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Article ; Online: Living with the physical and mental consequences of an ostomy: a study among 1-10-year rectal cancer survivors from the population-based PROFILES registry.

Mols, Floortje / Lemmens, Valery / Bosscha, Koop / van den Broek, Wim / Thong, Melissa S Y

2014 Volume 23, Issue 9, Page(s) 998–1004

Abstract: Background: This study examined the physical and mental consequences of an ostomy among 1-10-year rectal cancer survivors.: Methods: Patients with rectal cancer diagnosed from 2000 to 2009, as registered in the population-based Eindhoven Cancer ... ...

Abstract	Background: This study examined the physical and mental consequences of an ostomy among 1-10-year rectal cancer survivors. Methods: Patients with rectal cancer diagnosed from 2000 to 2009, as registered in the population-based Eindhoven Cancer Registry, received a questionnaire on quality of life (QOL; EORTC QLQ-C30), disease-specific health status (EORTC QLQ-CR38), depression and anxiety (HADS), illness perceptions (Brief Illness Perception Questionnaire), and health care utilization; 76% (n = 1019) responded. Results: A total of 408 (43%) rectal cancer survivors had an ostomy at survey and they reported a statistically significant and clinically relevant lower physical, role, and social functioning, and global health status/QOL but fewer problems with constipation and diarrhea compared with those without an ostomy. Also, they had a significantly worse body image, more male sexual problems, and fewer gastrointestinal problems although these differences were not clinically relevant. No differences regarding the prevalence of symptoms of anxiety and depression were found. Survivors with an ostomy believed that their illness have significantly more serious consequences, will last longer (clinically relevant), and were more concerned about their illness compared with those without an ostomy. Survivors with an ostomy visited their medical specialist, but not their general practitioner, significantly more often. Also, they more often received additional support after cancer treatment. Conclusions: Rectal cancer survivors with an ostomy have a lower QOL, worse illness perceptions, and a higher health care consumption compared with those without an ostomy 1-10 years after diagnosis.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Body Image ; Constipation/etiology ; Depression/etiology ; Depression/psychology ; Female ; Health Care Surveys ; Health Status ; Humans ; Male ; Middle Aged ; Ostomy/psychology ; Pain ; Patient Satisfaction ; Perception ; Prospective Studies ; Quality of Life ; Rectal Neoplasms/psychology ; Rectal Neoplasms/surgery ; Registries ; Socioeconomic Factors ; Survivors/psychology ; Survivors/statistics & numerical data
Language	English
Publishing date	2014-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1118536-3
ISSN	1099-1611 ; 1057-9249
ISSN (online)	1099-1611
ISSN	1057-9249
DOI	10.1002/pon.3517
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Article: The Nuclear Medicine Technologist in Europe - current status and future perspective.

van den Broek, Wim J M

Nuclear medicine review. Central & Eastern Europe

2003 Volume 6, Issue 2, Page(s) 135–137

MeSH term(s)	Allied Health Personnel/education ; Allied Health Personnel/standards ; Allied Health Personnel/trends ; Certification/standards ; Certification/trends ; Education, Continuing/methods ; Education, Continuing/standards ; Education, Continuing/trends ; Europe ; Job Description/standards ; Nuclear Medicine/organization & administration ; Professional Competence/standards ; Technology, Radiologic/organization & administration
Language	English
Publishing date	2003
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1467537-7
ISSN	1506-9680
ISSN	1506-9680
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Article ; Online: Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress.

Devos, Simon / Van Putte, Wouter / Vitse, Jolien / Van Driessche, Gonzalez / Stremersch, Stephan / Van Den Broek, Wim / Raemdonck, Koen / Braeckmans, Kevin / Stahlberg, Henning / Kudryashev, Misha / Savvides, Savvas N / Devreese, Bart

Environmental microbiology

2017 Volume 19, Issue 10, Page(s) 3930–3937

Abstract: Several bacterial species produce membrane vesicles (MVs) in response to antibiotic stress. However, the biogenesis and role of MVs in bacterial antibiotic resistance mechanisms have remained unclear. Here, we studied the effect of the fluoroquinolone ... ...

