Article ; Online: Pathogen clearance and immune adherence "revisited": Immuno-regulatory roles for CRIg.
2018 Volume 37, Page(s) 4–11
Abstract: Rapid elimination of microbes from the bloodstream, along with the ability to mount an adaptive immune response, are essential for optimal host-defense. Kupffer cells are strategically positioned in the liver sinusoids and efficiently capture circulating ...
| Abstract | Rapid elimination of microbes from the bloodstream, along with the ability to mount an adaptive immune response, are essential for optimal host-defense. Kupffer cells are strategically positioned in the liver sinusoids and efficiently capture circulating microbes from the hepatic artery and portal vein, thus preventing bacterial dissemination. In vivo and in vitro studies have probed how complement receptor of the immunoglobulin superfamily (CRIg), also referred to as Z39Ig and V-set and Ig domain-containing 4 (VSIG4), acts as a critical player in pathogen recognition and clearance. While recent data suggested that CRIg may bind bacterial cell wall components directly, the single transmembrane receptor is best known for its interaction with complement C3 opsonization products on the microbial surface. On Kupffer cells, CRIg must capture opsonized microbes against the shear forces of the blood flow. In vivo work reveals how immune adherence (IA), a process in which blood platelets or erythrocytes associate with circulating bacteria, plays a critical role in regulating pathogen capture by CRIg under flow conditions. In addition to its typical innate immune functions, CRIg was shown to directly and indirectly influence adaptive immune responses. Here, we review our current understanding of the diverse roles of CRIg in pathogen elimination, anti-microbial immunity and autoimmunity. In particular, we will explore how, through selective capturing by CRIg, an important balance is achieved between the immunological and clearance functions of liver and spleen. |
|---|---|
| MeSH term(s) | Agglutination ; Animals ; Bacterial Infections/immunology ; Complement C3/metabolism ; Host-Pathogen Interactions ; Humans ; Immunomodulation ; Kupffer Cells/physiology ; Opsonin Proteins/metabolism ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Receptors, Complement/metabolism ; Receptors, Pattern Recognition/metabolism |
| Chemical Substances | Complement C3 ; Opsonin Proteins ; Pathogen-Associated Molecular Pattern Molecules ; Receptors, Complement ; Receptors, Pattern Recognition ; VSIG4 protein, human |
| Language | English |
| Publishing date | 2018-03-21 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 1018141-6 |
| ISSN | 1096-3618 ; 1044-5323 |
| ISSN (online) | 1096-3618 |
| ISSN | 1044-5323 |
| DOI | 10.1016/j.smim.2018.02.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 2843: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.