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  1. Article ; Online: Niacin for reduction of cardiovascular risk.

    van den Oever, Inge A M / Nurmohamed, Michael T / Lems, Willem F

    The New England journal of medicine

    2014  Volume 371, Issue 20, Page(s) 1942

    MeSH term(s) Atherosclerosis/drug therapy ; Female ; Humans ; Hypercholesterolemia/drug therapy ; Hypolipidemic Agents/administration & dosage ; Indoles/administration & dosage ; Infection/chemically induced ; Male ; Niacin/administration & dosage ; Niacin/adverse effects
    Chemical Substances Hypolipidemic Agents ; Indoles ; Niacin (2679MF687A)
    Language English
    Publishing date 2014-11-13
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1411240#SA4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Management of cardiovascular risk in patients with rheumatoid arthritis: evidence and expert opinion.

    van den Oever, Inge A M / van Sijl, Alper M / Nurmohamed, Michael T

    Therapeutic advances in musculoskeletal disease

    2013  Volume 5, Issue 4, Page(s) 166–181

    Abstract: The risk of cardiovascular morbidity and mortality is increased in rheumatoid arthritis. The classical cardiovascular risk factors, including smoking, hypertension, dyslipidaemia, insulin resistance and diabetes mellitus, obesity and physical inactivity ... ...

    Abstract The risk of cardiovascular morbidity and mortality is increased in rheumatoid arthritis. The classical cardiovascular risk factors, including smoking, hypertension, dyslipidaemia, insulin resistance and diabetes mellitus, obesity and physical inactivity do not appear to explain the excess cardiovascular risk in rheumatoid arthritis, although they do contribute, albeit in a different way or to a lesser extent, to rheumatoid arthritis in comparison with the general population. A very important link between rheumatoid arthritis and cardiovascular disease is inflammation as it plays a key role in all stages of atherosclerosis: from endothelial dysfunction to plaque rupture and thrombosis. It also has an influence on and accentuates some traditional cardiovascular risk factors, such as dyslipidaemia, obesity and insulin resistance. To date, the exact pathophysiologic mechanism by which this relation between cardiovascular disease and rheumatoid arthritis can be explained is not completely clear. Cardiovascular risk management in rheumatoid arthritis is mandatory. Unfortunately, the way this should be done remains a point of discussion. In this review issues regarding cardiovascular risk in rheumatoid arthritis and its management will be addressed, according to evidence presented in the latest studies and our own experience-based opinion.
    Language English
    Publishing date 2013-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X13491025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus.

    van den Oever, Inge A M / Raterman, Hennie G / Nurmohamed, Mike T / Simsek, Suat

    Mediators of inflammation

    2010  Volume 2010, Page(s) 792393

    Abstract: Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, ... ...

    Abstract Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.
    MeSH term(s) Apoptosis/physiology ; Diabetes Complications/pathology ; Diabetes Complications/physiopathology ; Diabetes Mellitus/pathology ; Diabetes Mellitus/physiopathology ; Endothelium, Vascular/pathology ; Endothelium, Vascular/physiopathology ; Humans ; Inflammation/pathology ; Inflammation/physiopathology ; Signal Transduction/immunology
    Language English
    Publishing date 2010-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2010/792393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparing inflammatory cell density in the myocardium and coronary arteries in rheumatoid arthritis patients versus controls with myocardial infarction: A post-mortem case-control study.

    van den Oever, Inge A M / van Sijl, Alper M / Baylan, Umit / Ter Wee, Marieke M / Schalkwijk, Casper G / Krijnen, Paul A J / Nurmohamed, Michael T / Voskuyl, Alexandre E / Niessen, Hans W M / Simsek, Suat

    International journal of cardiology

    2016  Volume 209, Page(s) 74–76

    MeSH term(s) Aged ; Aged, 80 and over ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Autopsy ; Case-Control Studies ; Coronary Vessels/immunology ; Coronary Vessels/pathology ; Cytokines/immunology ; Female ; Humans ; Male ; Myocardial Infarction/immunology ; Myocardial Infarction/pathology ; Myocardium/immunology ; Myocardium/pathology
    Chemical Substances Cytokines
    Language English
    Publishing date 2016-04-15
    Publishing country Netherlands
    Document type Comparative Study ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2016.02.065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1673: Show issues Location:
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  5. Article ; Online: Cardiovascular risk management in rheumatoid arthritis patients still suboptimal: the Implementation of Cardiovascular Risk Management in Rheumatoid Arthritis project.

    van den Oever, Inge A M / Heslinga, Maaike / Griep, Ed N / Griep-Wentink, Hanneke R M / Schotsman, Rob / Cambach, Walter / Dijkmans, Ben A C / Smulders, Yvo M / Lems, Willem F / Boers, Maarten / Voskuyl, Alexandre E / Peters, Mike J L / van Schaardenburg, Dirkjan / Nurmohamed, Micheal T

    Rheumatology (Oxford, England)

    2017  Volume 56, Issue 9, Page(s) 1472–1478

    Abstract: Objective: To assess the 10-year cardiovascular (CV) risk score and to identify treatment and undertreatment of CV risk factors in patients with established RA.: Methods: Demographics, CV risk factors and prevalence of cardiovascular disease (CVD) ... ...

    Abstract Objective: To assess the 10-year cardiovascular (CV) risk score and to identify treatment and undertreatment of CV risk factors in patients with established RA.
    Methods: Demographics, CV risk factors and prevalence of cardiovascular disease (CVD) were assessed by questionnaire. To calculate the 10-year CV risk score according to the Dutch CV risk management guideline, systolic blood pressure was measured and cholesterol levels were determined from fasting blood samples. Patients were categorized into four groups: indication for treatment but not treated; inadequately treated, so not meeting goals (systolic blood pressure ⩽140 mmHg and/or low-density lipoprotein ⩽2.5 mmol/l); adequately treated; or no treatment necessary.
    Results: A total of 720 consecutive RA patients were included, 375 from Reade and 345 from the Antonius Hospital. The mean age of patients was 59 years (s.d. 12) and 73% were female. Seventeen per cent of the patients had a low 10-year CV risk (<10%), 21% had an intermediate risk (10-19%), 53% a high risk (⩾20%) and 9% had CVD. In total, 69% had an indication for preventive treatment (cholesterol-lowering or antihypertensive drugs). Of those, 42% received inadequate treatment and 40% received no treatment at all.
    Conclusion: Optimal CV risk management remains a major challenge and better awareness and management are urgently needed to reduce the high risk of CVD in the RA population.
    MeSH term(s) Aged ; Antihypertensive Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/physiopathology ; Blood Pressure/physiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Cholesterol/blood ; Cross-Sectional Studies ; Drug Therapy, Combination ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Middle Aged ; Netherlands/epidemiology ; Prevalence ; Risk Assessment/methods ; Risk Factors ; Risk Management/methods ; Risk Management/standards
    Chemical Substances Antihypertensive Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2017-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kew497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 240: Show issues Location:
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