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  1. Article ; Online: Enteric neuro-immune interactions in intestinal health and disease.

    van Baarle, Lies / Stakenborg, Michelle / Matteoli, Gianluca

    Seminars in immunology

    2023  Volume 70, Page(s) 101819

    Abstract: The enteric nervous system is an autonomous neuronal circuit that regulates many processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of enteric neurons and enteric glial cells, can engage in many intercellular ... ...

    Abstract The enteric nervous system is an autonomous neuronal circuit that regulates many processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of enteric neurons and enteric glial cells, can engage in many intercellular interactions shaping the homeostatic microenvironment in the gut. Perhaps the most well documented interactions taking place, are the intestinal neuro-immune interactions which are essential for the fine-tuning of oral tolerance. In the context of intestinal disease, compelling evidence demonstrates both protective and detrimental roles for this bidirectional neuro-immune signaling. This review discusses the different immune cell types that are recognized to engage in neuronal crosstalk during intestinal health and disease. Highlighting the molecular pathways involved in the neuro-immune interactions might inspire novel strategies to target intestinal disease.
    MeSH term(s) Humans ; Neuroimmunomodulation ; Intestinal Diseases ; Homeostasis ; Enteric Nervous System
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Neurite outgrowth in symptomatic uncomplicated diverticular disease.

    De Simone, Veronica / van Baarle, Lies / Matteoli, Gianluca

    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

    2019  Volume 31, Issue 9, Page(s) e13680

    Abstract: Diverticulosis is the presence of small, bulging pouches in the lining of the intestinal colonic mucosal and submucosal layers. This condition is usually asymptomatic. The few patients (25%) that do develop abdominal symptoms are diagnosed with ... ...

    Abstract Diverticulosis is the presence of small, bulging pouches in the lining of the intestinal colonic mucosal and submucosal layers. This condition is usually asymptomatic. The few patients (25%) that do develop abdominal symptoms are diagnosed with symptomatic uncomplicated diverticular disease (SUDD). Up to now it is not clear which pathophysiological events trigger the transition from asymptomatic diverticulosis to SUDD. However, data from Barbaro and colleagues published in the current issue of Neurogastroenterology and Motility showed extensive axonal sprouting and increased macrophage infiltration in SUDD compared to asymptomatic diverticulosis patients. Thereby they provide more evidence suggesting that enteric neuro-plasticity, whether or not affected by infiltrating macrophages, may underlie the development of symptoms in diverticulosis.
    MeSH term(s) Diverticular Diseases/diagnosis ; Diverticular Diseases/metabolism ; Diverticular Diseases/physiopathology ; Humans ; Neuronal Outgrowth/physiology ; Neuropeptides/metabolism
    Chemical Substances Neuropeptides
    Language English
    Publishing date 2019-08-21
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1186328-6
    ISSN 1365-2982 ; 1350-1925
    ISSN (online) 1365-2982
    ISSN 1350-1925
    DOI 10.1111/nmo.13680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2979: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: How Microbial Food Fermentation Supports a Tolerant Gut.

    Poppe, Jonas / van Baarle, Lies / Matteoli, Gianluca / Verbeke, Kristin

    Molecular nutrition & food research

    2020  Volume 65, Issue 5, Page(s) e2000036

    Abstract: The gastrointestinal tract harbors a complex resident microbial ecosystem, comprising over 500 species, spanning commensals, mutualist, opportunistic, and professional pathogens thriving on undigested food components originating from the diet and ... ...

