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  1. Article ; Online: Assessment of thimerosal effects in sublethal concentrations on zebrafish (Danio rerio) embryos exploring NMR-based metabolomics profile.

    da Rocha Junior, Edmilson Rodrigues / Porto, Viviane Amaral / Crispim, Alessandre Carmo / Ursulino, Jeferson Santana / de Jesus, Lázaro Wender Oliveira / de Souza Bento, Edson / Santos, Josué Carinhanha Caldas / de Aquino, Thiago Mendonça

    Environmental toxicology and pharmacology

    2024  Volume 106, Page(s) 104361

    Abstract: Thimerosal, a preservative commonly used in the pharmaceutical and cosmetic industry, has raised concerns regarding its potentially toxic effects as an organic mercury compound. Within this context, using an NMR-based metabolomics profile and chemometric ...

    Abstract Thimerosal, a preservative commonly used in the pharmaceutical and cosmetic industry, has raised concerns regarding its potentially toxic effects as an organic mercury compound. Within this context, using an NMR-based metabolomics profile and chemometric analysis, zebrafish embryos were used as an in vivo model to study the effects of thimerosal in metabolic profiles after exposure to sublethal concentrations of the mercury compound. The thimerosal concentrations of 40 and 80 nM were employed, corresponding to 40% and 80% of the LC
    MeSH term(s) Animals ; Zebrafish ; Thimerosal/toxicity ; Metabolomics ; Amino Acids ; Mercury
    Chemical Substances Thimerosal (2225PI3MOV) ; Amino Acids ; Mercury (FXS1BY2PGL)
    Language English
    Publishing date 2024-01-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2024.104361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4490: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Production of levan from Bacillus subtilis var. natto and apoptotic effect on SH-SY5Y neuroblastoma cells

    Vieira, Amanda Mota / Zahed, Farrah / Crispim, Alessandre Carmo / de Souza Bento, Edson / França, Rafael de Freitas Oliveira / Pinheiro, Irapuan Oliveira / Pardo, Luis A. / Carvalho, Bruno Melo

    Carbohydrate polymers. 2021 Dec. 01, v. 273

    2021  

    Abstract: Levan is a high-valued polysaccharide of fructose produced by several microbial species. These polysaccharides have been described as effective therapeutic agents in some human disease conditions, such as cancer, heart diseases and diabetes. The ... ...

    Abstract Levan is a high-valued polysaccharide of fructose produced by several microbial species. These polysaccharides have been described as effective therapeutic agents in some human disease conditions, such as cancer, heart diseases and diabetes. The objective of this study was to examine the effect of levan (β-(2 → 6)-fructan) produced through sucrose fermentation by B. subtilis var. natto on the proliferation rate, cytotoxicity, and apoptosis of human neuroblastoma SH-SY5Y cells. It was obtained 41.44 g/L of levan in 18 h by biotechnological fermentation and SH-SY5Y cells were exposed to 1000 μg/mL of levan. The treatment with 1000 μg/mL of levan induced apoptosis in SH-SY5Y cancer cells by the significant increase in Annexin V/7-AAD and caspase 3/7 activation, but did not decrease proliferation or triggered a cytotoxic effect. 1000 μg/mL levan treatment is a promising therapeutic strategy for SH-SY5Y neuroblastoma cells.
    Keywords Bacillus subtilis var. natto ; apoptosis ; cytotoxicity ; diabetes ; fermentation ; fructose ; heart ; human diseases ; humans ; levan ; sucrose ; therapeutics
    Language English
    Dates of publication 2021-1201
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2021.118613
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: The rating of perceived exertion is able to differentiate the post-matches metabolomic profile of elite U-20 soccer players.

    Marinho, Alisson Henrique / Sousa, Filipe Antonio de Barros / Vilela, Rubens de Alcântara Moura Pimentel / Balikian, Pedro / de Souza Bento, Edson / de Mendonça Aquino, Thiago / Crispim, Alessandre / Ataide-Silva, Thays / de Araujo, Gustavo Gomes

    European journal of applied physiology

    2021  Volume 122, Issue 2, Page(s) 371–382

    Abstract: Purpose: The study aimed to assess the metabolic impact of elite Brazilian U-20 players using the rating of perceived exertion scale (RPE) to discriminate metabolomics sensitivity post-two soccer games separated by a short recovery interval.: Methods!# ...

    Abstract Purpose: The study aimed to assess the metabolic impact of elite Brazilian U-20 players using the rating of perceived exertion scale (RPE) to discriminate metabolomics sensitivity post-two soccer games separated by a short recovery interval.
    Methods: Urine was collected immediately and then 20 h after two soccer matches of elite Brazilian U-20 players. RPE was collected after games. The spectra were pre-processed using TopSpin
    Results: The results showed that the metabolic pathways related to energy production, cellular damage, and organic stresses were changed immediately after the game. 20 h after the games, antioxidant and anti-inflammatory pathways related to cell recovery were identified (e.g., gallic acid, ascorbate, and betaine). The matrix of positive correlations between metabolites was more predominant and stronger after game 2 than game 1. T-distribution registered metabolites discriminated below and above 7 on the RPE scale. Athletes with higher RPE values showed a high metabolite profile related to muscle damage (e.g., creatine, creatinine, and glycine) and energy production (e.g., creatine, formate, pyruvate, 1,3 dihydroxyacetone) 20 h post-soccer match. There was a different metabolic profile between athletes with higher and lower RPE values.
    Conclusion: Metabolomics analysis made it possible to observe the metabolic impacts of energy production and muscular damage. RPE identified internal load changes within the group as a result of match intensity in soccer. The correlation matrix indicated a greater predominance of positive and strong correlations between metabolites in the second game compared to the first game.
    MeSH term(s) Athletic Performance/physiology ; Biomarkers/urine ; Brazil ; Humans ; Male ; Metabolomics ; Physical Exertion/physiology ; Soccer/physiology ; Young Adult
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-11-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-021-04838-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.195: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Production of levan from Bacillus subtilis var. natto and apoptotic effect on SH-SY5Y neuroblastoma cells.

