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  1. Article ; Online: Effects of portable pedal machines at work on lipoprotein subfraction profile in sedentary workers - the REMOVE study.

    Nasir, Hijrah / Dutheil, Frederic / Ramos, Ines / Guirado, Terry / de Saint-Vincent, Sarah / Thivel, David / Metz, Lore / Duclos, Martine

    Lipids in health and disease

    2024  Volume 23, Issue 1, Page(s) 105

    Abstract: Background: Sedentary behaviour at work is a major cause of atherosclerosis, particularly in tertiary workers. However, no studies have ever assessed the effect of active workstation on lipoprotein subfraction profile. This study aimed to evaluate the ... ...

    Abstract Background: Sedentary behaviour at work is a major cause of atherosclerosis, particularly in tertiary workers. However, no studies have ever assessed the effect of active workstation on lipoprotein subfraction profile. This study aimed to evaluate the effect of 12-week portable pedal machines (PPMs) on lipoprotein subfraction profile among healthy sedentary workers.
    Methods: Healthy administrative workers were randomized into an intervention group using PPMs for 12 weeks or a control group using normal-desk. Lipoprotein subfractions were assessed using Lipoprint® electrophoresis. Main outcomes were explored using mixed models with sensitivity analyses (four models).
    Results: We included 40 participants (43.7 ± 8.6 years old, 100% women, BMI 23.8 ± 3.4 kg/m
    Conclusions: Lipoprotein profile was improved after a 12-week PPMs intervention at work in healthy administrative workers. Changes were mainly showed for LDL and LDL subfractions. Lipoprotein profile was worsened by stress at work, BMI and age.
    Trial registration: NCT04153214.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Middle Aged ; Atherosclerosis ; Cholesterol ; Health Status ; Lipoproteins ; Lipoproteins, LDL
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Lipoproteins ; Lipoproteins, LDL
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2091381-3
    ISSN 1476-511X ; 1476-511X
    ISSN (online) 1476-511X
    ISSN 1476-511X
    DOI 10.1186/s12944-024-02098-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis.

    Dutheil, Frédéric / de Saint Vincent, Sarah / Pereira, Bruno / Schmidt, Jeannot / Moustafa, Farès / Charkhabi, Morteza / Bouillon-Minois, Jean-Baptiste / Clinchamps, Maëlys

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 688367

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.688367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Deleterious Effect of High-Fat Diet on Skeletal Muscle Performance Is Prevented by High-Protein Intake in Adult Rats but Not in Old Rats.

    Poggiogalle, Eleonora / Rossignon, Fanny / Carayon, Aude / Capel, Fréderic / Rigaudière, Jean-Paul / De Saint Vincent, Sarah / Le-Bacquer, Olivier / Salles, Jérôme / Giraudet, Christophe / Patrac, Véronique / Lebecque, Patrice / Walrand, Stéphane / Boirie, Yves / Martin, Vincent / Guillet, Christelle

    Frontiers in physiology

    2022  Volume 12, Page(s) 749049

    Abstract: The phenotype of sarcopenic obesity is frequently associated with impaired muscle strength and performance. Ectopic lipid deposition may interfere with muscle anabolic response especially during aging. Evidence is scarce concerning the potential ... ...

    Abstract The phenotype of sarcopenic obesity is frequently associated with impaired muscle strength and performance. Ectopic lipid deposition may interfere with muscle anabolic response especially during aging. Evidence is scarce concerning the potential interplay among aging and nutrient imbalance on skeletal muscle functionality. The objective of the present study was to investigate the impact of protein intake in the context of an obesogenic diet on skeletal muscle functional properties and intramuscular lipid infiltration. Two groups of forty-two adult and thirty-seven old male Wistar rats were randomly divided into four groups: isocaloric standard diet (12% protein, 14% lipid, as ST12); isocaloric standard (high-protein) diet (25% protein, 14% lipid, ST25); hypercaloric high-fat (normal-protein) diet (12% protein, 45% lipid, HF12); and hypercaloric high-fat (high-protein) diet (25% protein, 45% lipid, HF25). The nutritional intervention lasted 10 weeks. Total body composition was measured through Echo-MRI. Lipids were extracted from tibialis anterior muscle and analyzed by gas-liquid chromatography. The functional properties of the plantarflexor muscles were evaluated
    Language English
    Publishing date 2022-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.749049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Impact of Job-Demand-Control-Support on Leptin and Ghrelin as Biomarkers of Stress in Emergency Healthcare Workers.

    Bouillon-Minois, Jean-Baptiste / Outrey, Justin / Pereira, Bruno / Adeyemi, Oluwaseun John / Sapin, Vincent / Bouvier, Damien / Thivel, David / de Saint-Vincent, Sarah / Ugbolue, Ukadike Chris / Baker, Julien S / Bagheri, Reza / Schmidt, Jeannot / Trousselard, Marion / Dutheil, Frédéric

    Nutrients

    2022  Volume 14, Issue 23

    Abstract: Despite the available literature on the consequences of night shiftwork on stress and food intake, its impact on leptin and ghrelin has never been studied. We previously demonstrated that leptin and ghrelin were biomarkers related to stress, and acute ... ...

