LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 126

Search options

  1. Article: Young GI Angle: How to apply for a grant.

    Bokun, Tomislav / van den Brink, Gijs R

    United European gastroenterology journal

    2017  Volume 5, Issue 1, Page(s) 142–143

    Language English
    Publishing date 2017-02
    Publishing country England
    Document type News
    ISSN 2050-6406
    ISSN 2050-6406
    DOI 10.1177/0144739417691023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: House dust mite: a new player in intestinal inflammation?

    Wildenberg, Manon E / van den Brink, Gijs R

    Gut

    2016  Volume 65, Issue 5, Page(s) 727–728

    MeSH term(s) Animals ; Asthma ; Humans ; Inflammation ; Pyroglyphidae
    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2015-311042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Grp78 is required for intestinal Kras-dependent glycolysis proliferation and adenomagenesis.

    Spaan, Claudia N / de Boer, Ruben J / Smit, Wouter L / van der Meer, Jonathan Hm / van Roest, Manon / Vermeulen, Jacqueline Lm / Koelink, Pim J / Becker, Marte Aj / Go, Simei / Silva, Joana / Faller, William J / van den Brink, Gijs R / Muncan, Vanesa / Heijmans, Jarom

    Life science alliance

    2023  Volume 6, Issue 11

    Abstract: In development of colorectal cancer, mutations ... ...

    Abstract In development of colorectal cancer, mutations in
    MeSH term(s) Animals ; Mice ; Cell Proliferation ; Endoplasmic Reticulum Chaperone BiP ; Glucose ; Glucose Transporter Type 1/genetics ; Glycolysis/genetics ; Intestines ; Proto-Oncogene Proteins p21(ras)/genetics
    Chemical Substances Endoplasmic Reticulum Chaperone BiP ; Glucose (IY9XDZ35W2) ; Glucose Transporter Type 1 ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Hspa5 protein, mouse ; Hras protein, mouse (EC 3.6.5.2)
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202301912
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer.

    Shah, Yatrik M / van den Brink, Gijs R

    Gastroenterology

    2015  Volume 149, Issue 3, Page(s) 534–537

    MeSH term(s) Animals ; Biomarkers, Tumor/metabolism ; Cell Differentiation ; Cell Proliferation ; Colonic Neoplasms/enzymology ; Humans ; Neoplastic Stem Cells/enzymology ; Paracrine Communication ; Proto-Oncogene Proteins c-kit/metabolism ; Signal Transduction ; Stem Cell Factor/metabolism
    Chemical Substances Biomarkers, Tumor ; Stem Cell Factor ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2015-09
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2015.07.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 572: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease.

    Levin, Alon D / Wildenberg, Manon E / van den Brink, Gijs R

    Journal of Crohn's & colitis

    2016  Volume 10, Issue 8, Page(s) 989–997

    Abstract: Several anti-tumour necrosis factor [TNF] blocking strategies have been evaluated in patients with Crohn's disease. Compounds that have been tested included the full monoclonal IgG1 antibodies infliximab and adalimumab, the pegylated anti-TNF F[ab']2 ... ...

    Abstract Several anti-tumour necrosis factor [TNF] blocking strategies have been evaluated in patients with Crohn's disease. Compounds that have been tested included the full monoclonal IgG1 antibodies infliximab and adalimumab, the pegylated anti-TNF F[ab']2 fragment certolizumab, an IgG4 anti-TNF CDP571 with reduced affinity for the Fc receptor, the soluble TNF receptor I onercept, and the TNF receptor II-Fc fusion protein etanercept. The endpoints of these studies suggest that not all methods of blocking TNF are equal. Here we will review the differences in the clinical, biochemical, and endoscopic endpoints of the major clinical studies. Collectively the data suggest that only IgG1 monoclonal antibodies have the ability to induce complete clinical, biochemical, and endoscopic remission. We discuss the potential multiple modes of action that may contribute to the response to full IgG1 anti-TNFs, focusing on the rapid induction of lamina propria T cell apoptosis and Fc receptor-dependent induction of M2-type wound-healing macrophages. We discuss how novel insights into the mechanism of action of anti-TNFs in Crohn's disease may contribute to the development of novel anti-TNFs with improved efficacy.
    MeSH term(s) Adalimumab/pharmacology ; Adalimumab/therapeutic use ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Apoptosis/drug effects ; Biomarkers/metabolism ; Certolizumab Pegol/pharmacology ; Certolizumab Pegol/therapeutic use ; Endoscopy, Gastrointestinal ; Humans ; Inflammatory Bowel Diseases/diagnostic imaging ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Infliximab/pharmacology ; Infliximab/therapeutic use ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Wound Healing/drug effects
    Chemical Substances Anti-Inflammatory Agents ; Biomarkers ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842) ; Certolizumab Pegol (UMD07X179E)
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjw053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6634: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Selective inhibition of mucosal serotonin as treatment for IBD?

