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  1. Article ; Online: Predictive value of General Movements Assessment for developmental delay at 18 months in children with complex congenital heart disease.

    Huisenga, Darlene C / la Bastide-van Gemert, Sacha / Van Bergen, Andrew H / Sweeney, Jane K / Hadders-Algra, Mijna

    Early human development

    2023  Volume 188, Page(s) 105916

    Abstract: Background: Infants with complex congenital heart disease are at increased risk of impaired fetal brain growth, brain injury, and developmental impairments. The General Movement Assessment (GMA) is a valid and reliable tool to predict cerebral palsy (CP) ...

    Abstract Background: Infants with complex congenital heart disease are at increased risk of impaired fetal brain growth, brain injury, and developmental impairments. The General Movement Assessment (GMA) is a valid and reliable tool to predict cerebral palsy (CP), especially in preterm infants. Predictive properties of the GMA in infants with complex congenital heart disease (CCHD) are unknown.
    Aim: To evaluate predictive properties of the GMA to predict developmental outcomes, including cerebral palsy (CP), at 18-months corrected age (CA) in children with CCHD undergoing heart surgery in the first month of life.
    Methods: A prospective cohort of 56 infants with CCHD (35 males, 21 females) was assessed with GMA at writhing age (0-6 weeks CA) and fidgety age (7-17 weeks CA) and the Bayley Scales of Infant Development at 18 months. GMA focused on markedly reduced GM-variation and complexity (definitely abnormal (DA) GM-complexity) and fidgety movements. Predictive values of GMA for specific cognitive, language and motor delay (composite scores <85th percentile) and general developmental delay (delay in all domains) were calculated at 18 months.
    Results: At fidgety age, all infants had fidgety movements and no child was diagnosed with CP. DA GM-complexity at fidgety age predicted general developmental delay at 18 months (71 % sensitivity, 90 % specificity), but predicted specific developmental delay less robustly. DA GM-complexity at writhing age did not predict developmental delay, nor did it improve prediction based on DA GM-complexity at fidgety age.
    Conclusions: In infants with CCHD and fidgety movements, DA GM-complexity at fidgety age predicted general developmental delay.
    MeSH term(s) Infant ; Male ; Female ; Infant, Newborn ; Humans ; Infant, Premature ; Cerebral Palsy/diagnosis ; Prospective Studies ; Movement ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/surgery
    Language English
    Publishing date 2023-12-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2023.105916
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  2. Article ; Online: Longer duration of gestation in term singletons is associated with better infant neurodevelopment.

    Hadders-Algra, Mijna / van Iersel, Patricia A M / Heineman, Kirsten R / la Bastide-van Gemert, Sacha

    Early human development

    2023  Volume 181, Page(s) 105779

    Abstract: Background: Longer gestation at term and post-term age is associated with increased perinatal mortality. Nonetheless, recent neuroimaging studies indicated that longer gestation is also associated with better functioning of the child's brain.: Aims: ... ...

    Abstract Background: Longer gestation at term and post-term age is associated with increased perinatal mortality. Nonetheless, recent neuroimaging studies indicated that longer gestation is also associated with better functioning of the child's brain.
    Aims: to assess whether longer gestation in term and post-term (in short: term) singletons is associated with better infant neurodevelopment.
    Study design: cross-sectional observational study.
    Subjects: Participants were all singleton term infants (n = 1563) aged 2-18 months of the IMP-SINDA project that collected normative data for the Infant Motor Profile (IMP) and Standardized Infant NeuroDevelopmental Assessment (SINDA). The group was representative of the Dutch population.
    Outcome measures: Total IMP score was the primary outcome. Secondary outcomes were atypical total IMP scores (scores <15th percentile) and SINDA's neurological and developmental scores.
    Results: Duration of gestation had a quadratic relationship with IMP and SINDA developmental scores. IMP scores were lowest at a gestation of 38·5 weeks, SINDA developmental scores at 38·7 weeks. Next, both scores increased with increasing duration of gestation. Infants born at 41-42 weeks had significantly less often atypical IMP scores (adjusted OR [95 % CI]: 0·571 [0·341-0·957] and atypical SINDA developmental scores (adjusted OR: 0·366 [0·195-0·688]) than infants born at 39-40 weeks. Duration of gestation was not associated with SINDA's neurological score.
    Conclusions: In term singleton infants representative of the Dutch population longer gestation is associated with better infant neurodevelopment scores suggesting better neural network efficiency. Longer gestation in term infants is not associated with atypical neurological scores.
    MeSH term(s) Child ; Pregnancy ; Female ; Humans ; Infant ; Cross-Sectional Studies ; Brain ; Pregnancy Outcome ; Gestational Age
    Language English
    Publishing date 2023-04-25
    Publishing country Ireland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2023.105779
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  3. Article ; Online: The Dutch Lifelines Cohort: The risk of developmental coordination disorder runs in families.

