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  1. Article ; Online: Screening for tuberculosis among migrants in Europe: harmonising approaches during a humanitarian crisis?

    den Boon, Saskia / Yedilbayev, Askar

    The European respiratory journal

    2023  Volume 62, Issue 4

    MeSH term(s) Humans ; Transients and Migrants ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Europe
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01537-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Economic evaluations of immunization programs as an indispensable tool for policymakers.

    den Boon, Saskia / Ahmed, Sayem / Sarker, Abdur Razzaque

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 1284

    Abstract: Introducing new vaccines within national immunization programs requires careful consideration of disease- and vaccine-related issues as well as of the strength of the program and the affected health system. Economic evaluations play an essential role in ... ...

    Abstract Introducing new vaccines within national immunization programs requires careful consideration of disease- and vaccine-related issues as well as of the strength of the program and the affected health system. Economic evaluations play an essential role in this process. In this editorial, we set the context and invite contributions for a BMC Health Services Research Collection of articles titled 'Economic Evaluations of Vaccine Programs'.
    MeSH term(s) Humans ; Cost-Benefit Analysis ; Vaccination ; Vaccines ; Immunization Programs ; Health Services Research ; Immunization
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Editorial
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-10071-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: PASS to End TB in Europe: Accelerated efforts on prevention and systematic screening to end tuberculosis in the WHO European Region by 2030.

    Dadu, Andrei / Yedilbayev, Askar / Migliori, Giovanni Battista / Ahmedov, Sevim / Falzon, Dennis / den Boon, Saskia / Kanchar, Avinash / Matteelli, Alberto

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 141S, Page(s) 106980

    Abstract: Objectives: Outline the objectives, methods, and initial stages of the Prevention and Systematic Screening (PASS) initiative, a complimentary element of the innovative new approach of technical assistance mechanisms of WHO and its partners to countries ... ...

    Abstract Objectives: Outline the objectives, methods, and initial stages of the Prevention and Systematic Screening (PASS) initiative, a complimentary element of the innovative new approach of technical assistance mechanisms of WHO and its partners to countries aligned to the Regional TB Action Plan to End TB in the European Region by 2030.
    Design: To provide an objective and critical overview of the existing landscape on TB epidemic in the WHO European Region (the European Region) and ii) identify the strategic significance of proactive measures aimed at approaching TB pre-elimination in the Region.
    Results: Interventions primarily include systematic screening for TB disease and treatment for TB infection (TBI).
    Conclusions: PASS to End TB is an exemplary initiative of how technical and funding partners are joining hands to support national health programmes to work towards global commitments to curb major public health challenges like TB.
    MeSH term(s) Humans ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Europe/epidemiology ; Public Health ; World Health Organization
    Language English
    Publishing date 2024-02-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.02.023
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  4. Article ; Online: Global reporting on tuberculosis preventive treatment among contacts.

    Falzon, Dennis / den Boon, Saskia / Kanchar, Avinash / Zignol, Matteo / Migliori, Giovanni Battista / Kasaeva, Tereza

    The European respiratory journal

    2022  Volume 59, Issue 3

    MeSH term(s) Contact Tracing ; Humans ; Latent Tuberculosis/epidemiology ; Latent Tuberculosis/prevention & control
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02753-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Scaling Up TB Screening and TB Preventive Treatment Globally: Key Actions and Healthcare Service Costs.

    Satyanarayana, Srinath / Pretorius, Carel / Kanchar, Avinash / Garcia Baena, Ines / Den Boon, Saskia / Miller, Cecily / Zignol, Matteo / Kasaeva, Tereza / Falzon, Dennis

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 4

    Abstract: The 2018 United Nations High-Level Meeting on Tuberculosis (UNHLM) set targets for case detection and TB preventive treatment (TPT) by 2022. However, by the start of 2022, about 13.7 million TB patients still needed to be detected and treated, and 21.8 ... ...

    Abstract The 2018 United Nations High-Level Meeting on Tuberculosis (UNHLM) set targets for case detection and TB preventive treatment (TPT) by 2022. However, by the start of 2022, about 13.7 million TB patients still needed to be detected and treated, and 21.8 million household contacts needed to be given TPT globally. To inform future target setting, we examined how the 2018 UNHLM targets could have been achieved using WHO-recommended interventions for TB detection and TPT in 33 high-TB burden countries in the final year of the period covered by the UNHLM targets. We used OneHealth-TIME model outputs combined with the unit cost of interventions to derive the total costs of health services. Our model estimated that, in order to achieve UNHLM targets, >45 million people attending health facilities with symptoms would have needed to be evaluated for TB. An additional 23.1 million people with HIV, 19.4 million household TB contacts, and 303 million individuals from high-risk groups would have required systematic screening for TB. The estimated total costs amounted to ~USD 6.7 billion, of which ~15% was required for passive case finding, ~10% for screening people with HIV, ~4% for screening household contacts, ~65% for screening other risk groups, and ~6% for providing TPT to household contacts. Significant mobilization of additional domestic and international investments in TB healthcare services will be needed to reach such targets in the future.
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8040214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A new online toolkit to support implementation research to enhance the use of digital innovations to End TB.