Abstract	Several bacterial species produce membrane vesicles (MVs) in response to antibiotic stress. However, the biogenesis and role of MVs in bacterial antibiotic resistance mechanisms have remained unclear. Here, we studied the effect of the fluoroquinolone ciprofloxacin on MV secretion by Stenotrophomonas maltophilia using a combination of electron microscopy and proteomic approaches. We found that in addition to the classical outer membrane vesicles (OMV), ciprofloxacin-stimulated cultures produced larger vesicles containing both outer and inner membranes termed outer-inner membrane vesicles (OIMV), and that such MVs are enriched with cytosolic proteins. Remarkably, OIMV were found to be decorated with filamentous structures identified as fimbriae. In addition, ciprofloxacin stress leads to the release of bacteriophages and phage tail-like particles. Prophage induction by ciprofloxacin has been linked to pathogenesis and horizontal gene transfer in several bacterial species. Together, our findings show that ciprofloxacin treatment of S. maltophilia leads to the secretion of a heterogeneous pool of MVs and the induction of prophages that are potentially involved in adverse side-effects during antibiotic treatment.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Ciprofloxacin/pharmacology ; Drug Resistance, Bacterial/drug effects ; Fluoroquinolones/metabolism ; Microbial Sensitivity Tests ; Prophages/genetics ; Prophages/physiology ; Proteomics ; Secretory Vesicles/drug effects ; Secretory Vesicles/ultrastructure ; Stenotrophomonas maltophilia/drug effects ; Stenotrophomonas maltophilia/ultrastructure ; Stenotrophomonas maltophilia/virology ; Virus Activation/drug effects
Chemical Substances	Anti-Bacterial Agents ; Fluoroquinolones ; Ciprofloxacin (5E8K9I0O4U)
Language	English
Publishing date	2017-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/1462-2920.13793
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Article ; Online: Half-time bone scintigraphy in prostate and breast cancer patients.

Grootjans, Willem / Serém, Sara J / Gomes, Monique I / Heijmen, Linda / Bulten, Ben F / Mijnheere, Eddy P / Hermsen, Rick / van den Broek, Wim J

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

2016 Volume 62, Issue 3, Page(s) 303–312

Abstract: Background: Developments in image reconstruction techniques for planar imaging, also known as enhanced planar processing (EPP), enable the possibility to reconstruct planar scintigraphic images with low count statistics, providing the opportunity to ... ...

Abstract	Background: Developments in image reconstruction techniques for planar imaging, also known as enhanced planar processing (EPP), enable the possibility to reconstruct planar scintigraphic images with low count statistics, providing the opportunity to reduce image acquisition time. In this study, the performance of EPP for oncologic half-time bone scintigraphy images was evaluated. Methods: The EPP software was evaluated for different imaging conditions using standardized phantom experiments. Additionally, 51 patients with prostate and breast cancer were prospectively included and underwent bone scintigraphy using a standard and half-time protocol. Independent reading was performed on three image types (standard, half-time non-processed, and half-time EPP) by three observers, scoring the number and anatomical location of lesions, image quality, and diagnostic confidence by which the definitive diagnosis was made. Results: EPP images had improved contrast and lower noise levels compared to the non-processed half-time images. It was determined that EPP images acquired at double scan speed had similar image quality to the standard non-processed images. There was substantial agreement with respect to diagnosis and diagnostic confidence based on all three image types between the observers. Image quality in the EPP images was higher with respect to the non-processed half-time images, and was comparable to the standard images. Conclusions: Diagnostic confidence was not affected by reduction in image acquisition time. There was substantial agreement between all three observers with respect to the diagnosis provided in all three image types. Subjective and objective image quality improved when half-time images were processed with EPP software.
MeSH term(s)	Aged ; Bone and Bones/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Phantoms, Imaging ; Prostatic Neoplasms/diagnostic imaging ; Radionuclide Imaging/methods ; Time Factors
Language	English
Publishing date	2016-02-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1281687-5
ISSN	1827-1936 ; 0392-0208 ; 1125-0135 ; 1824-4661 ; 1824-4785
ISSN (online)	1827-1936
ISSN	0392-0208 ; 1125-0135 ; 1824-4661 ; 1824-4785
DOI	10.23736/S1824-4785.16.02830-2
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Article: Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum

