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Article ; Online: Patterns of knee osteoarthritis management in general practice: a retrospective cohort study using electronic health records.

Arslan, Ilgin G / van Berkel, A C / Damen, J / Bindels, P / de Wilde, M / Bierma-Zeinstra, S M A / Schiphof, D

BMC primary care

2024 Volume 25, Issue 1, Page(s) 2

Abstract: Objective: This study determined patterns of knee osteoarthritis (OA) management by general practitioners (GPs) using routine healthcare data from Dutch general practices from 2011 to 2019.: Design: A retrospective cohort study was conducted using ... ...

Abstract	Objective: This study determined patterns of knee osteoarthritis (OA) management by general practitioners (GPs) using routine healthcare data from Dutch general practices from 2011 to 2019. Design: A retrospective cohort study was conducted using the Integrated Primary Care Information database between 2011 and 2019. Electronic health records (EHRs) of n = 750 randomly selected knee OA patients (with either codified or narrative diagnosis) were reviewed against eligibility criteria and n = 503 patients were included. Recorded information was extracted on GPs' management from six months before to three years after diagnosis and patterns of management were analysed. Results: An X-ray referral was the most widely recorded management modality (63.2%). The next most widely recorded management modalities were a referral to secondary care (56.1%) and medication prescription or advice (48.3%). Records of recommendation of/referral to other primary care practitioners (e.g. physiotherapists) were found in only one third of the patients. Advice to lose weight was least common (1.2%). Records of medication prescriptions or recommendation of/referral to other primary care practitioners were found more frequently in patients with an X-ray referral compared to patients without, while records of secondary care referrals were found less frequently. Records of an X-ray referral were often found in narratively diagnosed knee OA patients before GPs recorded a code for knee OA in their EHR. Conclusion: These findings emphasize the importance of better implementing non-surgical management of knee OA in general practice and on initiatives for reducing the overuse of X-rays for diagnosing knee OA in general practice.
MeSH term(s)	Humans ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/epidemiology ; Osteoarthritis, Knee/therapy ; Electronic Health Records ; Retrospective Studies ; Family Practice ; General Practice
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ISSN	2731-4553
ISSN (online)	2731-4553
DOI	10.1186/s12875-023-02198-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Patient's Expectations Regarding Alcohol Misuse Prevention in General Hospitals.

Patigny, Pierre / De Wilde, Mathias / Jacques, Denis

Psychiatria Danubina

2023 Volume 35, Issue Suppl 2, Page(s) 332–335

Abstract: Background: The general hospital can be regarded as a suitable place to provide secondary prevention for patients with alcohol misuse. It appears that screening and/or brief interventions on alcohol are acceptable for patients in hospital wards. The aim ...

Abstract	Background: The general hospital can be regarded as a suitable place to provide secondary prevention for patients with alcohol misuse. It appears that screening and/or brief interventions on alcohol are acceptable for patients in hospital wards. The aim of this exploration study is to assess patients' expectations regarding the prevention of alcohol misuse carried out in general hospitals. Method: This study is based on the results of an online survey conducted in February 2023. The survey was in free access on the CHU UCL Namur hospital's website. Results: Only the alcohol consumption of 18.9% of our sample is usually assessed by hospital caregivers; however, we observe a high level of satisfaction with receiving information on the prevention of alcohol misuse. Among the proposed prevention interventions, screening feedback seems to be the most popular approach. Conclusion: This study confirms the recommendations on the role of the general hospital in the prevention of alcohol misuse. The big challenge remains to understand why the level of screening for alcohol misuse in general hospitals is so low. Future studies should assess the determinants of alcohol abuse screening behaviors among caregivers to understand why the screening rate is so low.
MeSH term(s)	Humans ; Alcoholism/epidemiology ; Alcoholism/prevention & control ; Hospitals, General ; Motivation ; Alcohol Drinking/prevention & control ; Surveys and Questionnaires
Language	English
Publishing date	2023-09-20
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
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Article ; Online: Priorities and Future of the ISBER Standards Community of Practice and Pediatric Special Interest Group.

Allocca, Clare / De Wilde, Mieke / Labib, Rania

Biopreservation and biobanking

2023 Volume 21, Issue 1, Page(s) 114–115

MeSH term(s)	Humans ; Child ; Public Opinion ; Reference Standards ; Biological Specimen Banks
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2593993-2
ISSN	1947-5543 ; 1947-5535
ISSN (online)	1947-5543
ISSN	1947-5535
DOI	10.1089/bio.2023.29116.cja
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Article ; Online: A High-Fidelity Combined ATC-Rxnorm Drug Hierarchy for Large-Scale Observational Research.

Ostropolets, Anna / Talapova, Polina / De Wilde, Marcel / Abedtash, Hamed / Rijnbeek, Peter / Reich, Christian G

Studies in health technology and informatics

2024 Volume 310, Page(s) 53–57

Abstract: Observational research utilizes patient information from many disparate databases worldwide. To be able to systematically analyze data and compare the results of such research studies, information about exposure to drugs or classes of drugs needs to be ... ...

