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  1. Article ; Online: MicroRNAs are dysregulated in peripheral blood mononuclear cells in multiple sclerosis and correlate with T cell mediators.

    Perdaens, Océane / van Pesch, Vincent

    Journal of neuroimmunology

    2023  Volume 386, Page(s) 578196

    Abstract: T cell mediators and microRNAs are involved in the pathogenesis of multiple sclerosis (MS), but their interaction largely remains undetermined. We investigated by RT-qPCR the dysregulation of microRNAs in peripheral blood mononuclear cells of MS patients ...

    Abstract T cell mediators and microRNAs are involved in the pathogenesis of multiple sclerosis (MS), but their interaction largely remains undetermined. We investigated by RT-qPCR the dysregulation of microRNAs in peripheral blood mononuclear cells of MS patients versus healthy controls, according to radiological disease activity or treatment. Several microRNAs correlated positively/negatively with IL21/FOXP3 mRNA expression, but not with serum neurofilament light chain levels. Cytokine expression is conceivably balanced by several regulators, whereas microRNAs possibly target upstream transcription factors rather than directly cytokine mRNAs. Functional studies are needed to investigate their interaction, notably for the predicted targeting of FOXP3 by miR-34c-5p.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Multiple Sclerosis/genetics ; Multiple Sclerosis/pathology ; Leukocytes, Mononuclear/metabolism ; T-Lymphocytes/metabolism ; Cytokines/genetics ; Forkhead Transcription Factors
    Chemical Substances MicroRNAs ; Cytokines ; Forkhead Transcription Factors
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2023.578196
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  2. Article ; Online: Exosomal profiling should be used to monitor disease activity in MS patients: No.

    Deltombe, Matthieu / van Pesch, Vincent

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Volume 29, Issue 10, Page(s) 1206–1207

    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231195859
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  3. Article: MicroRNAs dysregulated in multiple sclerosis affect the differentiation of CG-4 cells, an oligodendrocyte progenitor cell line.

    Perdaens, Océane / Bottemanne, Pauline / van Pesch, Vincent

    Frontiers in cellular neuroscience

    2024  Volume 18, Page(s) 1336439

    Abstract: Introduction: Demyelination is one of the hallmarks of multiple sclerosis (MS). While remyelination occurs during the disease, it is incomplete from the start and strongly decreases with its progression, mainly due to the harm to oligodendrocyte ... ...

    Abstract Introduction: Demyelination is one of the hallmarks of multiple sclerosis (MS). While remyelination occurs during the disease, it is incomplete from the start and strongly decreases with its progression, mainly due to the harm to oligodendrocyte progenitor cells (OPCs), causing irreversible neurological deficits and contributing to neurodegeneration. Therapeutic strategies promoting remyelination are still very preliminary and lacking within the current treatment panel for MS.
    Methods: In a previous study, we identified 21 microRNAs dysregulated mostly in the CSF of relapsing and/or remitting MS patients. In this study we transfected the mimics/inhibitors of several of these microRNAs separately in an OPC cell line, called CG-4. We aimed (1) to phenotypically characterize their effect on OPC differentiation and (2) to identify corroborating potential mRNA targets via immunocytochemistry, RT-qPCR analysis, RNA sequencing, and Gene Ontology enrichment analysis.
    Results: We observed that the majority of 13 transfected microRNA mimics decreased the differentiation of CG-4 cells. We demonstrate, by RNA sequencing and independent RT-qPCR analyses, that miR-33-3p, miR-34c-5p, and miR-124-5p arrest OPC differentiation at a late progenitor stage and miR-145-5p at a premyelinating stage as evidenced by the downregulation of premyelinating oligodendrocyte (OL) [
    Conclusion: miR-33-3p, miR-34c-5p, and miR-124-5p arrest OPC differentiation at a late progenitor stage and miR-145-5p at a premyelinating stage, whereas miR-214-3p promotes the differentiation of CG-4 cells. We propose several potential mRNA targets and hypothetical mechanisms by which each microRNA exerts its effect. We hereby open new perspectives in the research on OPC differentiation and the pathophysiology of demyelination/remyelination, and possibly even in the search for new remyelinating therapeutic strategies in the scope of MS.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2024.1336439
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  4. Article ; Online: Long-term follow up of alemtuzumab-treated patients: a retrospective study in a Belgian tertiary care center.

    van Pesch, Vincent / Hanganu, Andreea-Raluca / Sankari, Souraya El

    Acta neurologica Belgica

    2024  

    Abstract: Background: Pivotal studies have reported a significant proportion of patients achieving no evidence of disease activity (NEDA) after 2 cycles of treatment with alemtuzumab (ATZ), that can be maintained for several years. Long-term real-world evidence ... ...

