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Article: Subsets of Cytokines and Chemokines from DENV-4-Infected Patients Could Regulate the Endothelial Integrity of Cultured Microvascular Endothelial Cells.

Cipitelli, Marcio da Costa / Paiva, Iury Amancio / Badolato-Corrêa, Jéssica / Marinho, Cíntia Ferreira / Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / de Azeredo, Elzinandes Leal / de Souza, Luiz José / da Cunha, Rivaldo Venâncio / de-Oliveira-Pinto, Luzia Maria

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2022-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11050509
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Chikungunya Virus Multiepitope Recombinant Protein Expressed from the Binary System Insect Cell/Recombinant Baculovirus Is Useful for Laboratorial Diagnosis of Chikungunya

Silva, Leonardo Assis da / Lima, Monique da Rocha Queiroz / de Camargo, Brenda Rabello / Guimarães, Dyeferson Kened da Silva Coelho / Barbastefano, Anabele Azevedo Lima / Lima, Raquel Curtinhas de / Damasco, Paulo Vieira / Cunha, Rivaldo Venâncio da / de Souza, Luiz José / de Azeredo, Elzinandes Leal / de-Oliveira-Pinto, Luzia Maria / Nagata, Tatsuya / Ardisson-Araújo, Daniel M. P. / dos Santos, Flavia Barreto / Morais Ribeiro, Bergmann

Microorganisms. 2022 July 18, v. 10, no. 7

2022

Abstract: Chikungunya virus (CHIKV) is an arbovirus currently distributed worldwide, causing a disease that shares clinical signs and symptoms with other illnesses, such as dengue and Zika and leading to a challenging clinical differential diagnosis. In Brazil, ... ...

Abstract	Chikungunya virus (CHIKV) is an arbovirus currently distributed worldwide, causing a disease that shares clinical signs and symptoms with other illnesses, such as dengue and Zika and leading to a challenging clinical differential diagnosis. In Brazil, CHIKV emerged in 2014 with the simultaneous introduction of both Asian and East/Central/South African (ECSA) genotypes. Laboratorial diagnosis of CHIKV is mainly performed by molecular and serological assays, with the latter more widely used. Although many commercial kits are available, their costs are still high for many underdeveloped and developing countries where the virus circulates. Here we described the development and evaluation of a multi-epitope recombinant protein-based IgG-ELISA (MULTREC IgG-ELISA) test for the specific detection of anti-CHIKV antibodies in clinical samples, as an alternative approach for laboratorial diagnosis. The MULTREC IgG-ELISA showed 86.36% of sensitivity and 100% of specificity, and no cross-reactivity with other exanthematic diseases was observed. The recombinant protein was expressed from the binary system insect cell/baculovirus using the crystal-forming baculoviral protein polyhedrin as a carrier of the target recombinant protein to facilitate recovery. The crystals were at least 10 times smaller in size and had an amorphous shape when compared to the polyhedrin wild-type crystal. The assay uses a multi-epitope antigen, representing two replicates of 18 amino acid sequences from the E2 region and a sequence of 17 amino acids from the nsP3 region of CHIKV. The recombinant protein was highly expressed, easy to purify and has demonstrated its usefulness in confirming chikungunya exposure, indeed showing a good potential tool for epidemiological surveillance.
Keywords	Baculoviridae ; Chikungunya virus ; antigens ; arboviruses ; cross reaction ; dengue ; insects ; monitoring ; recombinant proteins ; Brazil
Language	English
Dates of publication	2022-0718
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10071451
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus.

Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / Dos Santos, Caroline Fernandes / Corrêa, Gladys / Cipitelli, Márcio da Costa / Dornelas Ribeiro, Marcos / de Souza, Luiz José / Damasco, Paulo Vieira / da Cunha, Rivaldo Venâncio / Dos Santos, Flavia Barreto / de Oliveira Pinto, Luzia Maria / de Azeredo, Elzinandes Leal

Viruses

2021 Volume 13, Issue 9

Abstract: The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile ...

