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Article: Prognostic Significance of β-Catenin in Relation to the Tumor Immune Microenvironment in Oral Cancer.

Lequerica-Fernández, Paloma / Rodríguez-Santamarta, Tania / García-García, Eduardo / Blanco-Lorenzo, Verónica / Torres-Rivas, Héctor E / Rodrigo, Juan P / Suárez-Sánchez, Faustino J / García-Pedrero, Juana M / De Vicente, Juan Carlos

Biomedicines

2023 Volume 11, Issue 10

Abstract: The aim of this study was to investigate the prognostic relevance of β-catenin expression in oral squamous cell carcinoma (OSCC) and to explore relationships with the tumor immune microenvironment. Expression of β-catenin and PD-L1, as well as lymphocyte ...

Abstract	The aim of this study was to investigate the prognostic relevance of β-catenin expression in oral squamous cell carcinoma (OSCC) and to explore relationships with the tumor immune microenvironment. Expression of β-catenin and PD-L1, as well as lymphocyte and macrophage densities, were evaluated by immunohistochemistry in 125 OSCC patient specimens. Membranous β-catenin expression was detected in 102 (81.6%) and nuclear β-catenin in 2 (1.6%) tumors. There was an association between β-catenin expression, tumoral, and stromal CD8
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11102675
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Article ; Online: Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders.

de Villalaín, Lucas / Álvarez-Teijeiro, Saúl / Rodríguez-Santamarta, Tania / Fernández Del Valle, Álvaro / Allonca, Eva / Rodrigo, Juan P / de Vicente, Juan Carlos / García-Pedrero, Juana M

International journal of molecular sciences

2023 Volume 24, Issue 18

Abstract: The aim of this study was to evaluate the expression of the senescence markers, Decoy Receptor 2 (DcR2) and Differentiated Embryo-Chondrocyte expressed gen 1 (DEC1), in oral potentially malignant disorders (OPMDs) to ascertain their possible association ... ...

Abstract	The aim of this study was to evaluate the expression of the senescence markers, Decoy Receptor 2 (DcR2) and Differentiated Embryo-Chondrocyte expressed gen 1 (DEC1), in oral potentially malignant disorders (OPMDs) to ascertain their possible association with oral cancer risk. The immunohistochemical analysis of DcR2 and DEC1 expression (along with p16 and Ki67 expression) was carried out in 60 patients with clinically diagnosed oral leukoplakia. Fifteen cases (25%) subsequently developed an invasive carcinoma. Correlations between protein marker expression, histological grade and oral cancer risk were assessed. DcR2, DEC1 and Ki67 protein expressions were found to correlate significantly with increased oral cancer risk, and also with an increased grade of dysplasia. Multivariate analysis demonstrated that DcR2 and Ki67 expression are independent predictors of oral cancer development. Our results evidence for the first time the potential of DcR2 as an early biomarker to assess oral cancer risk in patients with oral leukoplakia (HR = 59.7,
MeSH term(s)	Humans ; Ki-67 Antigen ; Precancerous Conditions ; Leukoplakia, Oral ; Mouth Neoplasms/pathology ; Hyperplasia
Chemical Substances	Ki-67 Antigen
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241814382
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Article ; Online: Effect of region-dependent viscoelastic properties on the TMJ articular disc relaxation under prolonged clenching.

García, Natalia / Fernández, Pelayo / Tanaka, Eiji / Barrientos, Eva / Lamela-Rey, María Jesús / Fernández-Canteli, Alfonso / de Vicente, Juan Carlos

Journal of the mechanical behavior of biomedical materials

2021 Volume 119, Page(s) 104522

Abstract: The disc of the temporomandibular joint (TMJ) is located between the mandibular condyle and temporal bone, and has an important load-bearing and stress absorbing function. The TMJ disc presents viscoelastic characteristics that are largely dependent on ... ...

