Article: Identification of Eschweilenol C in derivative of Terminalia fagifolia Mart. and green synthesis of bioactive and biocompatible silver nanoparticles
Industrial crops and products. 2019 Oct. 01, v. 137
2019
Abstract: A green synthetic route was developed to prepare silver nanoparticles (AgNPs) in aqueous solution for biological applications. Eschweilenol C, a compound derivative ellagic acid was identified as the main constituent of the aqueous fraction of the ... ...
| Abstract | A green synthetic route was developed to prepare silver nanoparticles (AgNPs) in aqueous solution for biological applications. Eschweilenol C, a compound derivative ellagic acid was identified as the main constituent of the aqueous fraction of the ethanolic extract of Terminalia fagifolia Mart. by NMR analysis. In the green synthesis, the ethanolic extract of T. fagifolia and its aqueous fraction were used to promote silver reduction and nanoparticle stabilization. The synthesized AgNPs presented a spherical or polygonal morphology shape by TEM analysis and AgNPs showed high levels of antioxidant and considerable antibacterial and antifungal activities. Synthesized nanoparticles presented significant antioxidant activity by sequestration of DPPH and ABTS radicals, in addition to iron reduction (FRAP assay) and measurement of antioxidant capacity in ORAC units, in addition, AgNP synthesized with the aqueous fraction also demonstrated antioxidant potential in microglial cells. Gram-positive and Gram-negative bacteria were susceptible to growth inhibition by the nanoparticles, among which the AgNPs formed by the ethanolic extract was the most effective. The data obtained by AFM images suggested that AgNPs could lead to the lysis of bacteria and subsequent death. The antifungal assays showed high efficiency against yeasts and dermatophytes. This work represents the first description of antifungal activity by AgNPs against Fonsecaea pedrosoi, the etiologic agent of chromoblastomycosis. In relation to biocompatibility, the AgNPs induced lower haemolysis than AgNO3. |
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| Keywords | 2,2-diphenyl-1-picrylhydrazyl ; Gram-negative bacteria ; Terminalia ; antifungal properties ; antioxidant activity ; aqueous solutions ; biocompatibility ; death ; ellagic acid ; free radicals ; hemolysis ; iron ; keratinophilic fungi ; nanoparticles ; nanosilver ; neuroglia ; nuclear magnetic resonance spectroscopy ; silver ; silver nitrate ; transmission electron microscopy ; yeasts | |||||
| Language | English | |||||
| Dates of publication | 2019-1001 | |||||
| Size | p. 52-65. | |||||
| Publishing place | Elsevier B.V. | |||||
| Document type | Article | |||||
| ZDB-ID | 1132158-1 | |||||
| ISSN | 1872-633X ; 0926-6690 | |||||
| ISSN (online) | 1872-633X | |||||
| ISSN | 0926-6690 | |||||
| DOI | 10.1016/j.indcrop.2019.05.012 | |||||
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| Database | NAL-Catalogue (AGRICOLA) |
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