Abstract	Observational research utilizes patient information from many disparate databases worldwide. To be able to systematically analyze data and compare the results of such research studies, information about exposure to drugs or classes of drugs needs to be harmonized across these data. The NLM's RxNorm drug terminology and WHO's ATC classification serve these needs but are currently not satisfactorily combined into a common system. Creating such system is hampered by a number of challenges, resulting from different approaches to representing attributes of drugs and ontological rules. Here, we present a combined ATC-RxNorm drug hierarchy, allowing to use ATC classes for retrieval of drug information in large scale observational data. We present the heuristic for maintaining this resource and evaluate it in a real world database containing drug and drug classification information.
MeSH term(s)	Humans ; RxNorm ; Vocabulary, Controlled ; Databases, Factual ; Heuristics
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230926
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Article ; Online: Designing trust

de Wilde, M. / Spaargaren, G.

Building Research and Information

how strategic intermediaries choreograph homeowners’ low-carbon retrofit experience

2019 Volume 47, Issue 4

Abstract: In the Netherlands, as in other European countries, the uncertain, fragmented character of the low-carbon retrofit market hampers a transition towards sustainable housing. Connecting homeowners to supply-side actors of low-carbon retrofit procedures, ... ...

Abstract	In the Netherlands, as in other European countries, the uncertain, fragmented character of the low-carbon retrofit market hampers a transition towards sustainable housing. Connecting homeowners to supply-side actors of low-carbon retrofit procedures, products and technologies in ways satisfactory to homeowners forms an important, challenging task. Service design for the benefit of a customer-centric perspective might be a solution. This paper investigates the potential role of strategic intermediaries as agents of change located between supply-side actors and homeowners. It asks how strategic intermediaries choreograph low-carbon retrofit experiences of homeowners through the design of a ‘customer journey’. Trust is a crucial determinant. This paper distinguishes between three customer-journey designs in which, depending on the role envisioned for homeowners, a different trust relation is foregrounded: a private design envisions homeowners as passive consumers who trust in the expertise offered by the intermediary; a civic design envisions homeowners as engaged consumer-citizens who trust their neighbours as reliable service representatives; and a public design envisions homeowners as critical customers who trust in the retrofit technologies and products offered. This implies an important role for policy actors in realizing ways for scaling up and institutionalizing all three low-carbon retrofit customer-journey designs on a national level
Keywords	houses ; market transformation ; middle-out ; retrofit ; service design ; strategic intermediaries ; sustainable buildings ; trust
Subject code	650
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	1481969-7
ISSN	1466-4321 ; 0961-3218
ISSN (online)	1466-4321
ISSN	0961-3218
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Can increased vigilance for chronic kidney disease in hospitalised patients decrease late referral and improve dialysis-free survival?

De Wilde, M / Speeckaert, M / Van Biesen, W

BMC nephrology

2018 Volume 19, Issue 1, Page(s) 74

Abstract: Background: Insufficient vigilance for renal insufficiency is associated with late referral, increased morbidity and mortality. The present study examines whether increased vigilance for chronic kidney disease (CKD) leads to quicker referral to and ... ...

Abstract	Background: Insufficient vigilance for renal insufficiency is associated with late referral, increased morbidity and mortality. The present study examines whether increased vigilance for chronic kidney disease (CKD) leads to quicker referral to and better follow-up by a nephrologist, and whether it is associated with an improved outcome. Methods: Patients with an eGFR < 45 ml/min/1.73 m Results: Of the 72 included patients, 54 had proven CKD, with eGFR consistently < 45 ml/min/1.73 m Conclusion: Vigilance for CKD is poor. Simple interventions to augment the vigilance for CKD, as presented in this study, lead to a quicker referral to and follow-up by a nephrologist, which may result in better outcome.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Glomerular Filtration Rate/physiology ; Hospitalization/trends ; Humans ; Male ; Nephrologists/standards ; Nephrologists/trends ; Referral and Consultation/standards ; Referral and Consultation/trends ; Renal Dialysis/standards ; Renal Dialysis/trends ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy
Language	English
Publishing date	2018-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-018-0869-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The sustainable housing question

de Wilde, Mandy

Energy Research and Social Science

On the role of interpersonal, impersonal and professional trust in low-carbon retrofit decisions by homeowners

2019 Volume 51

Abstract: Trust is critical for facilitating energy transitions in both general and market exchange, and most particularly in consumer engagement. However, little research has been done to demonstrate how trust is established and how it influences the decision- ... ...