Rinaldi, Manuela / Dreesen, Leentje / Hoorens, Prisca R / Li, Robert W / Claerebout, Edwin / Goddeeris, Bruno / Vercruysse, Jozef / Van Den Broek, Wim / Geldhof, Peter

Veterinary research. 2011 Dec., v. 42, no. 1

2011

Abstract: The mucus layer in the gastrointestinal (GI) tract is considered to be the first line of defense to the external environment. Alteration in mucus components has been reported to occur during intestinal nematode infection in ruminants, but the role of ... ...

Abstract	The mucus layer in the gastrointestinal (GI) tract is considered to be the first line of defense to the external environment. Alteration in mucus components has been reported to occur during intestinal nematode infection in ruminants, but the role of mucus in response to abomasal parasites remains largely unclear. The aim of the current study was to analyze the effects of an Ostertagia ostertagi infection on the abomasal mucus biosynthesis in cattle. Increased gene expression of MUC1, MUC6 and MUC20 was observed, while MUC5AC did not change during infection. Qualitative changes of mucins, related to sugar composition, were also observed. AB-PAS and HID-AB stainings highlighted a decrease in neutral and an increase in acidic mucins, throughout the infection. Several genes involved in mucin core structure synthesis, branching and oligomerization, such as GCNT3, GCNT4, A4GNT and protein disulphide isomerases were found to be upregulated. Increase in mucin fucosylation was observed using the lectin UEA-I and through the evaluation of fucosyltransferases gene expression levels. Finally, transcription levels of 2 trefoil factors, TFF1 and TFF3, which are co-expressed with mucins in the GI tract, were also found to be significantly upregulated in infected animals. Although the alterations in mucus biosynthesis started early during infection, the biggest effects were found when adult worms were present on the surface of the abomasal mucosa and are likely caused by the alterations in mucosal cell populations, characterized by hyperplasia of mucus secreting cells.
Keywords	Ostertagia ; abomasum ; adults ; biosynthesis ; cattle ; gastrointestinal nematodes ; gene expression ; gene expression regulation ; genes ; hyperplasia ; isomerases ; lectins ; mucins ; mucosa ; mucus ; nematode infections
Language	English
Dates of publication	2011-12
Size	p. 61.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1146298-x
ISSN	1297-9716 ; 0928-4249
ISSN (online)	1297-9716
ISSN	0928-4249
DOI	10.1186/1297-9716-42-61
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Article ; Online: Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum

Rinaldi Manuela / Dreesen Leentje / Hoorens Prisca R / Li Robert W / Claerebout Edwin / Goddeeris Bruno / Vercruysse Jozef / Van Den Broek Wim / Geldhof Peter

Veterinary Research, Vol 42, Iss 1, p

2011 Volume 61

Abstract: Abstract The mucus layer in the gastrointestinal (GI) tract is considered to be the first line of defense to the external environment. Alteration in mucus components has been reported to occur during intestinal nematode infection in ruminants, but the ... ...