    Vieira, Amanda Mota / Zahed, Farrah / Crispim, Alessandre Carmo / de Souza Bento, Edson / França, Rafael de Freitas Oliveira / Pinheiro, Irapuan Oliveira / Pardo, Luis A / Carvalho, Bruno Melo

    Carbohydrate polymers

    2021  Volume 273, Page(s) 118613

    Abstract: Levan is a high-valued polysaccharide of fructose produced by several microbial species. These polysaccharides have been described as effective therapeutic agents in some human disease conditions, such as cancer, heart diseases and diabetes. The ... ...

    Abstract Levan is a high-valued polysaccharide of fructose produced by several microbial species. These polysaccharides have been described as effective therapeutic agents in some human disease conditions, such as cancer, heart diseases and diabetes. The objective of this study was to examine the effect of levan (β-(2 → 6)-fructan) produced through sucrose fermentation by B. subtilis var. natto on the proliferation rate, cytotoxicity, and apoptosis of human neuroblastoma SH-SY5Y cells. It was obtained 41.44 g/L of levan in 18 h by biotechnological fermentation and SH-SY5Y cells were exposed to 1000 μg/mL of levan. The treatment with 1000 μg/mL of levan induced apoptosis in SH-SY5Y cancer cells by the significant increase in Annexin V/7-AAD and caspase 3/7 activation, but did not decrease proliferation or triggered a cytotoxic effect. 1000 μg/mL levan treatment is a promising therapeutic strategy for SH-SY5Y neuroblastoma cells.
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Bacillus subtilis/metabolism ; Caspase 3/metabolism ; Caspase 7/metabolism ; Cell Line, Tumor ; Fructans/biosynthesis ; Fructans/chemistry ; Fructans/pharmacology ; Humans
    Chemical Substances Antineoplastic Agents ; Fructans ; levan (9013-95-0) ; CASP3 protein, human (EC 3.4.22.-) ; CASP7 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 7 (EC 3.4.22.-)
    Language English
    Publishing date 2021-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2021.118613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular Modeling and Physicochemical Properties of Supramolecular Complexes of Limonene with α- and β-Cyclodextrins.

    Dos Passos Menezes, Paula / Dos Santos, Polliana Barbosa Pereira / Dória, Grace Anne Azevedo / de Sousa, Bruna Maria Hipólito / Serafini, Mairim Russo / Nunes, Paula Santos / Quintans-Júnior, Lucindo José / de Matos, Iara Lisboa / Alves, Péricles Barreto / Bezerra, Daniel Pereira / Mendonça Júnior, Francisco Jaime Bezerra / da Silva, Gabriel Francisco / de Aquino, Thiago Mendonça / de Souza Bento, Edson / Scotti, Marcus Tullius / Scotti, Luciana / de Souza Araujo, Adriano Antunes

    AAPS PharmSciTech

    2017  Volume 18, Issue 1, Page(s) 49–57

    Abstract: This study evaluated three different methods for the formation of an inclusion complex between alpha- and beta-cyclodextrin (α- and β-CD) and limonene (LIM) with the goal of improving the physicochemical properties of limonene. The study samples were ... ...

    Abstract This study evaluated three different methods for the formation of an inclusion complex between alpha- and beta-cyclodextrin (α- and β-CD) and limonene (LIM) with the goal of improving the physicochemical properties of limonene. The study samples were prepared through physical mixing (PM), paste complexation (PC), and slurry complexation (SC) methods in the molar ratio of 1:1 (cyclodextrin:limonene). The complexes prepared were evaluated with thermogravimetry/derivate thermogravimetry, infrared spectroscopy, X-ray diffraction, complexation efficiency through gas chromatography/mass spectrometry analyses, molecular modeling, and nuclear magnetic resonance. The results showed that the physical mixing procedure did not produce complexation, but the paste and slurry methods produced inclusion complexes, which demonstrated interactions outside of the cavity of the CDs. However, the paste obtained with β-cyclodextrin did not demonstrate complexation in the gas chromatographic technique because, after extraction, most of the limonene was either surface-adsorbed by β-cyclodextrin or volatilized during the procedure. We conclude that paste complexation and slurry complexation are effective and economic methods to improve the physicochemical character of limonene and could have important applications in pharmacological activities in terms of an increase in solubility.
    MeSH term(s) Chromatography, Gas/methods ; Cyclohexenes/chemistry ; Magnetic Resonance Spectroscopy/methods ; Mass Spectrometry/methods ; Models, Molecular ; Solubility ; Spectrophotometry, Infrared/methods ; Terpenes/chemistry ; Thermogravimetry/methods ; X-Ray Diffraction/methods ; alpha-Cyclodextrins/chemistry ; beta-Cyclodextrins/chemistry
    Chemical Substances Cyclohexenes ; Terpenes ; alpha-Cyclodextrins ; beta-Cyclodextrins ; limonene (9MC3I34447) ; alpha-cyclodextrin (Z1LH97KTRM)
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ISSN 1530-9932
    ISSN (online) 1530-9932
    DOI 10.1208/s12249-016-0516-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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