LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 39

Search options

  1. Article ; Online: Setting the global research agenda for community-based HIV service delivery through the faith sector.

    Ndlovu-Teijema, Martha T / Kok, Maarten O / van Elsland, Sabine L / Smeets, Hilleen / Barstow, David / van Rooyen, Lyn / van Furth, A M

    Health research policy and systems

    2021  Volume 19, Issue 1, Page(s) 81

    Abstract: Background: While leading AIDS organizations expect faith and health collaborations to play a crucial role in organizing and scaling up community-based HIV services, it is unclear how this can be realized. Little primary research has been conducted into ...

    Abstract Background: While leading AIDS organizations expect faith and health collaborations to play a crucial role in organizing and scaling up community-based HIV services, it is unclear how this can be realized. Little primary research has been conducted into which strategies for collaboration and service provision are most effective, efficient, scalable and sustainable. Seeking to align research with urgent needs, enhance coordination and increase the likelihood that results are used, this study aimed to set an inclusive global research agenda that reflects priority research questions from key stakeholders at the intersection of HIV healthcare and faith.
    Methods: In order to develop this global research agenda, we drew from document analyses, focus group discussions, interviews with purposively selected key informants from all continents (policy-makers, healthcare providers, faith leaders, academics and HIV activists), an online questionnaire, and expert meetings at several global conferences. We carried out focus group discussions and interviews with faith leaders in South Africa. Other stakeholder focus groups and interviews were carried out online or in person in France, Switzerland, the Netherlands and South Africa, and virtual questionnaires were distributed to stakeholders worldwide. Respondents were purposively sampled.
    Results: We interviewed 53 participants, and 110 stakeholders responded to the online questionnaire. The participants worked in 54 countries, with the majority having research experience (84%), experience with policy processes (73%) and/or experience as a healthcare provider (60%) and identifying as religious (79%). From interviews (N = 53) and questionnaires (N = 110), we identified 10 research themes: addressing sexuality, stigma, supporting specific populations, counselling and disclosure, agenda-setting, mobilizing and organizing funding, evaluating faith-health collaborations, advantage of faith initiatives, gender roles, and education. Respondents emphasized the need for more primary research and prioritized two themes: improving the engagement of faith communities in addressing sexuality and tackling stigma.
    Conclusions: A wide range of respondents participated in developing the research agenda. To align research to the prioritized themes and ensure that results are used, it is essential to further engage key users, funders, researchers and other stakeholders, strengthen the capacity for locally embedded research and research uptake and contextualize priorities to diverse religious traditions, key populations and local circumstances.
    MeSH term(s) Community Health Services ; France ; HIV Infections/therapy ; Humans ; Netherlands ; South Africa ; Switzerland
    Language English
    Publishing date 2021-05-17
    Publishing country England
    Document type Journal Article
    ISSN 1478-4505
    ISSN (online) 1478-4505
    DOI 10.1186/s12961-021-00718-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Destitution, treatment adherence and survival of children with Burkitt lymphoma in a twinning programme in Northwest Cameroon.

    Afungchwi, Glenn M / Hesseling, Peter / van Elsland, Sabine L / Kouya, Francine / Kruger, Mariana

    Pediatric blood & cancer

    2019  Volume 66, Issue 12, Page(s) e27946

    Abstract: Background: Burkitt lymphoma (BL) is a curable childhood cancer. Treatment adherence is crucial for a good outcome, but is potentially problematic in low- and middle-income countries owing to parental financial constraints.: Aims: To investigate the ... ...

    Abstract Background: Burkitt lymphoma (BL) is a curable childhood cancer. Treatment adherence is crucial for a good outcome, but is potentially problematic in low- and middle-income countries owing to parental financial constraints.
    Aims: To investigate the association of destitution with treatment adherence and its effect on the survival of patients with BL.
    Methods: Patients received free medical treatment from a twinning programme at two Cameroon Baptist hospitals. A destitution assessment questionnaire, based on socioeconomic status, was completed at diagnosis. Medical records were reviewed for treatment adherence and survival. Chi-squared and Fisher's exact tests were used to compare groups. Kaplan-Meier plots were used to calculate overall survival, and log-rank chi-squared tests when comparing survival rates between patient subgroups. Significance was measured at P < .05.
    Results: The 225 children with BL had a mean age of 8.2 years (median 8.0) and the overall survival was 52%. The mean family destitution score was 56% on a linear scale. Few (8%) patients delayed treatment appointments. A quarter (25%) experienced more than a 1-week follow-up delay and 9.8% absconded within 1 year. The destitution score was not significantly associated with delay of treatment, but with delay in follow-up (P < .001). Guardian relationship (single mother) and patient's age were significantly associated with overall survival (P = .025).
    Conclusions: Though linked to poor follow-up, destitution was not significantly associated with absconding patients, poor outcome or poor adherence to treatment, probably due to comprehensive financial support from the international twinning programme. However, additional support for single mothers should be considered.
    MeSH term(s) Adolescent ; Burkitt Lymphoma/economics ; Burkitt Lymphoma/mortality ; Burkitt Lymphoma/psychology ; Burkitt Lymphoma/therapy ; Cameroon ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Poverty/psychology ; Prognosis ; Socioeconomic Factors ; Surveys and Questionnaires ; Survival Rate ; Treatment Adherence and Compliance/psychology ; Treatment Adherence and Compliance/statistics & numerical data
    Language English
    Publishing date 2019-08-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.27946
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Outcome of retinoblastoma treatment protocol in Cameroon as per SIOP-PODC recommendation for a low-income setting.

