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Article ; Online: Commentary on a Classic JHC Article on the Histochemical Measurement of DNA Content in Cells.

van Noorden, Cornelis J F

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

2023 Volume 71, Issue 6, Page(s) 345–346

Abstract: This article comments on the significance of a highly cited review article on DNA cytochemical quantitation that was published in ... ...

Abstract	This article comments on the significance of a highly cited review article on DNA cytochemical quantitation that was published in the
MeSH term(s)	DNA/analysis ; Histocytochemistry
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-06-13
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	218208-7
ISSN	1551-5044 ; 0022-1554
ISSN (online)	1551-5044
ISSN	0022-1554
DOI	10.1369/00221554231182467
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Article ; Online: Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.

Rezzani, Rita / Gianò, Marzia / Pinto, Daniela / Rinaldi, Fabio / van Noorden, Cornelis J F / Favero, Gaia

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology is not well understood. It is known that genetic and nongenetic factors determine alterations in several organs, such as the liver, in individuals with this ... ...

Abstract	Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its etiology is not well understood. It is known that genetic and nongenetic factors determine alterations in several organs, such as the liver, in individuals with this disorder. The aims of the present study were to analyze morphological and biological alterations in the liver of an autistic mouse model, BTBR T + Itpr3tf/J (BTBR) mice, and to identify therapeutic strategies for alleviating hepatic impairments using melatonin administration. We studied hepatic cytoarchitecture, oxidative stress, inflammation and ferroptosis in BTBR mice and used C57BL6/J mice as healthy control subjects. The mice were divided into four groups and then treated and not treated with melatonin, respectively. BTBR mice showed (a) a retarded development of livers and (b) iron accumulation and elevated oxidative stress and inflammation. We demonstrated that the expression of ferroptosis markers, the transcription factor nuclear factor erythroid-related factor 2 (NFR2), was upregulated, and the Kelch-like ECH-associated protein 1 (KEAP1) was downregulated in BTBR mice. Then, we evaluated the effects of melatonin on the hepatic alterations of BTBR mice; melatonin has a positive effect on liver cytoarchitecture and metabolic functions.
MeSH term(s)	Humans ; Animals ; Mice ; Autistic Disorder/drug therapy ; Autistic Disorder/genetics ; Kelch-Like ECH-Associated Protein 1 ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Autism Spectrum Disorder/drug therapy ; Autism Spectrum Disorder/genetics ; Ferroptosis ; NF-E2-Related Factor 2/genetics ; Liver ; Inflammation/drug therapy ; Oxidative Stress ; Disease Models, Animal ; Mice, Inbred C57BL
Chemical Substances	Kelch-Like ECH-Associated Protein 1 ; Melatonin (JL5DK93RCL) ; NF-E2-Related Factor 2
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021086
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Article ; Online: Relation Between Reactive Oxygen Species Production and Transient Receptor Potential Vanilloid1 Expression in Human Skin During Aging.

Favero, Gaia / Gianò, Marzia / Franco, Caterina / Pinto, Daniela / van Noorden, Cornelis J F / Rinaldi, Fabio / Rezzani, Rita

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

2024 Volume 72, Issue 3, Page(s) 157–171

Abstract: Skin sensitivity and impaired epidermal barrier function are associated with aging and are at least partly due to increased production of reactive oxygen species (ROS). Transient receptor potential vanilloid1 (TRPV1) is expressed in keratinocytes, ... ...

Abstract	Skin sensitivity and impaired epidermal barrier function are associated with aging and are at least partly due to increased production of reactive oxygen species (ROS). Transient receptor potential vanilloid1 (TRPV1) is expressed in keratinocytes, fibroblasts, mast cells, and endothelial cells in skin. We investigated in skin biopsies of adult and elderly donors whether TRPV1 expression is involved in the skin aging process. We found that aging skin showed a strongly reduced epidermal thickness, strongly increased oxidative stress, protease expression, and mast cell degranulation and strongly increased TRPV1 expression both in epidermis and dermis. Based on our findings, the aging-related changes observed in the epidermis of the skin level are associated with increased ROS production, and hypothesized alterations in TRPV1 expression are mechanistically linked to this process.
MeSH term(s)	Adult ; Aged ; Humans ; Aging ; Endothelial Cells/metabolism ; Epidermis ; Keratinocytes ; Reactive Oxygen Species/metabolism ; Skin/metabolism
Chemical Substances	Reactive Oxygen Species ; TRPV1 protein, human
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	218208-7
ISSN	1551-5044 ; 0022-1554
ISSN (online)	1551-5044
ISSN	0022-1554
DOI	10.1369/00221554241236537
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Article ; Online: Transient Receptor Potential Channels in the Healthy and Diseased Blood-Brain Barrier.

