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  1. Article ; Online: Impaired immunomodulatory effects of seminal plasma may play a role in unexplained recurrent pregnancy loss: Results of an in vitro study.

    du Fossé, N A / Lashley, E E L O / Anholts, J D H / van Beelen, E / le Cessie, S / van Lith, J M M / Eikmans, M / van der Hoorn, M L P

    Journal of reproductive immunology

    2022  Volume 151, Page(s) 103500

    Abstract: Background: Seminal plasma contains signaling molecules capable of modulating the maternal immune environment to support implantation and pregnancy. Prior studies indicated that seminal plasma induces changes in gene transcription of maternal immune ... ...

    Abstract Background: Seminal plasma contains signaling molecules capable of modulating the maternal immune environment to support implantation and pregnancy. Prior studies indicated that seminal plasma induces changes in gene transcription of maternal immune cells. Reduced immune suppressive capacity may lead to pregnancy loss. The aim of this study was to investigate the immunomodulating effects of seminal plasma on T cells and monocytes in the context of recurrent pregnancy loss (RPL).
    Methods: Female T cells and monocytes were incubated with seminal plasma of 20 males in unexplained RPL couples (RPL males) and of 11 males whose partners had ongoing pregnancies (control males). The effect of seminal plasma on messenger RNA (mRNA) expression of immune cells was measured. Levels of mRNA expression were related to key signaling molecules present in the seminal plasma. Agglomerative hierarchical cluster analysis was performed on seminal plasma expression profiles and on mRNA expression profiles.
    Results: Expression of CD25 and anti-inflammatory IL-10 by female T cells was significantly lower after stimulation with seminal plasma of RPL males compared to control males. Female monocytes treated with seminal plasma of RPL males showed an immune activation signature of relatively elevated HLA-DR expression. Expression of these T cell and monocyte components was particularly correlated with the amounts of TGF-β and VEGF in the seminal plasma.
    Conclusion: Our findings indicate that seminal plasma has immunomodulating properties on female immune cells compatible with the induction of a more regulatory phenotype, which may be impaired in cases of unexplained RPL.
    MeSH term(s) Abortion, Habitual ; Female ; Humans ; Immunomodulation ; Male ; Pregnancy ; RNA, Messenger/metabolism ; Semen ; T-Lymphocytes/metabolism
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2022-02-19
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2022.103500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Exploring gender differences among couples with unexplained recurrent pregnancy loss regarding preferences for supportive care.

    du Fossé, N A / Lashley, E E L O / Treurniet, T T / van Lith, J M M / le Cessie, S / Boosman, H / van der Hoorn, M L P

    BMC pregnancy and childbirth

    2021  Volume 21, Issue 1, Page(s) 796

    Abstract: Background: International guidelines recommend to offer supportive care during a next pregnancy to couples affected by recurrent pregnancy loss (RPL). In previous research, several options for supportive care have been identified and women's preferences ...

    Abstract Background: International guidelines recommend to offer supportive care during a next pregnancy to couples affected by recurrent pregnancy loss (RPL). In previous research, several options for supportive care have been identified and women's preferences have been quantified. Although it is known that RPL impacts the mental health of both partners, male preferences for supportive care have hardly been explored.
    Methods: A cross-sectional study was conducted in couples who visited a specialized RPL clinic in the Netherlands between November 2018 and December 2019. Both members of the couples received a questionnaire that quantified their preferences for supportive care in a next pregnancy and they were asked to complete this independently from each other. Preferences for each supportive care option were analysed on a group level (by gender) and on a couple level, by comparing preferences of both partners.
    Results: Ninety-two questionnaires (completed by 46 couples) were analysed. The overall need for supportive care indicated on a scale from 1 to 10 was 6.8 for men and 7.9 for women (P = 0.002). Both genders preferred to regularly see the same doctor with knowledge of their obstetric history, to make a plan for the first trimester and to have frequent ultrasound examinations. A lower proportion of men preferred a doctor that shows understanding (80% of men vs. 100% of women, P = 0.004) and a doctor that informs on wellbeing (72% vs. 100%, P = ≤0.000). Fewer men preferred support from friends (48% vs. 74%, P = 0.017). Thirty-seven percent of men requested more involvement of the male partner at the outpatient clinic, compared to 70% of women (P = 0.007). In 28% of couples, partners had opposing preferences regarding peer support.
    Conclusions: While both women and men affected by RPL are in need of supportive care, their preferences may differ. Current supportive care services may not entirely address the needs of men. Health care professionals should focus on both partners and development of novel supportive care programs with specific attention for men should be considered.
    MeSH term(s) Abortion, Habitual/psychology ; Adult ; Cross-Sectional Studies ; Fathers/psychology ; Female ; Humans ; Male ; Netherlands ; Patient Preference/psychology ; Prenatal Care ; Psychosocial Support Systems ; Surveys and Questionnaires
    Language English
    Publishing date 2021-11-30
    Publishing country England
    Document type Journal Article
    ISSN 1471-2393
    ISSN (online) 1471-2393
    DOI 10.1186/s12884-021-04277-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of distinct seminal plasma cytokine profiles associated with male age and lifestyle characteristics in unexplained recurrent pregnancy loss.

    du Fossé, N A / Lashley, E E L O / van Beelen, E / Meuleman, T / le Cessie, S / van Lith, J M M / Eikmans, M / van der Hoorn, M L P

    Journal of reproductive immunology

    2021  Volume 147, Page(s) 103349

    Abstract: Background: Seminal plasma contains a wide range of cytokines, chemokines and growth factors. Part of these signalling molecules assist in inducing a state of active maternal immune tolerance towards the fetus. Disbalances in seminal plasma content may ... ...

