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Article: Antiviral immune responses by human langerhans cells and dendritic cells in HIV-1 infection.

van den Berg, Linda M / Geijtenbeek, Teunis B H

Advances in experimental medicine and biology

2013 Volume 762, Page(s) 45–70

Abstract: The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites. Langerhans cells (LCs) and dendritic cells (DCs) are amongst the first ... ...

Abstract	The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites. Langerhans cells (LCs) and dendritic cells (DCs) are amongst the first immune cells encountering HIV-1 since these cells line these mucosal tissues. Both LCs and DCs are equipped with specific pattern recognition receptors that not only sense pathogens, but induce specific immune responses against these pathogens. LCs express the C-type lectin receptor langerin, which provides protection against HIV-1 infection. In contrast, DCs express the C-type lectin receptor DC-SIGN, which facilitates capture as well as infection of DCs and subsequent transmission to CD4(+) T cells. This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host. HIV-1 infection ultimately leads to the worldwide pandemic acquired immunodeficiency syndrome (AIDS).
MeSH term(s)	Dendritic Cells/immunology ; HIV Infections/immunology ; HIV-1 ; Humans ; Langerhans Cells/immunology
Language	English
Publishing date	2013
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-1-4614-4433-6_2
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Article ; Online: An evolutionary perspective on C-type lectins in infection and immunity.

van den Berg, Linda M / Gringhuis, Sonja I / Geijtenbeek, Teunis B H

Annals of the New York Academy of Sciences

2012 Volume 1253, Page(s) 149–158

Abstract: Host-pathogen interactions have coevolved for many years. On the one hand, the human immune system consists of innate and adaptive immune cells that function to defeat pathogens, and on the other hand, pathogens have coevolved to use the system for their ...

Abstract	Host-pathogen interactions have coevolved for many years. On the one hand, the human immune system consists of innate and adaptive immune cells that function to defeat pathogens, and on the other hand, pathogens have coevolved to use the system for their own propagation. C-type lectins are conserved receptors recognizing carbohydrate structures on viruses, bacteria, parasites, and fungi. C-type lectins such as DC-SIGN, langerin, and dectin-1 are expressed by dendritic cell subsets and macrophages. Pathogen recognition by C-type lectins triggers signaling pathways that lead to the expression of specific cytokines which subsequently instruct adaptive T helper immune responses. T helper cell differentiation is crucial for initiating proper adaptive immune responses; some pathogens, however, use pattern recognition receptors like C-type lectins to subvert immune responses for survival. This review provides an update on the role of C-type lectins in HIV-1, mycobacterial, and Candida infections, and the coevolution of hosts and pathogens.
MeSH term(s)	Animals ; Biological Evolution ; Candidiasis/immunology ; HIV Infections/immunology ; HIV-1 ; Host-Pathogen Interactions/immunology ; Humans ; Infection/immunology ; Lectins, C-Type/immunology ; Models, Immunological ; Mycobacterium Infections/immunology ; Signal Transduction/immunology
Chemical Substances	Lectins, C-Type
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/j.1749-6632.2011.06392.x
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Article: Development of a Biosecurity Checklist for Laboratory Assessment and Monitoring.

Brizee, Sabrina / van Passel, Mark W J / van den Berg, Linda M / Feakes, Daniel / Izar, Ana / Lin, Kathryn Tham Bee / Podin, Yuwana / Yunus, Zalini / Bleijs, Diederik A

Applied biosafety : journal of the American Biological Safety Association

2019 Volume 24, Issue 2, Page(s) 83–89

Abstract: Introduction: Laboratory biosecurity is of continuously growing interest due to increasing concerns about deliberate misuse of biological materials and emerging biological risks. These risks continue to be magnified by globalization, the rapid pace of ... ...

