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Article: Repurposing HLA genotype data of renal transplant patients to prevent severe drug hypersensitivity reactions.

Manson, Lisanne E N / Delwig, Sander J / Drabbels, Jos J M / Touw, Daan J / De Vries, Aiko P J / Roelen, Dave L / Guchelaar, Henk-Jan

Frontiers in genetics

2023 Volume 14, Page(s) 1289015

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1289015
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Article ; Online: Diagnosis and treatment of allograft rejection in islet transplantation.

Landstra, Cyril P / Nijhoff, Michiel F / Roelen, Dave L / de Vries, Aiko P J / de Koning, Eelco J P

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2023 Volume 23, Issue 9, Page(s) 1425–1433

Abstract: Islet transplantation stabilizes glycemic control in patients with complicated diabetes mellitus. Rapid functional decline could be due to islet allograft rejection. However, there is no reliable method to assess rejection, and treatment protocols are ... ...

Abstract	Islet transplantation stabilizes glycemic control in patients with complicated diabetes mellitus. Rapid functional decline could be due to islet allograft rejection. However, there is no reliable method to assess rejection, and treatment protocols are absent. We aimed to characterize diagnostic features of islet allograft rejection and assess effectiveness of high-dose methylprednisolone treatment. Over a median follow-up of 61.8 months, 22% (9 of 41) of islet transplant recipients experienced 10 suspected rejection episodes (SREs). All first SREs occurred within 18 months after transplantation. Important features were unexplained hyperglycemia (all cases), unexplained C-peptide decrease (ΔC-peptide, 77.1% [-59.1% to -91.6%]; ΔC-peptide:glucose, -76.3% [-49.2% to -90.4%]), predisposing event (5 of 10 cases), and increased immunologic risk (5 of 10 cases). At 6 months post-SRE, patients who received protocolized methylprednisolone (n = 4) had significantly better islet function than untreated patients (n = 4), according to C-peptide (1.39 ± 0.59 vs 0.14 ± 0.19 nmol/L; P = .007), Igls score (good [4 of 4 cases] vs failure [3 of 4 cases] or marginal [1 of 4 cases]; P = .018) and β score (6.0 [6.0-6.0] vs 1.0 [0.0-3.5]; P = .013). SREs are prevalent among islet transplant recipients and are associated with loss of islet graft function. Timely treatment with high-dose methylprednisolone mitigates this loss. Unexplained hyperglycemia, unexpected C-peptide decrease, a predisposing event, and elevated immunologic risk are diagnostic indicators for SRE.
MeSH term(s)	Humans ; Islets of Langerhans Transplantation/methods ; C-Peptide ; Peptides ; Hyperglycemia/diagnosis ; Hyperglycemia/drug therapy ; Hyperglycemia/etiology ; Allografts
Chemical Substances	C-Peptide ; Peptides
Language	English
Publishing date	2023-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1016/j.ajt.2023.05.035
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Article ; Online: Impact of a Public Health Emergency on Behavior, Stress, Anxiety and Glycemic Control in Patients With Pancreas or Islet Transplantation for Type 1 Diabetes.

Landstra, Cyril P / Ruissen, Merel M / Regeer, Hannah / Nijhoff, Michiel F / Ballieux, Bart E P B / van der Boog, Paul J M / de Vries, Aiko P J / Huisman, Sasja D / de Koning, Eelco J P

Transplant international : official journal of the European Society for Organ Transplantation

2024 Volume 37, Page(s) 12278

Abstract: A public health emergency such as the COVID-19 pandemic has behavioral, mental and physical implications in patients with type 1 diabetes (T1D). To what extent the presence of a transplant further increases this burden is not known. Therefore, we ... ...

Abstract	A public health emergency such as the COVID-19 pandemic has behavioral, mental and physical implications in patients with type 1 diabetes (T1D). To what extent the presence of a transplant further increases this burden is not known. Therefore, we compared T1D patients with an islet or pancreas transplant (β-cell Tx;
MeSH term(s)	Female ; Humans ; Male ; Anxiety ; Blood Glucose ; Blood Glucose Self-Monitoring ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/surgery ; Glycemic Control ; Insulin-Secreting Cells ; Islets of Langerhans Transplantation ; Pandemics ; Public Health
Chemical Substances	Blood Glucose
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Observational Study
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2024.12278
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Article ; Online: Vulnerabilities in kidney transplant recipients with COVID-19: a single center experience.

Meziyerh, Soufian / van der Helm, Danny / de Vries, Aiko P J

Transplant international : official journal of the European Society for Organ Transplantation

2020 Volume 33, Issue 11, Page(s) 1557–1561

MeSH term(s)	Adult ; Aged ; COVID-19/etiology ; COVID-19/mortality ; COVID-19/therapy ; Case-Control Studies ; Female ; Humans ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Male ; Middle Aged ; Postoperative Complications/mortality ; Postoperative Complications/therapy ; Risk Factors ; Survival Analysis ; United States/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-08-26
Publishing country	Switzerland
Document type	Letter
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.1111/tri.13714
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Article ; Online: C3 glomerulopathy.