Rezzani, Rita / Favero, Gaia / Gianò, Marzia / Pinto, Daniela / Labanca, Mauro / van Noorden, Cornelis J F / Rinaldi, Fabio

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

2024 Volume 72, Issue 4, Page(s) 199–231

Abstract: The large family of transient receptor potential (TRP) channels are integral membrane proteins that function as environmental sensors and act as ion channels after activation by mechanical (touch), physical (heat, pain), and chemical stimuli (pungent ... ...

Abstract	The large family of transient receptor potential (TRP) channels are integral membrane proteins that function as environmental sensors and act as ion channels after activation by mechanical (touch), physical (heat, pain), and chemical stimuli (pungent compounds such as capsaicin). Most TRP channels are localized in the plasma membrane of cells but some of them are localized in membranes of organelles and function as intracellular Ca
MeSH term(s)	Humans ; Transient Receptor Potential Channels/metabolism ; Blood-Brain Barrier ; Endothelial Cells/metabolism ; TRPV Cation Channels ; Nervous System Diseases
Chemical Substances	Transient Receptor Potential Channels ; TRPV Cation Channels
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	218208-7
ISSN	1551-5044 ; 0022-1554
ISSN (online)	1551-5044
ISSN	0022-1554
DOI	10.1369/00221554241246032
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Article ; Online: Correction to: Cancer-Related Fatigue: Causes and Current Treatment Options.

Thong, Melissa S Y / van Noorden, Cornelis J F / Steindorf, Karen / Arndt, Volker

Current treatment options in oncology

2022 Volume 23, Issue 3, Page(s) 450–451

Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2057351-0
ISSN	1534-6277 ; 1527-2729
ISSN (online)	1534-6277
ISSN	1527-2729
DOI	10.1007/s11864-021-00916-2
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Article: CXCR4 Antagonists as Stem Cell Mobilizers and Therapy Sensitizers for Acute Myeloid Leukemia and Glioblastoma?

Hira, Vashendriya V V / Van Noorden, Cornelis J F / Molenaar, Remco J

Biology

2020 Volume 9, Issue 2

Abstract: Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly- ... ...

Abstract	Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs are localized in protective hypoxic peri-arteriolar niches where these aforementioned stemness properties are maintained. We previously showed that hypoxic peri-arteriolar GSC niches in human glioblastoma are functionally similar to hypoxic peri-arteriolar hematopoietic stem cell (HSC) niches in human bone marrow. GSCs and HSCs express the receptor C-X-C receptor type 4 (CXCR4), which binds to the chemoattractant stromal-derived factor-1α (SDF-1α), which is highly expressed in GSC niches in glioblastoma and HSC niches in bone marrow. This receptor-ligand interaction retains the GSCs/HSCs in their niches and thereby maintains their slowly-dividing state. In acute myeloid leukemia (AML), leukemic cells use the SDF-1α-CXCR4 interaction to migrate to HSC niches and become slowly-dividing and therapy-resistant leukemic stem cells (LSCs). In this communication, we aim to elucidate how disruption of the SDF-1α-CXCR4 interaction using the FDA-approved CXCR4 inhibitor plerixafor (AMD3100) may be used to force slowly-dividing cancer stem cells out of their niches in glioblastoma and AML. Ultimately, this strategy aims to induce GSC and LSC differentiation and their sensitization to therapy.
Language	English
Publishing date	2020-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology9020031
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Article ; Online: Quantitative Assessment of the Apical and Basolateral Membrane Expression of VEGFR2 and NRP2 in VEGF-A-stimulated Cultured Human Umbilical Vein Endothelial Cells.

