Article ; Online: Cytomegalovirus antibody levels and mortality among hospitalised elderly patients.
2020 Volume 52, Issue 8, Page(s) 497–505
Abstract: Background: The impact of cytomegalovirus infection in elderly subjects remains unclear. This study examined the relationship between humoral immune response to cytomegalovirus (CMV) and all-cause mortality in a cohort of elderly hospitalised patients.!# ...
| Abstract | Background: The impact of cytomegalovirus infection in elderly subjects remains unclear. This study examined the relationship between humoral immune response to cytomegalovirus (CMV) and all-cause mortality in a cohort of elderly hospitalised patients. Methods: Data were obtained from a random sample of 715 patients (≥65 years old) admitted for any cause in a third level hospital. Serum IgG antibody against CMV was determined by enzyme-linked immunosorbent (ELISA) assay. Results: A total of 480 deaths occurred in seropositive patients ( Conclusions: Increased IgG antibody levels against CMV are associated with increased short and long-term mortality in elderly hospitalised patients, especially in patients without cardiovascular disease. Key Messages The outcome of elderly hospitalised patients in relation to CMV is unknown. We demonstrate an association between increased anti-CMV IgG levels and mortality. This association is greater in elderly patients without cardiovascular disease. |
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| MeSH term(s) | Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Cause of Death ; Cytomegalovirus/immunology ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/blood ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Hospital Mortality ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Male ; Prospective Studies ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; Risk Factors ; Seroepidemiologic Studies |
| Chemical Substances | Antibodies, Viral ; Immunoglobulin G |
| Language | English |
| Publishing date | 2020-08-24 |
| Publishing country | England |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 1004226-x |
| ISSN | 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387 |
| ISSN (online) | 1365-2060 ; 1651-2219 |
| ISSN | 0785-3890 ; 1743-1387 |
| DOI | 10.1080/07853890.2020.1811888 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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