Koopman, Jacob J E / de Vries, Aiko P J / Bajema, Ingeborg M

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2019 Volume 36, Issue 4, Page(s) 594–596

Language	English
Publishing date	2019-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfz201
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: International consensus on post-transplantation diabetes mellitus.

Sharif, Adnan / Chakkera, Harini / de Vries, Aiko P J / Eller, Kathrin / Guthoff, Martina / Haller, Maria C / Hornum, Mads / Nordheim, Espen / Kautzky-Willer, Alexandra / Krebs, Michael / Kukla, Aleksandra / Kurnikowski, Amelie / Schwaiger, Elisabeth / Montero, Nuria / Pascual, Julio / Jenssen, Trond G / Porrini, Esteban / Hecking, Manfred

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2024 Volume 39, Issue 3, Page(s) 531–549

Abstract: Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk ... ...

Abstract	Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk stratification and management. However, the last decade has seen significant advancements in our PTDM knowledge complemented by rapidly changing treatment algorithms for management of diabetes in the general population. In view of these developments, and to ensure reduced variation in clinical practice, a 3rd international PTDM Consensus Meeting was planned and held from 6-8 May 2022 in Vienna, Austria involving global delegates with PTDM expertise to update the previous reports. This update includes opinion statements concerning optimal diagnostic tools, recognition of prediabetes (impaired fasting glucose and/or impaired glucose tolerance), new mechanistic insights, immunosuppression modification, evidence-based strategies to prevent PTDM, treatment hierarchy for incorporating novel glucose-lowering agents and suggestions for the future direction of PTDM research to address unmet needs. Due to the paucity of good quality evidence, consensus meeting participants agreed that making GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) recommendations would be flawed. Although kidney-allograft centric, we suggest that these opinion statements can be appraised by the transplantation community for implementation across different solid organ transplant cohorts. Acknowledging the paucity of published literature, this report reflects consensus expert opinion. Attaining evidence is desirable to ensure establishment of optimized care for any solid organ transplant recipient at risk of, or who develops, PTDM as we strive to improve long-term outcomes.
MeSH term(s)	Humans ; Consensus ; Kidney Transplantation/adverse effects ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Organ Transplantation/adverse effects ; Glucose ; Risk Factors ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/epidemiology
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad258
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Article: Meltdose Tacrolimus Population Pharmacokinetics and Limited Sampling Strategy Evaluation in Elderly Kidney Transplant Recipients.

Kamp, Jasper / Zwart, Tom C / Meziyerh, Soufian / van der Boog, Paul J M / Nijgh, Esther E / van Duin, Koen / de Vries, Aiko P J / Moes, Dirk Jan A R

Pharmaceutics

2023 Volume 16, Issue 1

Abstract: Background: Meltdose tacrolimus (Envarsus: Methods: A total of 34 kidney transplant recipients aged ≥65 years, starting on meltdose tacrolimus directly after transplantation, were included. An eight-point whole blood AUC: Results: The PK data were ...

Abstract	Background: Meltdose tacrolimus (Envarsus Methods: A total of 34 kidney transplant recipients aged ≥65 years, starting on meltdose tacrolimus directly after transplantation, were included. An eight-point whole blood AUC Results: The PK data were best described using a two-compartment model, including three transit compartments and a mixture model for oral absorption. The best three-sample LSS was T = 0, 2, 6 h. The best four-sample LSSs were T = 0, 2, 6, 8 h and T = 0, 1, 6, 8 h. Conclusions: The developed population PK model adequately described the tacrolimus PK data in a population of elderly kidney transplant recipients. In addition, the developed population PK model and LSS showed an adequate estimation of tacrolimus exposure, and may therefore be used to aid in tacrolimus dose individualization.
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16010017
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Article ; Online: The Clinical Utility of Post-Transplant Monitoring of Donor-Specific Antibodies in Stable Renal Transplant Recipients: A Consensus Report With Guideline Statements for Clinical Practice.

van den Broek, Dennis A J / Meziyerh, Soufian / Budde, Klemens / Lefaucheur, Carmen / Cozzi, Emanuele / Bertrand, Dominique / López Del Moral, Covadonga / Dorling, Anthony / Emonds, Marie-Paule / Naesens, Maarten / de Vries, Aiko P J

Transplant international : official journal of the European Society for Organ Transplantation

2023 Volume 36, Page(s) 11321

Abstract: Solid phase immunoassays improved the detection and determination of the antigen-specificity of donor-specific antibodies (DSA) to human leukocyte antigens (HLA). The widespread use of SPI in kidney transplantation also introduced new clinical dilemmas, ... ...

