Article ; Online: The
2021 Volume 15, Issue 2, Page(s) 341–345
Abstract: During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid ... ...
Abstract | During the past 17 years, the coronaviruses have become a global public emergency, with the first appearance in 2012 in Saudi Arabia of the Middle East respiratory syndrome. Among the structural proteins encoded in the viral genome, the nucleocapsid protein is the most abundant in infected cells. It is a multifunctional phosphoprotein involved in the capsid formation, in the modulation and regulation of the viral life cycle. The N-terminal domain of N protein specifically interacts with transcriptional regulatory sequence (TRS) and is involved in the discontinuous transcription through the melting activity of double-stranded TRS (dsTRS). |
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MeSH term(s) | Middle East Respiratory Syndrome Coronavirus ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Nucleocapsid Proteins/chemistry ; Protein Domains |
Chemical Substances | Nucleocapsid Proteins |
Language | English |
Publishing date | 2021-04-29 |
Publishing country | Netherlands |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2388861-1 |
ISSN | 1874-270X ; 1874-2718 |
ISSN (online) | 1874-270X |
ISSN | 1874-2718 |
DOI | 10.1007/s12104-021-10027-6 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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