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  1. Article ; Online: Use and efficacy of dry-mouth interventions in Sjögren's disease patients and possible association with perceived oral dryness and patients' discomfort.

    Assy, Z / van Santen, J S / Brand, H S / Bikker, F J

    Clinical oral investigations

    2023  Volume 27, Issue 9, Page(s) 5529–5537

    Abstract: Objectives: Sjögren's disease (SjD) patients use various interventions to relief their oral dryness. However, the use and efficacy of these interventions have only partially been evaluated. The present study aims to investigate whether there is an ... ...

    Abstract Objectives: Sjögren's disease (SjD) patients use various interventions to relief their oral dryness. However, the use and efficacy of these interventions have only partially been evaluated. The present study aims to investigate whether there is an association between the perceived oral dryness and discomfort of SjD patients and their use of specific interventions.
    Materials and methods: A cross-sectional study was performed among SjD patients, who completed several questionnaires to assess the severity of their oral dryness and an inventory of dry-mouth interventions. The perceived efficacy of each intervention was reported on a 5-point Likert-scale.
    Results: The questionnaires were returned by 92 SjD patients. For relief of oral dryness, they mostly used "eating fruit", "drinking tea", "moistening the lips", "drinking water, and "drinking small volumes" (> 50%). Three interventions had a frequency of use ranging from 2-6 times/day, whereas, "drinking water" and "drinking small volumes" showed higher frequencies (> 14). The highest overall efficacy (≥ 3.5) was reported for "chewing gum" and "using a mouth gel". Furthermore, various dry-mouth interventions showed significant associations with oral dryness scores and/or patients' discomfort. For example, "drinking small volumes" and "using XyliMelts" were associated with the Bother Index score.
    Conclusion: Great variation was found in the use of dry-mouth interventions by the participants and the severity of the oral dryness and/or patients' discomfort seemed to affect their choice of intervention. Notably, the mostly used interventions did not show the highest reported efficacy.
    Clinical relevance: These findings might help SjD patients and clinicians in their choice of effective dry-mouth interventions.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Xerostomia/therapy ; Xerostomia/complications ; Sjogren's Syndrome/complications ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-07-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-023-05172-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Implementation of exergaming for people with dementia: facilitators, barriers, and recommendations.

    van Santen, Joeke / Dröes, Rose-Marie / Blanson Henkemans, Olivier / Schoone, Marian / Valk, Ronald / Straten, Annemieke van / Meiland, Franka

    Aging & mental health

    2023  Volume 28, Issue 2, Page(s) 244–253

    Abstract: Objectives: To identify facilitators, barriers, and formulate recommendations for the implementation of exergames for people with dementia (PWD) in day-care centers (DCCs).: Methods: Within a randomized controlled trial into the effectiveness of ... ...

    Abstract Objectives: To identify facilitators, barriers, and formulate recommendations for the implementation of exergames for people with dementia (PWD) in day-care centers (DCCs).
    Methods: Within a randomized controlled trial into the effectiveness of exergaming, 73 PWD with their informal caregivers (IC) from 11 DCCs in the Netherlands and two exergame providers participated in a process evaluation. This was a mixed-methods study using focus groups, semi-structured interviews, the Measurement Instrument for Determinants of Innovations, forms for DCC staff, and a short satisfaction questionnaire. We used descriptive statistics for the quantitative outcomes, and thematic analysis for qualitative data. The Medical Research Council guidance for process evaluation was used to identify facilitators and barriers to the implementation, mechanisms of impact, and context.
    Results: Implementation-related facilitators and barriers were the availability of budget, staff, equipment, instructions, location, and supervision. Mechanisms of impact-related facilitators were experienced positive effects on physical functioning and mobility, cognitive, emotional, and social functioning, and quality of life. Barriers were mainly linked to the need to customize the intervention for each participant. Contextual facilitators were support and enthusiasm from others; barriers were costs and planning. Recommendations by DCC staff involved technical support, instructions, responsibility, location, supervision, planning, and exergaming as a group or individually.
    Conclusion: Users, IC, and staff positively valued exergaming. We found various facilitators and barriers leading to recommendations for successful implementation. We recommend further research into tailoring exergaming to specific users and contexts, and into usability and cost-effectiveness. This may contribute to further dissemination and implementation of exergaming for PWD.
    MeSH term(s) Humans ; Exergaming ; Quality of Life/psychology ; Caregivers/psychology ; Focus Groups ; Dementia/therapy ; Dementia/psychology
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2023.2238259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Automatic Ambiguity Detection

    Sproat, Richard / van Santen, Jan

    2019  

    Abstract: Most work on sense disambiguation presumes that one knows beforehand -- e.g. from a thesaurus -- a set of polysemous terms. But published lists invariably give only partial coverage. For example, the English word tan has several obvious senses, but one ... ...