Abstract	The disc of the temporomandibular joint (TMJ) is located between the mandibular condyle and temporal bone, and has an important load-bearing and stress absorbing function. The TMJ disc presents viscoelastic characteristics that are largely dependent on its collagen fibre and proteoglycan composition and organization. The purpose of this study is to investigate the possible effects of region-specific dynamic viscoelastic properties on stress relaxation during prolonged clenching. Two finite element models were used to compare the stress distribution within the TMJ disc, namely, one with uniform disc material property and another one with region-specific disc material properties. Similar results were observed in both models with slight differences in the location of maximum stress. Larger stresses were observed in all cases for the model with uniform disc material property. Moreover, the higher values for the model with uniform disc material property appeared in the lateral region, while in the model with region-specific disc properties, these values moved to the lateral and central region. This investigation confirms that both models are sufficiently accurate to investigate stress distribution in the TMJ disc, and, particularly, the model with the region-specific disc material properties ensure better simulations of the TMJ disc behaviour.
MeSH term(s)	Finite Element Analysis ; Mandibular Condyle ; Stress, Mechanical ; Temporomandibular Joint ; Temporomandibular Joint Disc ; Weight-Bearing
Language	English
Publishing date	2021-04-20
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2021.104522
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Article ; Online: Genes involved in the epithelial-mesenchymal transition in oral cancer: A systematic review.

Vallina, Carmen / López-Pintor, Rosa María / González-Serrano, José / de Vicente, Juan Carlos / Hernández, Gonzalo / Lorz, Corina

Oral oncology

2021 Volume 117, Page(s) 105310

Abstract: Objective: Epithelial-mesenchymal transition (EMT) is considered the initial step in the invasion-metastasis cascade. The aim of this systematic review was to study the signature of genes involved in the EMT process in oral cancer (OC) confirmed by ... ...

Abstract	Objective: Epithelial-mesenchymal transition (EMT) is considered the initial step in the invasion-metastasis cascade. The aim of this systematic review was to study the signature of genes involved in the EMT process in oral cancer (OC) confirmed by protein expression and its possible relationship with oral squamous cell carcinoma (OSCC) prognostic variables. Materials and methods: A search of the scientific literature was carried out with no start date restriction until 17 September 2020 in the electronic databases Pubmed/MEDLINE, Web of Science, Cochrane Library and Scopus, following specific eligibility criteria. The methodological quality of the included studies was assessed using the Newcastle-Ottawa tool. Results: A total of 8 retrospective cohort studies were included, all of them performed in China and with low risk of bias. Overexpression of the genes HNRNPC, ITGA5, HMGA2 and SRSF3, and low expression of ALDH3A1 and ARID2 promote EMT in OC. The more advanced clinical stages of the TNM classification were significantly associated with overexpression of HNRNPC, ITGA5, HMGA2 and SRSF3, and low expression of ARID2. Conclusions: HNRNPC, ITGA5, HMGA2, SRSF3, ALDH3A1 and ARID2 genes were associated with EMT process. Over- or under-expression of these genes is associated with worse stages of OSCC and/or worse prognosis of the tumor. Further studies on this topic are needed in different countries to be able to confirm these results, since the detection of these genes can help to know which tumors have a worse prognosis.
MeSH term(s)	Epithelial-Mesenchymal Transition/genetics ; Humans ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/pathology ; Transcription Factors/metabolism
Chemical Substances	Transcription Factors
Language	English
Publishing date	2021-04-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2021.105310
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Effects of loading direction in prolonged clenching on stress distribution in the temporomandibular joint.

Barrientos, Eva / Pelayo, Fernández / Tanaka, Eiji / Lamela-Rey, María Jesús / Fernández-Canteli, Alfonso / de Vicente, Juan Carlos

Journal of the mechanical behavior of biomedical materials

2020 Volume 112, Page(s) 104029

Abstract: Parafunctional habits, such as bruxism and prolonged clenching, have been associated with dysfunctional hyperactivity of the masticatory muscles, including the lateral pterygoid muscle. The resultant loading to the temporomandibular joint (TMJ) is ... ...