Abstract	Introduction: Laboratory biosecurity is of continuously growing interest due to increasing concerns about deliberate misuse of biological materials and emerging biological risks. These risks continue to be magnified by globalization, the rapid pace of scientific development, and dual-use technologies. Worldwide laboratory capacities are expanding, which calls for concrete actions to improve laboratory biosafety and biosecurity practices to protect researchers and the community. Hence, laboratories require comprehensive biorisk management programs to minimize the risk of accidental and deliberate release of infectious biological materials. Objective: Malaysia has prioritized the concern of national biosecurity and aims to consolidate laboratory biosecurity performance to detect and prevent the deliberate release of biological agents. Methods: Two 3-day workshops were organized over the course of four months in which Malaysia collaborated with The Netherlands. This bilateral engagement aimed to integrate biosecurity practices in their national biorisk management programs, and resulted into a comprehensive biosecurity checklist for laboratory assessment and monitoring. Results: This biosecurity checklist is based on Malaysian and Dutch expert opinions and national and international guidelines and regulations. The biosecurity checklist is a survey-driven tool that consists of a set of concrete questions for each key biosecurity area, which are discussion points for assessment. Conclusion: We display a practical biosecurity checklist for laboratory assessment and monitoring. Although the presented checklist was the template for the specific Malaysia checklist, it could serve as a template for other countries.
Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Journal Article
ISSN	1535-6760
ISSN	1535-6760
DOI	10.1177/1535676019838077
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Article ; Online: Dectin-1 activation induces proliferation and migration of human keratinocytes enhancing wound re-epithelialization.

van den Berg, Linda M / Zijlstra-Willems, Esther M / Richters, Cornelia D / Ulrich, Magda M W / Geijtenbeek, Teunis B H

Cellular immunology

2014 Volume 289, Issue 1-2, Page(s) 49–54

Abstract: Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type ... ...

Abstract	Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the role of dectin-1 expressed by keratinocytes (KCs) in wound healing. Curdlan enhanced migration, proliferation and wound closure of human KCs in a dectin-1 dependent manner, both in vitro and ex vivo. Our data suggest that curdlan induces human KC proliferation and migration and could therefore be used in creams to enhance wound healing.
MeSH term(s)	Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Humans ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Keratinocytes/immunology ; Lectins, C-Type/metabolism ; Polysaccharides, Bacterial/immunology ; Polysaccharides, Bacterial/pharmacology ; Re-Epithelialization/drug effects ; Re-Epithelialization/immunology ; Skin ; beta-Glucans/immunology ; beta-Glucans/pharmacology
Chemical Substances	CLEC7A protein, human ; Lectins, C-Type ; Polysaccharides, Bacterial ; beta-Glucans ; curdlan (6930DL209R)
Language	English
Publishing date	2014-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2014.03.007
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Article: The Vulnerability Scan, a Web Tool to Increase Institutional Biosecurity Resilience.

Meulenbelt, Stephanie E / van Passel, Mark W J / de Bruin, Arnout / van den Berg, Linda M / Schaap, Mirjam M / Rutjes, Saskia A / Jacobi, André J / Agterberg, Marja C / de Hoog, Carin / van Willigen, Gijsbert / Kampert, Evelien / Heres, Jan H J / van den Berg, Ruud / van den Berg, Harold H J L / Bleijs, Diederik A

Frontiers in public health

2019 Volume 7, Page(s) 47

Abstract: The importance of vigilance within organizations working with high-risk biological material receives increasing attention. However, an in-depth and comprehensive tool, dedicated to increase awareness of potential risks and to assess an organization's ... ...

Abstract	The importance of vigilance within organizations working with high-risk biological material receives increasing attention. However, an in-depth and comprehensive tool, dedicated to increase awareness of potential risks and to assess an organization's current biosecurity vulnerabilities, has not been available yet. We developed the "Biosecurity Vulnerability Scan," a web tool that identifies biosecurity gaps in an organization based on eight biosecurity pillars of good practice. Although the tool aims primarily to assist biosafety and biosecurity officers, it can also be useful to researchers working with dangerous pathogens, their principal investigators, management, or those responsible for security issues in the life sciences. Results are only stored locally and are provided in an "overview report," which includes information on relevant risks and control measures. This can support well-substantiated decision-making on strengthening biosecurity measures within a specific organization. With this article, we aim to support institutes to increase their overall security resilience and to improve institutional biosecurity in particular by providing practical recommendations. The Biosecurity Vulnerability Scan is available at www.biosecurityvulnerabilityscan.nl.
Language	English
Publishing date	2019-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2019.00047
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Article ; Online: The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells.

Sorvillo, Nicoletta / Pos, Wouter / van den Berg, Linda M / Fijnheer, Rob / Martinez-Pomares, Luisa / Geijtenbeek, Teunis B / Herczenik, Eszter / Voorberg, Jan

Blood

2012 Volume 119, Issue 16, Page(s) 3828–3835

Abstract: ADAMTS13 is a plasma metalloproteinase that regulates platelet adhesion and aggregation by cleaving ultra-large VWF multimers on the surfaces of endothelial cells. Autoantibodies directed against ADAMTS13 prohibit the processing of VWF multimers, ... ...