    Abstract Despite the available literature on the consequences of night shiftwork on stress and food intake, its impact on leptin and ghrelin has never been studied. We previously demonstrated that leptin and ghrelin were biomarkers related to stress, and acute stress-induced a decrease in leptin levels and an increase in ghrelin levels. We performed a prospective observational study to assess the influence of night work, nutrition, and stress on the levels of ghrelin and leptin among emergency healthcare workers (HCWs). We took salivary samples at the beginning of a day shift and/or at the end of a night shift. We also monitored stress using the job demand-control-support model of Karasek. We recorded 24-h food intake during the day shift and the consecutive night shift and during night work and the day before. We included 161 emergency HCWs. Emergency HCWs had a tendency for decreased levels of leptin following the night shift compared to before the dayshift (
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14235009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An Integrated Analysis of miRNA and Gene Expression Changes in Response to an Obesogenic Diet to Explore the Impact of Transgenerational Supplementation with Omega 3 Fatty Acids.

    Corral-Jara, Karla Fabiola / Cantini, Laura / Poupin, Nathalie / Ye, Tao / Rigaudière, Jean Paul / De Saint Vincent, Sarah / Pinel, Alexandre / Morio, Béatrice / Capel, Frédéric

    Nutrients

    2020  Volume 12, Issue 12

    Abstract: Insulin resistance decreases the ability of insulin to inhibit hepatic gluconeogenesis, a key step in the development of metabolic syndrome. Metabolic alterations, fat accumulation, and fibrosis in the liver are closely related and contribute to the ... ...

    Abstract Insulin resistance decreases the ability of insulin to inhibit hepatic gluconeogenesis, a key step in the development of metabolic syndrome. Metabolic alterations, fat accumulation, and fibrosis in the liver are closely related and contribute to the progression of comorbidities, such as hypertension, type 2 diabetes, or cancer. Omega 3 (
    MeSH term(s) Animals ; Diet, High-Fat/adverse effects ; Diet, High-Fat/methods ; Dietary Supplements ; Disease Models, Animal ; Fatty Acids, Omega-3/administration & dosage ; Fatty Acids, Omega-3/blood ; Gene Expression/drug effects ; Liver/metabolism ; Male ; Metabolic Syndrome/blood ; Mice ; Mice, Inbred C57BL ; MicroRNAs/blood ; MicroRNAs/drug effects
    Chemical Substances Fatty Acids, Omega-3 ; MicroRNAs
    Language English
    Publishing date 2020-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12123864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: EPA prevents fat mass expansion and metabolic disturbances in mice fed with a Western diet.

    Pinel, Alexandre / Pitois, Elodie / Rigaudiere, Jean-Paul / Jouve, Chrystele / De Saint-Vincent, Sarah / Laillet, Brigitte / Montaurier, Christophe / Huertas, Alain / Morio, Beatrice / Capel, Frederic

    Journal of lipid research

    2016  Volume 57, Issue 8, Page(s) 1382–1397

    Abstract: The impact of alpha linolenic acid (ALA), EPA, and DHA on obesity and metabolic complications was studied in mice fed a high-fat, high-sucrose (HF) diet. HF diets were supplemented with ALA, EPA, or DHA (1% w/w) and given to C57BL/6J mice for 16 weeks ... ...

    Abstract The impact of alpha linolenic acid (ALA), EPA, and DHA on obesity and metabolic complications was studied in mice fed a high-fat, high-sucrose (HF) diet. HF diets were supplemented with ALA, EPA, or DHA (1% w/w) and given to C57BL/6J mice for 16 weeks and to Ob/Ob mice for 6 weeks. In C57BL/6J mice, EPA reduced plasma cholesterol (-20%), limited fat mass accumulation (-23%) and adipose cell hypertrophy (-50%), and reduced plasma leptin concentration (-60%) compared with HF-fed mice. Furthermore, mice supplemented with EPA exhibited a higher insulin sensitivity (+24%) and glucose tolerance (+20%) compared with HF-fed mice. Similar effects were observed in EPA-supplemented Ob/Ob mice, although fat mass accumulation was not prevented. By contrast, in comparison with HF-fed mice, DHA did not prevent fat mass accumulation, increased plasma leptin concentration (+128%) in C57BL/6J mice, and did not improve glucose homeostasis in C57BL/6J and Ob/Ob mice. In 3T3-L1 adipocytes, DHA stimulated leptin expression whereas EPA induced adiponectin expression, suggesting that improved leptin/adiponectin balance may contribute to the protective effect of EPA. In conclusion, supplementation with EPA, but not ALA and DHA, could preserve glucose homeostasis in an obesogenic environment and limit fat mass accumulation in the early stage of weight gain.
    MeSH term(s) 3T3-L1 Cells ; Adipogenesis ; Adipokines/metabolism ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Adipose Tissue, White/pathology ; Adiposity/drug effects ; Animals ; Anti-Obesity Agents/pharmacology ; Cell Membrane/metabolism ; Diet, Western/adverse effects ; Drug Evaluation, Preclinical ; Eicosapentaenoic Acid/pharmacology ; Erythrocytes/metabolism ; Gene Expression ; Glucose Intolerance ; Insulin Resistance ; Leptin/genetics ; Leptin/metabolism ; Lipid Metabolism/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/drug therapy ; Obesity/etiology ; Obesity/metabolism ; Phospholipids/metabolism
    Chemical Substances Adipokines ; Anti-Obesity Agents ; Leptin ; Phospholipids ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Language English
    Publishing date 2016-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.M065458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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