Abstract	Parafunctional habits, such as bruxism and prolonged clenching, have been associated with dysfunctional hyperactivity of the masticatory muscles, including the lateral pterygoid muscle. The resultant loading to the temporomandibular joint (TMJ) is subject to the degradation of bone, cartilage and disc in the TMJ. In this study, we examined the effect of clenching direction on the stress distribution in the TMJ. In this line, we hypothesised that asymmetrical clenching involved in parafunction might result in increased stresses on the TMJ disc as well as on the condylar and temporal articular surfaces. The distribution of stress for various directional loadings was analysed using a three-dimensional finite element model of the TMJ, with viscoelastic properties for the disc. The numerical results revealed that load direction influenced the amount and distribution of stresses on the disc surfaces. In particular, the lateral region of the disc suffered higher stress values. Moreover, the results showed a significant stress relaxation in the disc that revealed its capacity for stress energy dissipation. From the present study, it can be established that during prolonged clenching, the higher stresses are concentrated in the lateral region, which could imply that TMJ disorders related to damage or wear in the disc and the condylar cartilage, overall, occur when lateral dysfunctional displacements are present.
MeSH term(s)	Bruxism ; Finite Element Analysis ; Humans ; Mandibular Condyle ; Temporomandibular Joint ; Temporomandibular Joint Disc ; Temporomandibular Joint Disorders
Language	English
Publishing date	2020-08-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2020.104029
Database	MEDical Literature Analysis and Retrieval System OnLINE

2021 Volume 9, Issue 6

Abstract: This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral ... ...

Abstract	This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4
Language	English
Publishing date	2021-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9060653
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Article: Tumor-Infiltrating CD20

Suárez-Sánchez, Faustino Julián / Lequerica-Fernández, Paloma / Rodrigo, Juan Pablo / Hermida-Prado, Francisco / Suárez-Canto, Julián / Rodríguez-Santamarta, Tania / Domínguez-Iglesias, Francisco / García-Pedrero, Juana M / de Vicente, Juan Carlos

Cancers

2021 Volume 13, Issue 3

Abstract: Immunohistochemical analysis of stromal/tumoral ... ...

Abstract	Immunohistochemical analysis of stromal/tumoral CD20
Language	English
Publishing date	2021-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13030395
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Article ; Online: Implant treatment in immunosuppressed renal transplant patients: A prospective case-controlled study.

Hernández, Gonzalo / Paredes, Víctor / López-Pintor, Rosa María / de Andrés, Amado / de Vicente, Juan Carlos / Sanz, Mariano

Clinical oral implants research

2019 Volume 30, Issue 6, Page(s) 524–530

Abstract: Objectives: The aim of this clinical study was to evaluate long-term outcomes of implant therapy in a cohort of immunosuppressed renal transplant patients compared with a matched control group.: Material and methods: Pharmacologically ... ...

Abstract	Objectives: The aim of this clinical study was to evaluate long-term outcomes of implant therapy in a cohort of immunosuppressed renal transplant patients compared with a matched control group. Material and methods: Pharmacologically immunosuppressed renal transplant patients received dental implant treatment between 2001 and 2011. Periodontal, clinical and radiographic parameters were prospectively measured with a mean follow-up of 116.8 months (range from 84 to 192 months). A matched controlled non-transplant sample receiving similar implant treatment in the same time was included as a control group. Results: Implant survival rate was over 98% in both test and control groups (100% and 98.84%, respectively). Peri-implant mucositis was diagnosed in 46.80% of the implants in the study group and in 48.80% in the control group. Peri-implantitis occurred in 5.10% of the implants in the study group and in 8.10% of the controls. Wound healing and post-operative pain were similar in both groups. Conclusions: Despite the limitations of this study, pharmacological immunosuppression in renal transplant patients did not affect implant outcomes. Renal transplant patients should be carefully controlled periodically after implant treatment. Clinical implications: The results from this investigation justify the use of dental implants for the dentalrehabilitation of immunosuppressed patients after renal transplantation provided they follow the necessarylong-term monitoring and regular maintenance of their oral and systemic health.
MeSH term(s)	Dental Implants ; Humans ; Kidney Transplantation ; Mucositis ; Peri-Implantitis ; Prospective Studies
Chemical Substances	Dental Implants
Language	English
Publishing date	2019-04-29
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1067626-0
ISSN	1600-0501 ; 0905-7161
ISSN (online)	1600-0501
ISSN	0905-7161
DOI	10.1111/clr.13437
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Functional results of swallowing and aspiration after oral cancer treatment and microvascular free flap reconstruction: A retrospective observational assessment.

de Vicente, Juan Carlos / Rúa-Gonzálvez, Laura / Barroso, José María / Fernández Del Valle-Fernández, Álvaro / de Villalaín, Lucas / Peña, Ignacio / Cobo, Juan Luis

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2021 Volume 49, Issue 10, Page(s) 959–970

Abstract: This study aimed to assess the functional swallowing outcomes in cohort of oral cancer patients treated with tumor resection and reconstruction by means of microvascular free flaps. Duration from onset to the last examination was classified into three ... ...

