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  1. Article ; Online: Lessons Learned in Elective Surgeries After 6 Pandemic Waves of SARS-CoV-2. A Single European Center Experience.

    García-Botella, Alejandra / De la Serna Esteban, Sofía / López-Antoñanzas, Leyre / Avellana-Moreno, Rocío / Dziakova, Jana / Cano Valderrama, Oscar / Martín-Antona, Esteban / Serrano-García, Irene / Torres García, Antonio José

    World journal of surgery

    2023  Volume 47, Issue 12, Page(s) 2958–2965

    Abstract: Background: The reported high surgical morbidity and mortality in patients with SARS-CoV-2 prompted preoperative screening and modification of surgical protocols. Although vaccination and treatment of COVID-19 have resulted in lower hospitalization ... ...

    Abstract Background: The reported high surgical morbidity and mortality in patients with SARS-CoV-2 prompted preoperative screening and modification of surgical protocols. Although vaccination and treatment of COVID-19 have resulted in lower hospitalization rates and infection severity, publications on postoperative results have not been updated. The aim of the study was to analyze the outcomes of patients undergoing surgery in two periods with high incidence of SARS-CoV-2 infection, before and after vaccination.
    Materials and methods: This is a prospective cohort study of patients undergoing surgery in two periods: March-June 2020 (Group2020) and December 2021-February 2022 (Group2022) (after massive vaccination).
    Results: In total, 618 patients who underwent surgery were included in the analysis (Group2020: 343 vs. Group2022: 275). Significantly more oncological procedures were performed in Group2020, and there were no differences in postoperative complications. Nosocomial SARS-CoV-2 infection occurred in 4 patients in Group2020 and 1 patient in Group2022. In Group 2022, 70 patients (25.4%) had COVID-19 prior to surgery, and 68 (97.1%) were vaccinated. Comparative analysis between patients with past COVID-19 and those without showed no difference in postoperative morbidity and mortality. According to the time elapsed between SARS-CoV-2 infection and surgery (≤ 7 or > 7 weeks), comparative analysis showed no significant differences.
    Conclusion: The establishment of preoperative screening protocols for SARS-CoV-2 infection results in a low incidence of nosocomial infection and optimal postoperative outcomes. Preoperative SARS-CoV-2 infection in vaccinated patients was not associated with increased postoperative complications, even in shorter periods after infection. In surgical patients, individualized preoperative evaluation after SARS-CoV-2 infection may be more important than strict time limitation.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics ; Prospective Studies ; Elective Surgical Procedures ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-023-07222-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Hepatic reactive lymphoid hyperplasia: a difficult differential diagnosis with hepatocarcinoma.

    Avellana Moreno, Rocío / De la Serna Esteban, Sofía / García-Botella, Alejandra

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2020  Volume 113, Issue 7, Page(s) 552

    Abstract: Hepatic reactive lymphoid hyperplasia (HRLH) is an uncommon lesion. We present the case of a 58-year-old patient with a liver nodule incidentally found by abdominal ultrasonography (US). Liver function, tumor markers, viral serology and immunology were ... ...

    Abstract Hepatic reactive lymphoid hyperplasia (HRLH) is an uncommon lesion. We present the case of a 58-year-old patient with a liver nodule incidentally found by abdominal ultrasonography (US). Liver function, tumor markers, viral serology and immunology were normal. Magnetic resonance imaging (MRI) showed a 16 mm nodule in segment VI-VII, with hypervascular enhancement in the arterial phase, wash-out in late phases, without contrast-retention in the hepatobiliary phase and restriction on diffusion-weighted imaging, suggestive of hepatocellular carcinoma (HCC).
    MeSH term(s) Carcinoma, Hepatocellular/diagnostic imaging ; Contrast Media ; Diagnosis, Differential ; Humans ; Liver Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging ; Middle Aged ; Pseudolymphoma/diagnostic imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2020-11-16
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2020.7462/2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Portal venous gas and pneumatosis intestinalis secondary to intestinal subocclusion: success of non-surgical management.

    de la Serna Esteban, Sofía / Sanz-Ortega, Gonzalo / Vázquez Romero, Manuel

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2020  Volume 112, Issue 7, Page(s) 575–576

    Abstract: The association of intestinal and portal pneumatosis in the same patient usually occurs in intestinal ischemic-necrotic processes, with ominous prognosis. However, there are forms of presentation outside this context, with a radically different ... ...

    Abstract The association of intestinal and portal pneumatosis in the same patient usually occurs in intestinal ischemic-necrotic processes, with ominous prognosis. However, there are forms of presentation outside this context, with a radically different management and evolution. We present the case of a patient with portal and gastric pneumatosis, managed conservatively successfully. The clinical presentation and a multidisciplinary management will be critical in the decision-making process to obtain favorable results.
    MeSH term(s) Humans ; Intestines ; Necrosis ; Pneumatosis Cystoides Intestinalis/diagnostic imaging ; Pneumatosis Cystoides Intestinalis/etiology ; Pneumatosis Cystoides Intestinalis/therapy ; Portal Vein/diagnostic imaging ; Prognosis
    Language English
    Publishing date 2020-06-24
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2020.6676/2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Factores pronósticos en el adenocarcinoma de ampolla duodenal.