    Abstract The gastrointestinal tract harbors a complex resident microbial ecosystem, comprising over 500 species, spanning commensals, mutualist, opportunistic, and professional pathogens thriving on undigested food components originating from the diet and endogenous secretions. Despite this high concentration of food and bacterial antigens, a healthy gut has a near absent level of inflammation, a status called intestinal immune homeostasis. This immune homeostasis is built and maintained in the presence, and interestingly, with cooperation of the microbiota. The microbiota ferments undigested food components into a wide variety of metabolites, some of which interact with the intestinal immune system. In particular short-chain fatty acids, aryl hydrocarbon receptor ligands, and bile acid metabolites have been involved in the induction of intestinal immune homeostasis. The production of these metabolites is influenced by the microbial load and community structure, as well as the availability of substrates and the gut environment which are directly or indirectly modulated by food intake. In this manuscript, the factors that influence the production of these metabolites and their interaction with the immune cells that play key roles in maintaining intestinal immune homeostasis in the healthy gut are reviewed.
    MeSH term(s) Bile Acids and Salts/metabolism ; Fermentation ; Food ; Food Microbiology ; Gastrointestinal Microbiome/physiology ; Humans ; Immune Tolerance/physiology ; Immunologic Factors/metabolism ; Intestines/cytology ; Intestines/immunology ; Phylogeny ; Tryptophan/metabolism
    Chemical Substances Bile Acids and Salts ; Immunologic Factors ; Tryptophan (8DUH1N11BX)
    Language English
    Publishing date 2020-11-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2160372-8
    ISSN 1613-4133 ; 1613-4125
    ISSN (online) 1613-4133
    ISSN 1613-4125
    DOI 10.1002/mnfr.202000036
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  4. Article: Cytological, molecular, cytogenetic, and physiological characterization of a novel immortalized human enteric glial cell line.

    Zanoletti, Lisa / Valdata, Aurora / Nehlsen, Kristina / Faris, Pawan / Casali, Claudio / Cacciatore, Rosalia / Sbarsi, Ilaria / Carriero, Francesca / Arfini, Davide / van Baarle, Lies / De Simone, Veronica / Barbieri, Giulia / Raimondi, Elena / May, Tobias / Moccia, Francesco / Bozzola, Mauro / Matteoli, Gianluca / Comincini, Sergio / Manai, Federico

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1170309

    Abstract: Enteric glial cells (EGCs), the major components of the enteric nervous system (ENS), are implicated in the maintenance of gut homeostasis, thereby leading to severe pathological conditions when impaired. However, due to technical difficulties associated ...

    Abstract Enteric glial cells (EGCs), the major components of the enteric nervous system (ENS), are implicated in the maintenance of gut homeostasis, thereby leading to severe pathological conditions when impaired. However, due to technical difficulties associated with EGCs isolation and cell culture maintenance that results in a lack of valuable
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1170309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation.

    Stakenborg, Michelle / Abdurahiman, Saeed / De Simone, Veronica / Goverse, Gera / Stakenborg, Nathalie / van Baarle, Lies / Wu, Qin / Pirottin, Dimitri / Kim, Jung-Seok / Chappell-Maor, Louise / Pintelon, Isabel / Thys, Sofie / Pollenus, Emilie / Boon, Louis / Van den Steen, Philippe / Hao, Marlene / Van Ginderachter, Jo A / Boeckxstaens, Guy E / Timmermans, Jean-Pierre /
    Jung, Steffen / Marichal, Thomas / Ibiza, Sales / Matteoli, Gianluca

    Mucosal immunology

    2022  Volume 15, Issue 6, Page(s) 1296–1308

    Abstract: Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors are responsible for monocyte recruitment and anti-inflammatory Mφ differentiation in this paradigm. Here, ... ...

    Abstract Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors are responsible for monocyte recruitment and anti-inflammatory Mφ differentiation in this paradigm. Here, we investigate Mφ heterogeneity at different stages of muscularis inflammation and determine how environmental cues can attract and activate tissue-protective Mφs. Results showed that muscularis inflammation induced marked alterations in mononuclear phagocyte populations associated with a rapid infiltration of Ly6c
    MeSH term(s) Humans ; Macrophages ; Monocytes ; Inflammation ; Neuroglia ; Anti-Inflammatory Agents
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-022-00563-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6796: Show issues Location:
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