Abstract	Solid phase immunoassays improved the detection and determination of the antigen-specificity of donor-specific antibodies (DSA) to human leukocyte antigens (HLA). The widespread use of SPI in kidney transplantation also introduced new clinical dilemmas, such as whether patients should be monitored for DSA pre- or post-transplantation. Pretransplant screening through SPI has become standard practice and DSA are readily determined in case of suspected rejection. However, DSA monitoring in recipients with stable graft function has not been universally established as standard of care. This may be related to uncertainty regarding the clinical utility of DSA monitoring as a screening tool. This consensus report aims to appraise the clinical utility of DSA monitoring in recipients without overt signs of graft dysfunction, using the Wilson & Junger criteria for assessing the validity of a screening practice. To assess the evidence on DSA monitoring, the European Society for Organ Transplantation (ESOT) convened a dedicated workgroup, comprised of experts in transplantation nephrology and immunology, to review relevant literature. Guidelines and statements were developed during a consensus conference by Delphi methodology that took place in person in November 2022 in Prague. The findings and recommendations of the workgroup on subclinical DSA monitoring are presented in this article.
MeSH term(s)	Humans ; Kidney Transplantation ; Graft Rejection ; Isoantibodies ; Kidney ; Organ Transplantation ; HLA Antigens ; Graft Survival ; Transplant Recipients ; Tissue Donors ; Histocompatibility Testing ; Retrospective Studies
Chemical Substances	Isoantibodies ; HLA Antigens
Language	English
Publishing date	2023-07-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2023.11321
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Article ; Online: European Society for Organ Transplantation (ESOT)-TLJ 3.0 Consensus on Histopathological Analysis of Pre-Implantation Donor Kidney Biopsy: Redefining the Role in the Process of Graft Assessment.

Zaza, Gianluigi / Cucchiari, David / Becker, Jan Ulrich / de Vries, Aiko P J / Eccher, Albino / Florquin, Sandrine / Kers, Jesper / Rabant, Marion / Rossini, Michele / Pengel, Liset / Marson, Lorna / Furian, Lucrezia

Transplant international : official journal of the European Society for Organ Transplantation

2023 Volume 36, Page(s) 11410

Abstract: The ESOT TLJ 3.0. consensus conference brought together leading experts in transplantation to develop evidence-based guidance on the standardization and clinical utility of pre-implantation kidney biopsy in the assessment of grafts from Expanded Criteria ...

Abstract	The ESOT TLJ 3.0. consensus conference brought together leading experts in transplantation to develop evidence-based guidance on the standardization and clinical utility of pre-implantation kidney biopsy in the assessment of grafts from Expanded Criteria Donors (ECD). Seven themes were selected and underwent in-depth analysis after formulation of PICO (patient/population, intervention, comparison, outcomes) questions. After literature search, the statements for each key question were produced, rated according the GRADE approach [Quality of evidence: High (A), Moderate (B), Low (C); Strength of Recommendation: Strong (1), Weak (2)]. The statements were subsequently presented in-person at the Prague kick-off meeting, discussed and voted. After two rounds of discussion and voting, all 7 statements reached an overall agreement of 100% on the following issues: needle core/wedge/punch technique representatively [B,1], frozen/paraffin embedded section reliability [B,2], experienced/non-experienced on-call renal pathologist reproducibility/accuracy of the histological report [A,1], glomerulosclerosis/other parameters reproducibility [C,2], digital pathology/light microscopy in the measurement of histological variables [A,1], special stainings/Haematoxylin and Eosin alone comparison [A,1], glomerulosclerosis reliability
MeSH term(s)	Humans ; Kidney Transplantation/methods ; Reproducibility of Results ; Kidney/pathology ; Biopsy ; Tissue Donors ; Organ Transplantation ; Graft Survival
Language	English
Publishing date	2023-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2023.11410
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Article ; Online: Tacrolimus and Mycophenolic Acid Exposure Are Associated with Biopsy-Proven Acute Rejection: A Study to Provide Evidence for Longer-Term Target Ranges.

Meziyerh, Soufian / van Gelder, Teun / Kers, Jesper / van der Helm, Danny / van der Boog, Paul J M / de Fijter, Johan W / Moes, Dirk Jan A R / de Vries, Aiko P J

Clinical pharmacology and therapeutics

2023 Volume 114, Issue 1, Page(s) 192–200

Abstract: Evidence to define target ranges for tacrolimus (Tac) and mycophenolic acid (MPA) exposure after the first year of kidney transplantation is limited. We investigated the association of measurements at 1 year and repeated measurements of real-world Tac- ... ...

Abstract	Evidence to define target ranges for tacrolimus (Tac) and mycophenolic acid (MPA) exposure after the first year of kidney transplantation is limited. We investigated the association of measurements at 1 year and repeated measurements of real-world Tac-trough levels (C
MeSH term(s)	Humans ; Tacrolimus/adverse effects ; Mycophenolic Acid/adverse effects ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Graft Rejection/prevention & control
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Mycophenolic Acid (HU9DX48N0T) ; Immunosuppressive Agents
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2915
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