Abstract	Trust is critical for facilitating energy transitions in both general and market exchange, and most particularly in consumer engagement. However, little research has been done to demonstrate how trust is established and how it influences the decision-making process of important change agents in energy transitions. On the basis of 40 in-depth interviews with homeowners who adopted a domestic low-carbon retrofit measure, this paper distinguishes three modes of trust that play a role in a retrofit decision-making process. First, interpersonal trust builds on the familiarity and social identification within social networks. Second, impersonal trust develops through certified tools and standards generated by governmental bodies and other actors perceived as independent. Finally, professional trust arises due to the perceived professional capacities and ethics of supply-side actors in the construction industry, and insulation and installation businesses. The paper demonstrates the various roles that modes of trust have in the decision-making process. Moreover, the paper shows the interaction between these different modes of trust and their mediators. Tailoring domestic low-carbon retrofit campaigns and services to different modes of trust is imperative in order to persuade homeowners to retrofit their homes, to engage with energy issues and to contribute to a transition to sustainable housing.
Keywords	Homeowners ; Low-carbon retrofit ; Mediators ; Professionals ; Social networks ; Standards ; Sustainable housing ; Trust
Subject code	690
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2763226-X
ISSN	2214-6296
ISSN	2214-6296
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke.

De Wilde, Maaike / Desender, Linda / Tersteeg, Claudia / Vanhoorelbeke, Karen / De Meyer, Simon F

Research and practice in thrombosis and haemostasis

2022 Volume 7, Issue 1, Page(s) 100028

Abstract: Background: Thromboinflammatory processes modulate the complex pathophysiology of cerebral ischemia-reperfusion (I/R) injury in ischemic stroke, but the exact underlying mechanisms remain poorly understood. Emerging evidence indicates that neutrophil ... ...

Abstract	Background: Thromboinflammatory processes modulate the complex pathophysiology of cerebral ischemia-reperfusion (I/R) injury in ischemic stroke, but the exact underlying mechanisms remain poorly understood. Emerging evidence indicates that neutrophil extracellular traps (NETs) might play an important role in the thromboinflammatory cascade. In addition, the link between von Willebrand factor (VWF) and neutrophil recruitment in the ischemic brain might promote thromboinflammation, possibly by the formation of NETs. Objectives: To study NET formation in a murine model of cerebral I/R injury in ischemic stroke. Methods: The filament-induced transient middle cerebral artery occlusion model was used to induce 60 minutes of focal cerebral ischemia after which reperfusion was allowed. At different time points postischemia, NETs were identified in the ischemic mouse brain using quantitative immunofluorescence microscopy. Results: NETs could be identified in the ipsilateral brain hemisphere. Interestingly, NETs could already be detected at 6 hours poststroke. Their presence increased at 12 hours, was highest at 24 hours, and decreased again 48 hours postischemia. Remarkably, NETs were predominantly localized within the brain vasculature postischemia, suggesting that NETs play a role in secondary microthrombosis. Strikingly, NET formation was significantly decreased in VWF-deficient mice compared to littermate wild-type mice 24 hours postischemia, indicating a possible role for VWF in promoting NETosis in the ischemic brain. Conclusion: This study identified the spatiotemporal profile of NET formation in a mouse model of cerebral I/R injury in ischemic stroke. NETs, potentially in combination with VWF, might be attractive targets for the development of novel therapeutic strategies in ischemic stroke treatment.
Language	English
Publishing date	2022-12-23
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1016/j.rpth.2022.100028
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Article ; Online: The European Commission's Green Deal is an opportunity to rethink harmful practices of research and innovation policy.

Bernstein, Michael J / Franssen, Thomas / Smith, Robert D J / de Wilde, Mandy

Ambio

2022 Volume 52, Issue 3, Page(s) 508–517

Abstract: The European Union's Green Deal and associated policies, aspiring to long-term environmental sustainability, now require economic activities to 'do no significant harm' to EU environmental objectives. The way the European Commission is enacting the do no ...

Abstract	The European Union's Green Deal and associated policies, aspiring to long-term environmental sustainability, now require economic activities to 'do no significant harm' to EU environmental objectives. The way the European Commission is enacting the do no significant harm principle relies on quantitative tools that try to identify harm and adjudicate its significance. A reliance on established technical approaches to assessing such questions ignores the high levels of imprecision, ambiguity, and uncertainty-levels often in flux-characterizing the social contexts in which harms emerge. Indeed, harm, and its significance, are relational, not absolute. A better approach would thus be to acknowledge the relational nature of harm and develop broad capabilities to engage and 'stay with' the harm. We use the case of European research and innovation activities to expose the relational nature of harm, and explore an alternative and potentially more productive approach that departs from attempts to unilaterally or uniformly claim to know or adjudicate what is or is not significantly harmful. In closing, we outline three ways research and innovation policy-makers might experiment with reconfiguring scientific and technological systems and practices to better address the significant harms borne by people, other-than-human beings, and ecosystems.
MeSH term(s)	Humans ; Ecosystem ; Policy ; Technology
Language	English
Publishing date	2022-11-02
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	120759-3
ISSN	1654-7209 ; 0044-7447
ISSN (online)	1654-7209
ISSN	0044-7447
DOI	10.1007/s13280-022-01802-3
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Article ; Online: Domesticating, festivalizing and contesting space

de Wilde, Mandy

Place, Diversity and Solidarity ; ISBN: 9781138654976

Spatial acts of citizenship in a superdiverse neighbourhood in Amsterdam

2017

Keywords	Life Science
Language	English
Publisher	Taylor & Francis
Publishing country	nl
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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