Abstract	Abstract The mucus layer in the gastrointestinal (GI) tract is considered to be the first line of defense to the external environment. Alteration in mucus components has been reported to occur during intestinal nematode infection in ruminants, but the role of mucus in response to abomasal parasites remains largely unclear. The aim of the current study was to analyze the effects of an Ostertagia ostertagi infection on the abomasal mucus biosynthesis in cattle. Increased gene expression of MUC1 , MUC6 and MUC20 was observed, while MUC5AC did not change during infection. Qualitative changes of mucins, related to sugar composition, were also observed. AB-PAS and HID-AB stainings highlighted a decrease in neutral and an increase in acidic mucins, throughout the infection. Several genes involved in mucin core structure synthesis, branching and oligomerization, such as GCNT3 , GCNT4 , A4GNT and protein disulphide isomerases were found to be upregulated. Increase in mucin fucosylation was observed using the lectin UEA-I and through the evaluation of fucosyltransferases gene expression levels. Finally, transcription levels of 2 trefoil factors, TFF1 and TFF3 , which are co-expressed with mucins in the GI tract, were also found to be significantly upregulated in infected animals. Although the alterations in mucus biosynthesis started early during infection, the biggest effects were found when adult worms were present on the surface of the abomasal mucosa and are likely caused by the alterations in mucosal cell populations, characterized by hyperplasia of mucus secreting cells.
Keywords	Veterinary medicine ; SF600-1100
Subject code	572
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article: Minimally invasive esophageal resection.

Cuesta, Miguel A / van den Broek, Wim T / van der Peet, Donald L / Meijer, Sijbren

Seminars in laparoscopic surgery

2004 Volume 11, Issue 3, Page(s) 147–160

Abstract: Esophagus resection is the adequate treatment for some benign esophageal diseases, especially caustic and peptic stenosis and end-stage motility dysfunction. However, the most frequent indications for esophageal resection are the high-grade dysplasia of ... ...

Abstract	Esophagus resection is the adequate treatment for some benign esophageal diseases, especially caustic and peptic stenosis and end-stage motility dysfunction. However, the most frequent indications for esophageal resection are the high-grade dysplasia of Barrett esophagus and nonmetastasized esophageal cancer. Different procedures have been developed to perform esophageal resection given the 5-year survival rate among operated patients of only 18%. The disadvantage of the conventional approach is the high morbidity rate, especially with pulmonary complications. Minimally invasive esophageal resections, which were first performed in 1991, may reduce this important morbidity and preserve the oncologic outcome. The first reports of morbidity and respiratory complications with this approach were discouraging and it seemed likely that the procedure would have to be abandoned. However, in the last 5 years, an important impetus for these techniques was given by Japanese groups and the group of Luketich in Pittsburgh. The outcomes of these new series are different than those of the beginning period, leading to an enormous expansion worldwide. Important factors for this change are the standardization of the operative technique, the experience of many surgeons with more advanced laparoscopic procedures, important improvements in instruments for dissection and division of tissues, a better anesthesia technique, and a better selection of patients for operation. Two minimally invasive techniques are being perfected: the three-stage operation by right thoracoscopy and laparoscopy, and the transhiatal laparoscopic approach. It seems that the first approach may be applied successfully for any tumor in the esophagus, whereas the transhiatal seems ideal for distal esophageal and esophagogastric junction tumors. This review paper discusses all these aspects, with special attention for indications and operative technique.
MeSH term(s)	Esophageal Diseases/surgery ; Esophageal Neoplasms/surgery ; Esophagectomy/methods ; Esophagoscopy ; Humans ; Laparoscopy ; Microsurgery ; Minimally Invasive Surgical Procedures ; Postoperative Complications ; Thoracoscopy
Language	English
Publishing date	2004-10-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1233569-1
ISSN	1071-5517
ISSN	1071-5517
DOI	10.1177/107155170401100304
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Article ; Online: Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum.

