Article ; Online: Molecular targets for Chagas disease: validation, challenges and lead compounds for widely exploited targets.
Expert opinion on therapeutic targets
2023 Volume 27, Issue 10, Page(s) 911–925
Abstract: Introduction: Chagas disease (CD) imposes social and economic burdens, yet the available treatments have limited efficacy in the disease's chronic phase and cause serious adverse effects. To address this challenge, target-based approaches are a possible ...
| Abstract | Introduction: Chagas disease (CD) imposes social and economic burdens, yet the available treatments have limited efficacy in the disease's chronic phase and cause serious adverse effects. To address this challenge, target-based approaches are a possible strategy to develop new, safe, and active treatments for both phases of the disease. Areas covered: This review delves into target-based approaches applied to CD drug discovery, emphasizing the studies from the last five years. We highlight the proteins cruzain (CZ), trypanothione reductase (TR), sterol 14 α-demethylase (CPY51), iron superoxide dismutase (Fe-SOD), proteasome, cytochrome Expert opinion: Target-based approaches toward developing potential CD therapeutics have yielded promising leads in recent years. We expect a significant advance in this field in the next decade, fueled by the new options for |
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| MeSH term(s) | Humans ; Chagas Disease/drug therapy ; Trypanosoma cruzi/genetics ; Drug Discovery | |||||
| Language | English | |||||
| Publishing date | 2023-10-30 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2055208-7 | |||||
| ISSN | 1744-7631 ; 1472-8222 | |||||
| ISSN (online) | 1744-7631 | |||||
| ISSN | 1472-8222 | |||||
| DOI | 10.1080/14728222.2023.2264512 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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