    la Bastide-Van Gemert, Sacha / van Hoorn, Jessika F / Burgerhof, Johannes G M / Schoemaker, Marina M / van der Sluis, Corry K / Hadders-Algra, Mijna

    Acta paediatrica (Oslo, Norway : 1992)

    2024  

    Language English
    Publishing date 2024-04-10
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.17239
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  4. Article ; Online: Radiation-induced xerostomia is related to stem cell dose-dependent reduction of saliva production.

    van Rijn-Dekker, Maria I / la Bastide-van Gemert, Sacha / Stokman, Monique A / Vissink, Arjan / Coppes, Robert P / Langendijk, Johannes A / van Luijk, Peter / Steenbakkers, Roel J H M

    International journal of radiation oncology, biology, physics

    2024  

    Abstract: Background and purpose: Previous studies have shown that the mean dose to the parotid gland stem cell rich regions (D: Material/methods: In 570 head and neck cancer patients treated with definitive radiation therapy (RT), flow from the parotid (FLOW!# ...

    Abstract Background and purpose: Previous studies have shown that the mean dose to the parotid gland stem cell rich regions (D
    Material/methods: In 570 head and neck cancer patients treated with definitive radiation therapy (RT), flow from the parotid (FLOW
    Results: D
    Conclusion: Higher SCR region dose reduced parotid gland saliva production, subsequently resulting in higher daytime xerostomia scores. Consequently, this study supports the clinical implementation of stem cell sparing RT to preserve salivary flow with the aim of reducing the risk of xerostomia.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2024.04.012
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  5. Article ; Online: Development of muscle tone impairments in high-risk infants: Associations with cerebral palsy and cystic periventricular leukomalacia.

    Straathof, Elisabeth J M / Hamer, Elisa G / Hensens, Kilian J / La Bastide-van Gemert, Sacha / Heineman, Kirsten R / Hadders-Algra, Mijna

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2022  Volume 37, Page(s) 12–18

    Abstract: Aim: To assess the prevalence and development of muscle tone impairments in infants at high risk of developmental disorders, and their associations with cerebral palsy (CP) and cystic periventricular leukomalacia (cPVL).: Method: Longitudinal ... ...

    Abstract Aim: To assess the prevalence and development of muscle tone impairments in infants at high risk of developmental disorders, and their associations with cerebral palsy (CP) and cystic periventricular leukomalacia (cPVL).
    Method: Longitudinal exploration of muscle tone in 39 infants at high risk of CP (LEARN2MOVE 0-2 project) mostly due to an early lesion of the brain. Muscle tone was assessed ≥4 times between 0 and 21 months corrected age (CA) with the Touwen Infant Neurological Examination. Diagnosis of CP was determined at 21 months CA. Neonatal neuro-imaging was available. Developmental trajectories were calculated using generalized linear mixed effect models.
    Results: Infants showed atypical muscle tone in three or four body parts in 93% (172/185) of the assessments. The most prevalent muscle tone pattern was hypotonia of neck and trunk with hypertonia of the limbs (28%). From 7 months CA onwards hypertonia of the arms was associated with CP. Asymmetric arm tone during infancy was associated with unilateral CP. At 18-21 months CA ankle hypertonia was associated with CP at 21 months; leg hypertonia in infancy was not associated with CP. Leg hypertonia was associated with cPVL, regardless of age.
    Interpretation: High-risk infants due to an early lesion of the brain often present with muscle tone impairment. In these infants, hypertonia and asymmetric muscle tone of the arms were from 7 months onwards associated with the diagnosis of CP at 21 months; hypertonia of the legs was not.
    MeSH term(s) Brain ; Cerebral Palsy/complications ; Cerebral Palsy/diagnostic imaging ; Cerebral Palsy/epidemiology ; Humans ; Infant ; Infant, Newborn ; Leukomalacia, Periventricular/complications ; Leukomalacia, Periventricular/diagnostic imaging ; Leukomalacia, Periventricular/epidemiology ; Muscle Tonus ; Neurologic Examination
    Language English
    Publishing date 2022-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1397146-3
    ISSN 1532-2130 ; 1090-3798
    ISSN (online) 1532-2130
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2021.12.015
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  6. Article ; Online: Motor development in infants with complex congenital heart disease: A longitudinal study.

