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  1. Book ; Online ; E-Book: PET and SPECT of neurobiological systems

    Dierckx, Rudi A.J.O. / Otte, Andreas / de Vries, Erik F.J. / van Waarde, Aren / Lammertsma, Adriaan A.

    2021  

    Author's details Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, Adriaan A. Lammertsma editors
    Keywords Nuclear medicine ; Radiology ; Neurology
    Subject code 616.07548
    Language English
    Size 1 Online-Ressource (xii, 1132 Seiten), Illustrationen
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020614560
    ISBN 978-3-030-53176-8 ; 9783030531751 ; 3-030-53176-7 ; 3030531759
    DOI 10.1007/978-3-030-53176-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: PET and SPECT in psychiatry

    Dierckx, Rudi A. J. O. / Otte, Andreas / de Vries, Erik F. J. / van Waarde, Aren / Sommer, Iris E.

    2021  

    Author's details Rudi A. J. O. Dierckx, Andreas Otte, Erik F. J. de Vries, Aren van Waarde editors ; Iris E. Sommer guest editor
    Keywords Nuclear medicine ; Radiology ; Psychiatry
    Subject code 616.07548
    Language English
    Size 1 Online-Ressource (xii, 1084 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020699720
    ISBN 978-3-030-57231-0 ; 9783030572303 ; 3-030-57231-5 ; 3030572307
    DOI 10.1007/978-3-030-57231-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Short-latency afferent inhibition as a biomarker of cholinergic degeneration compared to PET imaging in Parkinson's disease.

    d'Angremont, Emile / Sommer, Iris E C / van der Zee, Sygrid / van Laar, Teus / de Vries, Erik F J / Zijdewind, Inge

    Parkinsonism & related disorders

    2024  Volume 121, Page(s) 106032

    Abstract: Introduction: Short-latency afferent inhibition (SAI) is a relatively cheap and non-invasive method that has been proposed as a cholinergic marker in Parkinson's disease (PD). We aim to verify the clinical feasibility of SAI as a cholinergic marker in ... ...

    Abstract Introduction: Short-latency afferent inhibition (SAI) is a relatively cheap and non-invasive method that has been proposed as a cholinergic marker in Parkinson's disease (PD). We aim to verify the clinical feasibility of SAI as a cholinergic marker in PD using positron emission tomography (PET) with the tracer (2R,3R)-5-(2-[
    Methods: We examined relations between SAI and [
    Results: 30 PD patients with varying degrees of cognitive dysfunction and 10 healthy controls (HC) were included in the analysis. SAI was not related to tracer uptake in M1 in the PD group (p = .291) or the HC group (p = .206). We could not replicate the previously published relations between SAI and cholinergic symptoms, such as cognition, psychotic experiences and olfactory function.
    Conclusion: SAI was not related to [
    MeSH term(s) Humans ; Parkinson Disease ; Positron-Emission Tomography ; Cholinergic Agents ; Biomarkers ; Neural Inhibition/physiology
    Chemical Substances Cholinergic Agents ; Biomarkers
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2024.106032
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    Zs.A 4553: Show issues Location:
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  4. Article ; Online: PET imaging of animal models with depressive-like phenotypes.

    Vazquez-Matias, Daniel Aaron / de Vries, Erik F J / Dierckx, Rudi A J O / Doorduin, Janine

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 6, Page(s) 1564–1584

    Abstract: Major depressive disorder is a growing and poorly understood pathology. Due to technical and ethical limitations, a significant proportion of the research on depressive disorders cannot be performed on patients, but needs to be investigated in animal ... ...

    Abstract Major depressive disorder is a growing and poorly understood pathology. Due to technical and ethical limitations, a significant proportion of the research on depressive disorders cannot be performed on patients, but needs to be investigated in animal paradigms. Over the years, animal studies have provided new insight in the mechanisms underlying depression. Several of these studies have used PET imaging for the non-invasive and longitudinal investigation of the brain physiology. This review summarises the findings of preclinical PET imaging in different experimental paradigms of depression and compares these findings with observations from human studies. Preclinical PET studies in animal models of depression can be divided into three main different approaches: (a) investigation of glucose metabolism as a biomarker for regional and network involvement, (b) evaluation of the availability of different neuroreceptor populations associated with depressive phenotypes, and (c) monitoring of the inflammatory response in phenotypes of depression. This review also assesses the relevance of the use of PET imaging techniques in animal paradigms for the understanding of specific aspects of the depressive-like phenotypes, in particular whether it might contribute to achieve a more detailed characterisation of the clinical depressive phenotypes for the development of new therapies for depression.
    MeSH term(s) Animals ; Humans ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Major/pathology ; Positron-Emission Tomography ; Models, Animal ; Phenotype ; Brain/metabolism ; Disease Models, Animal
    Language English
    Publishing date 2023-01-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-06073-4
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    Zs.A 1227: Show issues Location:
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  5. Article ; Online: Immune Activation in Pregnant Rats Affects Brain Glucose Consumption, Anxiety-like Behaviour and Recognition Memory in their Male Offspring.