    Abstract Most work on sense disambiguation presumes that one knows beforehand -- e.g. from a thesaurus -- a set of polysemous terms. But published lists invariably give only partial coverage. For example, the English word tan has several obvious senses, but one may overlook the abbreviation for tangent. In this paper, we present an algorithm for identifying interesting polysemous terms and measuring their degree of polysemy, given an unlabeled corpus. The algorithm involves: (i) collecting all terms within a k-term window of the target term; (ii) computing the inter-term distances of the contextual terms, and reducing the multi-dimensional distance space to two dimensions using standard methods; (iii) converting the two-dimensional representation into radial coordinates and using isotonic/antitonic regression to compute the degree to which the distribution deviates from a single-peak model. The amount of deviation is the proposed polysemy index
    Keywords Computer Science - Computation and Language
    Subject code 006
    Publishing date 2019-05-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Delphi consensus of risk factors for development and progression of finger interphalangeal joint osteoarthritis.

    Shah, Karishma / van Santen, James / Furniss, Dominic

    The Journal of hand surgery, European volume

    2019  Volume 44, Issue 10, Page(s) 1089–1090

    MeSH term(s) Consensus ; Delphi Technique ; Disease Progression ; Female ; Finger Joint/pathology ; Finger Joint/surgery ; Humans ; Male ; Osteoarthritis/pathology ; Osteoarthritis/surgery ; Risk Factors
    Language English
    Publishing date 2019-07-31
    Publishing country England
    Document type Letter
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/1753193419865872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cost-effectiveness of exergaming compared to regular day-care activities in dementia: Results of a randomised controlled trial in The Netherlands.

    van Santen, Joeke / Meiland, Franka J M / Dröes, Rose-Marie / van Straten, Annemieke / Bosmans, Judith E

    Health & social care in the community

    2021  Volume 30, Issue 5, Page(s) e1794–e1804

    Abstract: The growing number of people living with dementia will result in increased costs of dementia worldwide. The e-Health intervention 'Exergaming' may improve health and quality of life of people with dementia, but the cost-effectiveness is unknown. We ... ...

    Abstract The growing number of people living with dementia will result in increased costs of dementia worldwide. The e-Health intervention 'Exergaming' may improve health and quality of life of people with dementia, but the cost-effectiveness is unknown. We assessed the cost-effectiveness of exergaming compared to regular activities from a societal perspective in day-care centres (DCC) for people with dementia and their informal caregivers (IC) alongside a cluster randomised controlled trial. We included 112 dyads (person with dementia and IC) from 20 psychogeriatric DCCs (11 exergaming, 9 control) across the Netherlands. Exergaming consisted of interactive cycling at least twice a week for 6 months. Measurements were conducted at baseline (T0), after 3 (T1) and 6 (T2) months. Primary outcomes were minutes of physical activity, mobility of the participants with dementia (Short Physical Performances Battery, SPPB), and Quality-Adjusted Life-Years (QALYs) of participants with dementia and ICs. ICs filled out cost diaries to measure healthcare and informal care utilisation during the study. There were no statistically significant differences in outcomes or costs between the groups at the level of participants with dementia, the ICs or the dyad. With regard to QALYs and SPPB, the probability that exergaming is cost-effective compared to control was low for all possible willingness-to-pay (WTP) thresholds. However, for physical activity at WTP thresholds of 0, 50 and 250 Euros per additional minute of physical activity, the probability of cost-effectiveness is 0.46, 0.84 and 0.87, respectively. Exergaming in DCC was not cost-effective compared to usual activities. However, considering the small sample size and the large number of missing observations, findings should be interpreted with caution. Future studies with larger samples are recommended to obtain definitive answers on the cost-effectiveness of exergaming. This trial was registered in the Netherlands Trial Register (NTR5537/NL5420).
    MeSH term(s) Caregivers ; Cost-Benefit Analysis ; Dementia/therapy ; Humans ; Netherlands ; Quality of Life
    Language English
    Publishing date 2021-10-17
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1155902-0
    ISSN 1365-2524 ; 0966-0410
    ISSN (online) 1365-2524
    ISSN 0966-0410
    DOI 10.1111/hsc.13608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: AUTOMATIC SCORING OF A NONWORD REPETITION TEST.

