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  1. Article: De diagnostische accuratesse van de anticitrullinebepaling voor het vaststellen van reumatoïde artritis door de huisarts.

    van Venrooij, W J

    Nederlands tijdschrift voor geneeskunde

    2008  Volume 152, Issue 21, Page(s) 1243–4; author reply 1244–5

    Title translation The diagnostic accuracy of anti-citrulline antibody assessment in the diagnosis of patients suspected of rheumatoid arthritis by a general practitioner.
    MeSH term(s) Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/diagnosis ; Citrulline/immunology ; Diagnostic Tests, Routine/standards ; Humans ; Sensitivity and Specificity
    Chemical Substances Citrulline (29VT07BGDA)
    Language Dutch
    Publishing date 2008-05-24
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.18: Show issues Location:
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  2. Article: Intracellular amino acids and protein synthesis in Hela cells.

    van Venrooij, W J / van Loon-Klaassen, L

    Molecular biology reports

    2013  Volume 1, Issue 3, Page(s) 167–171

    Abstract: 1) When the intracellular amino acid pool is prelabelled and subsequently chased in non-radioactive medium, the radioactivity of the amino acid pool is not found to have been incorporated into protein. (2) Leucine transport into Hela cells is reduced in ...

    Abstract (1) When the intracellular amino acid pool is prelabelled and subsequently chased in non-radioactive medium, the radioactivity of the amino acid pool is not found to have been incorporated into protein. (2) Leucine transport into Hela cells is reduced in the presence of 10 mM valine in the medium. This results in a lower specific radioactivity of leucine in the intracellular amino acid pool. However, neither the overall rate of protein synthesis nor the incorporation of radioactive leucine into protein is affected. From these experiments it is concluded that incoming amino acids entering the intracellular amino acid pool are not used for de novo synthesis of protein.
    Language English
    Publishing date 2013-11-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/BF00357158
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  3. Article ; Online: Autoantibody testing in the evaluation of idiopathic inflammatory myopathies: myositis-specific autoantibodies: are they ready to leave the bench for the bedside?

    van Engelen, B G / van Venrooij, W J

    Journal of clinical neuromuscular disease

    2008  Volume 2, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2008-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1454947-5
    ISSN 1537-1611 ; 1522-0443
    ISSN (online) 1537-1611
    ISSN 1522-0443
    DOI 10.1097/00131402-200009000-00001
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    Zs.A 5293: Show issues Location:
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  4. Article: What is going to happen tomorrow in the field of soluble anti-nuclear antigen antibodies?

    Van Venrooij, W J

    Annales de medecine interne

    1992  Volume 143, Issue 3, Page(s) 171–172

    MeSH term(s) Antibodies, Antinuclear/biosynthesis ; Antibodies, Antinuclear/immunology ; Antibodies, Antinuclear/physiology ; Autoantigens/immunology ; Epitopes/immunology ; RNA, Small Cytoplasmic ; Ribonucleoproteins ; SS-B Antigen
    Chemical Substances Antibodies, Antinuclear ; Autoantigens ; Epitopes ; RNA, Small Cytoplasmic ; RO60 protein, human ; Ribonucleoproteins ; SS-A antigen
    Language English
    Publishing date 1992
    Publishing country France
    Document type Interview
    ZDB-ID 215082-7
    ISSN 0003-410X
    ISSN 0003-410X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Modifications of arginines and their role in autoimmunity.

    van Boekel, M A M / van Venrooij, W J

    Autoimmunity reviews

    2003  Volume 2, Issue 2, Page(s) 57–62

    Abstract: Posttranslational modifications of proteins often perform a key role in the biological functioning of proteins. Some of these modifications also change the immunogenicity of proteins and peptides and create 'self'-antigens which might induce autoimmune ... ...

    Abstract Posttranslational modifications of proteins often perform a key role in the biological functioning of proteins. Some of these modifications also change the immunogenicity of proteins and peptides and create 'self'-antigens which might induce autoimmune responses. In particular modifications of arginines within a defined protein context can lead to a specific B-cell immune response. This review discusses the generation of such modifications and their relevance for autoimmunity.
    MeSH term(s) Animals ; Arginine/metabolism ; Autoimmunity/immunology ; B-Lymphocytes/immunology ; Humans ; Peptides/immunology ; Peptides/metabolism ; Protein Processing, Post-Translational/immunology
    Chemical Substances Peptides ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2003-06-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1568-9972
    ISSN 1568-9972
    DOI 10.1016/s1568-9972(02)00128-3
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    Zs.A 5913: Show issues Location:
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  6. Article: Use and significance of anti-CCP autoantibodies in rheumatoid arthritis.

    Zendman, A J W / van Venrooij, W J / Pruijn, G J M

    Rheumatology (Oxford, England)

    2006  Volume 45, Issue 1, Page(s) 20–25

    MeSH term(s) Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Autoantibodies/analysis ; Autoantibodies/immunology ; Biomarkers/analysis ; Forecasting ; Humans ; Peptides, Cyclic/immunology ; Prognosis ; Sensitivity and Specificity
    Chemical Substances Autoantibodies ; Biomarkers ; Peptides, Cyclic ; cyclic citrullinated peptide
    Language English
    Publishing date 2006-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kei111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 497: Show issues

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  7. Article: Anticitrullinated protein/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis.