    Kruger, Mariana / van Elsland, Sabine L / Afungchwi, Glenn M / Bardin, Richard / Njodzeka, Bernard / Kouya, Francine / Nfor, Patience / Nana, Philippa / Wharin, Paul / Hesseling, Peter B

    Pediatric blood & cancer

    2022  Volume 69, Issue 8, Page(s) e29642

    Abstract: Introduction: The International Society of Paediatric Oncology-Paediatric Oncology in Developing Countries (SIOP-PODC) group recommended graduated-intensity retinoblastoma treatment for children in low- and middle-income countries with limited local ... ...

    Abstract Introduction: The International Society of Paediatric Oncology-Paediatric Oncology in Developing Countries (SIOP-PODC) group recommended graduated-intensity retinoblastoma treatment for children in low- and middle-income countries with limited local resources.
    Aim: The aim was to improve outcome of children with retinoblastoma by means of a treatment protocol for low-income settings as recommended by the SIOP-PODC recommendation in Cameroon.
    Methods: Children diagnosed with retinoblastoma between 2012 and 2016 were treated in two Baptist Mission hospitals in Cameroon, staging according to the International Retinoblastoma Staging System. Treatment included local therapy and combination chemotherapy (vincristine, cyclophosphamide, and doxorubicin) with or without surgery as per SIOP-PODC guidelines for low-income countries. Endpoint was survival at 24 months. Kaplan-Meier curves with log-rank (Mantel-Cox) chi-square (χ
    Results: Eighty-two children were included, of whom 79.3% had unilateral disease. The majority were males (61.0%) with median age 24 months (range 1-112 months; standard deviation [SD] 19). Limited disease was diagnosed in 58.5%, metastatic disease in 35.4%, and unknown stage in 6.1%. Overall survival (OS) was 50.0% at 24 months post diagnosis, but 68.8% for limited disease. Estimated cumulative survival at 24 months was 0.528 (standard error [SE] 0.056). Causes of death included disease progression/relapses (60.5%), neutropenic sepsis (15.9%), unknown causes (18.4%), unrelated infection (2.6%), and death post surgery (2.6%). Stage was significantly associated with OS (p < .001).
    Conclusion: Stage was the most significant factor for good OS and demonstrated the efficacy and feasibility of the SIOP-PODC-proposed management guidelines for retinoblastoma in a lower middle-income setting.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cameroon ; Child ; Child, Preschool ; Clinical Protocols ; Developing Countries ; Female ; Humans ; Infant ; Male ; Neoplasm Recurrence, Local/drug therapy ; Retinal Neoplasms/drug therapy ; Retinoblastoma/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29642
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Off-label Use in Ambulatory Paediatric Clinics in a Central South African Hospital.

    Kruger, Mariana / Makiwane, Memela M / Ramoroka, Sekgele / van Elsland, Sabine L / Lawrence, Katherine / Rosenkranz, Bernd

    Journal of tropical pediatrics

    2018  Volume 65, Issue 4, Page(s) 380–388

    Abstract: Aim: The aim of this article was to determine off-label (OL) use in paediatric ambulatory clinics in a South African central hospital.: Patients and methods: OL medicine events were documented in three paediatric clinics (general, highly specialized ... ...