    Levin, Alon D / van den Brink, Gijs R

    Gut

    2014  Volume 63, Issue 6, Page(s) 866–867

    MeSH term(s) Animals ; Colitis/metabolism ; Down-Regulation/drug effects ; Enzyme Inhibitors/pharmacology ; Gene Expression/drug effects ; Intestinal Mucosa/metabolism ; Male ; Neurons/metabolism ; Serotonin/biosynthesis
    Chemical Substances Enzyme Inhibitors ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2013-305283
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Foxf2: a mesenchymal regulator of intestinal adenoma development.

    van den Brink, Gijs R / Rubin, Deborah C

    Gastroenterology

    2013  Volume 144, Issue 5, Page(s) 873–876

    MeSH term(s) Adenoma/genetics ; Animals ; Colonic Neoplasms/genetics ; Fibroblasts/metabolism ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation, Neoplastic ; RNA, Neoplasm/genetics ; Stem Cells/pathology
    Chemical Substances Forkhead Transcription Factors ; Foxf2 protein, mouse ; RNA, Neoplasm
    Language English
    Publishing date 2013-03-22
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2013.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 572: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation.

    Westendorp, Florien / Karpus, Olga N / Koelink, Pim J / Vermeulen, Jacqueline L M / Meisner, Sander / Koster, Jan / Büller, Nikè V J A / Wildenberg, Manon E / Muncan, Vanesa / van den Brink, Gijs R

    Oncogene

    2021  Volume 40, Issue 9, Page(s) 1628–1643

    Abstract: Indian Hedgehog (Ihh) is a morphogen expressed by epithelial cells in the small intestine and colon that signals in a paracrine manner to gp38+ stromal cells. The loss of Ihh signaling results in increased epithelial proliferation, lengthening and ... ...

    Abstract Indian Hedgehog (Ihh) is a morphogen expressed by epithelial cells in the small intestine and colon that signals in a paracrine manner to gp38+ stromal cells. The loss of Ihh signaling results in increased epithelial proliferation, lengthening and multiplication of intestinal crypts and the activation of a stromal cell immune response. How Ihh controls epithelial proliferation through the stroma and how it affects colorectal cancer development remains poorly defined. To study the influence of Ihh signaling on the earliest stage of colorectal carcinogenesis, we used a well characterized mouse model in which both alleles of the Adenoma Polyposis Coli (Apc) gene could be inducibly deleted, leading to instant transformation of the colonic epithelium to an adenomatous phenotype. Concurrent deletion of Ihh from the adenomatous colonic epithelium of Apc inducible double mutant mice resulted in a remarkable increase in the hyperproliferative epithelial phenotype and increased accumulation of Lgr5+ stem cells. Transcriptional profiling of sorted colonic gp38+ fibroblasts showed upregulation of three ErbB pathway ligands (EREG, BTC, and NRG1) in Apc
    MeSH term(s) Animals ; Carcinogenesis/genetics ; Cell Proliferation/genetics ; Colon/metabolism ; Colon/pathology ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Disease Models, Animal ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Epithelium/metabolism ; Epithelium/pathology ; ErbB Receptors/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Hedgehog Proteins/genetics ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestine, Small/metabolism ; Intestine, Small/pathology ; Membrane Glycoproteins/genetics ; Mice ; Neuregulin-1/genetics ; Receptors, G-Protein-Coupled/genetics ; Signal Transduction/genetics
    Chemical Substances Hedgehog Proteins ; LGR5 protein, human ; Membrane Glycoproteins ; NRG1 protein, human ; Neuregulin-1 ; PDPN protein, human ; Receptors, G-Protein-Coupled ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-020-01633-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: A prospective study comparing patient-reported outcomes in Crohn's disease.

