LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article: Absence of citrulline-specific autoantibodies in animal models of autoimmunity.

    Vossenaar, Erik R / van Boekel, Martinus A M / van Venrooij, Walther J / López-Hoyoz, Marcos / Merino, Jesús / Merino, Ramón / Joosten, Leo A B

    Arthritis and rheumatism

    2004  Volume 50, Issue 7, Page(s) 2370–2372

    MeSH term(s) Animals ; Antibody Specificity ; Arthritis, Rheumatoid/immunology ; Autoantibodies/analysis ; Autoantibodies/blood ; Autoantibodies/immunology ; Autoimmunity/immunology ; Citrulline/immunology ; Disease Models, Animal ; Humans ; Mice ; Mice, Inbred MRL lpr ; Mice, Transgenic ; Peptides, Cyclic/immunology
    Chemical Substances Autoantibodies ; Peptides, Cyclic ; cf0-cyc peptide ; cyclic citrullinated peptide ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2004-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.20296
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 523: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value.

    van Boekel, Martinus A M / Vossenaar, Erik R / van den Hoogen, Frank H J / van Venrooij, Walther J

    Arthritis research

    2001  Volume 4, Issue 2, Page(s) 87–93

    Abstract: The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be ...

    Abstract The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be very useful. Most autoimmune diseases are characterized by a polyclonal B-cell response targeting multiple autoantigens. These immune responses are often not specific for a single disease. In this review, the most important autoantibody/autoantigen systems associated with RA are described and their utility as a diagnostic and prognostic tool, including their specificity, sensitivity and practical application, is discussed. We conclude that, at present, the antibody response directed to citrullinated antigens has the most valuable diagnostic and prognostic potential for RA.
    MeSH term(s) Antibody Specificity/immunology ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Autoantibodies/immunology ; Autoantigens/blood ; Autoimmunity/immunology ; Citrulline/immunology ; Citrulline/metabolism ; Humans ; Serologic Tests
    Chemical Substances Autoantibodies ; Autoantigens ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2001-11-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2007393-8
    ISSN 1465-9913 ; 1465-9905
    ISSN (online) 1465-9913
    ISSN 1465-9905
    DOI 10.1186/ar395
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The Influence of Some Post-Translational Modifications on the Chaperone-Like Activity of α-Crystallin

    van Boekel, Martinus A.M. / Hoogakker, Simone E.A. / Harding, John J. / de Jong, Wilfried W.

    Ophthalmic Research - Journal for Research in Experimental and Clinical Ophthalmology

    1996  Volume 28, Issue S1, Page(s) 32–38

    Abstract: We investigated the influence of phosphorylation, glycation, carbamylation and oxidative modification on the capacity of α-crystallin to protect β-crystallins against heat denaturation. Simple modification of lysine residues by early glycation or ... ...

    Abstract We investigated the influence of phosphorylation, glycation, carbamylation and oxidative modification on the capacity of α-crystallin to protect β-crystallins against heat denaturation. Simple modification of lysine residues by early glycation or carbamylation had no effect. However, late (cross-linking) glycation products and oxidative modifications decreased the chaperone-like activity of α-crystallin. Homopolymers of αA-crystallin had a higher protecting capacity compared with those of αB-crystallin. The in vivo phosphorylated forms of especially αA- but also αB-crystallin revealed a somewhat better protecting ability than the respective non-phosphorylated forms.
    Keywords Eye lens ; Glycation ; Phosphorylation ; Crystallin ; Chaperone
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 205708-6
    ISBN 978-3-8055-6304-8 ; 3-8055-6304-3
    ISSN 1423-0259 ; 0030-3747 ; 0030-3747
    ISSN (online) 1423-0259
    ISSN 0030-3747
    DOI 10.1159/000267940
    Database Karger publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 559: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Chaperone function of mutant versions of αA‐ and αB‐crystallin prepared to pinpoint chaperone binding sites

    Derham, Barry K / van Boekel, Martinus A. M / Muchowski, Paul J / Clark, John I / Horwitz, Joseph / Hepburne‐Scott, Henry W / de Jong, W. W / Crabbe, M. James C / Harding, John J

    European journal of biochemistry. 2001 Feb., v. 268, no. 3

    2001  

    Abstract: A major stress protein, α‐crystallin, functions as a chaperone. Site‐directed mutagenesis has been used to identify regions of the protein necessary for chaperone function. In this work we have taken some of the previously described mutants produced and ... ...

    Abstract A major stress protein, α‐crystallin, functions as a chaperone. Site‐directed mutagenesis has been used to identify regions of the protein necessary for chaperone function. In this work we have taken some of the previously described mutants produced and assessed their chaperone function by both a traditional heat‐induced aggregation method at elevated temperature and using enzyme methods at 37 °C. In general the different assays gave parallel results indicating that the same property is being measured. Discrepancies were explicable by the heat lability of some mutants. Most mutants had full chaperone function showing the robust nature of α‐crystallin. A mutant corresponding to a minor component of rodent αA‐crystallin, αAins‐crystallin, had decreased chaperone function. Decreased chaperone function was also found for human Ser139→ Arg, Thr144→Arg, Ser59→Ala mutants of αB‐crystallin and double mutants Ser45→Ala/Ser59→Ala, Lys103→ Leu/His104→Ile, and Glu110→His/His111→Glu. A mutant Phe27→Arg that was the subject of previous controversy was shown to be fully active at physiological temperatures.
    Keywords binding sites ; heat stability ; humans ; mutants ; rodents ; site-directed mutagenesis ; temperature
    Language English
    Dates of publication 2001-02
    Size p. 713-721.
    Publishing place Blackwell Science Ltd
    Document type Article
    ZDB-ID 3032-6
    ISSN 1432-1033 ; 0014-2956
    ISSN (online) 1432-1033
    ISSN 0014-2956
    DOI 10.1046/j.1432-1327.2001.01929.x
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 2151: Show issues
    Z 5.2: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top