    Asgari, Meysam / Van Santen, Jan / Papadakis, Katina

    Proceedings of the ... International Conference on Machine Learning and Applications. International Conference on Machine Learning and Applications

    2018  Volume 2017, Page(s) 304–308

    Abstract: In this study, we explore the feasibility of speech-based techniques to automatically evaluate a nonword repetition (NWR) test. NWR tests, a useful marker for detecting language impairment, require repetition of pronounceable nonwords, such as "D OY F", ... ...

    Abstract In this study, we explore the feasibility of speech-based techniques to automatically evaluate a nonword repetition (NWR) test. NWR tests, a useful marker for detecting language impairment, require repetition of pronounceable nonwords, such as "D OY F", presented aurally by an examiner or via a recording. Our proposed method leverages ASR techniques to first transcribe verbal responses. Second, it applies machine learning techniques to ASR output for predicting gold standard scores provided by speech and language pathologists. Our experimental results for a sample of 101 children (42 with autism spectrum disorders, or ASD; 18 with specific language impairment, or SLI; and 41 typically developed, or TD) show that the proposed approach is successful in predicting scores on this test, with averaged product-moment correlations of 0.74 and mean absolute error of 0.06 (on a observed score range from 0.34 to 0.97) between observed and predicted ratings.
    Language English
    Publishing date 2018-01-18
    Publishing country United States
    Document type Journal Article
    DOI 10.1109/icmla.2017.0-143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Views from an asylum: a retrospective case note analysis of a nineteenth century asylum.

    Chu, Elvina May-Yin / van Santen, Joeke / Harbishettar, Vijay

    Social psychiatry and psychiatric epidemiology

    2018  Volume 53, Issue 10, Page(s) 1141–1147

    Abstract: Purpose: To investigate whether lifelong admission to psychiatric asylum care was usual practice before community psychiatric care was introduced.: Methods: Historical archives (1838-1938) for 50 patients at the Northampton General Lunatic Asylum in ... ...

    Abstract Purpose: To investigate whether lifelong admission to psychiatric asylum care was usual practice before community psychiatric care was introduced.
    Methods: Historical archives (1838-1938) for 50 patients at the Northampton General Lunatic Asylum in England were studied. Regression analyses were performed to investigate associations between predictor variables (age, gender, marital status, social class) and outcomes (diagnoses, length of stay and admission outcomes).
    Results: 30 patients (70%) were discharged into the community. 15 (31%) patients were admitted longer than 1 year. Diagnosis of mania was significantly higher in patients who were married. Trend associations were observed for melancholia being diagnosed in higher social class patients and monomania being diagnosed in unmarried patients. No associations were found between predictor variables and length of stay or admission outcomes.
    Conclusions: These findings challenge the myth that asylum incarceration was a usual practice before the advent of community care. Most patients were discharged from psychiatric asylum hospital within a year of admission even before the advent of psychotropic medication.
    MeSH term(s) Adult ; Bipolar Disorder/history ; Community Mental Health Services/history ; England ; Female ; History, 19th Century ; History, 20th Century ; Hospitalization/statistics & numerical data ; Hospitals, Psychiatric/history ; Humans ; Length of Stay ; Male ; Marital Status ; Mental Disorders/history ; Middle Aged ; Patient Discharge ; Psychotherapy ; Regression Analysis ; Retrospective Studies ; Social Class ; Time Factors
    Language English
    Publishing date 2018-08-06
    Publishing country Germany
    Document type Historical Article ; Journal Article
    ZDB-ID 623071-4
    ISSN 1433-9285 ; 0037-7813 ; 0933-7954
    ISSN (online) 1433-9285
    ISSN 0037-7813 ; 0933-7954
    DOI 10.1007/s00127-018-1575-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Digitally augmented, parent-led CBT versus treatment as usual for child anxiety problems in child mental health services in England and Northern Ireland: a pragmatic, non-inferiority, clinical effectiveness and cost-effectiveness randomised controlled trial.

