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Article ; Online: Impact of a Public Health Emergency on Behavior, Stress, Anxiety and Glycemic Control in Patients With Pancreas or Islet Transplantation for Type 1 Diabetes.

Landstra, Cyril P / Ruissen, Merel M / Regeer, Hannah / Nijhoff, Michiel F / Ballieux, Bart E P B / van der Boog, Paul J M / de Vries, Aiko P J / Huisman, Sasja D / de Koning, Eelco J P

Transplant international : official journal of the European Society for Organ Transplantation

2024 Volume 37, Page(s) 12278

Abstract: A public health emergency such as the COVID-19 pandemic has behavioral, mental and physical implications in patients with type 1 diabetes (T1D). To what extent the presence of a transplant further increases this burden is not known. Therefore, we ... ...

Abstract	A public health emergency such as the COVID-19 pandemic has behavioral, mental and physical implications in patients with type 1 diabetes (T1D). To what extent the presence of a transplant further increases this burden is not known. Therefore, we compared T1D patients with an islet or pancreas transplant (β-cell Tx;
MeSH term(s)	Female ; Humans ; Male ; Anxiety ; Blood Glucose ; Blood Glucose Self-Monitoring ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/surgery ; Glycemic Control ; Insulin-Secreting Cells ; Islets of Langerhans Transplantation ; Pandemics ; Public Health
Chemical Substances	Blood Glucose
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Observational Study
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2024.12278
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Article: Meltdose Tacrolimus Population Pharmacokinetics and Limited Sampling Strategy Evaluation in Elderly Kidney Transplant Recipients.

Kamp, Jasper / Zwart, Tom C / Meziyerh, Soufian / van der Boog, Paul J M / Nijgh, Esther E / van Duin, Koen / de Vries, Aiko P J / Moes, Dirk Jan A R

Pharmaceutics

2023 Volume 16, Issue 1

Abstract: Background: Meltdose tacrolimus (Envarsus: Methods: A total of 34 kidney transplant recipients aged ≥65 years, starting on meltdose tacrolimus directly after transplantation, were included. An eight-point whole blood AUC: Results: The PK data were ...

Abstract	Background: Meltdose tacrolimus (Envarsus Methods: A total of 34 kidney transplant recipients aged ≥65 years, starting on meltdose tacrolimus directly after transplantation, were included. An eight-point whole blood AUC Results: The PK data were best described using a two-compartment model, including three transit compartments and a mixture model for oral absorption. The best three-sample LSS was T = 0, 2, 6 h. The best four-sample LSSs were T = 0, 2, 6, 8 h and T = 0, 1, 6, 8 h. Conclusions: The developed population PK model adequately described the tacrolimus PK data in a population of elderly kidney transplant recipients. In addition, the developed population PK model and LSS showed an adequate estimation of tacrolimus exposure, and may therefore be used to aid in tacrolimus dose individualization.
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16010017
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Article ; Online: Psychological Distress and Self-Management in CKD: A Cross-Sectional Study.

Cardol, Cinderella K / Meuleman, Yvette / van Middendorp, Henriët / van der Boog, Paul J M / Hilbrands, Luuk B / Navis, Gerjan / Sijpkens, Yvo W J / Sont, Jacob K / Evers, Andrea W M / van Dijk, Sandra

Kidney medicine

2023 Volume 5, Issue 10, Page(s) 100712

Abstract: Rationale & objective: Patients with chronic kidney disease (CKD) not receiving dialysis, including kidney transplant recipients, often experience difficulties regarding self-management. An important barrier for adherence to self-management ... ...

