Article: Sputum induction for assessment of biomarkers in early respiratory drug development .
International journal of clinical pharmacology and therapeutics
2019 Volume 57, Issue 1, Page(s) 20–23
Abstract: Objective: To study the success rate and reproducibility of sputum induction (SI) in healthy subjects (HS) and asthma patients (AP).: Materials and methods: 130 HSs/APs were recruited for early-phase studies to evaluate sputum biomarkers. SI and ... ...
| Abstract | Objective: To study the success rate and reproducibility of sputum induction (SI) in healthy subjects (HS) and asthma patients (AP). Materials and methods: 130 HSs/APs were recruited for early-phase studies to evaluate sputum biomarkers. SI and sample processing were performed according to standard protocols. Results: Adequate samples were obtained from 46% of HSs and 80% of APs. There was no difference between the groups with adequate and nonadequate samples. Differences between HS and AP groups were minor. Reproducibility was 56.0% in HSs and 90.6% in APs. Conclusion: Sputum induction for biomarker assessment in early drug development is feasible in HSs and APs, but only modestly reproducible in HSs. The technique is complex and time consuming. . |
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| MeSH term(s) | Asthma ; Biomarkers/chemistry ; Drug Development ; Humans ; Reproducibility of Results ; Sputum/chemistry | |||||
| Chemical Substances | Biomarkers | |||||
| Language | English | |||||
| Publishing date | 2019-01-09 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 124384-6 | |||||
| ISSN | 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879 | |||||
| ISSN | 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879 | |||||
| DOI | 10.5414/CP203294 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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