    Abstract Background: Pivotal studies have reported a significant proportion of patients achieving no evidence of disease activity (NEDA) after 2 cycles of treatment with alemtuzumab (ATZ), that can be maintained for several years. Long-term real-world evidence regarding ATZ as well as subsequent treatment trajectories is still scarce.
    Objective: To analyze the effectiveness and safety of ATZ-treated patients in a tertiary care Belgian center.
    Methods: A retrospective cohort study including 32 patients treated with ATZ between 2015 and 2021 was performed.
    Results: 32 patients received 2 ATZ courses with a mean follow-up (FU) duration of 5.6 years (range: 2.25-8.2). 21.75% patients were treatment naïve. 40.5% were previously treated with natalizumab or fingolimod. NEDA-3 was achieved in 61.3-85% of patients, with failure mostly attributed to recurrence of radiological disease activity. During FU, annualized relapse rates remained very low (0.06-0.14), disability improvement occurred in up to 40.5%, whereas disability worsening occurred in up to 13.5%. Retreatment risk was associated with younger age (< 45 years old, Odds Ratio 8.0, p = 0.02) and a higher number of previous DMTs (Hazard ratio 2.7, 95%CI 1.3-7.4, p = 0.02). Safety in our cohort was consistent with the known profile of ATZ. At the end of FU, 65.6% patients remained untreated after 2 or 3 courses of ATZ, while the remaining switched to anti-CD20 therapy or cladribine.
    Conclusion: ATZ is a high efficacy therapy for active MS, providing long-term remission in a significant proportion of patients. Retreatment was more frequent in younger patients or patients having failed a higher number of previous DMTs.
    Language English
    Publishing date 2024-04-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-024-02542-9
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  5. Article: Molecular Mechanisms of Immunosenescene and Inflammaging: Relevance to the Immunopathogenesis and Treatment of Multiple Sclerosis.

    Perdaens, Océane / van Pesch, Vincent

    Frontiers in neurology

    2022  Volume 12, Page(s) 811518

    Abstract: Aging is characterized, amongst other features, by a complex process of cellular senescence involving both innate and adaptive immunity, called immunosenescence and associated to inflammaging, a low-grade chronic inflammation. Both processes fuel each ... ...

    Abstract Aging is characterized, amongst other features, by a complex process of cellular senescence involving both innate and adaptive immunity, called immunosenescence and associated to inflammaging, a low-grade chronic inflammation. Both processes fuel each other and partially explain increasing incidence of cancers, infections, age-related autoimmunity, and vascular disease as well as a reduced response to vaccination. Multiple sclerosis (MS) is a lifelong disease, for which considerable progress in disease-modifying therapies (DMTs) and management has improved long-term survival. However, disability progression, increasing with age and disease duration, remains. Neurologists are now involved in caring for elderly MS patients, with increasing comorbidities. Aging of the immune system therefore has relevant implications for MS pathogenesis, response to DMTs and the risks mediated by these treatments. We propose to review current evidence regarding markers and molecular mechanisms of immunosenescence and their relevance to understanding MS pathogenesis. We will focus on age-related changes in the innate and adaptive immune system in MS and other auto-immune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. The consequences of these immune changes on MS pathology, in interaction with the intrinsic aging process of central nervous system resident cells will be discussed. Finally, the impact of immunosenescence on disease evolution and on the safety and efficacy of current DMTs will be presented.
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.811518
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  6. Article ; Online: Anti-NMDA-receptor encephalitis, a challenging case leading to the discovery of a rapidly growing tumor.

    Wénin, Julie / Bronchain, Maroussia / Sellimi, Amina / van Pesch, Vincent

    Acta neurologica Belgica

    2023  Volume 123, Issue 6, Page(s) 2413–2415

    MeSH term(s) Humans ; Neoplasms ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications ; Receptors, N-Methyl-D-Aspartate
    Chemical Substances Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2023-03-20
    Publishing country Italy
    Document type Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-023-02241-x
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  7. Article ; Online: Clinical usefulness of the CSF β-amyloid Aβ1-42/Aβ1-40 ratio for Alzheimer's disease diagnosis: a retrospective study in a Belgian academic hospital.