    Huisenga, Darlene / la Bastide-van Gemert, Sacha / Van Bergen, Andrew H / Sweeney, Jane K / Hadders-Algra, Mijna

    Developmental medicine and child neurology

    2022  Volume 65, Issue 1, Page(s) 117–125

    Abstract: Aim: To evaluate whether infants with complex congenital heart disease (CCHD) have an increased risk of impaired quality of motor behavior and delayed motor milestones.: Method: A cohort of 69 infants with CCHD (43 males, 26 females) were assessed ... ...

    Abstract Aim: To evaluate whether infants with complex congenital heart disease (CCHD) have an increased risk of impaired quality of motor behavior and delayed motor milestones.
    Method: A cohort of 69 infants with CCHD (43 males, 26 females) were assessed with the Infant Motor Profile (IMP) at three time periods between 6 to 18 months, mean ages in months (SD): 6.4 (0.7); 12.7 (1.0); 18.5 (0.7) IMP data were available from a reference sample of 300 Dutch infants. Analyses included multivariable logistic regression analysis to estimate differences in IMP scores below the 15th centile between children with CCHD and the reference group, and linear mixed-effects models to assess the effect of ventricular physiology and systemic oxygen saturation (SpO2) of less than 90% on IMP outcomes.
    Results: Infants with CCHD had increased risks of total IMP scores below the 15th centile (lowest odds ratio [OR] at 18mo: 6.82 [95% confidence interval {CI} 2.87-16.19]), especially because of lower scores in the domains of variation, adaptability, and performance. Children with single ventricle CCHD scored consistently 3.03% (95% CI 1.00-5.07) lower than those with two ventricle physiology, mainly from contributions of the variation and performance domains. SpO2 of less than 90% was associated with 2.52% (95% CI 0.49-4.54) lower IMP scores.
    Interpretation: CCHD, especially single ventricle physiology, increases risk of impaired motor development.
    What this paper adds: Complex congenital heart disease (CCHD) substantially increases risk of impaired motor development. CCHD is associated with motor delay and reduced motor variation and adaptability. Single ventricle physiology increases the risk of impaired motor behavior.
    MeSH term(s) Child ; Female ; Humans ; Infant ; Male ; Cohort Studies ; Heart Defects, Congenital/complications ; Longitudinal Studies ; Odds Ratio
    Language English
    Publishing date 2022-06-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.15287
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  7. Article ; Online: Infant motor behaviour and functional and cognitive outcome at school-age: A follow-up study in very high-risk children.

    Straathof, Elisabeth J M / Heineman, Kirsten R / La Bastide-van Gemert, Sacha / Hamer, Elisa G / Hadders-Algra, Mijna

    Early human development

    2022  Volume 170, Page(s) 105597

    Abstract: Background: The Infant Motor Profile (IMP) is an appropriate tool to assess and monitor infant motor behaviour over time. Infants at very high risk (VHR) due to a lesion of the brain generally show impaired motor development. They may grow into or out ... ...