Rinaldi, Manuela / Dreesen, Leentje / Hoorens, Prisca R / Li, Robert W / Claerebout, Edwin / Goddeeris, Bruno / Vercruysse, Jozef / Van Den Broek, Wim / Geldhof, Peter

Veterinary research

2011 Volume 42, Page(s) 61

Abstract	The mucus layer in the gastrointestinal (GI) tract is considered to be the first line of defense to the external environment. Alteration in mucus components has been reported to occur during intestinal nematode infection in ruminants, but the role of mucus in response to abomasal parasites remains largely unclear. The aim of the current study was to analyze the effects of an Ostertagia ostertagi infection on the abomasal mucus biosynthesis in cattle. Increased gene expression of MUC1, MUC6 and MUC20 was observed, while MUC5AC did not change during infection. Qualitative changes of mucins, related to sugar composition, were also observed. AB-PAS and HID-AB stainings highlighted a decrease in neutral and an increase in acidic mucins, throughout the infection. Several genes involved in mucin core structure synthesis, branching and oligomerization, such as GCNT3, GCNT4, A4GNT and protein disulphide isomerases were found to be upregulated. Increase in mucin fucosylation was observed using the lectin UEA-I and through the evaluation of fucosyltransferases gene expression levels. Finally, transcription levels of 2 trefoil factors, TFF1 and TFF3, which are co-expressed with mucins in the GI tract, were also found to be significantly upregulated in infected animals. Although the alterations in mucus biosynthesis started early during infection, the biggest effects were found when adult worms were present on the surface of the abomasal mucosa and are likely caused by the alterations in mucosal cell populations, characterized by hyperplasia of mucus secreting cells.
MeSH term(s)	Abomasum/metabolism ; Abomasum/parasitology ; Alcian Blue ; Animals ; Cattle ; Cattle Diseases/genetics ; Cattle Diseases/parasitology ; Coloring Agents ; Gene Expression Regulation ; Indoles ; Mucus/metabolism ; Ostertagia/physiology ; Ostertagiasis/genetics ; Ostertagiasis/parasitology ; Ostertagiasis/veterinary ; Periodic Acid-Schiff Reaction/veterinary ; Random Allocation
Chemical Substances	Coloring Agents ; Indoles ; high iron diamine-alcian blue ; Alcian Blue (P4448TJR7J)
Language	English
Publishing date	2011-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146298-x
ISSN	1297-9716 ; 0928-4249
ISSN (online)	1297-9716
ISSN	0928-4249
DOI	10.1186/1297-9716-42-61
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Article: Scoring and diagnostic laparoscopy for suspected appendicitis.

van den Broek, Wim T / Bijnen, Bart B / Rijbroek, Bram / Gouma, Dirk J

The European journal of surgery = Acta chirurgica

2002 Volume 168, Issue 6, Page(s) 349–354

Abstract: Objective: To develop a reproducible scoring system to identify patients who present with a doubtful diagnosis of appendicitis and who would benefit from diagnostic laparoscopy.: Design: Prospective observational study.: Setting: Regional teaching ...

Abstract	Objective: To develop a reproducible scoring system to identify patients who present with a doubtful diagnosis of appendicitis and who would benefit from diagnostic laparoscopy. Design: Prospective observational study. Setting: Regional teaching hospital, The Netherlands. Subjects: 577 consecutive patients during the period 1994-5, and 343 who presented during the period 1996-7. Interventions: The variables that seemed to be predictive of acute appendicitis were abstracted from the earlier group. a logistic regression analysis applied, and score created. The score was validated on the 343 patients who presented during 1996-7, and then the groups were combined for further analysis. Main outcome measures: Reproducibility of the scoring system obtained by comparing odds ratios (OR) of the two groups; its effectiveness judged by comparing the delayed and normal appendicectomy rates. Results: The following variables were significantly correlated with the presence of acute appendicitis: white cell count 10 x 10(9)/L or more (score 3), rebound tenderness and male sex (score 2 each); and symptoms present for < 48 hrs and temperature 38 degrees C or more (score 1 each). The OR for the two groups were 1.80 and 1.76, respectively, indicating that score was reproducible. With a sensitivity of 93% and a specificity of 83% it would be at least as accurate as clinical judgment. The normal appendicectomy rate would be 7% instead of 9%. and the negative exploration rates (laparoscopy and primary appendicectomy) would both be 22%. The score would also result in a lower perforation rate (2% compared with 17%). Conclusion: The score can indicate when there is an indication for laparoscopy in patients with suspected appendicitis.
MeSH term(s)	Adult ; Appendicitis/diagnosis ; Child ; Female ; Humans ; Laparoscopy ; Male ; Odds Ratio ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity
Language	English
Publishing date	2002
Publishing country	England
Document type	Journal Article
ZDB-ID	1065288-7
ISSN	1102-4151 ; 1102-416X ; 0001-5482 ; 1102-1101
ISSN	1102-4151 ; 1102-416X ; 0001-5482 ; 1102-1101
DOI	10.1080/11024150260284860
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Article ; Online: Laparoscopic versus open sigmoid resection for diverticular disease: follow-up assessment of the randomized control Sigma trial.

