Article ; Online: Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation.
2016 Volume 54, Page(s) 38–44
Abstract: Background: In a previous study, we found an up-regulated inflammatory monocyte gene expression profile in major depressive disorder (MDD) patients aged ⩾ 28 years and a down-regulated inflammatory gene expression profile in MDD patients aged<28 years. ... ...
| Abstract | Background: In a previous study, we found an up-regulated inflammatory monocyte gene expression profile in major depressive disorder (MDD) patients aged ⩾ 28 years and a down-regulated inflammatory gene expression profile in MDD patients aged<28 years. In the same sample of patients, we aimed to investigate immune dysregulation in the lymphocyte arm of the immune system, particularly in the context of the described monocyte (de-)activation states. Methods: From deep frozen leukocytes, circulating percentages of monocytes, lymphocytes, B, T, and natural killer (NK) cells, and various functional subsets of T and T helper (Th) cells (Th1, Th2, Th17, and natural T regulatory cells) were measured in N=50 MDD patients and N=58 age- and gender-matched healthy controls (HC). In addition, serum levels of interleukin (IL)-6, sCD25, IL-7, IL-3, SCF, IGF-BP2, and EGF were evaluated. Results: MDD patients were in general characterized by an impaired maturation of Th2 cells, Th17 cells, and NK cells and by decreased serum levels of IL-7 and sCD25. MDD patients aged ⩾ 28 years additionally exhibited decreased percentages of CD4(+)CD25(high)FoxP3(+) T regulatory cells, next to signs of the above described partial T cell defects. Natural T regulatory cells were inversely associated with the pro-inflammatory state of the monocytes (r=-.311; p=.034) that characterized this patient subgroup. Conclusions: Deficiencies of the NK and T (regulatory) cell system and inflammatory monocyte immune activation co-occur as partly interrelated phenomena within the same MDD patients. |
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| MeSH term(s) | Adult ; Case-Control Studies ; Cytokines/metabolism ; Depressive Disorder, Major/immunology ; Depressive Disorder, Major/metabolism ; Depressive Disorder, Major/pathology ; Female ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Lymphocyte Activation ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/pathology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology ; Th17 Cells/immunology ; Th17 Cells/pathology ; Th2 Cells/immunology ; Th2 Cells/pathology |
| Chemical Substances | Cytokines |
| Language | English |
| Publishing date | 2016-05 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 639219-2 |
| ISSN | 1090-2139 ; 0889-1591 |
| ISSN (online) | 1090-2139 |
| ISSN | 0889-1591 |
| DOI | 10.1016/j.bbi.2015.12.003 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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