Bosma, Esmeralda K / Darwesh, Shahan / Zheng, Jia Y / van Noorden, Cornelis J F / Schlingemann, Reinier O / Klaassen, Ingeborg

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

2022 Volume 70, Issue 8, Page(s) 557–569

Abstract: Endothelial cells (ECs) form a precisely regulated polarized monolayer in capillary walls. Vascular endothelial growth factor-A (VEGF-A) induces endothelial hyperpermeability, and VEGF-A applied to the basolateral side, but not the apical side, has been ... ...

Abstract	Endothelial cells (ECs) form a precisely regulated polarized monolayer in capillary walls. Vascular endothelial growth factor-A (VEGF-A) induces endothelial hyperpermeability, and VEGF-A applied to the basolateral side, but not the apical side, has been shown to be a strong barrier disruptor in blood-retinal barrier ECs. We show here that VEGF-A presented to the basolateral side of human umbilical vein ECs (HUVECs) induces higher permeability than apical stimulation, which is similar to results obtained with bovine retinal ECs. We investigated with immunocytochemistry and confocal imaging the distribution of VEGF receptor-2 (VEGFR2) and neuropilin-2 (NRP2) in perinuclear apical and basolateral membrane domains. Orthogonal z-sections of cultured HUVECs were obtained, and the fluorescence intensity at the apical and basolateral membrane compartments was measured. We found that VEGFR2 and NRP2 are evenly distributed throughout perinuclear apical and basolateral membrane compartments in unstimulated HUVECs grown on Transwell inserts, whereas basolateral VEGF-A stimulation induces a shift toward basolateral VEGFR2 and NRP2 localization. When HUVECs were grown on coverslips, the distribution of VEGFR2 and NRP2 across the perinuclear apical and basolateral membrane domains was different. Our findings demonstrate that HUVECs dynamically regulate VEGFR2 and NRP2 localization on membrane microdomains, depending on growth conditions and the polarity of VEGF-A stimulation.
MeSH term(s)	Animals ; Cattle ; Cell Membrane/metabolism ; Cells, Cultured ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Neuropilin-2/metabolism ; Retina/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Chemical Substances	Neuropilin-2 ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2022-07-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	218208-7
ISSN	1551-5044 ; 0022-1554
ISSN (online)	1551-5044
ISSN	0022-1554
DOI	10.1369/00221554221115767
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Article: Hyperthermia as a Potential Cornerstone of Effective Multimodality Treatment with Radiotherapy, Cisplatin and PARP Inhibitor in

Khurshed, Mohammed / Prades-Sagarra, Elia / Saleh, Sarah / Sminia, Peter / Wilmink, Johanna W / Molenaar, Remco J / Crezee, Hans / van Noorden, Cornelis J F

Cancers

2022 Volume 14, Issue 24

Abstract: Mutations in the isocitrate dehydrogenase 1 (IDH1MUT) gene occur in various types of malignancies, including ~60% of chondrosarcomas, ~30% of intrahepatic cholangiocarcinomas and >80% of low-grade gliomas. IDH1MUT are causal in the development and ... ...

Abstract	Mutations in the isocitrate dehydrogenase 1 (IDH1MUT) gene occur in various types of malignancies, including ~60% of chondrosarcomas, ~30% of intrahepatic cholangiocarcinomas and >80% of low-grade gliomas. IDH1MUT are causal in the development and progression of these types of cancer due to neomorphic production of the oncometabolite D-2-hydroxyglutarate (D-2HG). Intracellular accumulation of D-2HG has been implicated in suppressing homologous recombination and renders IDH1MUT cancer cells sensitive to DNA-repair-inhibiting agents, such as poly-(adenosine 5′-diphosphate−ribose) polymerase inhibitors (PARPi). Hyperthermia increases the efficacy of DNA-damaging therapies such as radiotherapy and platinum-based chemotherapy, mainly by inhibition of DNA repair. In the current study, we investigated the additional effects of hyperthermia (42 °C for 1 h) in the treatment of IDH1MUT HCT116 colon cancer cells and hyperthermia1080 chondrosarcoma cancer cells in combination with radiation, cisplatin and/or a PARPi on clonogenic cell survival, cell cycle distribution and the induction and repair of DNA double-strand breaks. We found that hyperthermia in combination with radiation or cisplatin induces an increase in double-strand breaks and cell death, up to 10-fold in IDH1MUT cancer cells compared to IDH1 wild-type cells. This vulnerability was abolished by the IDH1MUT inhibitor AGI-5198 and was further increased by the PARPi. In conclusion, our study shows that IDH1MUT cancer cells are sensitized to hyperthermia in combination with irradiation or cisplatin and a PARPi. Therefore, hyperthermia may be an efficacious sensitizer to cytotoxic therapies in tumors where the clinical application of hyperthermia is feasible, such as IDH1MUT chondrosarcoma of the extremities.
Language	English
Publishing date	2022-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14246228
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Article: CXCR4 Antagonists as Stem Cell Mobilizers and Therapy Sensitizers for Acute Myeloid Leukemia and Glioblastoma?