    Creswell, Cathy / Taylor, Lucy / Giles, Sophie / Howitt, Sophie / Radley, Lucy / Whitaker, Emily / Brooks, Emma / Knight, Fauzia / Raymont, Vanessa / Hill, Claire / van Santen, James / Williams, Nicola / Mort, Sam / Harris, Victoria / Yu, Shuye / Pollard, Jack / Violato, Mara / Waite, Polly / Yu, Ly-Mee

    The lancet. Psychiatry

    2024  Volume 11, Issue 3, Page(s) 193–209

    Abstract: Background: Anxiety problems are common in children, yet few affected children access evidence-based treatment. Digitally augmented psychological therapies bring potential to increase availability of effective help for children with mental health ... ...

    Abstract Background: Anxiety problems are common in children, yet few affected children access evidence-based treatment. Digitally augmented psychological therapies bring potential to increase availability of effective help for children with mental health problems. This study aimed to establish whether therapist-supported, digitally augmented, parent-led cognitive behavioural therapy (CBT) could increase the efficiency of treatment without compromising clinical effectiveness and acceptability.
    Methods: We conducted a pragmatic, unblinded, two-arm, multisite, randomised controlled non-inferiority trial to evaluate the clinical effectiveness and cost-effectiveness of therapist-supported, parent-led CBT using the Online Support and Intervention (OSI) for child anxiety platform compared with treatment as usual for child (aged 5-12 years) anxiety problems in 34 Child and Adolescent Mental Health Services in England and Northern Ireland. We examined acceptability of OSI plus therapist support via qualitative interviews. Participants were randomly assigned (1:1) to OSI plus therapist support or treatment as usual, minimised by child age, gender, service type, and baseline child anxiety interference. Outcomes were assessed at week 14 and week 26 after randomisation. The primary clinical outcome was parent-reported interference caused by child anxiety at week 26 assessment, using the Child Anxiety Impact Scale-parent report (CAIS-P). The primary measure of health economic effect was quality-adjusted life-years (QALYs). Outcome analyses were conducted blind in the intention-to-treat (ITT) population with a standardised non-inferiority margin of 0·33 for clinical analyses. The trial was registered with ISRCTN, 12890382.
    Findings: Between Dec 5, 2020, and Aug 3, 2022, 706 families (706 children and their parents or carers) were referred to the study information. 444 families were enrolled. Parents reported 255 (58%) child participants' gender to be female, 184 (41%) male, three (<1%) other, and one (<1%) preferred not to report their child's gender. 400 (90%) children were White and the mean age was 9·20 years (SD 1·79). 85% of families for whom clinicians provided information in the treatment as usual group received CBT. OSI plus therapist support was non-inferior for parent-reported anxiety interference on the CAIS-P (SMD 0·01, 95% CI -0·15 to 0·17; p<0·0001) and all secondary outcomes. The mean difference in QALYs across trial arms approximated to zero, and OSI plus therapist support was associated with lower costs than treatment as usual. OSI plus therapist support was likely to be cost effective under certain scenarios, but uncertainty was high. OSI plus therapist support acceptability was good. No serious adverse events were reported.
    Interpretation: Digitally augmented intervention brought promising savings without compromising outcomes and as such presents a valuable tool for increasing access to psychological therapies and meeting the demand for treatment of child anxiety problems.
    Funding: Department for Health and Social Care and United Kingdom Research and Innovation Research Grant, National Institute for Health and Care (NIHR) Research Policy Research Programme, Oxford and Thames Valley NIHR Applied Research Collaboration, Oxford Health NIHR Biomedical Research Centre.
    MeSH term(s) Child ; Female ; Humans ; Male ; Anxiety ; Cognitive Behavioral Therapy ; Cost-Benefit Analysis ; England ; Mental Health Services ; Northern Ireland ; Treatment Outcome
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Equivalence Trial ; Journal Article ; Pragmatic Clinical Trial ; Randomized Controlled Trial
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(23)00429-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: SNGuess

    Miranda, N. / Freytag, J. C. / Nordin, J. / Biswas, R. / Brinnel, V. / Fremling, C. / Kowalski, M. / Mahabal, A. / Reusch, S. / van Santen, J.

    A method for the selection of young extragalactic transients

    2022  

    Abstract: With a rapidly rising number of transients detected in astronomy, classification methods based on machine learning are increasingly being employed. Their goals are typically to obtain a definitive classification of transients, and for good performance ... ...