Abstract	The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF-α (
MeSH term(s)	Adult ; Biomarkers/blood ; Blood Coagulation Factors/classification ; Blood Coagulation Factors/immunology ; Brazil ; Chemokines/blood ; Chemokines/classification ; Chemokines/immunology ; Cytokines/blood ; Cytokines/classification ; Cytokines/immunology ; Dengue/blood ; Dengue/immunology ; Dengue Virus/immunology ; Female ; Humans ; Inflammation ; Male ; Middle Aged ; Severity of Illness Index
Chemical Substances	Biomarkers ; Blood Coagulation Factors ; Chemokines ; Cytokines
Language	English
Publishing date	2021-09-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13091789
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increased circulating levels of High Mobility Group Box 1 (HMGB1) in acute-phase Chikungunya virus infection: Potential disease biomarker.

Rocha, Daniele C P / Souza, Thiara Manuelle Alves / Nunes, Priscila Conrado Guerra / Mohana-Borges, Ronaldo / Paes, Marciano V / Guimarães, Gabriel M C / Arcila, Juan C S / Paiva, Iury Amâncio / Azeredo, Elzinandes Leal de / Damasco, Paulo Vieira / de Souza, Luiz José / Dos Santos, Flavia B / Allonso, Diego

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2021 Volume 146, Page(s) 105054

Abstract: Background: Chikungunya virus (CHIKV) causes a febrile syndrome with intense and debilitating arthralgia that can persist for several months or years after complete virus clearance. As there is no specific antiviral treatment or vaccine against CHIKV, ... ...

Abstract	Background: Chikungunya virus (CHIKV) causes a febrile syndrome with intense and debilitating arthralgia that can persist for several months or years after complete virus clearance. As there is no specific antiviral treatment or vaccine against CHIKV, identification of serological markers that help clinical management of CHIKV patients is urgent. The High Mobility Group Box 1 (HMGB1) protein is secreted to extracellular milieu and triggers an intense inflammatory process by inducing the overexpression of pro-inflammatory cytokines. HMGB1 plays an important role in several virus diseases as well as in rheumatoid arthritis. Objectives: This study focus on the investigation of HMGB1 serum levels in a sera panel from CHIKV-infected patients in an attempt to assess its potential as a biomarker for chikungunya clinical management. Study design: Eighty CHIKV-positive samples and 32 samples from healthy donors were subjected to a quantitative HMGB1 ELISA assay to assess the HMGB1 circulating levels. Results: HMGB1 levels were significantly higher in CHIKV-positive samples (516.12 ng/mL, SEM ± 48.83 ng/mL) compared to negative control (31.20 ng/mL, SEM ± 3.24 ng/mL, p < 0.0001). Circulating levels of HMGB1 persisted elevated during the whole acute-phase of disease and correlated with virus titer (p < 0.05). Conclusions: The present study is the first to describe increased serum levels of HMGB1 in CHIKV infection and its positive correlation with virus titer, suggesting its potential use as a biomarker for diagnosis and treatment of chikungunya fever.
MeSH term(s)	Biomarkers ; Case-Control Studies ; Chikungunya Fever ; Chikungunya virus ; Enzyme-Linked Immunosorbent Assay ; HMGB1 Protein/blood ; Humans
Chemical Substances	Biomarkers ; HMGB1 Protein ; HMGB1 protein, human
Language	English
Publishing date	2021-12-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2021.105054
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Histopathological and immunological characteristics of placentas infected with chikungunya virus.

Salomão, Natália / Rabelo, Kíssila / Avvad-Portari, Elyzabeth / Basílio-de-Oliveira, Carlos / Basílio-de-Oliveira, Rodrigo / Ferreira, Fátima / Ferreira, Luiz / de Souza, Thiara Manuele / Nunes, Priscila / Lima, Monique / Sales, Anna Paula / Fernandes, Regina / de Souza, Luiz José / Dias, Laura / Brasil, Patrícia / Dos Santos, Flavia / Paes, Marciano

Frontiers in microbiology

2022 Volume 13, Page(s) 1055536

Abstract: Although vertical transmission of CHIKV has been reported, little is known about the role of placenta in the transmission of this virus and the effects of infection on the maternal-fetal interface. In this work we investigated five placentas from ... ...