Abstract	Rationale & objective: Patients with chronic kidney disease (CKD) not receiving dialysis, including kidney transplant recipients, often experience difficulties regarding self-management. An important barrier for adherence to self-management recommendations may be the presence of psychological distress, consisting of depressive and anxiety symptoms. We investigated relationships between psychological distress and adherence to self-management recommendations. Study design: Cross-sectional online questionnaire data as part of the E-GOAL study. Setting & participants: Patients with CKD (estimated glomerular filtration rate, 20-89 mL/min/1.73 m Exposures: Psychological distress, depressive symptoms, and anxiety symptoms. Outcomes: Dietary adherence, physical activity, medication adherence, smoking, body mass index, and a CKD self-management index (ie, the sum of 5 binary indicators of nonadherence to the recommended self-management factors). Analytical approach: Adjusted multivariable regression and ordinal logistic regression analyses. Results: In our sample (N = 460), 27.2% of patients reported psychological distress, and 69.8% were nonadherent to 1 or more recommendations. Higher psychological distress was significantly associated with poorer dietary adherence (β Limitations: Cross-sectional design, possible residual confounding, and self-report. Conclusions: Many people with CKD experience psychological distress, of whom most have difficulties self-managing their CKD. Given the relationship between psychological distress and adherence to CKD self-management recommendations, behavioral interventions are needed to identify and treat psychological distress as a potential barrier to CKD self-management. Plain-language summary: This online questionnaire study investigated relationships between psychological distress and self-management among 460 people with chronic kidney disease. Over a quarter of them reported mild-to-severe psychological distress. Alarmingly, 4 out of 5 patients with psychological distress were also nonadherent to 1 or more self-management recommendations, and higher levels of psychological distress were associated with poorer dietary and medication adherence and lower physical activity. Moreover, patients who suffered from moderate-to-severe distress were relatively more often nonadherent to 3 or more recommendations compared with patients with no or mild distress symptoms. So, it seems that psychological distress can be a barrier for self-management. To support patients in managing chronic kidney disease, researchers and health professionals should not overlook patients' mental health.
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Journal Article
ISSN	2590-0595
ISSN (online)	2590-0595
DOI	10.1016/j.xkme.2023.100712
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Article ; Online: Tacrolimus and Mycophenolic Acid Exposure Are Associated with Biopsy-Proven Acute Rejection: A Study to Provide Evidence for Longer-Term Target Ranges.

Meziyerh, Soufian / van Gelder, Teun / Kers, Jesper / van der Helm, Danny / van der Boog, Paul J M / de Fijter, Johan W / Moes, Dirk Jan A R / de Vries, Aiko P J

Clinical pharmacology and therapeutics

2023 Volume 114, Issue 1, Page(s) 192–200

Abstract: Evidence to define target ranges for tacrolimus (Tac) and mycophenolic acid (MPA) exposure after the first year of kidney transplantation is limited. We investigated the association of measurements at 1 year and repeated measurements of real-world Tac- ... ...

Abstract	Evidence to define target ranges for tacrolimus (Tac) and mycophenolic acid (MPA) exposure after the first year of kidney transplantation is limited. We investigated the association of measurements at 1 year and repeated measurements of real-world Tac-trough levels (C
MeSH term(s)	Humans ; Tacrolimus/adverse effects ; Mycophenolic Acid/adverse effects ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Graft Rejection/prevention & control
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Mycophenolic Acid (HU9DX48N0T) ; Immunosuppressive Agents
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2915
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Article ; Online: Age and gender differences in symptom experience and health-related quality of life in kidney transplant recipients: a cross-sectional study.

Veltkamp, Denise M J / Wang, Yiman / Meuleman, Yvette / Dekker, Friedo W / Michels, Wieneke M / van der Boog, Paul J M / de Vries, Aiko P J

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 38, Issue 7, Page(s) 1707–1718

Abstract: Background: Health-related quality of life (HRQOL) is an increasingly important patient-reported outcome in kidney transplant recipients (KTRs). This study explored relationships between symptom prevalence and burden with HRQOL, and age and gender ... ...

Abstract	Background: Health-related quality of life (HRQOL) is an increasingly important patient-reported outcome in kidney transplant recipients (KTRs). This study explored relationships between symptom prevalence and burden with HRQOL, and age and gender differences in symptom experience. Methods: Eligible Dutch KTRs transplanted in Leiden University Medical Center were invited for this cross-sectional study. HRQOL, and occurrence and burden of 62 symptoms were measured using validated questionnaires. Univariate and multivariate regression analysis were used for investigating the associations of symptom experience with mental and physical HRQOL, and differences in symptom experience between genders and KTRs of diverse age groups. Results: A total of 631 KTRs were analyzed; the mean (standard deviation) age was 61.3 (11.3) years, and 62% were male. The median (interquartile range) number of symptoms was 14 (7-22), with a burden of 20 (8-37; range 0-244). Per extra symptom, physical and mental HRQOL decreased [-0.41 (-0.50; -0.31) and -0.51 (-0.59; -0.42), respectively, P < .001]. Most occurring symptoms were bruises, tiredness, lack of energy, urge to urinate at night and dry skin. Sexual problems were considered most burdensome. Female KTRs reported more symptoms than men. Amongst others, younger KTRs experienced more (18-50 > 50-65 ≥65 years) feelings of depression and both female and younger KTRs reported higher symptom prevalence concerning changes in physical appearance. Conclusion: KRTs' symptom experience differed depending on gender and age, highlighting the need to develop tailored treatment strategies to reduce symptom experience and subsequently improve HRQOL.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Quality of Life ; Cross-Sectional Studies ; Kidney Transplantation/adverse effects ; Sex Factors ; Regression Analysis ; Transplant Recipients
Language	English
Publishing date	2023-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad023
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

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Article ; Online: Mycophenolic Acid Exposure Determines Antibody Formation Following SARS-CoV-2 Vaccination in Kidney Transplant Recipients: A Nested Cohort Study.

