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  1. Article ; Online: Discrete symmetries tested at 10

    Moskal, Paweł / Czerwiński, Eryk / Raj, Juhi / Bass, Steven D / Beyene, Ermias Y / Chug, Neha / Coussat, Aurélien / Curceanu, Catalina / Dadgar, Meysam / Das, Manish / Dulski, Kamil / Gajos, Aleksander / Gorgol, Marek / Hiesmayr, Beatrix C / Jasińska, Bożena / Kacprzak, Krzysztof / Kaplanoglu, Tevfik / Kapłon, Łukasz / Klimaszewski, Konrad /
    Konieczka, Paweł / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech / Kumar, Deepak / Moyo, Simbarashe / Mryka, Wiktor / Niedźwiecki, Szymon / Parzych, Szymon / Del Río, Elena Pérez / Raczyński, Lech / Sharma, Sushil / Choudhary, Shivani / Shopa, Roman Y / Silarski, Michał / Skurzok, Magdalena / Stępień, Ewa Ł / Tanty, Pooja / Ardebili, Faranak Tayefi / Ardebili, Keyvan Tayefi / Eliyan, Kavya Valsan / Wiślicki, Wojciech

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 78

    Abstract: Discrete symmetries play an important role in particle physics with violation of CP connected to the matter-antimatter imbalance in the Universe. We report the most precise test of P, T and CP invariance in decays of ortho-positronium, performed with ... ...

    Abstract Discrete symmetries play an important role in particle physics with violation of CP connected to the matter-antimatter imbalance in the Universe. We report the most precise test of P, T and CP invariance in decays of ortho-positronium, performed with methodology involving polarization of photons from these decays. Positronium, the simplest bound state of an electron and positron, is of recent interest with discrepancies reported between measured hyperfine energy structure and theory at the level of 10
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44340-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Comparative studies of the sensitivities of sparse and full geometries of Total-Body PET scanners built from crystals and plastic scintillators

    Dadgar, Meysam / Parzych, Szymon / Baran, Jakub / Chug, Neha / Curceanu, Catalina / Czerwiński, Eryk / Dulski, Kamil / Elyan, Kavya / Gajos, Aleksander / Hiesmayr, Beatrix / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech / Kumar, Deepak / Niedźwiecki, Szymon / Panek, Domonik /
    del Rio, Eleną Perez / Raczyński, Lech / Sharma, Sushil / Shivani / Shopa, Roman / Skurzok, Magdalena / Stępień, Ewa / Ardebili, Faranak. Tayefi / Ardebili, Keyvan. Tayefi / Vandenberghe, Stefaan. / Wiślicki, Wojciech. / Moskal, Paweł.

    2023  

    Abstract: Background: Total-Body imaging offers high sensitivity, single-bed position, and low dose, but high construction costs limit worldwide utilization. This study compares existing and developing tomographs using plastic scintillators via simulations to ... ...

    Abstract Background: Total-Body imaging offers high sensitivity, single-bed position, and low dose, but high construction costs limit worldwide utilization. This study compares existing and developing tomographs using plastic scintillators via simulations to propose a cost-efficient Total-Body PET scanner. Methods: Simulations of eight uEXPLORER tomographs with different scintillator materials, axial field-of-view, and detector configuration, and eight J-PET scanners with various field-of-view, plastic scintillator cross-sections, and layers were performed. Biograph Vision was also simulated. Two types of simulations were conducted with a central source and a water-filled phantom. Results: BGO crystal-based scanners showed the best sensitivity (350 cps/kBq at the center). Sparse geometry or LYSO crystals reduced sensitivity. J-PET design showed similar sensitivity to sparse LYSO detectors, with full body coverage and additional gain for brain imaging. Conclusion: The J-PET tomography system using plastic scintillators could be a cost-efficient alternative for Total-Body PET scanners, overcoming high construction costs while maintaining sensitivity
    Keywords Physics - Medical Physics
    Subject code 600 ; 621
    Publishing date 2023-04-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: ProTheRaMon - a GATE simulation framework for proton therapy range monitoring using PET imaging.

