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  1. AU="de Vries, Florentine R"
  2. AU="Tsai, Y-T" AU="Tsai, Y-T"
  3. AU="Gonakoti, Sriram"
  4. AU="Wulf, J"
  5. AU="Mardsen, D"
  6. AU="James, David B A"
  7. AU="Montabone, Erika"
  8. AU="Susan J. Burke"
  9. AU="Chen, Yuguang"
  10. AU="Zhao, Zhenghuan"
  11. AU="De Chiara, Anna Rosaria"
  12. AU="Savage, Anne"
  13. AU="Salamanca, Albert"
  14. AU="Zhong, Xiao-Song"
  15. AU="Deguchi, Masashi"
  16. AU="Żmuda, J"
  17. AU="Liao, Yanyan"
  18. AU="Zhu, Jin-Wei"
  19. AU="Khan, Azkia"
  20. AU="Folkman, Judah"
  21. AU=Bhatia Rajesh
  22. AU="Thobois, Stéphane"
  23. AU="Lai, Chien-Chih"
  24. AU="Ahn, Bo Young"
  25. AU="Jeje, Olamide"
  26. AU="Fine, Samson W"
  27. AU="Riemann, Burkhard"
  28. AU="Nazir, Ahsan"
  29. AU="Kawakita, Emi"
  30. AU="Wang, Junnian"
  31. AU="Nie, Chong"

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  1. Artikel ; Online: Argon laser photocoagulation in polypoidal choroidal vasculopathy.

    Sirks, Marc J / Feenstra, Helena M A / de Vries, Florentine R / Dijkman, Greet / Boon, Camiel J F / van Dijk, Elon H C

    Clinical & experimental ophthalmology

    2022  Band 51, Heft 2, Seite(n) 177–179

    Mesh-Begriff(e) Humans ; Argon ; Polypoidal Choroidal Vasculopathy ; Choroid Diseases/diagnosis ; Choroid Diseases/surgery ; Light Coagulation ; Lasers ; Choroid ; Fluorescein Angiography ; Choroidal Neovascularization
    Chemische Substanzen Argon (67XQY1V3KH)
    Sprache Englisch
    Erscheinungsdatum 2022-11-23
    Erscheinungsland Australia
    Dokumenttyp Letter
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14191
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.

    Pons, Douwe / de Vries, Florentine R / van den Elsen, Peter J / Heijmans, Bastiaan T / Quax, Paul H A / Jukema, J Wouter

    European heart journal

    2009  Band 30, Heft 3, Seite(n) 266–277

    Abstract: Significant progress has been made in the clinical management of a variety of cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current treatment modalities for atherosclerosis and restenosis is not fully sufficient in a large ... ...

    Abstract Significant progress has been made in the clinical management of a variety of cardiovascular diseases. Nevertheless, the therapeutic efficacy of the current treatment modalities for atherosclerosis and restenosis is not fully sufficient in a large proportion of patients. One of the major contributing factors is the clinical and biological heterogeneity of these still life-threatening diseases, which involve processes that we do not fully understand at the moment. Over the past decades, it has become increasingly clear that part of the gene-environmental interactions relevant for complex diseases is regulated by epigenetic mechanisms such as histone acetylation and DNA methylation. Epigenetic processes modulate gene expression patterns without modifying the actual DNA sequence and have profound effects on the cellular repertoire of expressed genes. They contribute to the expression of genes that play a key role in extracellular matrix formation, inflammation, and proliferation, processes involved in cardiovascular pathologies such as atherosclerosis and restenosis. Therefore, in this review, we argue that epigenetic regulators involved in histone acetylating and deacetylating activities contribute to the pathogenesis of atherosclerosis and restenosis. Furthermore, as alterations in chromatin structure are reversible, these epigenetic modifications are amendable to pharmacological intervention, which may prove to be an effective treatment modality for the management of cardiovascular diseases.
    Mesh-Begriff(e) Acetylation ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cell Proliferation ; Epigenesis, Genetic ; Extracellular Matrix/metabolism ; Histone Acetyltransferases/physiology ; Histone Deacetylases/physiology ; Humans ; Muscle, Smooth, Vascular/pathology
    Chemische Substanzen Histone Acetyltransferases (EC 2.3.1.48) ; Histone Deacetylases (EC 3.5.1.98)
    Sprache Englisch
    Erscheinungsdatum 2009-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehn603
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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