    Abstract With a rapidly rising number of transients detected in astronomy, classification methods based on machine learning are increasingly being employed. Their goals are typically to obtain a definitive classification of transients, and for good performance they usually require the presence of a large set of observations. However, well-designed, targeted models can reach their classification goals with fewer computing resources. This paper presents SNGuess, a model designed to find young extragalactic nearby transients with high purity. SNGuess works with a set of features that can be efficiently calculated from astronomical alert data. Some of these features are static and associated with the alert metadata, while others must be calculated from the photometric observations contained in the alert. Most of the features are simple enough to be obtained or to be calculated already at the early stages in the lifetime of a transient after its detection. We calculate these features for a set of labeled public alert data obtained over a time span of 15 months from the Zwicky Transient Facility (ZTF). The core model of SNGuess consists of an ensemble of decision trees, which are trained via gradient boosting. Approximately 88% of the candidates suggested by SNGuess from a set of alerts from ZTF spanning from April 2020 to August 2021 were found to be true relevant supernovae (SNe). For alerts with bright detections, this number ranges between 92% and 98%. Since April 2020, transients identified by SNGuess as potential young SNe in the ZTF alert stream are being published to the Transient Name Server (TNS) under the AMPEL_ZTF_NEW group identifier. SNGuess scores for any transient observed by ZTF can be accessed via a web service. The source code of SNGuess is publicly available.

    Comment: 14 pages, 10 figures, Astronomy & Astrophysics (A&A), Forthcoming article, source code https://github.com/nmiranda/SNGuess
    Keywords Astrophysics - Instrumentation and Methods for Astrophysics ; Computer Science - Machine Learning
    Publishing date 2022-08-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Quantitative and semi-quantitative assessment of synovitis on MRI and the relationship with symptoms in symptomatic knee osteoarthritis.

    Perry, Thomas A / Yang, Xiaotian / van Santen, James / Arden, Nigel K / Kluzek, Stefan

    Rheumatology (Oxford, England)

    2020  Volume 60, Issue 4, Page(s) 1763–1773

    Abstract: Objectives: Synovitis in symptomatic knee OA (KOA) is common and is associated with joint symptoms. Optimal synovial measurement on MRI is, however, unclear. Our aims were to examine the relationship between MRI measures of synovitis and knee symptoms ... ...

    Abstract Objectives: Synovitis in symptomatic knee OA (KOA) is common and is associated with joint symptoms. Optimal synovial measurement on MRI is, however, unclear. Our aims were to examine the relationship between MRI measures of synovitis and knee symptoms in symptomatic KOA.
    Methods: Data from a randomized, multicentre, placebo-controlled trial (UK-VIDEO) of vitamin-D therapy in symptomatic KOA were utilized. Participants reported knee symptoms using WOMAC at baseline and annually. On contrast-enhanced (CE) MRI, synovial thickness was measured using established, semi-quantitative methods whilst synovial tissue volume (STV) was assessed as absolute STV (aSTV) and relative to the width of femoral condyle (rSTV). STV of the infrapatellar region was also assessed. Associations between synovial measures and symptoms were analysed using multiple linear regression modelling.
    Results: No linear association was observed between knee symptoms and synovitis thickness scores. Whole-joint aSTV (0.88, 95% CI: 0.17, 1.59) and infrapatellar aSTV (5.96, 95% CI: 1.22, 10.7) were positively associated with knee pain. Whole-joint rSTV had a stronger association with pain (7.96, 95% CI: 2.60, 13.33) and total scores (5.63, 95% CI: 0.32, 10.94). Even stronger associations were found for infrapatellar rSTV with pain (55.47, 95% CI: 19.99, 90.96), function (38.59, 95% CI: 2.1, 75.07) and total scores (41.64, 95% CI: 6.56, 76.72).
    Conclusions: Whole-joint and site-specific infrapatellar STV measures on CE-MRI were associated with knee pain, respectively. Volumes relative to the size of the femoral condyle may be promising outcome measures in KOA trials.
    MeSH term(s) Aged ; Arthralgia/etiology ; Contrast Media ; Female ; Humans ; Linear Models ; Magnetic Resonance Imaging ; Male ; Osteoarthritis, Knee/complications ; Pain Measurement ; Synovial Membrane/diagnostic imaging ; Synovitis/diagnostic imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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