    van Venrooij, W J / Hazes, J M / Visser, H

    The Netherlands journal of medicine

    2002  Volume 60, Issue 10, Page(s) 383–388

    MeSH term(s) Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/diagnosis ; Autoantibodies/blood ; Biomarkers/blood ; Humans ; Peptide Fragments/immunology ; Prognosis ; Sensitivity and Specificity
    Chemical Substances Autoantibodies ; Biomarkers ; Peptide Fragments
    Language English
    Publishing date 2002-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 193149-0
    ISSN 1872-9061 ; 0300-2977
    ISSN (online) 1872-9061
    ISSN 0300-2977
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    Zs.A 576: Show issues Location:
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  8. Article: Autoantibodies against small nuclear ribonucleoprotein components.

    van Venrooij, W J

    The Journal of rheumatology. Supplement

    1987  Volume 14 Suppl 13, Page(s) 78–82

    Abstract: Sera from patients with systemic rheumatic diseases often contain antibodies against nuclear antigens. Among these are proteins complexed with the small nuclear RNA (snRNA) U1, U2, U4, U5 and U6. In human cells, at least 11 different polypeptides (called ...

    Abstract Sera from patients with systemic rheumatic diseases often contain antibodies against nuclear antigens. Among these are proteins complexed with the small nuclear RNA (snRNA) U1, U2, U4, U5 and U6. In human cells, at least 11 different polypeptides (called 70K, A, A', B', B", B, C, D, E, F and G) ranging in molecular weight from 70 to 11 kDa, are associated with the snRNA, constituting the snRNP particles. In this report characteristics of 3 classes of autoantibodies are described. Anti-(U1) RNP antibodies recognize the U1 specific 70K and/or A and/or C proteins. Anti-Sm antibodies recognize proteins associated with all U snRNA, primarily the B', B and D proteins. Anti-(U1,U2) RNP sera contain antibodies directed against the U2 specific A' or B" proteins. These antibodies are useful tools for studying the structure and function of U snRNP complexes. Using mutant U2 snRNA and monospecific antibodies directed against the U2 specific proteins, we analyzed the interactions between proteins and RNA in the U2 snRNP particle. We have also isolated recombinant clones containing cDNA of mRNA coding for a number of snRNA associated proteins. Possible directions of future research are discussed.
    MeSH term(s) Antibodies, Antinuclear/analysis ; Antibody Specificity ; Humans ; Molecular Weight ; Peptides/immunology ; Rheumatic Diseases/immunology ; Ribonucleoproteins/immunology ; Ribonucleoproteins, Small Nuclear
    Chemical Substances Antibodies, Antinuclear ; Peptides ; Ribonucleoproteins ; Ribonucleoproteins, Small Nuclear
    Language English
    Publishing date 1987-06
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0380-0903
    ISSN 0380-0903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Citrullination: a small change for a protein with great consequences for rheumatoid arthritis.

    van Venrooij , W J / Pruijn, G J

    Arthritis research

    2000  Volume 2, Issue 4, Page(s) 249–251

    Abstract: A new autoantibody activity, which is almost 100% specific for rheumatoid arthritis (RA), has been found. The essential part of the B-cell epitope is a modified form of arginine (ie citrulline). The conversion of protein-contained arginine to citrulline ... ...

    Abstract A new autoantibody activity, which is almost 100% specific for rheumatoid arthritis (RA), has been found. The essential part of the B-cell epitope is a modified form of arginine (ie citrulline). The conversion of protein-contained arginine to citrulline is an enzymatic process that is carried out by peptidylarginine deiminase (PAD), an enzyme that appears to be hormonally controlled. Because of its remarkable specificity, citrullination and related processes might open new possibilities for studying the aetiology of RA.
    MeSH term(s) Animals ; Apoptosis/physiology ; Arginine/metabolism ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/metabolism ; Autoantibodies/immunology ; Autoantibodies/metabolism ; Autoantigens/immunology ; Autoantigens/metabolism ; Citrulline/immunology ; Citrulline/metabolism ; Humans
    Chemical Substances Autoantibodies ; Autoantigens ; Citrulline (29VT07BGDA) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2000-05-24
    Publishing country England
    Document type Comment ; Journal Article ; Review
    ZDB-ID 2007393-8
    ISSN 1465-9913 ; 1465-9905
    ISSN (online) 1465-9913
    ISSN 1465-9905
    DOI 10.1186/ar95
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5490: Show issues Location:
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  10. Article: The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma.

    Brouwer, R / Pruijn, G J / van Venrooij, W J

    Arthritis research

    2000  Volume 3, Issue 2, Page(s) 102–106

    Abstract: The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 ...

    Abstract The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' --> 5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.
    MeSH term(s) Autoantigens/chemistry ; Autoantigens/immunology ; Exoribonucleases/chemistry ; Exoribonucleases/immunology ; Exosome Multienzyme Ribonuclease Complex ; Humans ; Multienzyme Complexes/chemistry ; Multienzyme Complexes/immunology ; Polymyositis/enzymology ; Polymyositis/immunology ; Scleroderma, Systemic/enzymology ; Scleroderma, Systemic/immunology
    Chemical Substances Autoantigens ; Multienzyme Complexes ; Exoribonucleases (EC 3.1.-) ; Exosome Multienzyme Ribonuclease Complex (EC 3.1.-) ; EXOSC10 protein, human (EC 3.1.13.-)
    Language English
    Publishing date 2000-12-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2007393-8
    ISSN 1465-9913 ; 1465-9905
    ISSN (online) 1465-9913
    ISSN 1465-9905
    DOI 10.1186/ar147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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