Abstract	Although vertical transmission of CHIKV has been reported, little is known about the role of placenta in the transmission of this virus and the effects of infection on the maternal-fetal interface. In this work we investigated five placentas from pregnant women who became infected during the gestational period. Four formalin-fixed paraffin-embedded samples of placenta (cases 1-4) were positive for CHIKV by RT-PCR. One (case 5) had no positive test of placenta, but had positive RT-PCR for CHIKV in the serum of the mother and the baby, confirming vertical transmission. The placentas were analyzed regarding histopathological and immunological aspects. The main histopathological changes were: deciduitis, villous edema, deposits, villous necrosis, dystrophic calcification, thrombosis and stem vessel obliteration. In infected placentas we noted increase of cells (CD8
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.1055536
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses' Outbreak in Rio de Janeiro, Brazil.

de Souza, Thiara Manuele Alves / de Lima, Raquel Curtinhas / Solórzano, Victor Edgar Fiestas / Damasco, Paulo Vieira / de Souza, Luiz José / Sanchez-Arcila, Juan Camilo / Guimarães, Gabriel Macedo Costa / Paiva, Iury Amâncio / da Rocha Queiroz Lima, Monique / de Bruycker-Nogueira, Fernanda / Tomé, Larissa Cristina Teixeira / Coelho, Mariana Rosa Inácio / da Silva, Sandro Patroca / de Oliveira-Pinto, Luzia Maria / de Azeredo, Elzinandes Leal / Dos Santos, Flavia Barreto

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 2

Abstract: The co-circulation of chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV) in Rio de Janeiro (RJ), Brazil, caused a challenging triple epidemic, as they share similar clinical signs and symptoms and geographical distribution. Here, we ... ...

Abstract	The co-circulation of chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV) in Rio de Janeiro (RJ), Brazil, caused a challenging triple epidemic, as they share similar clinical signs and symptoms and geographical distribution. Here, we aimed to investigate the clinical and laboratorial aspects of chikungunya suspected cases assisted in RJ during the 2018 outbreak, focusing on the differential diagnosis with dengue and zika. All suspected cases were submitted to molecular and/or serological differential diagnostic approaches to arboviruses. A total of 242 cases suspected of arbovirus infection were investigated and 73.6% (178/242) were molecular and/or serologically confirmed as chikungunya. In RT-qPCR confirmed cases, cycle threshold (Ct) values ranged from 15.46 to 35.13, with acute cases presenting lower values. Chikungunya cases were mainly in females (64%) and the most frequently affected age group was adults between 46 to 59 years old (27%). Polyarthralgia affected 89% of patients, especially in hands and feet. No dengue virus (DENV) and Zika virus (ZIKV) infections were confirmed by molecular diagnosis, but 9.5% (23/242) had serological evidence of DENV exposure by the detection of specific anti-DENV IgM or NS1, and 42.7% (76/178) of chikungunya positive cases also presented recent DENV exposure reflected by a positive anti-DENV IgM or NS1 result. A significantly higher frequency of arthritis (
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11020245
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Chikungunya Virus Multiepitope Recombinant Protein Expressed from the Binary System Insect Cell/Recombinant Baculovirus Is Useful for Laboratorial Diagnosis of Chikungunya.

Silva, Leonardo Assis da / Lima, Monique da Rocha Queiroz / de Camargo, Brenda Rabello / Guimarães, Dyeferson Kened da Silva Coelho / Barbastefano, Anabele Azevedo Lima / Lima, Raquel Curtinhas de / Damasco, Paulo Vieira / Cunha, Rivaldo Venâncio da / de Souza, Luiz José / de Azeredo, Elzinandes Leal / de-Oliveira-Pinto, Luzia Maria / Nagata, Tatsuya / Ardisson-Araújo, Daniel M P / Dos Santos, Flavia Barreto / Morais Ribeiro, Bergmann