    Guerrin, Cyprien G J / Shoji, Alexandre / Doorduin, Janine / de Vries, Erik F J

    Molecular imaging and biology

    2022  Volume 24, Issue 5, Page(s) 740–749

    Abstract: Purpose: Prenatal infection during pregnancy is a risk factor for schizophrenia, as well as for other developmental psychiatric disorders, such as autism and bipolar disorder. Schizophrenia patients were reported to have altered brain metabolism and ... ...

    Abstract Purpose: Prenatal infection during pregnancy is a risk factor for schizophrenia, as well as for other developmental psychiatric disorders, such as autism and bipolar disorder. Schizophrenia patients were reported to have altered brain metabolism and neuroinflammation. However, the link between prenatal infection, altered brain inflammation and metabolism, and schizophrenia remains unclear. In this project, we aimed to evaluate whether there are changes in brain glucose consumption and microglia activation in the offspring of pregnant rats exposed to maternal immune activation (MIA), and if so, whether these changes occur before or after the initiation of schizophrenia-like behaviour.
    Procedures: Pregnant rats were treated with the viral mimic polyinosinic-polycytidylic acid (MIA group) or saline (control group) on gestational day 15. Static PET scans of the male offspring were acquired on postnatal day (PND) 21, 60, and 90, using [11C]-PK11195 and deoxy-2-[18F]fluoro-D-glucose ([18F]-FDG) as tracers to measure TSPO expression in activated microglia and brain glucose consumption, respectively. On PND60 and PND90, anxiety-like behaviour, recognition memory, and sensorimotor gating were measured using the open field test (OFT), novel object recognition test (NOR), and prepulse inhibition test (PPI).
    Results: [18F]-FDG PET demonstrated that MIA offspring displayed higher brain glucose consumption in the whole brain after weaning (p = 0.017), and in the frontal cortex during late adolescence (p = 0.001) and adulthood (p = 0.037) than control rats. [11C]-PK11195 PET did not reveal any changes in TSPO expression in MIA offspring. Prenatal infection induced age-related behavioural alterations. Adolescent MIA offspring displayed a more anxious state in the OFT than controls (p = 0.042). Adult MIA offspring showed recognition memory deficits in the NOR (p = 0.003). Our study did not show any PPI deficits.
    Conclusions: Our results suggest that prenatal immune activation changed neurodevelopment, resulting in increased brain glucose consumption, but not in microglia activation. The increased brain glucose consumption in the frontal cortex of MIA offspring remained until adulthood and was associated with increased anxiety-like behaviour during adolescence and recognition memory deficits in adulthood.
    MeSH term(s) Pregnancy ; Female ; Humans ; Animals ; Rats ; Male ; Poly I-C/metabolism ; Poly I-C/pharmacology ; Prenatal Exposure Delayed Effects/metabolism ; Behavior, Animal/physiology ; Glucose/metabolism ; Fluorodeoxyglucose F18/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Anxiety ; Memory Disorders/metabolism ; Disease Models, Animal ; Receptors, GABA/metabolism
    Chemical Substances Poly I-C (O84C90HH2L) ; Glucose (IY9XDZ35W2) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Carbon-11 ; TSPO protein, human ; Receptors, GABA
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-022-01723-3
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    Zs.A 6468: Show issues Location:
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  6. Article: Social adversity during juvenile age but not adulthood increases susceptibility to an immune challenge later in life.

    Guerrin, Cyprien G J / Doorduin, Janine / Prasad, Kavya / Vazquez-Matias, Daniel A / Barazzuol, Lara / de Vries, Erik F J

    Neurobiology of stress

    2023  Volume 23, Page(s) 100526

    Abstract: Adverse experiences in early life can increase mental vulnerability to immune challenges experienced later in life, which may induce the development of stress-related psychopathologies. Here, we investigated whether the combined effect of both events is ... ...

    Abstract Adverse experiences in early life can increase mental vulnerability to immune challenges experienced later in life, which may induce the development of stress-related psychopathologies. Here, we investigated whether the combined effect of both events is higher if the first adverse experience occurs when the brain is still in development. Therefore, male Wistar rats were exposed to repeated social defeat (RSD, first hit) during juvenile age or adulthood and to an immune challenge consisting of a single injection of lipopolysaccharide (LPS, second hit) in adulthood. Control animals were not exposed to RSD, but only to the LPS challenge. Translocator protein density, a marker for reactive microglia, microglia cell density and plasma corticosterone levels were measured using in vivo [
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2816500-7
    ISSN 2352-2895
    ISSN 2352-2895
    DOI 10.1016/j.ynstr.2023.100526
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  7. Article: Molecular imaging as biomarker for treatment response and outcome in breast cancer.

    van Geel, Jasper J L / de Vries, Erik F J / van Kruchten, Michel / Hospers, Geke A P / Glaudemans, Andor W J M / Schröder, Carolina P

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231170738

    Abstract: Molecular imaging, such as positron emission tomography (PET), is increasingly used as biomarker to predict and assess treatment response in breast cancer. The number of biomarkers is expanding with specific tracers for tumour characteristics throughout ... ...

