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  1. Article: Antiviral and anti-inflammatory drugs to combat COVID-19: Effects on cardiac ion channels and risk of ventricular arrhythmias.

    Cubeddu, Luigi X / de la Rosa, Daisy / Ameruoso, Michele

    BioImpacts : BI

    2021  Volume 12, Issue 1, Page(s) 9–20

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-12-22
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2604624-6
    ISSN 2228-5660 ; 2228-5652
    ISSN (online) 2228-5660
    ISSN 2228-5652
    DOI 10.34172/bi.2021.23630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of pharmacy-supported interventions on proportion of patients receiving non-indicated acid suppressive therapy upon discharge: A systematic review and meta-analysis.

    Singh-Franco, Devada / Mastropietro, David R / Metzner, Miriam / Dressler, Michael D / Fares, Amneh / Johnson, Melinda / De La Rosa, Daisy / Wolowich, William R

    PloS one

    2020  Volume 15, Issue 12, Page(s) e0243134

    Abstract: Objective: Conduct a systematic review and meta-analysis to estimate the impact of pharmacy-supported interventions on the proportion of patients discharged from the hospital on inappropriate acid suppressive therapy (AST).: Methods: To identify ... ...

    Abstract Objective: Conduct a systematic review and meta-analysis to estimate the impact of pharmacy-supported interventions on the proportion of patients discharged from the hospital on inappropriate acid suppressive therapy (AST).
    Methods: To identify studies, the following databases were systematically searched on October 14th, 2018 and repeated on September 12th, 2019: Ovid MEDLINE(R) and In-Process & Other Non-Indexed Citations and Daily, Embase.com, CINAHL, Web of Science, Cochrane CENTRAL (EBSCO), and ClinicalTrials.gov. Eligible studies consisted of adults, intervention and historical/usual care groups, description of active pharmacy-supported intervention, and proportion of patients discharged on inappropriate AST. Qualitative assessments and quantitative analyses were performed. Modified funnel plot analysis assessed heterogeneity. Preferred reporting items of systematic reviews and meta-analyses (PRISMA) methodology was used to evaluate studies in this review.
    Results: Seventeen publications resulting in 16 studies were included in the review. Using random effects model, meta-analysis showed a significant reduction in the odds of being discharged on inappropriate AST from the hospital in the pharmacist-supported intervention arm versus comparator (Odds Ratio 0.33 [95%CI 0.20 to 0.53]), with significant heterogeneity (I2 = 86%). Eleven studies favored pharmacy-supported interventions, four were inconclusive and one favored usual care. Using modified funnel plot analysis, our final evaluation was distilled to 11 studies and revealed a similar outcome (OR 0.36 [95%CI 0.27 to 0.48]), but with less heterogeneity (I2 = 36%).
    Conclusion: This systematic review and meta-analysis showed that pharmacy-supported interventions were associated with a significantly reduced probability of patients discharged on inappropriate AST. However, heterogeneity was high and may affect interpretation of results. Using funnel plot optimization method, three positive and two negative studies were objectively removed from analyses, resulting in a similar effect size, but with less heterogeneity. To improve study quality, future researchers should consider utilizing a pre-post, multi-arm, prospective design with sampling randomization, training of data extractors (preferably two extractors), re-evaluating a small dataset to check for agreement and providing a comprehensive methodology in subsequent publications.
    MeSH term(s) Antacids/adverse effects ; Antacids/therapeutic use ; Anti-Ulcer Agents/adverse effects ; Anti-Ulcer Agents/therapeutic use ; Humans ; Intensive Care Units ; Patient Discharge ; Pharmacies ; Pharmacists ; Proton Pump Inhibitors/adverse effects ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Antacids ; Anti-Ulcer Agents ; Proton Pump Inhibitors
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0243134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Using resident health advocates to improve public health screening and follow-up among public housing residents, Boston, 2007-2008.

    Rorie, Jo-Anna / Smith, Adriana / Evans, Tegan / Horsburgh, C Robert / Brooks, Daniel R / Goodman, Rachel / Bunte, Doris / Strunin, Lee / de la Rosa, Daisy / Geller, Alan

    Preventing chronic disease

    2010  Volume 8, Issue 1, Page(s) A15

    Abstract: Introduction: Promoting screening for hypertension, high cholesterol, diabetes, and dental disease, particularly among residents of public housing, is a key strategy for achieving the objectives of Healthy People 2010. This community-based participatory ...

    Abstract Introduction: Promoting screening for hypertension, high cholesterol, diabetes, and dental disease, particularly among residents of public housing, is a key strategy for achieving the objectives of Healthy People 2010. This community-based participatory research study tested a resident health advocate (RHA) intervention in public housing to increase use of mobile screening and to assess postscreening follow-up care for people with positive screening results.
    Methods: During the summers of 2007 and 2008, a mobile health unit screened residents at 4 housing developments for hypertension, high cholesterol, diabetes risk, and dental disease. In the first summer, at 2 intervention sites, RHAs used personal contacts and repeated flyers to recruit residents; 2 control sites received standard recruitment, which was to leave flyers with the development manager. In the second summer, the 2 control sites from the previous year became intervention sites. For both summers combined, we calculated the number of people at intervention and control sites who used the van and we examined rates of appointments made and kept for residents who had positive screening test results.
    Results: Screening rates were higher in the intervention condition compared with the control condition (relative risk [RR], 1.55; 95% confidence interval [CI], 1.12-2.15). Approximately 65% of participants screened positive for at least 1 condition. The proportion of participants with screen-positive findings who had follow-up appointments increased from 15% in 2007 to 55% in 2008.
    Conclusion: The use of RHAs increased participation in health screening among public housing residents and rates of follow-up medical visits for people with positive screening results.
    MeSH term(s) Blood Glucose ; Boston ; Consumer Advocacy ; Diabetes Mellitus/prevention & control ; Humans ; Hypertension/prevention & control ; Pilot Projects ; Public Health Administration ; Public Housing ; Risk Factors ; Stomatognathic Diseases/prevention & control
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2010-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2135684-1
    ISSN 1545-1151 ; 1545-1151
    ISSN (online) 1545-1151
    ISSN 1545-1151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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