    Abstract Aim: The aim of this article was to determine off-label (OL) use in paediatric ambulatory clinics in a South African central hospital.
    Patients and methods: OL medicine events were documented in three paediatric clinics (general, highly specialized and dedicated HIV paediatric clinics) at Tygerberg Hospital, South Africa, and analysed according to South African medicine registration information.
    Results: There were 2167 medicine events for 658 children. Mean age was 5.6 years (interquartile range 1.8-8.8). There were 123 OL medicine events (6%). Extemporaneous OL use was most common (n = 58, 47%), followed by weight (n = 45, 37%) and lack of paediatric data (n = 38, 31%). Of note was OL use for weight for general paediatrics (n = 32, 78%, p < 0.001), lack of appropriate paediatric data for highly specialized paediatrics (n = 26, 61%, p = 0.004) and extemporaneous use for HIV-infected children (n = 34, 87%, p < 0.001), with significant less OL use for HIV-infected children (p = 0.009).
    Conclusions: Of note is significant extemporaneous OL use in HIV-infected children.
    MeSH term(s) Adolescent ; Ambulatory Care Facilities ; Child ; Child, Preschool ; Cohort Studies ; Drug Prescriptions/statistics & numerical data ; Female ; HIV Infections/drug therapy ; Hospital Units ; Humans ; Infant ; Male ; Off-Label Use/statistics & numerical data ; Practice Patterns, Physicians'/statistics & numerical data ; Prospective Studies
    Language English
    Publishing date 2018-11-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 800065-7
    ISSN 1465-3664 ; 0449-3281 ; 0142-6338
    ISSN (online) 1465-3664
    ISSN 0449-3281 ; 0142-6338
    DOI 10.1093/tropej/fmy065
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Disclosure of human immunodeficiency virus status to children in South Africa: A comprehensive analysis.

    van Elsland, Sabine L / Peters, Remco P H / Grobbelaar, Cornelis / Ketelo, Patiswa / Kok, Maarten O / Cotton, Mark F / van Furth, A Marceline

    Southern African journal of HIV medicine

    2019  Volume 20, Issue 1, Page(s) 884

    Abstract: Background: The extent of disclosure of HIV status to children and adolescents and the context facilitating their disclosure process have received little attention.: Objectives: To assess disclosure and provide a comprehensive analysis of ... ...

    Abstract Background: The extent of disclosure of HIV status to children and adolescents and the context facilitating their disclosure process have received little attention.
    Objectives: To assess disclosure and provide a comprehensive analysis of characteristics associated with disclosure to children (3-14 years) receiving antiretroviral treatment in a South African semi-urban clinic.
    Methods: This cross-sectional study used structured interview administered questionnaires which were supplemented with medical record data. Predictors included child, caregiver, clinical and socio-economic characteristics, viral suppression, immune response, adherence, health-related quality of life and family functioning.
    Results: We included 190 children of whom 45 (23.7%) received disclosure about their HIV status, of whom 28 (14.7%) were partially disclosed and 17 (8.9%) were fully disclosed. Older age of the child and higher education of the caregiver were strongly associated with disclosure. Female caregivers, detectable viral load, syrup formulation, protease inhibitor (PI) regimens with stavudine and didanosine, and self-reported non-adherence were strongly associated with non-disclosure.
    Conclusion: When children do well on treatment, caregivers feel less stringent need to disclose. Well-functioning families, higher educated caregivers and better socio-economic status enabled and promoted disclosure. Non-disclosure can indicate a sub-optimal social structure which could negatively affect adherence and viral suppression. There is an urgent need to address disclosure thoughtfully and proactively in the long-term disease management. For the disclosure process to be beneficial, an enabling supportive context is important, which will provide a great opportunity for future interventions.
    Language English
    Publishing date 2019-08-22
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2259791-8
    ISSN 2078-6751 ; 2078-6751
    ISSN (online) 2078-6751
    ISSN 2078-6751
    DOI 10.4102/sajhivmed.v20i1.884
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Paediatric ART Adherence in South Africa: A Comprehensive Analysis.

    van Elsland, Sabine L / Peters, Remco P H / Grobbelaar, Nelis / Ketelo, Patiswa / Kok, Maarten O / Cotton, Mark F / van Furth, A Marceline

    AIDS and behavior

    2018  Volume 23, Issue 2, Page(s) 475–488

    Abstract: Adherence to antiretroviral therapy (ART) remains a challenge for HIV-infected children. In this cross-sectional study, we used structured interview-administered questionnaires and medical records to measure adherence levels and factors associated with ... ...