Abstract	ADAMTS13 is a plasma metalloproteinase that regulates platelet adhesion and aggregation by cleaving ultra-large VWF multimers on the surfaces of endothelial cells. Autoantibodies directed against ADAMTS13 prohibit the processing of VWF multimers, initiating a rare and life-threatening disorder called acquired thrombotic thrombocytopenic purpura. The formation of autoantibodies depends on the activation of CD4(+) T cells. This process requires immune recognition, endocytosis, and subsequent processing of ADAMTS13 into peptides that are presented on MHC class II molecules to CD4(+) T cells by dendritic cells (DCs). In the present study, we investigated endocytosis of recombinant ADAMTS13 by immature monocyte-derived DCs using flow cytometry and confocal microscopy. After incubation of fluorescently labeled ADAMTS13 with DCs, significant uptake of ADAMTS13 was observed. Endocytosis of ADAMTS13 was completely blocked by the addition of EGTA and mannan. ADAMTS13 endocytosis was decreased in the presence of a blocking mAb directed toward the macrophage mannose receptor (MR). Furthermore, siRNA silencing of MR reduced the uptake of ADAMTS13 by DCs. In addition, in vitro binding studies confirmed the interaction of ADAMTS13 with the carbohydrate recognition domains of MR. The results of the present study indicate that sugar moieties on ADAMTS13 interact with MR, thereby promoting its endocytosis by APCs.
MeSH term(s)	ADAM Proteins/genetics ; ADAM Proteins/pharmacokinetics ; ADAMTS13 Protein ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Endocytosis/immunology ; Flow Cytometry ; Gene Silencing ; Humans ; Lectins, C-Type/metabolism ; Mannose-Binding Lectins/metabolism ; Microscopy, Confocal ; Monocytes/immunology ; Monocytes/metabolism ; Protein Binding/immunology ; Receptors, Cell Surface/metabolism
Chemical Substances	Lectins, C-Type ; Mannose-Binding Lectins ; Receptors, Cell Surface ; mannose receptor ; ADAM Proteins (EC 3.4.24.-) ; ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
Language	English
Publishing date	2012-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2011-09-377754
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Article ; Online: Langerhans Cell-Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1.

van den Berg, Linda M / Cardinaud, Sylvain / van der Aar, Angelic M G / Sprokholt, Joris K / de Jong, Marein A W P / Zijlstra-Willems, Esther M / Moris, Arnaud / Geijtenbeek, Teunis B H

Journal of immunology (Baltimore, Md. : 1950)

2015 Volume 195, Issue 4, Page(s) 1763–1773

Abstract: Human epidermal and mucosal Langerhans cells (LCs) express the C-type lectin receptor langerin that functions as a pattern recognition receptor. LCs are among the first immune cells to interact with HIV-1 during sexual transmission. In this study, we ... ...

Abstract	Human epidermal and mucosal Langerhans cells (LCs) express the C-type lectin receptor langerin that functions as a pattern recognition receptor. LCs are among the first immune cells to interact with HIV-1 during sexual transmission. In this study, we demonstrate that langerin not only functions as a pattern recognition receptor but also as an adhesion receptor mediating clustering between LCs and dendritic cells (DCs). Langerin recognized hyaluronic acid on DCs and removal of these carbohydrate structures partially abrogated LC-DC clustering. Because LCs did not cross-present HIV-1-derived Ags to CD8(+) T cells in a cross-presentation model, we investigated whether LCs were able to transfer Ags to DCs. LC-DC clustering led to maturation of DCs and facilitated Ag transfer of HIV-1 to DCs, which subsequently induced activation of CD8(+) cells. The rapid transfer of Ags to DCs, in contrast to productive infection of LCs, suggests that this might be an important mechanism for induction of anti-HIV-1 CD8(+) T cells. Induction of the enzyme hyaluronidase-2 by DC maturation allowed degradation of hyaluronic acid and abrogated LC-DC interactions. Thus, we have identified an important function of langerin in mediating LC-DC clustering, which allows Ag transfer to induce CTL responses to HIV-1. Furthermore, we showed this interaction is mediated by hyaluronidase-2 upregulation after DC maturation. These data underscore the importance of LCs and DCs in orchestrating adaptive immunity to HIV-1. Novel strategies might be developed to harness this mechanism for vaccination.
MeSH term(s)	Antigen Presentation/immunology ; Antigens, CD/metabolism ; CD8-Positive T-Lymphocytes/immunology ; Cell Communication/drug effects ; Cell Communication/immunology ; Cross-Priming/immunology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; HIV Antigens/immunology ; HIV Infections/immunology ; HIV-1/immunology ; Humans ; Hyaluronic Acid/metabolism ; Hyaluronic Acid/pharmacology ; Langerhans Cells/drug effects ; Langerhans Cells/immunology ; Langerhans Cells/metabolism ; Lectins, C-Type/metabolism ; Ligands ; Mannose-Binding Lectins/metabolism ; Protein Binding
Chemical Substances	Antigens, CD ; CD207 protein, human ; HIV Antigens ; Lectins, C-Type ; Ligands ; Mannose-Binding Lectins ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2015-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1402356
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Article ; Online: Burn injury suppresses human dermal dendritic cell and Langerhans cell function.