Abstract	This study aimed to assess the functional swallowing outcomes in cohort of oral cancer patients treated with tumor resection and reconstruction by means of microvascular free flaps. Duration from onset to the last examination was classified into three periods: less than 12 months, from 13 to 24 months, and more than 24 months. Type of feeding, dysphagia, and laryngeal aspiration were the dependent variables, and the study was mainly focused on the data from the multivariate analysis. Fifty-one patients were included in the study. Twenty-one patients had dysphagia, 11 showed stasis in vallecula and pyriform sinuses, 9 experienced laryngeal penetration, and 8 aspirations. Surgery combined with radiochemotherapy was associated with a higher prevalence of dysphagia (p = 0.03). Frequency of dysphagia was higher in the first year after treatment and less frequent after 24 months (p = 0.003). Dysphagia was associated with laryngeal penetration (p = 0.001), and this with aspiration (p < 0.0005). In conclusion, as it seems that the method of reconstruction has a major influence on swallowing, when there are relevant alternatives in the way the reconstruction is done, always the approach should be chosen that reduces dysphagia to a minimum.
MeSH term(s)	Deglutition ; Deglutition Disorders/etiology ; Free Tissue Flaps ; Humans ; Mouth Neoplasms/surgery ; Retrospective Studies
Language	English
Publishing date	2021-05-05
Publishing country	Scotland
Document type	Journal Article ; Observational Study
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2021.04.015
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Zs.A 882: Show issues

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Article ; Online: Implant treatment in pharmacologically immunosuppressed liver transplant patients: A prospective-controlled study.

Paredes, Víctor / López-Pintor, Rosa María / Torres, Jesús / de Vicente, Juan Carlos / Sanz, Mariano / Hernández, Gonzalo

Clinical oral implants research

2018 Volume 29, Issue 1, Page(s) 28–35

Abstract: Objectives: The main objective of this prospective study was to evaluate the long-term outcome of implant therapy in liver transplant patients (LTP). The secondary goal was to assess several implant- and patient-dependent variables, such as peri- ... ...

Abstract	Objectives: The main objective of this prospective study was to evaluate the long-term outcome of implant therapy in liver transplant patients (LTP). The secondary goal was to assess several implant- and patient-dependent variables, such as peri-implantitis (PI), peri-implant mucositis (PIM), bone loss (BL), and immediate postoperative complications. Material and methods: Two groups, including 16 pharmacologically immunosuppressed LTP and 16 matched controls, received 52 and 54 implants, respectively, between 1999 and 2008. After evaluating the postoperative healing, a mean follow-up of more than 8 years was carried out, and radiographic, clinical, and periodontal parameters were recorded to evaluate implant survival and implant- and patient-dependent outcomes. Results: The early postsurgical complications were similar in both groups. Implant survival rate was 100% in the LTP group and 98.15% in the CG. PIM was diagnosed in 35.42% of the implants and 64.29% of the patients of LTP group (LTPG) and in 43.40% of the implants and 56.25% of the patients in the CG. PI was detected in 4.17% of the implants and 7.10% of the patients in the LTPG and in 9.43% of the implants and 18.80% of the patients in the CG. Conclusion: Pharmacologically immunosuppression in liver transplant patients was not a risk factor for implant failure, nor for the incidence of peri-implant diseases. Liver transplant is not a contraindication for dental implant treatment, although these patients should be carefully monitored during follow-up care.
MeSH term(s)	Alveolar Bone Loss/etiology ; Case-Control Studies ; Dental Implants/adverse effects ; Dental Restoration Failure ; Female ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation ; Male ; Middle Aged ; Mucositis/etiology ; Peri-Implantitis/etiology ; Postoperative Complications ; Prospective Studies ; Risk Factors
Chemical Substances	Dental Implants ; Immunosuppressive Agents
Language	English
Publishing date	2018-01
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1067626-0
ISSN	1600-0501 ; 0905-7161
ISSN (online)	1600-0501
ISSN	0905-7161
DOI	10.1111/clr.13035
Database	MEDical Literature Analysis and Retrieval System OnLINE

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