Microorganisms

2022 Volume 10, Issue 7

Abstract	Chikungunya virus (CHIKV) is an arbovirus currently distributed worldwide, causing a disease that shares clinical signs and symptoms with other illnesses, such as dengue and Zika and leading to a challenging clinical differential diagnosis. In Brazil, CHIKV emerged in 2014 with the simultaneous introduction of both Asian and East/Central/South African (ECSA) genotypes. Laboratorial diagnosis of CHIKV is mainly performed by molecular and serological assays, with the latter more widely used. Although many commercial kits are available, their costs are still high for many underdeveloped and developing countries where the virus circulates. Here we described the development and evaluation of a multi-epitope recombinant protein-based IgG-ELISA (MULTREC IgG-ELISA) test for the specific detection of anti-CHIKV antibodies in clinical samples, as an alternative approach for laboratorial diagnosis. The MULTREC IgG-ELISA showed 86.36% of sensitivity and 100% of specificity, and no cross-reactivity with other exanthematic diseases was observed. The recombinant protein was expressed from the binary system insect cell/baculovirus using the crystal-forming baculoviral protein polyhedrin as a carrier of the target recombinant protein to facilitate recovery. The crystals were at least 10 times smaller in size and had an amorphous shape when compared to the polyhedrin wild-type crystal. The assay uses a multi-epitope antigen, representing two replicates of 18 amino acid sequences from the E2 region and a sequence of 17 amino acids from the nsP3 region of CHIKV. The recombinant protein was highly expressed, easy to purify and has demonstrated its usefulness in confirming chikungunya exposure, indeed showing a good potential tool for epidemiological surveillance.
Language	English
Publishing date	2022-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10071451
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil

Pathogens. 2022 Feb. 14, v. 11, no. 2

2022

Abstract	The co-circulation of chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV) in Rio de Janeiro (RJ), Brazil, caused a challenging triple epidemic, as they share similar clinical signs and symptoms and geographical distribution. Here, we aimed to investigate the clinical and laboratorial aspects of chikungunya suspected cases assisted in RJ during the 2018 outbreak, focusing on the differential diagnosis with dengue and zika. All suspected cases were submitted to molecular and/or serological differential diagnostic approaches to arboviruses. A total of 242 cases suspected of arbovirus infection were investigated and 73.6% (178/242) were molecular and/or serologically confirmed as chikungunya. In RT-qPCR confirmed cases, cycle threshold (Ct) values ranged from 15.46 to 35.13, with acute cases presenting lower values. Chikungunya cases were mainly in females (64%) and the most frequently affected age group was adults between 46 to 59 years old (27%). Polyarthralgia affected 89% of patients, especially in hands and feet. No dengue virus (DENV) and Zika virus (ZIKV) infections were confirmed by molecular diagnosis, but 9.5% (23/242) had serological evidence of DENV exposure by the detection of specific anti-DENV IgM or NS1, and 42.7% (76/178) of chikungunya positive cases also presented recent DENV exposure reflected by a positive anti-DENV IgM or NS1 result. A significantly higher frequency of arthritis (p = 0.023) and limb edema (p < 0.001) was found on patients with CHIKV monoinfection compared to dengue patients and patients exposed to both viruses. Lastly, phylogenetic analysis showed that the chikungunya cases were caused by the ECSA genotype. Despite the triple arboviruses’ epidemic in the state of RJ, most patients with fever and arthralgia investigated here were diagnosed as chikungunya cases, and the incidence of CHIKV/DENV co-detection was higher than that reported in other studies.
Keywords	Chikungunya virus ; Dengue virus ; Zika virus ; arboviruses ; arthritis ; dengue ; edema ; fever ; genotype ; geographical distribution ; phylogeny ; Brazil
Language	English
Dates of publication	2022-0214
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11020245
Database	NAL-Catalogue (AGRICOLA)

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Article: Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus

Fiestas Solórzano, Victor Edgar / da Costa Faria, Nieli Rodrigues / dos Santos, Caroline Fernandes / Corrêa, Gladys / Cipitelli, Márcio da Costa / Dornelas Ribeiro, Marcos / de Souza, Luiz José / Damasco, Paulo Vieira / da Cunha, Rivaldo Venâncio / dos Santos, Flavia Barreto / de Oliveira Pinto, Luzia Maria / de Azeredo, Elzinandes Leal