    Abstract Background: The Infant Motor Profile (IMP) is an appropriate tool to assess and monitor infant motor behaviour over time. Infants at very high risk (VHR) due to a lesion of the brain generally show impaired motor development. They may grow into or out of their neurodevelopmental deficit.
    Aims: Evaluate associations between IMP-trajectories, summarised by IMP-scores in early infancy and rates of change, and functional and cognitive outcome at school-age in VHR-children.
    Study design: Longitudinal study.
    Subjects: 31 VHR-children, mainly due to a brain lesion, who had multiple IMP-assessments during infancy, were re-assessed at 7-10 years (school-age).
    Outcome measures: Functional outcome was assessed with the Vineland-II, cognition with RAKIT 2. Associations between IMP-trajectories and outcome were tested by multivariable linear regression analyses.
    Results: When corrected for sex, maternal education and follow-up age, initial scores of total IMP, variation and performance domains, as well as their rates of change were associated with better functional outcome (unstandardised coefficients [95% CI]): 36.44 [19.60-53.28], 33.46 [17.43-49.49], 16.52 [7.58-25.46], and 513.15 [262.51-763.79], 356.70 [148.24-565.15], and 269 [130.57-407.43], respectively. Positive rates of change in variation scores were associated with better cognition at school-age: 34.81 [16.58-53.03].
    Conclusion: Our study indicated that in VHR-children IMP-trajectories were associated with functional outcome at school-age, and to a minor extent also with cognition. Initial IMP-scores presumably reflect the effect of an early brain lesion on brain functioning, whereas IMP rate of change reflects whether infants are able to grow into or out of their initial neurodevelopmental deficit.
    MeSH term(s) Adult ; Child Development ; Cognition ; Follow-Up Studies ; Humans ; Infant ; Infant Behavior ; Inosine Monophosphate ; Longitudinal Studies
    Chemical Substances Inosine Monophosphate (131-99-7)
    Language English
    Publishing date 2022-06-02
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752532-1
    ISSN 1872-6232 ; 0378-3782
    ISSN (online) 1872-6232
    ISSN 0378-3782
    DOI 10.1016/j.earlhumdev.2022.105597
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  8. Article ; Online: Plasma calprotectin and new-onset type 2 diabetes in the general population: a prospective cohort study.

    Bourgonje, Arno R / Bourgonje, Martin F / Sokooti, Sara / la Bastide-van Gemert, Sacha / Nilsen, Tom / Hidden, Clara / Gansevoort, Ron T / Mulder, Douwe J / Hillebrands, Jan-Luuk / Bakker, Stephan J L / van Beek, André / Dullaart, Robin P F / van Goor, Harry / Abdulle, Amaal E

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Background: Systemic inflammation plays a pivotal role in the development of type 2 diabetes (T2D). Here we hypothesized that circulating levels of calprotectin, a myeloid cell-derived biomarker of inflammation, is associated with the development of new- ...

    Abstract Background: Systemic inflammation plays a pivotal role in the development of type 2 diabetes (T2D). Here we hypothesized that circulating levels of calprotectin, a myeloid cell-derived biomarker of inflammation, is associated with the development of new-onset T2D in the general population.
    Methods: A total of 4,815 initially non-diabetic participants of the Prevention of Renal and Vascular ENd-stage Disease (PREVEND), a prospective population-based cohort study, were assessed for plasma levels of calprotectin at baseline. Circulating levels of calprotectin were investigated for potential associations with the risk of new-onset T2D, defined as a fasting plasma glucose level ≥7.0 mmol/l, a random plasma glucose level ≥11.1 mmol/l, a self-reported physician-based diagnosis of T2D, the use of glucose-lowering drugs, or any combinations thereof.
    Results: Median plasma calprotectin levels were 0.49 [0.35-0.69] mg/l. Plasma calprotectin levels were significantly associated with the risk of new-onset T2D (hazard ratio [HR] per doubling 1.42 [95% confidence interval: 1.22-1.66], P<0.001). The association remained independent of adjustment for age and sex (HR 1.34 [95%CI: 1.14-1.57], P<0.001), but not after further adjustment for potentially confounding factors (HR 1.11 [95% CI: 0.90-1.37], P=0.326), with adjustment for hyperlipidemia and high-sensitivity C-reactive protein explaining the loss of significance. Stratified analyses showed significant effect modification by hypertension, history of cardiovascular disease and HOMA-IR (Pinteraction≤0.001 for each), with higher HRs in individuals without hypertension, without history of cardiovascular disease and with below-median HOMA-IR.
    Conclusions: Elevated plasma levels of calprotectin are associated with a higher risk of developing T2D in the general population and may represent a moveable inflammatory biomarker. This association, however, does not represent a direct effect, and seems dependent on hyperlipidemia and systemic inflammation.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae130
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  9. Article: A Sex-Specific Comparative Analysis of Oxidative Stress Biomarkers Predicting the Risk of Cardiovascular Events and All-Cause Mortality in the General Population: A Prospective Cohort Study.

