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  1. Article ; Online: Response to "Tailored Use of Avacopan in a Case With Refractory Antineutrophil Cytoplasmic Autoantibody-Associated Renal Vasculitis and Concominant Complement System Activation".

    van Leeuwen, Jolijn R / Rabelink, Ton J / Teng, Y K Onno

    Kidney international reports

    2022  Volume 8, Issue 2, Page(s) 378

    Language English
    Publishing date 2022-11-25
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Preliminary Assessment of Safety and Tolerability of Avacopan During the Early Access Program for ANCA-Associated Vasculitis.

    van Leeuwen, Jolijn R / Popov, Tamara / Obergfell, Achim / Rabelink, Ton J / Teng, Y K Onno

    Biologics : targets & therapy

    2023  Volume 17, Page(s) 11–14

    Language English
    Publishing date 2023-01-25
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2415708-9
    ISSN 1177-5491 ; 1177-5475
    ISSN (online) 1177-5491
    ISSN 1177-5475
    DOI 10.2147/BTT.S394843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Using an artificial intelligence tool incorporating natural language processing to identify patients with a diagnosis of ANCA-associated vasculitis in electronic health records.

    van Leeuwen, Jolijn R / Penne, Erik L / Rabelink, Ton / Knevel, Rachel / Teng, Y K Onno

    Computers in biology and medicine

    2023  Volume 168, Page(s) 107757

    Abstract: Background: Because anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitis (AAV) is a rare, life-threatening, auto-immune disease, conducting research is difficult but essential. A long-lasting challenge is to identify rare AAV patients ... ...

    Abstract Background: Because anti-neutrophil cytoplasmatic antibody (ANCA)-associated vasculitis (AAV) is a rare, life-threatening, auto-immune disease, conducting research is difficult but essential. A long-lasting challenge is to identify rare AAV patients within the electronic-health-record (EHR)-system to facilitate real-world research. Artificial intelligence (AI)-search tools using natural language processing (NLP) for text-mining are increasingly postulated as a solution.
    Methods: We employed an AI-tool that combined text-mining with NLP-based exclusion, to accurately identify rare AAV patients within large EHR-systems (>2.000.000 records). We developed an identification method in an academic center with an established AAV-training set (n = 203) and validated the method in a non-academic center with an AAV-validation set (n = 84). To assess accuracy anonymized patient records were manually reviewed.
    Results: Based on an iterative process, a text-mining search was developed on disease description, laboratory measurements, medication and specialisms. In the training center, 608 patients were identified with a sensitivity of 97.0 % (95%CI [93.7, 98.9]) and positive predictive value (PPV) of 56.9 % (95%CI [52.9, 60.1]). NLP-based exclusion resulted in 444 patients increasing PPV to 77.9 % (95%CI [73.7, 81.7]) while sensitivity remained 96.3 % (95%CI [93.8, 98.0]). In the validation center, text-mining identified 333 patients (sensitivity 97.6 % (95%CI [91.6, 99.7]), PPV 58.2 % (95%CI [52.8, 63.6])) and NLP-based exclusion resulted in 223 patients, increasing PPV to 86.1 % (95%CI [80.9, 90.4]) with 98.0 % (95%CI [94.9, 99.4]) sensitivity. Our identification method outperformed ICD-10-coding predominantly in identifying MPO+ and organ-limited AAV patients.
    Conclusions: Our study highlights the advantages of implementing AI, notably NLP, to accurately identify rare AAV patients within large EHR-systems and demonstrates the applicability and transportability. Therefore, this method can reduce efforts to identify AAV patients and accelerate real-world research, while avoiding bias by ICD-10-coding.
    MeSH term(s) Humans ; Artificial Intelligence ; Natural Language Processing ; Electronic Health Records ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Software
    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.107757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The impact of reclassification by the 2022 ACR/EULAR classification criteria on risk factors for relapse in patients with ANCA-associated vasculitis.

    van Leeuwen, Jolijn R / Hafemann, Sophia / van der Boog, Paul / van der Woude, Diane / Rabelink, Ton / Teng, Y K Onno

    Clinical kidney journal

    2023  Volume 16, Issue 12, Page(s) 2754–2756

    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfad225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6587: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: ExploriNg DUrable Remission with Rituximab in ANCA-associatEd vasculitis (ENDURRANCE trial): protocol for a randomised controlled trial.

    Dirikgil, Ebru / van Leeuwen, Jolijn R / Bredewold, Obbo W / Ray, Argho / Jonker, Jacqueline T / Soonawala, Darius / Remmelts, Hilde H F / van Dam, Bastiaan / Bos, Willem Jan / van Kooten, Cees / Rotmans, Joris / Rabelink, Ton / Teng, Y K Onno

    BMJ open

    2022  Volume 12, Issue 9, Page(s) e061339

    Abstract: Introduction: Both rituximab (RTX) and cyclophosphamide (CYC) are effectively used in combination with steroids as remission induction therapy for patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Several studies have ...

    Abstract Introduction: Both rituximab (RTX) and cyclophosphamide (CYC) are effectively used in combination with steroids as remission induction therapy for patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Several studies have shown that the effect on achieving (clinical) remission, frequency and severity of relapses is equivalent for both therapies, but there is accumulating data that the long-term safety profile of RTX might outperform CYC. Combination of RTX with low-dose CYC (LD-CYC) has been investigated in only a few uncontrolled cohort studies, in which clinical remission and a favourable immunological state with low relapse rates was quickly achieved. In this randomised controlled trial, we aim to investigate whether the combination treatment (RTX+LD CYC) is superior in comparison to standard care with RTX only.
    Methods and analysis: This study is an open-label, multicentre, 1:1 randomised, prospective study for patients with AAV with generalised disease, defined as involvement of major organs, that is, kidneys, lungs, heart and nervous system. In total, 100 patients will be randomised 1:1 to receive either remission induction therapy with standard of care (RTX) or combination treatment (RTX+LD CYC) in addition to steroids and both arms are followed by maintenance with RTX retreatments (tailored to B-cell and ANCA status). Our primary outcome is the number of retreatments needed to maintain clinical remission over 2 years. Secondary outcomes are relevant clinical endpoints, safety, quality of life and immunological responses.
    Ethics and dissemination: This study has received approval of the Medical Ethics Committee of the Leiden University Medical Center (P18.216, NL67515.058.18, date: 7 March 2019). The results of this trial (positive and negative) will be submitted for publication in relevant peer-reviewed publications and the key findings presented at national and international conferences.
    Trial registration number: NCT03942887.
    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Antibodies, Antineutrophil Cytoplasmic ; Cyclophosphamide/therapeutic use ; Humans ; Immunosuppressive Agents/therapeutic use ; Multicenter Studies as Topic ; Neoplasm Recurrence, Local/drug therapy ; Prospective Studies ; Quality of Life ; Randomized Controlled Trials as Topic ; Remission Induction ; Rituximab ; Treatment Outcome
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-061339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Compassionate Use of Avacopan in Difficult-to-Treat Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

    van Leeuwen, Jolijn R / Bredewold, Obbo W / van Dam, Laura S / Werkman, Stella L / Jonker, Jacqueline T / Geelhoed, Miranda / Langeveld, Antonius P M / Remmelts, Hilde H F / van den Broecke, Maud M / Ray, Argho / Rabelink, Ton J / Teng, Y K Onno

    Kidney international reports

    2021  Volume 7, Issue 3, Page(s) 624–628

    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.11.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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