Article ; Online: Physiological relevance of ACOT8-Nef interaction in HIV infection.
2019 Volume 29, Issue 5, Page(s) e2057
Abstract: During human immunodeficiency virus (HIV) infection, Nef viral protein plays a crucial role in viral pathogenesis and progression of acquired immunodeficiency syndrome. Nef is expressed in the early stages of infection and alters the cellular environment ...
| Abstract | During human immunodeficiency virus (HIV) infection, Nef viral protein plays a crucial role in viral pathogenesis and progression of acquired immunodeficiency syndrome. Nef is expressed in the early stages of infection and alters the cellular environment increasing infectivity, viral replication, and the evasion of host immune response through several mechanisms. Nef has numerous functional domains that allow it to interact with a number of proteins, interfering with intracellular traffic. Among these proteins, human peroxisomal thioesterase 8, ACOT8, has been shown to be an important cellular partner of Nef. It has been suggested that this interaction may be involved in Nef-dependent endocytosis and also in the modulation of lipid composition in membrane rafts. However, the actual role of this interaction, as well as the mechanisms involved, has not yet been fully elucidated. In this review, we focused on the interplay between Nef and ACOT8 proteins, highlighting the possible physiological relevance in HIV infection. |
|---|---|
| MeSH term(s) | Biomarkers ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/physiology ; Host-Pathogen Interactions ; Humans ; Palmitoyl-CoA Hydrolase/metabolism ; Protein Binding ; nef Gene Products, Human Immunodeficiency Virus/metabolism |
| Chemical Substances | Biomarkers ; nef Gene Products, Human Immunodeficiency Virus ; ACOT8 protein, human (EC 3.1.2.2) ; Palmitoyl-CoA Hydrolase (EC 3.1.2.2) |
| Language | English |
| Publishing date | 2019-06-09 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 1086043-5 |
| ISSN | 1099-1654 ; 1052-9276 |
| ISSN (online) | 1099-1654 |
| ISSN | 1052-9276 |
| DOI | 10.1002/rmv.2057 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 3308: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.