    Bourgonje, Martin F / Abdulle, Amaal E / Kieneker, Lyanne M / la Bastide-van Gemert, Sacha / Bakker, Stephan J L / Gansevoort, Ron T / Gordijn, Sanne J / van Goor, Harry / Bourgonje, Arno R

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Oxidative stress plays a pivotal role in cardiovascular (CV) disease, but current biomarkers used to predict CV events are still insufficient. In this study, we comparatively assessed the utility of redox-related biomarkers in predicting the risk of CV ... ...

    Abstract Oxidative stress plays a pivotal role in cardiovascular (CV) disease, but current biomarkers used to predict CV events are still insufficient. In this study, we comparatively assessed the utility of redox-related biomarkers in predicting the risk of CV events and all-cause mortality in male and female subjects from the general population. Subjects (
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12030690
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  10. Article ; Online: Plasma Calprotectin Levels Associate With New-Onset Hypertension in the General Population: A Prospective Cohort Study.

    Bourgonje, Arno R / Bourgonje, Martin F / la Bastide-van Gemert, Sacha / Nilsen, Tom / Hidden, Clara / Gansevoort, Ron T / Bakker, Stephan J L / Mulder, Douwe J / Dullaart, Robin P F / Abdulle, Amaal E / van Goor, Harry

    Journal of the American Heart Association

    2023  Volume 13, Issue 1, Page(s) e031458

    Abstract: Background: Low-grade systemic inflammation is a relevant pathogenic mechanism underlying the development of hypertension. In this study, we hypothesized that plasma calprotectin levels, as a biomarker of neutrophil-mediated inflammation, is associated ... ...

    Abstract Background: Low-grade systemic inflammation is a relevant pathogenic mechanism underlying the development of hypertension. In this study, we hypothesized that plasma calprotectin levels, as a biomarker of neutrophil-mediated inflammation, is associated with developing new-onset hypertension in the general population.
    Methods and results: Plasma calprotectin levels were determined in 3524 participants who participated in the PREVEND (Prevention of Renal and Vascular End-Stage Disease) study, a prospective population-based cohort study. Plasma calprotectin levels were studied for associations with the risk of new-onset hypertension, defined as systolic blood pressure of at least 140 mm Hg, diastolic blood pressure of at least 90 mm Hg, or the first recorded use of antihypertensives. Participants with hypertension at baseline were excluded. Median plasma calprotectin levels were 0.48 (0.34-0.66) mg/L, and median systolic blood pressure was 117 (109-126) mm Hg. Plasma calprotectin levels were significantly associated with the risk of new-onset hypertension (hazard ratio [HR], per doubling 1.30 [95% CI, 1.21-1.41];
    Conclusions: Higher plasma calprotectin levels are associated with an increased risk of new-onset hypertension in the general population. This association is dependent on baseline systolic blood pressure and is particularly prominent in men compared with women.
    MeSH term(s) Male ; Humans ; Female ; Prospective Studies ; Cohort Studies ; Leukocyte L1 Antigen Complex ; Risk Factors ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypertension/complications ; Blood Pressure/physiology ; Inflammation/complications ; Albumins
    Chemical Substances Leukocyte L1 Antigen Complex ; Albumins
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031458
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