    Abstract Molecular imaging, such as positron emission tomography (PET), is increasingly used as biomarker to predict and assess treatment response in breast cancer. The number of biomarkers is expanding with specific tracers for tumour characteristics throughout the body and this information can be used to aid the decision-making process. These measurements include metabolic activity using [
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231170738
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  8. Article ; Online: Maternal infection during pregnancy aggravates the behavioral response to an immune challenge during adolescence in female rats.

    Guerrin, Cyprien G J / de Vries, Erik F J / Prasad, Kavya / Vazquez-Matias, Daniel A / Manusiwa, Lesley E / Barazzuol, Lara / Doorduin, Janine

    Behavioural brain research

    2023  Volume 452, Page(s) 114566

    Abstract: Prenatal and early postnatal infection have been associated with changes in microglial activity and the development of psychiatric disorders. Here, we investigated the effect of prenatal immune activation and postnatal immune challenge, alone and ... ...

    Abstract Prenatal and early postnatal infection have been associated with changes in microglial activity and the development of psychiatric disorders. Here, we investigated the effect of prenatal immune activation and postnatal immune challenge, alone and combined, on behavior and microglial cell density in female Wistar rats. Pregnant rats were injected with poly I:C to induce a maternal immune activation (MIA). Their female offspring were subsequently exposed to a lipopolysaccharide (LPS) immune challenge during adolescence. Anhedonia, social behavior, anxiety, locomotion, and working memory were measured with the sucrose preference, social interaction, open field, elevated-plus maze, and Y-maze test, respectively. Microglia cell density was quantified by counting the number of Iba-1 positive cells in the brain cortex. Female MIA offspring were more susceptible to the LPS immune challenge during adolescence than control offspring as demonstrated by a more pronounced reduction in sucrose preference and body weight on the days following the LPS immune challenge. Furthermore, only the rats exposed to both MIA and LPS showed long-lasting changes in social behavior and locomotion. Conversely, the combination MIA and LPS prevented the anxiety induced by MIA alone during adulthood. MIA, LPS, or their combination did not change microglial cell density in the parietal and frontal cortex of adult rats. The results of our study suggest that the maternal immune activation during pregnancy aggravates the response to an immune challenge during adolescence in female rats.
    MeSH term(s) Pregnancy ; Humans ; Rats ; Animals ; Female ; Rats, Wistar ; Lipopolysaccharides/pharmacology ; Prenatal Exposure Delayed Effects ; Brain ; Social Behavior ; Behavior, Animal/physiology ; Disease Models, Animal
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2023.114566
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    Zs.A 1599: Show issues Location:
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  9. Article ; Online: Pharmacokinetic Analysis of [

    Ghazanfari, Nafiseh / Doorduin, Janine / van der Weijden, Chris W J / Willemsen, Antoon T M / Glaudemans, Andor W J M / van Waarde, Aren / Dierckx, Rudi A J O / de Vries, Erik F J

    Molecular imaging and biology

    2024  Volume 26, Issue 2, Page(s) 351–359

    Abstract: Purpose: Estrogen receptors (ER) are implicated in psychiatric disorders. We assessed if ER availability in the human brain could be quantified using 16α-[: Procedures: Seven post‑menopausal women underwent a dynamic [: Results: The reversible two- ...

    Abstract Purpose: Estrogen receptors (ER) are implicated in psychiatric disorders. We assessed if ER availability in the human brain could be quantified using 16α-[
    Procedures: Seven post‑menopausal women underwent a dynamic [
    Results: The reversible two-tissue compartment model (2T4k) model with fixed K
    Conclusions: The optimal quantification method for [
    MeSH term(s) Humans ; Female ; Positron-Emission Tomography/methods ; Brain/metabolism ; Estradiol ; Receptors, Estrogen/metabolism ; Pituitary Gland/metabolism
    Chemical Substances Estradiol (4TI98Z838E) ; Receptors, Estrogen
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-023-01880-z
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  10. Article ; Online: Effects of the adenosine A

    Prasad, Kavya / de Vries, Erik F J / van der Meiden, Esther / Moraga-Amaro, Rodrigo / Vazquez-Matias, Daniel Aaron / Barazzuol, Lara / Dierckx, Rudi A J O / van Waarde, Aren

    Neuropharmacology

    2024  Volume 247, Page(s) 109862

    Abstract: Adenosine ... ...

    Abstract Adenosine A
    MeSH term(s) Rats ; Male ; Animals ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/drug therapy ; Dopamine ; Receptor, Adenosine A2A/metabolism ; Neuroinflammatory Diseases ; Adenosine/metabolism ; Raclopride ; Rats, Wistar ; Oxidopamine/toxicity ; Purines
    Chemical Substances istradefylline (2GZ0LIK7T4) ; Dopamine (VTD58H1Z2X) ; Receptor, Adenosine A2A ; Adenosine (K72T3FS567) ; Raclopride (430K3SOZ7G) ; Oxidopamine (8HW4YBZ748) ; Purines
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2024.109862
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