    Veronese, Vanessa / Miller, Cecily / Ogundahunsi, Olumide / Den Boon, Saskia / Xia, Yin Yin / Falzon, Dennis / Merle, Corinne S

    PLOS digital health

    2023  Volume 2, Issue 2, Page(s) e0000182

    Abstract: Digital technologies are playing an increasing role in the global response to tuberculosis (TB), however their effectiveness and impact are often shaped in the context in which they are implemented. Implementation research can help facilitate the ... ...

    Abstract Digital technologies are playing an increasing role in the global response to tuberculosis (TB), however their effectiveness and impact are often shaped in the context in which they are implemented. Implementation research can help facilitate the effective introduction of digital health technologies in TB programmes. In 2020, the Implementation Research for Digital Technologies and TB online toolkit (IR4DTB) was developed and launched by the Special Programme for Research and Training in Tropical Diseases, and the Global TB Programme at the World Health Organization (WHO), to build local capacity for IR and promote the effective use of digital technologies within TB programmes. This paper describes the development and piloting of the IR4DTB toolkit, a self-learning tool designed for TB programme implementers. The toolkit comprises six modules reflecting key steps of the IR process, practical instructions and guidance on how to complete these steps, and real-word case studies to illustrate key learning points. This paper also describes the launch of the IR4DTB during a five-day training workshop with TB staff from China, Uzbekistan, Pakistan, Malaysia. The workshop included facilitated sessions on the IR4DTB modules, and provided an opportunity for participants to work with facilitators to develop a comprehensive IR proposal addressing an identified challenge related to the implementation and/or scale-up of digital health technologies for TB care in their home country. Post-workshop evaluation revealed high level of satisfaction among participants with the workshop content and format. The IR4DTB toolkit is a replicable model which can be used to strengthen the TB staff capacity to innovate within a culture of continuous collection of evidence. Through continued trainings and adaptation of the toolkit alongside the integration of digital technologies within TB prevention and care, this model has the potential to contribute directly to all components of the End TB Strategy.
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3170
    ISSN (online) 2767-3170
    DOI 10.1371/journal.pdig.0000182
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  7. Article ; Online: Tuberculosis treatment monitoring tests during routine practice: study design guidance.

    MacLean, Emily Lai-Ho / Zimmer, Alexandra J / den Boon, Saskia / Gupta-Wright, Ankur / Cirillo, Daniela M / Cobelens, Frank / Gillespie, Stephen H / Nahid, Payam / Phillips, Patrick P / Ruhwald, Morten / Denkinger, Claudia M

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  Volume 30, Issue 4, Page(s) 481–488

    Abstract: Scope: The current tools for tuberculosis (TB) treatment monitoring, smear microscopy and culture, cannot accurately predict poor treatment outcomes. Research into new TB treatment monitoring tools (TMTs) is growing, but data are unreliable. In this ... ...

    Abstract Scope: The current tools for tuberculosis (TB) treatment monitoring, smear microscopy and culture, cannot accurately predict poor treatment outcomes. Research into new TB treatment monitoring tools (TMTs) is growing, but data are unreliable. In this article, we aim to provide guidance for studies investigating and evaluating TB TMT for use during routine clinical care. Here, a TB TMT would guide treatment during the course of therapy, rather than testing for a cure at the regimen's end. This article does not cover the use of TB TMTs as surrogate endpoints in the clinical trial context.
    Methods: Guidelines were initially informed by experiences during a systematic review of TB TMTs. Subsequently, a small content expert group was consulted for feedback on initial recommendations. After revision, feedback from substantive experts across sectors was sought.
    Questions addressed by the guideline and recommendations: The proposed considerations and recommendations for studies evaluating TB TMTs for use during the treatment in routine clinical care fall into eight domains. We provide specific recommendations regarding study design and recruitment, outcome definitions, reference standards, participant follow-up, clinical setting, study population, treatment regimen reporting, and index tests and data presentation. Overall, TB TMTs should be evaluated in a manner similar to diagnostic tests, but TB TMT accuracy must be assessed at multiple timepoints throughout the treatment course, and TB TMTs should be evaluated in study populations who have already received a diagnosis of TB. Study design and outcome definitions must be aligned with the developmental phase of the TB TMT under evaluation. There is no reference standard for TB treatment response, so different reference standards and comparator tests have been proposed, the selection of which will vary depending on the developmental phase of the TMT under assessment. The use of comparator tests can assist in generating evidence. Clarity is required when reporting of timepoints, TMT read-outs, and analysis results. Implementing these recommendations will lead to higher quality TB TMT studies that will allow data to be meaningfully compared, thereby facilitating the development of novel tools to guide individual TB therapy and improve treatment outcomes.
    MeSH term(s) Humans ; Research Design ; Treatment Outcome ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/microbiology
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Practice Guideline ; Systematic Review ; Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.12.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 284: Show issues