    Abstract Adherence to antiretroviral therapy (ART) remains a challenge for HIV-infected children. In this cross-sectional study, we used structured interview-administered questionnaires and medical records to measure adherence levels and factors associated with adherence and viral suppression. We included 195 South African children aged 2.1-12.9 on ART. Adherence levels ranged between 20.5% (pill count) and 89.1% (self-report). Boys were less adherent according to self-report, girls were less adherent according to pill count. Caregivers ensured medication was taken when the condition directly affected daily life. Well-functioning families and families with high SES provide a context supportive of adherence. Non-disclosure and difficulties administering medication negatively affected adherence and viral suppression. This study shows challenging levels of adherence impacting directly on viral suppression in a South African paediatric HIV program. Gender roles, non-disclosure and difficulty administering medication may undermine adherence and should be taken into account for clinical guidelines, policy design and inform strategies.
    MeSH term(s) Adolescent ; Adult ; Anti-HIV Agents/therapeutic use ; CD4 Lymphocyte Count ; Caregivers ; Child ; Child, Preschool ; Cross-Sectional Studies ; Disclosure ; Female ; HIV Infections/blood ; HIV Infections/drug therapy ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Quality of Life ; Sex Factors ; Social Class ; South Africa ; Surveys and Questionnaires ; Viral Load
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2018-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-018-2235-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Making health systems research work: time to shift funding to locally-led research in the South.

    Hasnida, Amalia / Borst, Robert A / Johnson, Anneke M / Rahmani, Nada R / van Elsland, Sabine L / Kok, Maarten O

    The Lancet. Global health

    2017  Volume 5, Issue 1, Page(s) e22–e24

    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(16)30331-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: A treatment-support intervention evaluated in South African paediatric populations with HIV infection or tuberculous meningitis.

    van Elsland, Sabine L / Peters, Remco P H / Kok, Maarten O / van Toorn, Ronald / Springer, Priscilla / Cotton, Mark F / Grobbelaar, Cornelis J / Aarnoutse, Rob / van Furth, A Marceline

    Tropical medicine & international health : TM & IH

    2018  Volume 23, Issue 10, Page(s) 1129–1140

    Abstract: Objectives: To evaluate a paediatric treatment-support intervention for home-based treatment of HIV infection or tuberculous meningitis (TBM).: Methods: A randomised-controlled study comparing local standard care (controls) with standard care plus ... ...

    Abstract Objectives: To evaluate a paediatric treatment-support intervention for home-based treatment of HIV infection or tuberculous meningitis (TBM).
    Methods: A randomised-controlled study comparing local standard care (controls) with standard care plus intervention (combining adherence education, reinforcement and monitoring) in children aged 0-14 years. We recorded adherence measures (self-report, pill-count, drug-assays for isoniazid and rifampicin in urine and pyrazinamide in saliva), difficulties administering medication and PedsQL™questionnaires for health-related quality-of-life (HRQoL) and family impact.
    Results: In the HIV group (6-months follow-up, n = 195), more children had above-median HRQoL-scores in the intervention group than in the control group (P = 0.009). Problems reported administering medication declined between baseline and follow-up for controls (P = 0.043). Disclosure of HIV status to the child increased between baseline and follow-up in both groups (intervention P < 0.001; control P = 0.031). In the TBM group (3-months follow-up, n = 43), all adherence measures remained high for both intervention and controls, except for rifampicin which declined between baseline and follow-up in the intervention group (P = 0.031). The intervention group maintained above median HRQoL-scores between baseline and follow-up, when the number of children with above-median HRQoL-scores decreased in the controls (P = 0.063). More children in the intervention group had above-median family impact-scores than controls (P = 0.040).
    Conclusions: The low-cost, culturally friendly treatment-support intervention had beneficial effects on health-related quality of life, family impact, caregiver disclosure of HIV status to the child, increased caregiver reporting of medication non-adherence and caregiver reporting of difficulties administering medication. Treatment adherence was not significantly affected in either HIV or TBM group.
    MeSH term(s) Adolescent ; Anti-HIV Agents/administration & dosage ; Antitubercular Agents/therapeutic use ; Child ; Child Welfare/psychology ; Child Welfare/statistics & numerical data ; Child, Preschool ; Female ; HIV Infections/drug therapy ; HIV Infections/psychology ; Humans ; Infant ; Infant, Newborn ; Male ; Medication Adherence/psychology ; Medication Adherence/statistics & numerical data ; Quality of Life/psychology ; South Africa ; Tuberculosis, Meningeal/drug therapy ; Tuberculosis, Meningeal/psychology
    Chemical Substances Anti-HIV Agents ; Antitubercular Agents
    Language English
    Publishing date 2018-09-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1314080-2
    ISSN 1365-3156 ; 1360-2276
    ISSN (online) 1365-3156
    ISSN 1360-2276
    DOI 10.1111/tmi.13134
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Short intensified treatment in children with drug-susceptible tuberculous meningitis.

    van Toorn, Ronald / Schaaf, H Simon / Laubscher, Jacoba A / van Elsland, Sabine L / Donald, Peter R / Schoeman, Johan F

    The Pediatric infectious disease journal

    2014  Volume 33, Issue 3, Page(s) 248–252

    Abstract: Background: The World Health Organization recommends 12-month treatment (2RHZE/10RH) for children with tuberculous meningitis (TBM). Studies evaluating length of antituberculous treatment for TBM report similar completion and relapse rates comparing 6- ... ...