Viruses. 2021 Sept. 08, v. 13, no. 9

2021

Abstract	The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF-α (p < 0.001), IL-6 (p = 0.005), IL-10 (p < 0.001), IL-18 (p = 0.001), CXCL8/IL-8 (p < 0.001), CCL2/MCP-1 (p < 0.001), CXCL10/IP-10 (p = 0.001), fibrinogen (p = 0.037), D-dimer (p = 0.01) and TFPI (p = 0.042) and lower levels of TF (p = 0.042) compared to healthy controls. A principal component analysis (PCA) distinguished between two profiles of mediators of inflammation and coagulation: protective (TNF-α, IL-1β and CXCL8/IL-8) and pathological (IL-6, TF and TFPI). Lastly, multivariate logistic regression analysis identified high aspartate aminotransferase-to-platelet ratio index (APRI) as independent risk factors associated with severity (adjusted OR: 1.33; 95% CI 1.03–1.71; p = 0.027), the area under the receiver operating characteristics curve (AUC) was 0.775 (95% CI 0.681–0.869) and an optimal cutoff value was 1.4 (sensitivity: 76%; specificity: 79%), so it could be a useful marker for the triage of patients attending primary care centers.
Keywords	Dengue virus ; aspartic acid ; biomarkers ; coagulation ; dengue ; fibrinogen ; inflammation ; interleukin-10 ; interleukin-18 ; interleukin-6 ; principal component analysis ; regression analysis ; Brazil ; Latin America
Language	English
Dates of publication	2021-0908
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13091789
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Zika Induces Human Placental Damage and Inflammation.

Rabelo, Kíssila / de Souza, Luiz José / Salomão, Natália Gedeão / Machado, Lara Nascentes / Pereira, Priscila Gomes / Portari, Elyzabeth Avvad / Basílio-de-Oliveira, Rodrigo / Dos Santos, Flávia Barreto / Neves, Laura Dias / Morgade, Luciana Faes / Provance, David William / Higa, Luiza Mendonça / Tanuri, Amilcar / de Carvalho, Jorge José / Paes, Marciano Viana

Frontiers in immunology

2020 Volume 11, Page(s) 2146

Abstract: In Brazil, an epidemic of Zika virus (ZIKV) infections was declared in 2015 that coincided with alarming reports of microcephaly in newborns associated with mother infection. Although the virus has placental tropism, changes in the tissue morphology and ... ...

Abstract	In Brazil, an epidemic of Zika virus (ZIKV) infections was declared in 2015 that coincided with alarming reports of microcephaly in newborns associated with mother infection. Although the virus has placental tropism, changes in the tissue morphology and immunity of infected patients have not yet been elucidated. Here, we investigated the histopathological and ultrastructural changes along with the immunological profile and the BDNF expression in rare placental material. Tissues were obtained in the 2015-2016 Brazilian epidemic, of ten ZIKV-infected patients during pregnancy, five resulting in cases of fetal microcephaly and five non-microcephaly, compared to five non-infected control placentae. Viral antigens were only detected in samples from the ZIKV infected patients. Infected placentae presented histopathological severe damage, while the ultrastructural evaluation showed abnormal organelles, such as clusters of virus-like particles consistent with the ZIKV dimensions. Increased infiltration of CD68
MeSH term(s)	Adult ; Antigens, Viral/analysis ; Brain-Derived Neurotrophic Factor/biosynthesis ; Brain-Derived Neurotrophic Factor/genetics ; Brazil/epidemiology ; Case-Control Studies ; Cesarean Section ; Collagen/biosynthesis ; Collagen/genetics ; Cytokines/biosynthesis ; Cytokines/genetics ; Disease Outbreaks ; Female ; Humans ; Inclusion Bodies, Viral ; Infant, Newborn ; Male ; Matrix Metalloproteinases/biosynthesis ; Matrix Metalloproteinases/genetics ; Microcephaly/etiology ; Placenta/metabolism ; Placenta/pathology ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/metabolism ; Pregnancy Complications, Infectious/pathology ; Pregnancy Complications, Infectious/virology ; Trophoblasts/ultrastructure ; Trophoblasts/virology ; Virus Replication ; Young Adult ; Zika Virus/immunology ; Zika Virus/isolation & purification ; Zika Virus/pathogenicity ; Zika Virus/physiology ; Zika Virus Infection/epidemiology ; Zika Virus Infection/immunology ; Zika Virus Infection/pathology
Chemical Substances	Antigens, Viral ; Brain-Derived Neurotrophic Factor ; Cytokines ; Collagen (9007-34-5) ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2020-09-01
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.02146
Database	MEDical Literature Analysis and Retrieval System OnLINE

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