    Deltombe, Matthieu / Fillee, Catherine / van Pesch, Vincent

    Acta neurologica Belgica

    2022  Volume 122, Issue 1, Page(s) 245–247

    MeSH term(s) Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/cerebrospinal fluid ; Belgium ; Biomarkers/cerebrospinal fluid ; Hospitals ; Hospitals, University ; Humans ; Peptide Fragments/cerebrospinal fluid ; Retrospective Studies
    Chemical Substances Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; amyloid beta-protein (1-40) ; amyloid beta-protein (1-42)
    Language English
    Publishing date 2022-01-17
    Publishing country Italy
    Document type Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-021-01846-4
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  8. Article ; Online: Alzheimer disease's cerebrospinal fluid biomarkers differences between immigrants and natives in a Belgian memory clinic.

    Lebrun, Louisien / Hanseeuw, Bernard / van Pesch, Vincent / Ivanoiu, Adrian

    Acta neurologica Belgica

    2022  Volume 123, Issue 2, Page(s) 537–544

    Abstract: Background: Diagnosis of neurodegenerative diseases can raise difficulties among immigrant patients due to language, educational or sociocultural differences with natives. CSF biomarkers of Alzheimer's disease are useful tools to early diagnose ... ...

    Abstract Background: Diagnosis of neurodegenerative diseases can raise difficulties among immigrant patients due to language, educational or sociocultural differences with natives. CSF biomarkers of Alzheimer's disease are useful tools to early diagnose neurodegeneration. Yet very few studies have investigated differences of those biomarkers between immigrant and native populations.
    Objective: We aimed to characterize differences between CSF biomarkers of Alzheimer's disease within Belgian native and immigrant patients analyzed at Saint Luc Neurochemistry Lab (Brussels, Belgium).
    Methods: CSF samples from patients consulting at Saint Luc Memory Clinic (n = 356) or at others hospitals (n = 2430) were analyzed by Saint Luc Neurochemistry Lab between 2010 and 2014. We conducted linear regressions predicting CSF biomarkers with demographic data: age, sex and presumed ethnic origin. For the last one, we subdivided the cohort in natives and immigrants according to their surnames.
    Results: Immigrant patients benefit from a CSF sample analysis at a younger age than natives (p < 0.001). After linear regressions, age showed a significant impact on all biomarkers (p < 0.005). Ethnicity showed a significant impact on T-Tau (p = 0.007) and on T-Tau/amyloid-β42 ratio (p = 0.009). Sex showed a significant impact on T-Tau (p = 0.002). ANCOVA analysis suggested that the effect of Age on Aβ
    Conclusion: This study shows higher T-Tau and T-Tau/amyloid-β42 ratio values in younger native patients from a Belgian Memory Clinic. Aβ
    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Alzheimer Disease/cerebrospinal fluid ; Belgium ; Amyloid beta-Peptides/cerebrospinal fluid ; tau Proteins/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid
    Chemical Substances Amyloid beta-Peptides ; tau Proteins ; Biomarkers
    Language English
    Publishing date 2022-11-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-022-02143-4
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  9. Article ; Online: Impact of calcitriol and PGD

    Mwema, Ariane / Gratpain, Viridiane / Ucakar, Bernard / Vanvarenberg, Kevin / Perdaens, Océane / van Pesch, Vincent / Muccioli, Giulio G / des Rieux, Anne

    Drug delivery and translational research

    2024  

    Abstract: Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system (CNS) in need of a curative treatment. MS research has recently focused on the development of pro-remyelinating treatments and neuroprotective therapies. ... ...

    Abstract Multiple sclerosis (MS) is a demyelinating and inflammatory disease of the central nervous system (CNS) in need of a curative treatment. MS research has recently focused on the development of pro-remyelinating treatments and neuroprotective therapies. Here, we aimed at favoring remyelination and reducing neuro-inflammation in a cuprizone mouse model of brain demyelination using nanomedicines. We have selected lipid nanocapsules (LNC) coated with the cell-penetrating peptide transactivator of translation (TAT), loaded with either a pro-remyelinating compound, calcitriol (Cal-LNC TAT), or an anti-inflammatory bioactive lipid, prostaglandin D
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-024-01535-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MOG antibody-related isolated rhombencephalitis revealed by paroxysmal dysarthria.

    Kollmann, Paul / van Pesch, Vincent

    Journal of the neurological sciences

    2019  Volume 405, Page(s) 116417

    MeSH term(s) Antibodies/adverse effects ; Antibodies/blood ; Dysarthria/complications ; Dysarthria/diagnostic imaging ; Dysarthria/immunology ; Dysarthria/pathology ; Encephalitis/complications ; Encephalitis/diagnostic imaging ; Encephalitis/immunology ; Encephalitis/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Neuroimaging ; Tegmentum Mesencephali/pathology
    Chemical Substances Antibodies ; Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2019-08-05
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2019.08.002
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