Klarenbeek, Bastiaan R / Bergamaschi, Roberto / Veenhof, Alexander A F A / van der Peet, Donald L / van den Broek, Wim T / de Lange, Elly S M / Bemelman, Willem A / Heres, Pieter / Lacy, Antonio M / Cuesta, Miguel A

Surgical endoscopy

2010 Volume 25, Issue 4, Page(s) 1121–1126

Abstract: Background: The short-term results of the Sigma trial show that laparoscopic sigmoid resection (LSR) used electively for diverticular disease offers advantages over open sigmoid resection (OSR). This study aimed to compare the overall mortality and ... ...

Abstract	Background: The short-term results of the Sigma trial show that laparoscopic sigmoid resection (LSR) used electively for diverticular disease offers advantages over open sigmoid resection (OSR). This study aimed to compare the overall mortality and morbidity rates after evaluation of the clinical outcomes at the 6-month follow-up evaluation. Methods: In a prospective, multicenter, double-blind, parallel-arm, randomized control trial, eligible patients were randomized to either LSR or OSR. The short-term results and methodologic details have been published previously. Follow-up evaluation was performed at the outpatient clinic 6 weeks and 6 months after surgery. Results: In this trial, 104 patients were randomized for either LSR or OSR, and the conversion rate was 19.2%. The LSR approach was associated with short-term benefits such as a 15.4% reduction in the major complications rate, less pain, and a shorter hospital stay at the cost of a longer operating time. At the 6-month follow-up evaluation, no significant differences in morbidity or mortality rates were found. Two patients died of cardiac causes (overall mortality, 3%). Late complications (7 LSR vs. 12 OSR; p = 0.205) consisted of three incisional hernias, five small bowel obstructions, four enterocutaneous fistulas, one intraabdominal abscess, one retained gauze, two anastomotic strictures, and three recurrent episodes of diverticulitis. Nine of these patients underwent additional surgical interventions. Consideration of the major morbidity over the total follow-up period (0-6 months) shows that the LSR patients experienced significantly fewer complications than the OSR patients (9 LSR vs. 23 OSR; p = 0.003). The Short Form-36 (SF-36) questionnaire showed significantly better quality of life for LSR at the 6-week follow-up assessment. However, at the 6-month follow-up assessment, these differences were decreased. Conclusions: The late clinical outcomes did not differ between LSR and OSR during the 30-day to 6-month follow-up period. Consideration of total postoperative morbidity shows a 27% reduction in major morbidity for patients undergoing laparoscopic surgery for diverticular disease.
MeSH term(s)	Comorbidity ; Diverticulitis, Colonic/surgery ; Diverticulosis, Colonic/surgery ; Double-Blind Method ; Elective Surgical Procedures/statistics & numerical data ; Follow-Up Studies ; Humans ; Ileostomy/methods ; Laparoscopy/methods ; Laparoscopy/statistics & numerical data ; Laparotomy/methods ; Laparotomy/statistics & numerical data ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Prospective Studies ; Quality of Life ; Recovery of Function ; Recurrence ; Sigmoid Diseases/surgery ; Time Factors
Language	English
Publishing date	2010-09-25
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-010-1327-0
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