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  1. Article ; Online: Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles.

    Correa, Thais Silva / Lima, William Gustavo / do Couto Campos, Aline Beatriz / Galdino, Alexsandro Sobreira / de Oliveira Lima, Emilia Celma / Cardoso, Valbert Nascimento / Antunes Fernandes, Simone Odília / Campos-da-Paz, Mariana

    Current pharmaceutical biotechnology

    2024  

    Abstract: Introduction: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals.: Method: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and ... ...

    Abstract Introduction: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals.
    Method: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV). MF and MFCEA nanoparticles were successfully radiolabeled with technetium-99m (99mTc) and intravenously injected in CEA-positive 4T1 tumor-bearing mice to perform biodistribution studies. Both 99mTc-MF and 99mTc-MFCEA had marked uptake by the liver and spleen, and the renal uptake of 99mTc-MFCEA was higher than that observed for 99mTc-MF at 20h. At 1 and 5 hours, the urinary excretion was higher for 99mTc-MF than for 99mTc-MFCEA.
    Results: These data suggest that anti-CEA decoration might be responsible for a delay in renal clearance. Regarding the tumor, 99mTc-MFCEA showed tumor uptake nearly two times higher than that observed for 99mTc-MFCEA. Similarly, the target-nontarget ratio was higher with 99mTc-MFCEA when compared to the group that received the 99mTc-MF.
    Conclusion: These data validated the ability of active tumor targeting by the as-developed antiCEA loaded nanoparticles and are very promising results for the future development of a nanodevice for the management of breast cancer and other types of CEA-positive tumors.
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010268872240104114444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
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  2. Article: Study of the influence of fecal material on the prognosis of intra-abdominal candidiasis using a murine model of technetium-99m (99mTc)-Candida albicans

    Lima, William Gustavo / do Couto-Campos, Aline Beatriz / Brito, Júlio César Moreira / Cardoso, Valbert Nascimento / Fernandes, Simone Odília Antunes

    Microbiological research. 2022 July 13,

    2022  

    Abstract: Intra-abdominal candidiasis (IAC) occurs due to the direct inoculation of Candida into the sterile peritoneal cavity or leakage of the gastrointestinal tract. An important difference between the two forms of the disease is the presence of fecal material, ...

    Abstract Intra-abdominal candidiasis (IAC) occurs due to the direct inoculation of Candida into the sterile peritoneal cavity or leakage of the gastrointestinal tract. An important difference between the two forms of the disease is the presence of fecal material, which is exclusive to the latter condition. However, the influence of fecal material on the prognosis of IAC is still poorly understood. Furthermore, methodologies that use the quantification of fungal load by culture methods have low sensitivity, as they do not adequately show the precocity of the infectious process. Here, we developed a new method to evaluate the aspects of the pathophysiology of IAC, mainly the influence of fecal material on the prognosis of infection, by using C. albicans radiolabeled with technetium-99m (⁹⁹ᵐTc). C. albicans was successfully radiolabeled with ⁹⁹ᵐTc (18.5 MBq) using dihydrate stannous chloride (100µM) as a reducing agent. This binding was stable for 72h. Viability, yeast-to-hyphae transition, morphology, and antifungal susceptibility were not altered by radiolabeling C. albicans with ⁹⁹ᵐTc. The biomass and the fungal load of ⁹⁹ᵐTc-C. albicans biofilms were reduced compared to the C. albicans non-radiolabeled after 72h and 48h of incubation, respectively. In the IAC model, the fungal load in the biodistribution of ⁹⁹ᵐTc-C. albicans and culture assays was higher in animals receiving fungal inoculum without fecal material, suggesting that the presence of this component reduces the invasiveness of the pathogen.
    Keywords animal models ; biofilm ; biomass ; candidiasis ; chlorides ; digestive tract ; early development ; feces ; fungi ; inoculum ; pathogens ; pathophysiology ; prognosis ; radiolabeling ; research ; viability
    Language English
    Dates of publication 2022-0713
    Publishing place Elsevier GmbH
    Document type Article
    Note Pre-press version
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2022.127132
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 1148: Show issues

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