Article ; Online: GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms.
2022 Volume 12, Issue 11, Page(s) 149
Abstract: Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription ... ...
| Abstract | Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription factors and signaling pathways that are critically important in normal T-cell biology, including those implicated in antigen-, costimulatory-, and cytokine-receptor signaling. The transcription factor GATA-3 regulates the growth and proliferation of both immature and mature T cells and has recently been implicated in T-cell neoplasms, including the most common mature T-cell lymphoma observed in much of the Western world. Here we show that GATA-3 is a proto-oncogene across the spectrum of T-cell neoplasms, including those derived from T-cell progenitors and their mature progeny, and further define the transcriptional programs that are GATA-3 dependent, which include therapeutically targetable gene products. The discovery that p300-dependent acetylation regulates GATA-3 mediated transcription by attenuating DNA binding has novel therapeutic implications. As most patients afflicted with GATA-3 driven T-cell neoplasms will succumb to their disease within a few years of diagnosis, these findings suggest opportunities to improve outcomes for these patients. |
|---|---|
| MeSH term(s) | Humans ; Cell Differentiation ; DNA-Binding Proteins/genetics ; Neoplasms/metabolism ; Proto-Oncogenes/genetics ; T-Lymphocyte Subsets ; Leukemia, Lymphoid |
| Chemical Substances | DNA-Binding Proteins |
| Language | English |
| Publishing date | 2022-11-04 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2600560-8 |
| ISSN | 2044-5385 ; 2044-5385 |
| ISSN (online) | 2044-5385 |
| ISSN | 2044-5385 |
| DOI | 10.1038/s41408-022-00745-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.