Meziyerh, Soufian / Bouwmans, Pim / van Gelder, Teun / van der Helm, Danny / Messchendorp, Lianne / van der Boog, Paul J M / de Fijter, Johan W / Moes, Dirk Jan A R / de Vries, Aiko P J

Clinical pharmacology and therapeutics

2023 Volume 114, Issue 1, Page(s) 118–126

Abstract: Despite (repeated) boosting, kidney transplant recipients (KTRs) may remain at increased risk of severe COVID-19 since a substantial number of individuals remain seronegative or with low antibody titers. In particular, mycophenolic acid use has been ... ...

Abstract	Despite (repeated) boosting, kidney transplant recipients (KTRs) may remain at increased risk of severe COVID-19 since a substantial number of individuals remain seronegative or with low antibody titers. In particular, mycophenolic acid use has been shown to affect antibody formation negatively and may be an important modifiable risk factor. We investigated the exposure-response relationship between mycophenolic acid 12-hour area under the curve (AUC
MeSH term(s)	Humans ; Antibodies ; Antibody Formation ; Cohort Studies ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Kidney Transplantation/adverse effects ; Mycophenolic Acid/adverse effects ; SARS-CoV-2 ; Vaccination
Chemical Substances	Antibodies ; COVID-19 Vaccines ; Mycophenolic Acid (HU9DX48N0T)
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2872
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Article ; Online: Self-Monitoring and Self-Efficacy in Patients with Chronic Kidney Disease During Low-Sodium Diet Self-Management Interventions: Secondary Analysis of the ESMO and SUBLIME Trials.

Hoekstra, Tiny / Dam, Manouk / Klaassen, Gerald / Bos, Willem Jan W / van der Boog, Paul J M / Vogt, Liffert / van Jaarsveld, Brigit / van Dijk, Sandra / Navis, Gerjan / Meuleman, Yvette

International journal of behavioral medicine

2023

Abstract: Background: Patients with chronic kidney disease are often requested to engage in self-monitoring sodium (i.e. salt) intake, but it is currently unknown how self-monitoring would empower them. This study aims to assess: (1) how frequent self-monitoring ... ...

Abstract	Background: Patients with chronic kidney disease are often requested to engage in self-monitoring sodium (i.e. salt) intake, but it is currently unknown how self-monitoring would empower them. This study aims to assess: (1) how frequent self-monitoring tools are being used during low-sodium diet self-management interventions; (2) whether self-efficacy (i.e. trust in own capability to manage the chronic disease) is associated with self-monitoring frequency; and (3) whether higher self-monitoring frequency is associated with an improvement in self-efficacy over time. Method: Data from two multicenter randomized controlled trials (ESMO [n = 151] and SUBLIME [n = 99]) among adult Dutch patients with chronic kidney disease (eGFR ≥ 20-25 mL/min/1.73 m Results: Large variations in self-monitoring frequency were observed. In both interventions, usage of self-monitoring tools was highest during the first month with sharp drops thereafter. The online food diary was the most frequently used tool. In the ESMO intervention, low baseline self-efficacy was associated with a higher usage frequency of self-monitoring tools. This finding was not confirmed in the SUBLIME intervention. No significant associations were found between usage frequency of self-monitoring tools and changes in self-efficacy over time. Conclusion: Patients with low self-efficacy might benefit most from frequent usage of self-monitoring tools when sufficient guidance and support is provided.
Language	English
Publishing date	2023-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1187972-5
ISSN	1532-7558 ; 1070-5503
ISSN (online)	1532-7558
ISSN	1070-5503
DOI	10.1007/s12529-023-10240-8
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Zs.A 5090: Show issues

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Article ; Online: COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study.

Dirikgil, Ebru / Brons, Kim / Duindam, Michael / Groeneveld, Geert H / Geelhoed, J J Miranda / Heringhaus, Christian / van der Boog, Paul J M / Rabelink, Ton J / Bos, Willem Jan W / Chavannes, Niels H / Atsma, Douwe E / Teng, Y K Onno

JMIR formative research

2022 Volume 6, Issue 7, Page(s) e38263

Abstract: Background: During the COVID-19 pandemic, several home monitoring programs have described the success of reducing hospital admissions, but only a few studies have investigated the experiences of patients and health care professionals.: Objective: The ...