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  8. Article ; Online: The case for assessing the full value of new tuberculosis vaccines.

    Gebreselassie, Nebiat / Hutubessy, Raymond / Vekemans, Johan / den Boon, Saskia / Kasaeva, Tereza / Zignol, Matteo

    The European respiratory journal

    2020  Volume 55, Issue 3

    MeSH term(s) BCG Vaccine ; Humans ; Mycobacterium tuberculosis ; Tuberculosis/diagnosis ; Tuberculosis/prevention & control ; Tuberculosis Vaccines
    Chemical Substances BCG Vaccine ; Tuberculosis Vaccines
    Language English
    Publishing date 2020-03-20
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02414-2019
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  9. Article: Incorporating health workers' perspectives into a WHO guideline on personal protective equipment developed during an Ebola virus disease outbreak.

    Den Boon, Saskia / Vallenas, Constanza / Ferri, Mauricio / Norris, Susan L

    F1000Research

    2018  Volume 7, Page(s) 45

    Abstract: Background: ...

    Abstract Background:
    Keywords covid19
    Language English
    Publishing date 2018-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.12922.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Personal protective equipment for use in a filovirus disease outbreak

    Den Boon, Saskia / Allegranzi, Benedetta

    rapid advice guideline

    2016  

    Abstract: These guidelines recognize that health workers must be protected at all times, not only because they are needed to deliver care and save lives during epidemics, but because they may unwittingly transmit pathogens if they are not properly protected. These ...

    Author's details Saskia den Boon [and 6 others] ; contributors, Benedetta Allegranzi [and 22 others]
    Abstract These guidelines recognize that health workers must be protected at all times, not only because they are needed to deliver care and save lives during epidemics, but because they may unwittingly transmit pathogens if they are not properly protected. These guidelines aim to provide the knowledge and advice needed to protect health workers against filovirus infections (Ebola, Marburg, etc.). Effective protection requires adequate equipment and practices. The West African Ebola outbreak taught public health planners important lessons about how best to protect those providing clinical care. These lessons - of what works, what does not, what is most practical and effective - have been collated, assessed by experts in clinical care and infection control and form the basis for these recommendations. This is an important step forward in evidence-based protection and safety for health care delivery during outbreaks.
    MeSH term(s) Filoviridae/pathogenicity ; Filoviridae Infections/prevention & control ; Personal Protective Equipment ; Infection Control/methods ; Disease Transmission, Infectious/prevention & control ; Surveys and Questionnaires
    Language English
    Size 1 online resource (1 PDF file (xiv, 53 pages)) :, illustrations
    Document type Book ; Online
    Note "These guidelines were produced by the World Health Organization Department of Pandemic and Epidemic Diseases under the coordination of Constanza Vallenas and Nahoko Shindo. They were written by Saskia den Boon (contractor), Ying Ling Lin, Elizabeth Mathai, Yukiko Nakatani, Nahoko Shindo, Constanza Vallenas, and Adriana Velazquez. The following WHO staff members also made contributions: Benedetta Allegranzi, Jean-Christophe Aze, Yolanda Bayugo, Sophie Boisson, Sylvie Briand, Caroline Cross, Irene Dolan, Sergey Eremin, Pierre Formenty, Robert Fowler, Ivan Ivanov, François Jorda, Edward Kelley, Jean-Bosco Ndihokubwayo, Junko Okumura, Carmem Pessoa-Silvia, Dina Pfeiffer, Charlotte Rasmussen, Andreas Reis, Jose Rovira Vilaplana, Lara Schwarz, Mikiko Senga and Rebekah Thomas Bosco. Susan L Norris provided valuable guidance on the WHO process of rapid guideline development."--Page vii.
    ISBN 9789241549721 ; 9241549726
    Database Catalogue of the US National Library of Medicine (NLM)

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