    Fernández Aceñero, M Jesús / Martínez Useros, Javier / Díez-Valladares, Luis / Ortega-Medina, Luis / Pérez Aguirre, Elia / de la Serna Esteban, Sofía / García Botella, Sandra / Díaz Del Arco, Cristina

    Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

    2018  Volume 51, Issue 4, Page(s) 210–215

    Abstract: Introduction: Ampullary adenocarcinoma seems less aggressive than other pancreato-biliary neoplasms. The aim of this study is to define determining prognostic factors.: Material and methods: Retrospective case series from a large tertiary Hospital ... ...

    Title translation Prognostic factors in adenocarcinoma of the ampulla of Vater.
    Abstract Introduction: Ampullary adenocarcinoma seems less aggressive than other pancreato-biliary neoplasms. The aim of this study is to define determining prognostic factors.
    Material and methods: Retrospective case series from a large tertiary Hospital including all patients diagnosed with ampullary adenocarcinoma who underwent cephalic pancreatoduodenectomy with curative intent. Outcome variables have been progression free survival and overall survival.
    Results: 24 patients were included. 54.2% were females and the mean age was 72.5 (45-85). Most cases were of intestinal type (50%), followed by pancreatobiliary (37.5%) and mucinous. Only 8.3% were high histopathological grade. Vessel invasion was detected in 31.8% of the cases and perineural infiltration in 20.8%. A large percentage of cases showed no lymph node involvement at the time of diagnosis (54.1%). Most cases were stage T1 or T3 (39.1 y 43.5%, respectively). 34.8% of the patients recurred, mainly in regional lymph nodes (62.5% of the recurrences) and they all died of tumor, mainly during the first year after diagnosis. Multivariate analysis with Cox regression model revealed that only lymph node involvement was independently associated to a shorter disease free progression interval and overall survival.
    Conclusions: Lymph node involvement was the most important predictive factor for ampullary adenocarcinoma in this series.
    MeSH term(s) Adenocarcinoma/epidemiology ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Aged, 80 and over ; Ampulla of Vater/pathology ; Ampulla of Vater/surgery ; Common Bile Duct Neoplasms/epidemiology ; Common Bile Duct Neoplasms/pathology ; Common Bile Duct Neoplasms/surgery ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Humans ; Inflammation ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Pancreaticoduodenectomy ; Prognosis ; Progression-Free Survival ; Proportional Hazards Models ; Retrospective Studies ; Smoking/epidemiology
    Language Spanish
    Publishing date 2018-04-13
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2463888-2
    ISSN 1988-561X ; 1699-8855
    ISSN (online) 1988-561X
    ISSN 1699-8855
    DOI 10.1016/j.patol.2018.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project).

    Serradilla-Martín, Mario / Villodre, Celia / Falgueras-Verdaguer, Laia / Zambudio-Carroll, Natalia / Castell-Gómez, José T / Blas-Laina, Juan L / Borrego-Estella, Vicente / Domingo-Del-Pozo, Carlos / García-Plaza, Gabriel / González-Rodríguez, Francisco J / Montalvá-Orón, Eva M / Moya-Herraiz, Ángel / Paterna-López, Sandra / Suárez-Muñoz, Miguel A / Alkorta-Zuloaga, Maialen / Blanco-Fernández, Gerardo / Dabán-Collado, Enrique / Gómez-Bravo, Miguel A / Miota-de-Llamas, José I /
    Rotellar, Fernando / Sánchez-Pérez, Belinda / Sánchez-Cabús, Santiago / Pacheco-Sánchez, David / Rodríguez-Sanjuan, Juan C / Varona-Bosque, María A / Carrión-Álvarez, Lucía / de la Serna-Esteban, Sofía / Dopazo, Cristina / Martín-Pérez, Elena / Martínez-Cecilia, David / Castro-Santiago, María J / Dorcaratto, Dimitri / Gutiérrez-Díaz, Marta L / Asencio-Pascual, José M / Burdío-Pinilla, Fernando / Carracedo-Iglesias, Roberto / Escartín-Arias, Alfredo / Ielpo, Benedetto / Rodríguez-Laiz, Gonzalo / Valdivieso-López, Andrés / De-Vicente-López, Emilio / Alonso-Orduña, Vicente / Ramia, José M

    Cancers

    2024  Volume 16, Issue 9

    Abstract: 1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present ... ...

    Abstract (1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%;
    Language English
    Publishing date 2024-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16091676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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