Abstract	Background: During the COVID-19 pandemic, several home monitoring programs have described the success of reducing hospital admissions, but only a few studies have investigated the experiences of patients and health care professionals. Objective: The objective of our study was to determine patients' and health care professionals' experiences and satisfaction with employing the COVID-box. Methods: In this single-center, retrospective, observational study, patients and health care professionals were asked to anonymously fill out multiple-choice questionnaires with questions on a 5-point or 10-point Likert scale. The themes addressed by patients were the sense of reassurance and safety, experiences with teleconsultations, their appreciation for staying at home, and the instructions for using the COVID-box. The themes addressed by health care professionals who treated patients with the COVID-box were the characteristics of the COVID-box, the technical support service and general satisfaction, and their expectations and support for this telemonitoring concept. Scores were interpreted as insufficient (≤2 or ≤5, respectively), sufficient (3 or 6-7, respectively), or good (≥4 or ≥8, respectively) on a 5-point or 10-point Likert scale. Results: A total of 117 patients and 25 health care professionals filled out the questionnaires. The median score was 4 (IQR 4-5) for the sense of safety, the appreciation for staying at home, and experiences with teleconsultations, with good scores from 76.5% (88/115), 86% (56/65), and 83.6% (92/110) of the patients, respectively. Further, 74.4% (87/117) of the patients scored the home monitoring program with a score of ≥8. Health care professionals scored the COVID-box with a minimum median score of 7 (IQR 7-10) on a 10-point scale for all domains (ie, the characteristics of the COVID-box and the technical support service and general satisfaction). For the sense of safety, user-friendliness, and additional value of the COVID-box, the median scores were 8 (IQR 8-10), 8 (IQR 7-9), and 10 (IQR 8-10), respectively, with good scores from 86% (19/22), 75% (15/20), and 96% (24/25) of the health care professionals, respectively. All health care professionals (25/25, 100%) gave a score of ≥8 for supporting this home monitoring concept, with a median score of 10 (IQR 10-10). Conclusions: The positive experiences and satisfaction of involved users are key factors for the successful implementation of a novel eHealth solution. In our study, patients, as well as health care professionals, were highly satisfied with the use of the home monitoring program-the COVID-box project. Remote home monitoring may be an effective approach in cases of increased demand for hospital care and high pressure on health care systems.
Language	English
Publishing date	2022-07-28
Publishing country	Canada
Document type	Journal Article
ISSN	2561-326X
ISSN (online)	2561-326X
DOI	10.2196/38263
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Article ; Online: Illness Perceptions and Medication Nonadherence to Immunosuppressants After Successful Kidney Transplantation: A Cross-Sectional Study.

Wang, Yiman / Veltkamp, Denise M J / van der Boog, Paul J M / Hemmelder, Marc H / Dekker, Friedo W / de Vries, Aiko P J / Meuleman, Yvette

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10073

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Cross-Sectional Studies ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Medication Adherence ; Transplant Recipients
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2022-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10073
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Zs.A 2358: Show issues

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Article ; Online: Didactical characteristics of Dutch websites about kidney transplantation targeted for kidney patients and living donors: An exploratory study.

van Klaveren, Charlotte W / de Jong, Peter G M / Hendriks, Renée A / Luk, Franka / de Vries, Aiko P J / van der Boog, Paul J M / Rabelink, A J / Reinders, Marlies E J

PEC innovation

2022 Volume 1, Page(s) 100026

Abstract: Objective: The aim was to explore the origin, content topics, teaching modes (instruction, interaction, and assessment), and corresponding social-epistemological dimensions (choices in knowledge transfer vs. knowledge building, and individual vs. group ... ...

Abstract	Objective: The aim was to explore the origin, content topics, teaching modes (instruction, interaction, and assessment), and corresponding social-epistemological dimensions (choices in knowledge transfer vs. knowledge building, and individual vs. group learning) of web-based information on kidney transplantation targeted for patients and living donors. Methods: Dutch websites on kidney transplantation were retrieved using the search engine Results: The majority of the websites had a professional organization as origin (20/24). The number and distribution of content topics varied among the websites. Of the 16 different teaching modes found, 11 were instructional, 4 were interactional, and 1 assessment mode was found. The websites offered almost exclusively teaching modes on individual and passive learning, whereas group learning and interactive knowledge building was hardly encountered. Conclusion: The diversity in teaching modes and social-epistemological dimensions of Dutch websites on kidney transplantation targeted for patients and living donors is limited. The websites only provided a partial view on kidney transplantation; information regarding contact with others, e.g. support, was limited. A more balanced availability of teaching approaches and content topics is desirable to fit with the didactical goals to make well-considered health decisions.
Language	English
Publishing date	2022-03-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-6282
ISSN (online)	2772-6282
DOI	10.1016/j.pecinn.2022.100026
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