    Abstract Background: Seminal plasma contains a wide range of cytokines, chemokines and growth factors. Part of these signalling molecules assist in inducing a state of active maternal immune tolerance towards the fetus. Disbalances in seminal plasma content may contribute to pregnancy loss. This study investigated cytokine expression profiles in seminal plasma of male partners of couples with unexplained recurrent pregnancy loss (RPL) and the association with clinical and lifestyle characteristics, including smoking, alcohol consumption and body mass index (BMI).
    Methods: In the seminal plasma of 52 men who visited a specialised RPL clinic the levels of 25 pre-selected cytokines, chemokines and growth factors were measured by Bio-Plex assay or ELISA. Two-way hierarchical cluster analysis was performed. Identified patient clusters were compared on clinical and lifestyle characteristics.
    Results: Two distinct cytokine expression profiles in the seminal plasma were revealed by cluster analysis. Patient cluster I showed relatively higher levels of pro-inflammatory cytokines, including IL-1α, IL-1β, IL-6, IL-8, IL-12, IL-18 and TNF-α, compared to Patient cluster II. Men belonging to Patient cluster I were significantly older and had significantly more lifestyle risk factors compared to men in Patient cluster II.
    Conclusion: Cluster analysis suggested the existence of a less favourable pro-inflammatory cytokine expression profile, being present in part of men affected by RPL and associated with advanced male age and lifestyle risk factors. These findings may serve as a starting point for further research into underlying mechanisms and ultimately lead to novel diagnostic and therapeutic approaches for couples with RPL.
    MeSH term(s) Abortion, Habitual/diagnosis ; Abortion, Habitual/immunology ; Adult ; Age Factors ; Biomarkers/analysis ; Biomarkers/metabolism ; Case-Control Studies ; Cytokines/analysis ; Cytokines/metabolism ; Female ; Healthy Volunteers ; Humans ; Male ; Pregnancy ; Prognosis ; Semen/immunology ; Semen/metabolism ; Semen Analysis/methods
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2021-07-08
    Publishing country Ireland
    Document type Journal Article ; Observational Study
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2021.103349
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Detailed immune monitoring of a pregnant woman with critical Covid-19.

    du Fossé, N A / Bronsgeest, K / Arbous, M S / Zlei, M / Myeni, S K / Kikkert, M / van Dongen, Jjm / Staal, Fjt / van der Hoorn, Mlp / van den Akker, T

    Journal of reproductive immunology

    2020  Volume 143, Page(s) 103243

    Abstract: A primigravid woman with Covid-19 related respiratory insufficiency was admitted into a tertiary Intensive Care Unit at 23 3/7 weeks' gestation. Highly sensitive flow cytometry of peripheral leukocytes indicated significantly suppressed naïve T- and B- ... ...

    Abstract A primigravid woman with Covid-19 related respiratory insufficiency was admitted into a tertiary Intensive Care Unit at 23 3/7 weeks' gestation. Highly sensitive flow cytometry of peripheral leukocytes indicated significantly suppressed naïve T- and B-cell compartments. The suppressed immune cell responses led us keep the initially started administration of corticosteroids for fetal and maternal indication at a low dose. After three weeks her B-cell response peaked, SARS-CoV-2 was cleared and clinical improvement ensued a week later. At 28 weeks' gestation, a son of 1570 g was born by cesarean section. She was extubated two days postpartum and discharged from hospital 5.5 weeks postpartum.
    MeSH term(s) Adult ; B-Lymphocytes/immunology ; COVID-19/diagnosis ; COVID-19/immunology ; Cesarean Section ; Critical Care ; Female ; Flow Cytometry ; Gravidity ; Humans ; Immunosuppression ; Pregnancy/immunology ; Pregnancy Complications, Infectious/diagnosis ; Respiratory Insufficiency/diagnosis ; SARS-CoV-2/physiology ; T-Lymphocytes/immunology
    Keywords covid19
    Language English
    Publishing date 2020-10-29
    Publishing country Ireland
    Document type Case Reports ; Journal Article
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2020.103243
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Detailed immune monitoring of a pregnant woman with critical Covid-19

    du Fossé, N A / Bronsgeest, K / Arbous, M S / Zlei, M / Myeni, S K / Kikkert, M / van Dongen, Jjm / Staal, Fjt / van der Hoorn, Mlp / van den Akker, T

    J Reprod Immunol

    Abstract: A primigravid woman with Covid-19 related respiratory insufficiency was admitted into a tertiary Intensive Care Unit at 23 3/7 weeks' gestation. Highly sensitive flow cytometry of peripheral leukocytes indicated significantly suppressed naïve T- and B- ... ...

    Abstract A primigravid woman with Covid-19 related respiratory insufficiency was admitted into a tertiary Intensive Care Unit at 23 3/7 weeks' gestation. Highly sensitive flow cytometry of peripheral leukocytes indicated significantly suppressed naïve T- and B-cell compartments. The suppressed immune cell responses led us keep the initially started administration of corticosteroids for fetal and maternal indication at a low dose. After three weeks her B-cell response peaked, SARS-CoV-2 was cleared and clinical improvement ensued a week later. At 28 weeks' gestation, a son of 1570 g was born by cesarean section. She was extubated two days postpartum and discharged from hospital 5.5 weeks postpartum.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #894079
    Database COVID19

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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