    Abstract Background: The World Health Organization recommends 12-month treatment (2RHZE/10RH) for children with tuberculous meningitis (TBM). Studies evaluating length of antituberculous treatment for TBM report similar completion and relapse rates comparing 6-month treatment with 12-month treatment.
    Methods: A prospective evaluation to determine whether short-course intensified treatment (6 RHZEth for HIV-infected and 9RHZEth for HIV-infected) is sufficient and safe in children with drug-susceptible TBM.
    Results: Of 184 children with TBM, median age 58 months and 90 (49%) male, 98 children (53%) presented at stage II TBM, 64 (35%) at stage III TBM and only 22 (12%) at stage I TBM. Ninety (49%) children were treated at home after the first month of therapy; all others received their full treatment in hospital. The HIV prevalence was 14% (22/155 children tested). Anti-TB drug-induced hepatotoxicity occurred in 5% (8 of 143 children tested), all tested negative for viral hepatitis; in all 8 cases, the original regimen was restarted without recurrence. After treatment completion, 147 (80%) children had a good outcome, 7 (3.8%) died. There was no difference in outcome between HIV-infected and HIV-uninfected children who completed treatment (P = 0.986) nor between TBM-hydrocephalic children who were medically treated or shunted (P = 0.166).
    Conclusion: Short intensified treatment is safe and effective in both HIV-infected and HIV-uninfected children with drug-susceptible TBM.
    MeSH term(s) Adolescent ; Antitubercular Agents/administration & dosage ; Antitubercular Agents/adverse effects ; Antitubercular Agents/therapeutic use ; Child ; Child, Preschool ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Infant ; Male ; Prospective Studies ; South Africa/epidemiology ; Treatment Outcome ; Tuberculosis, Meningeal/complications ; Tuberculosis, Meningeal/drug therapy ; Tuberculosis, Meningeal/epidemiology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2014-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000000065
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Commercial nucleic acid amplification tests in tuberculous meningitis--a meta-analysis.

    Solomons, Regan S / van Elsland, Sabine L / Visser, Douwe H / Hoek, Kim G P / Marais, Ben J / Schoeman, Johan F / van Furth, Anne M

    Diagnostic microbiology and infectious disease

    2014  Volume 78, Issue 4, Page(s) 398–403

    Abstract: Although nucleic acid amplification tests (NAATs) promise a rapid, definitive diagnosis of tuberculous meningitis, the performance of first-generation NAATs was suboptimal and variable. We conducted a meta-analysis of studies published between 2003 and ... ...

    Abstract Although nucleic acid amplification tests (NAATs) promise a rapid, definitive diagnosis of tuberculous meningitis, the performance of first-generation NAATs was suboptimal and variable. We conducted a meta-analysis of studies published between 2003 and 2013, using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool to evaluate methodological quality. The diagnostic accuracy of newer commercial NAATs was assessed. Pooled estimates of diagnostic accuracy for commercial NAATs measured against a cerebrospinal fluid Mycobacterium tuberculosis culture-positive gold standard were sensitivity 0.64, specificity 0.98, and diagnostic odds ratio 64.0. Heterogeneity was limited; P value = 0.147 and I(2) = 33.85%. The Xpert MTB/RIF® test was evaluated in 1 retrospective study and 4 prospective studies, with pooled sensitivity 0.70 and specificity 0.97. The QUADAS-2 tool revealed low risk of bias, as well as low concerns regarding applicability. Heterogeneity was pronounced among studies of in-house tests. Commercial NAATs proved to be highly specific with greatly reduced heterogeneity compared to in-house tests. Sub-optimal sensitivity remains a limitation.
    MeSH term(s) Humans ; Molecular Diagnostic Techniques/methods ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Nucleic Acid Amplification Techniques/methods ; Sensitivity and Specificity ; Tuberculosis, Meningeal/diagnosis
    Language English
    Publishing date 2014-04
    Publishing country United States
    Document type Comparative Study ; Evaluation Studies ; Journal Article ; Meta-Analysis
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2014.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top