Hira, Vashendriya V.V / Van Noorden, Cornelis J.F / Molenaar, Remco J

Biology. 2020 Feb. 17, v. 9, no. 2

2020

Abstract	Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs are localized in protective hypoxic peri-arteriolar niches where these aforementioned stemness properties are maintained. We previously showed that hypoxic peri-arteriolar GSC niches in human glioblastoma are functionally similar to hypoxic peri-arteriolar hematopoietic stem cell (HSC) niches in human bone marrow. GSCs and HSCs express the receptor C-X-C receptor type 4 (CXCR4), which binds to the chemoattractant stromal-derived factor-1α (SDF-1α), which is highly expressed in GSC niches in glioblastoma and HSC niches in bone marrow. This receptor–ligand interaction retains the GSCs/HSCs in their niches and thereby maintains their slowly-dividing state. In acute myeloid leukemia (AML), leukemic cells use the SDF-1α–CXCR4 interaction to migrate to HSC niches and become slowly-dividing and therapy-resistant leukemic stem cells (LSCs). In this communication, we aim to elucidate how disruption of the SDF-1α–CXCR4 interaction using the FDA-approved CXCR4 inhibitor plerixafor (AMD3100) may be used to force slowly-dividing cancer stem cells out of their niches in glioblastoma and AML. Ultimately, this strategy aims to induce GSC and LSC differentiation and their sensitization to therapy.
Keywords	CXCR4 receptor ; adults ; antagonists ; bone marrow ; brain neoplasms ; chemoattractants ; glioblastoma ; hematopoietic stem cells ; human diseases ; humans ; ligands ; myeloid leukemia ; neoplasm cells ; patients ; therapeutics
Language	English
Dates of publication	2020-0217
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology9020031
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cancer-Related Fatigue: Causes and Current Treatment Options.

Thong, Melissa S Y / van Noorden, Cornelis J F / Steindorf, Karen / Arndt, Volker

Current treatment options in oncology

2020 Volume 21, Issue 2, Page(s) 17

Abstract: Opinion statement: Cancer-related fatigue (CRF) is a problem for a significant proportion of cancer survivors during and after active cancer treatment. However, CRF is underdiagnosed and undertreated. Interventions are available for CRF although there ... ...

Abstract	Opinion statement: Cancer-related fatigue (CRF) is a problem for a significant proportion of cancer survivors during and after active cancer treatment. However, CRF is underdiagnosed and undertreated. Interventions are available for CRF although there is no gold standard. Based on current level of evidence, exercise seems to be most effective in preventing or ameliorating CRF during the active- and posttreatment phases.
MeSH term(s)	Age Factors ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cancer Survivors ; Clinical Decision-Making ; Combined Modality Therapy ; Comorbidity ; Disease Management ; Disease Susceptibility ; Fatigue/diagnosis ; Fatigue/epidemiology ; Fatigue/etiology ; Fatigue/therapy ; Humans ; Neoplasms/complications ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Prevalence ; Radiotherapy/adverse effects ; Radiotherapy/methods ; Risk Factors ; Survivorship ; Treatment Outcome
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057351-0
ISSN	1534-6277 ; 1527-2729
ISSN (online)	1534-6277
ISSN	1527-2729
DOI	10.1007/s11864-020-0707-5
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