    Borys, Damian / Baran, Jakub / Brzezinski, Karol W / Gajewski, Jan / Chug, Neha / Coussat, Aurelien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya Valsan / Gajos, Aleksander / Kacprzak, Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopec, Renata / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech /
    Kumar, Deepak / Lomax, Antony John / McNamara, Keegan / Niedźwiecki, Szymon / Olko, Pawel / Panek, Dominik / Parzych, Szymon / Del Río, Elena Pérez / Raczyński, Lech / Sharma, Sushil / Shivani, Shivani / Shopa, Roman Y / Skóra, Tomasz / Skurzok, Magdalena / Stasica, Paulina / Stępień, Ewa / Tayefi Ardebili, Keyvan / Tayefi, Faranak / Weber, Damien Charles / Winterhalter, Carla / Wiślicki, Wojciech / Moskal, Pawel / Rucinski, Antoni

    Physics in medicine and biology

    2022  

    Abstract: Objective: This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon ... ...

    Abstract Objective: This paper reports on the implementation and shows examples of the use of the ProTheRaMon framework for simulating the delivery of proton therapy treatment plans and range monitoring using positron emission tomography (PET). ProTheRaMon offers complete processing of proton therapy treatment plans, patient CT geometries, and intra-treatment PET imaging, taking into account therapy and imaging coordinate systems and activity decay during the PET imaging protocol specific to a given proton therapy facility. We present the ProTheRaMon framework and illustrate its potential use case and data processing steps for a patient treated at the Cyclotron Centre Bronowice (CCB) proton therapy center in Krakow, Poland.
    Approach: The ProTheRaMon framework is based on GATE Monte Carlo software, the CASToR reconstruction package and in-house developed Python and bash scripts. The framework consists of five separated simulation and data processing steps, that can be further optimized according to the user's needs and specific settings of a given proton therapy facility and PET scanner design.
    Main results: ProTheRaMon is presented using example data from a patient treated at CCB and the J-PET scanner to demonstrate the application of the framework for proton therapy range monitoring. The output of each simulation and data processing stage is described and visualized.
    Significance: We demonstrate that the ProTheRaMon simulation platform is a high-performance tool, capable of running on a computational cluster and suitable for multi-parameter studies, with databases consisting of large number of patients, as well as different PET scanner geometries and settings for range monitoring in a clinical environment. Due to its modular structure, the ProTheRaMon framework can be adjusted for different proton therapy centers and/or different PET detector geometries. It is available to the community via github.
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ac944c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Feasibility of the J-PET to monitor range of therapeutic proton beams

    Baran, Jakub / Borys, Damian / Brzeziński, Karol / Gajewski, Jan / Silarski, Michał / Chug, Neha / Coussat, Aurélien / Czerwiński, Eryk / Dadgar, Meysam / Dulski, Kamil / Eliyan, Kavya V. / Kacprzak, Aleksander Gajos Krzysztof / Kapłon, Łukasz / Klimaszewski, Konrad / Konieczka, Paweł / Kopeć, Renata / Korcyl, Grzegorz / Kozik, Tomasz / Krzemień, Wojciech /
    Kumar, Deepak / Lomax, Antony J. / McNamara, Keegan / Niedźwiecki, Szymon / Olko, Paweł / Panek, Dominik / Parzych, Szymon / del Rio, Elena Perez / Raczyński, Lech / Simbarashe, Moyo / Sharma, Sushil / Shivani / Shopa, Roman Y. / Skóra, Tomasz / Skurzok, Magdalena / Stasica, Paulina / Stępień, Ewa Ł. / Tayefi, Keyvan / Tayefi, Faranak / Weber, Damien C. / Winterhalter, Carla / Wiślicki, Wojciech / Moskal, Pawel / Rucinski, Antoni

    2023  

    Abstract: Objective: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Approach: The Monte Carlo simulation studies with GATE and PET image ... ...

    Abstract Objective: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring. Approach: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries (three dual-heads and three cylindrical). We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment. Main results: The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10$^{-5}$ coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple-layer dual-head geometry. Significance: We performed simulation studies demonstrating that the feasibility of the J-PET detector for PET-based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre-clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometry configurations seem promising for the future clinical application. Experimental tests are needed to confirm these findings.

    Comment: 19 pages, 7 pages
    Keywords Physics - Medical Physics
    Subject code 621
    Publishing date 2023-02-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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