    Hoekman, Daniël R / Löwenberg, Mark / van den Brink, Gijs R / Ponsioen, Cyriel Y / Benninga, Marc A / D'Haens, Geert R

    European journal of gastroenterology & hepatology

    2019  Volume 32, Issue 1, Page(s) 38–44

    Abstract: Background: Patient reported outcomes are important in Crohn's disease. In this prospective cohort, we investigated the performance of the Bristol Stool Form Scale (BSFS) and a visual analog scale (VAS) for abdominal pain as outcome measures in Crohn's ... ...

    Abstract Background: Patient reported outcomes are important in Crohn's disease. In this prospective cohort, we investigated the performance of the Bristol Stool Form Scale (BSFS) and a visual analog scale (VAS) for abdominal pain as outcome measures in Crohn's disease.
    Methods: Patients with active Crohn's disease starting glucocorticoids or anti-tumor necrosis factor were included. Before treatment and 10 weeks later we collected: clinical activity [Harvey Bradshaw Index (HBI) and Crohn's-Disease-Activity-Index (CDAI)], serum C-reactive protein (CRP) and fecal calprotectin, and BSFS (1-7) and a 100-mm VAS based on a 7-day diary. Clinical response was defined as a reduction by at least 3 and at least 100 of HBI and CDAI, respectively. Fecal calprotectin-response and CRP-response were defined as reduction of at least 50%.
    Results: Thirty-eight patients completed follow-up. At baseline, BSFS-parameters correlated more strongly with clinical activity (range: rs: 0.31-0.74) than with CRP (rs: -0.01 to 0.16) and fecal calprotectin (rs: 0.14-0.26). VAS scores correlated very weakly to moderately with clinical activity (rs: 0.18-0.45), and weakly to moderately with CRP (rs: 0.24-0.34) and fecal calprotectin (rs: 0.35-0.43). Changes in VAS scores correlated moderately to strongly (rs: 0.55-0.71) with changes in clinical activity, and weakly with changes in CRP and fecal calprotectin (rs: 0.21-0.35). Changes in BSFS parameters correlated weakly to moderately (rs: 0.23-0.53) with changes in clinical activity, and very weakly to weakly (rs: 0.01-0.35) with changes in CRP and fecal calprotectin. Responsiveness of VAS and BSFS was moderate to high (Guyatt's statistic 0.41-2.17) and highly dependent on the definition of response.
    Conclusions: The BSFS and a VAS appear to be responsive with moderate-to-strong construct validity to monitor patients with Crohn's disease.
    MeSH term(s) Biomarkers ; C-Reactive Protein/metabolism ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Feces/chemistry ; Humans ; Leukocyte L1 Antigen Complex ; Patient Reported Outcome Measures ; Prospective Studies ; Severity of Illness Index
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex ; C-Reactive Protein (9007-41-4)
    Keywords covid19
    Language English
    Publishing date 2019-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000001568
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2932: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: A major advance in ex vivo intestinal organ culture.

    Wildenberg, Manon E / van den Brink, Gijs R

    Gut

    2012  Volume 61, Issue 7, Page(s) 961–962

    MeSH term(s) Cytokines/metabolism ; Humans ; Inflammatory Bowel Diseases/therapy ; Intestinal Mucosa/microbiology ; Lactobacillus/metabolism ; Organ Culture Techniques/methods ; Probiotics/therapeutic use
    Chemical Substances Cytokines
    Language English
    Publishing date 2012-07
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2012-302021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top