van den Berg, Linda M / de Jong, Marein A W P / Witte, Lot de / Ulrich, Magda M W / Geijtenbeek, Teunis B H

Cellular immunology

2011 Volume 268, Issue 1, Page(s) 29–36

Abstract: Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we ... ...

Abstract	Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering both epidermal LC and dermal DC functions. We developed a human ex vivo burn injury model to study the function of DCs in thermally injured skin. No differences were observed in the capacity of both LCs and dermal DCs to migrate out of burned skin compared to unburned skin. Similarly, expression levels of co-stimulatory molecules were unaltered. Notably, we observed a strong reduction of T cell activation induced by antigen presenting cell (APC) subsets that migrated from burned skin through soluble burn factors. Further analyses demonstrated that both epidermal LCs and dermal DCs have a decreased T cell stimulatory capacity after burn injury. Restoring the T cell stimulatory capacity of DC subsets might improve tissue regeneration in patients with burn wounds.
MeSH term(s)	Burns/immunology ; Burns/pathology ; Cell Differentiation ; Cell Movement ; Cell Proliferation ; Humans ; Langerhans Cells/cytology ; Langerhans Cells/immunology ; Langerhans Cells/pathology ; Lymphocyte Activation/immunology ; T-Lymphocytes/immunology ; Wound Healing/physiology
Language	English
Publishing date	2011
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2011.01.007
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Article: Burn injury suppresses human dermal dendritic cell and Langerhans cell function

van den Berg, Linda M / de Jong, Marein A.W.P / Witte, Lot de / Ulrich, Magda M.W / Geijtenbeek, Teunis B.H

Cellular immunology. 2011, v. 268, no. 1

2011

Abstract	Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering both epidermal LC and dermal DC functions. We developed a human ex vivo burn injury model to study the function of DCs in thermally injured skin. No differences were observed in the capacity of both LCs and dermal DCs to migrate out of burned skin compared to unburned skin. Similarly, expression levels of co-stimulatory molecules were unaltered. Notably, we observed a strong reduction of T cell activation induced by antigen presenting cell (APC) subsets that migrated from burned skin through soluble burn factors. Further analyses demonstrated that both epidermal LCs and dermal DCs have a decreased T cell stimulatory capacity after burn injury. Restoring the T cell stimulatory capacity of DC subsets might improve tissue regeneration in patients with burn wounds.
Keywords	Langerhans cells ; T-lymphocytes ; adaptive immunity ; antigens ; humans ; models ; patients ; tissue repair
Language	English
Size	p. 29-36.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	80094-6
ISSN	1090-2163 ; 0008-8749
ISSN (online)	1090-2163
ISSN	0008-8749
DOI	10.1016/j.cellimm.2011.01.007
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Article: Novel dutch self-assessment biosecurity toolkit to identify biorisk gaps and to enhance biorisk awareness.

Sijnesael, Petra C C / van den Berg, Linda M / Bleijs, Diederik A / Odinot, Paul / de Hoog, Carin / Jansen, Mieke W J C / Kampert, Evelien / Rutjes, Saskia A / Broekhuijsen, Martien / Banus, Sander

Frontiers in public health

2014 Volume 2, Page(s) 197

Language	English
Publishing date	2014-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2014.00197
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