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  1. Book ; Online ; Thesis: Study of smooth muscle cell differentiation mediated by epigenetic mechanisms

    De La Cruz Thea, Benjamín Isaías [Verfasser] / Meister, Gunter [Akademischer Betreuer]

    2022  

    Author's details Benjamín Isaías De La Cruz Thea ; Betreuer: Gunter Meister
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language English
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: The Exosome-like Vesicles of

    Natali, Lautaro / Luna Pizarro, Gabriel / Moyano, Sofía / de la Cruz-Thea, Benjamin / Musso, Juliana / Rópolo, Andrea S / Eichner, Norbert / Meister, Gunter / Musri, Melina M / Feliziani, Constanza / Touz, María C

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: The genetically related assemblages of the intestinal protozoa ... ...

    Abstract The genetically related assemblages of the intestinal protozoa parasite
    MeSH term(s) Humans ; Animals ; Giardia/genetics ; Parasites ; RNA/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Giardiasis/parasitology ; RNA, Transfer/metabolism ; RNA, Ribosomal/metabolism
    Chemical Substances RNA (63231-63-0) ; RNA, Transfer (9014-25-9) ; RNA, Ribosomal
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Trypanosoma cruzi

    Volpini, Ximena / Natali, Lautaro / Brugo, Maria Belén / de la Cruz-Thea, Benjamin / Baigorri, Ruth Eliana / Cerbán, Fabio Marcelo / Fozzatti, Laura / Motran, Claudia Cristina / Musri, Melina Mara

    ACS infectious diseases

    2022  Volume 8, Issue 11, Page(s) 2271–2290

    Abstract: Chagas disease is an emerging global health problem; however, it remains neglected. Increased aortic stiffness (IAS), a predictor of cardiovascular events, has recently been reported in asymptomatic chronic Chagas patients. After vascular injury, smooth ... ...

    Abstract Chagas disease is an emerging global health problem; however, it remains neglected. Increased aortic stiffness (IAS), a predictor of cardiovascular events, has recently been reported in asymptomatic chronic Chagas patients. After vascular injury, smooth muscle cells (SMCs) can undergo alterations associated with phenotypic switch and transdifferentiation, promoting vascular remodeling and IAS. By studying different mouse aortic segments, we tested the hypothesis that
    MeSH term(s) Mice ; Animals ; Vascular Remodeling ; Actins/metabolism ; Chagas Disease ; Macrophages/metabolism ; Aorta/metabolism ; Biomarkers ; Muscle, Smooth/metabolism
    Chemical Substances Actins ; Biomarkers
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.2c00318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MicroRNA Dysregulation in Pulmonary Arteries from Chronic Obstructive Pulmonary Disease. Relationships with Vascular Remodeling.

    Musri, Melina M / Coll-Bonfill, Núria / Maron, Bradley A / Peinado, Víctor I / Wang, Rui-Sheng / Altirriba, Jordi / Blanco, Isabel / Oldham, William M / Tura-Ceide, Olga / García-Lucio, Jessica / de la Cruz-Thea, Benjamin / Meister, Gunter / Loscalzo, Joseph / Barberà, Joan A

    American journal of respiratory cell and molecular biology

    2018  Volume 59, Issue 4, Page(s) 490–499

    Abstract: Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small, noncoding RNAs that ... ...

    Abstract Pulmonary vascular remodeling is an angiogenic-related process involving changes in smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive pulmonary disease (COPD). MicroRNAs (miRNAs) are small, noncoding RNAs that regulate mRNA expression levels of many genes, leading to the manifestation of cell identity and specific cellular phenotypes. Here, we evaluate the miRNA expression profiles of pulmonary arteries (PAs) of patients with COPD and its relationship with the regulation of SMC phenotypic change. miRNA expression profiles from PAs of 12 patients with COPD, 9 smokers with normal lung function (SK), and 7 nonsmokers (NS) were analyzed using TaqMan Low-Density Arrays. In patients with COPD, expression levels of miR-98, miR-139-5p, miR-146b-5p, and miR-451 were upregulated, as compared with NS. In contrast, miR-197, miR-204, miR-485-3p, and miR-627 were downregulated. miRNA-197 expression correlated with both airflow obstruction and PA intimal enlargement. In an in vitro model of SMC differentiation, miR-197 expression was associated with an SMC contractile phenotype. miR-197 inhibition blocked the acquisition of contractile markers in SMCs and promoted a proliferative/migratory phenotype measured by both cell cycle analysis and wound-healing assay. Using luciferase assays, Western blot, and quantitative PCR, we confirmed that miR-197 targets the transcription factor E2F1. In PAs from patients with COPD, levels of E2F1 were increased as compared with NS. In PAs of patients with COPD, remodeling of the vessel wall is associated with downregulation of miR-197, which regulates SMC phenotype. The effect of miR-197 on PAs might be mediated, at least in part, by the key proproliferative factor, E2F1.
    MeSH term(s) Aged ; Cell Differentiation/genetics ; Cell Proliferation/genetics ; E2F1 Transcription Factor/metabolism ; Female ; Forced Expiratory Volume ; Gene Expression Regulation ; Gene Regulatory Networks ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Pulmonary Artery/metabolism ; Pulmonary Artery/physiopathology ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Severity of Illness Index ; Vascular Remodeling/genetics
    Chemical Substances E2F1 Transcription Factor ; MicroRNAs
    Language English
    Publishing date 2018-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2017-0040OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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