRP+aPDT+MB solubilized in water), and aPDT II (periodontitis and SRP+aPDT+MB solubilized in ethanol 20%). After 7days of removal of the ligature, the periodontal treatments were performed. At 7/15/30days, gingival tissue was removed for morphometric analysis. The erythrocytes were used to evaluate systemic oxidative status.
    Results: PC group showed higher lipoperoxidation levels at 7/15/30days. aPDT indicated a protective influence in erythrocytes at 15days observed by the elevation in levels of systemic antioxidant defense. aPDT II group was the only one that restored the total collagen area in 15days, and recovered the type I collagen area at the same time point.
    Conclusions: aPDT as an adjunct to the SRP can induce the systemic protective response against oxidative stress periodontitis-induced and recover the gingival collagen, thus promoting the healing periodontal, particularly when the MB is dissolved in ethanol 20%.
    Language English
    Publishing date 2017-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2017.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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