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  1. Article ; Online: Left atrial sphericity in relation to atrial strain and strain rate in atrial fibrillation patients.

    Hopman, Luuk H G A / Bhagirath, Pranav / Mulder, Mark J / Demirkiran, Ahmet / Mathari, Sulayman El / van der Laan, Anja M / van Rossum, Albert C / Kemme, Michiel J B / Allaart, Cornelis P / Götte, Marco J W

    The international journal of cardiovascular imaging

    2023  Volume 39, Issue 9, Page(s) 1753–1763

    Abstract: Purpose: Left atrial (LA) sphericity is a novel, geometry-based parameter that has been used to visualize and quantify LA geometrical remodeling in patients with atrial fibrillation (AF). This study examined the association between LA sphericity, and LA ...

    Abstract Purpose: Left atrial (LA) sphericity is a novel, geometry-based parameter that has been used to visualize and quantify LA geometrical remodeling in patients with atrial fibrillation (AF). This study examined the association between LA sphericity, and LA longitudinal strain and strain rate measured by feature-tracking in AF patients.
    Methods: 128 AF patients who underwent cardiovascular magnetic resonance (CMR) imaging in sinus rhythm prior to their pulmonary vein isolation (PVI) procedure were retrospectively analyzed. LA sphericity was calculated by segmenting the LA (excluding the pulmonary veins and the LA appendage) on a 3D contrast enhanced MR angiogram and comparing the resulting shape with a perfect sphere. LA global reservoir strain, conduit strain, contractile strain and corresponding strain rates were derived from cine images using feature-tracking. For statistical analysis, Pearson correlations, multivariable logistic regression analysis, and Student t-tests were used.
    Results: Patients with a spherical LA (dichotomized by the median value) had a lower reservoir strain and conduit strain compared to patients with a non-spherical LA (-15.4 ± 4.2% vs. -17.1 ± 3.5%, P = 0.02 and - 8.2 ± 3.0% vs. -9.5 ± 2.6%, P = 0.01, respectively). LA strain rate during early ventricular diastole was also different between both groups (-0.7 ± 0.3s
    Conclusions: LA passive strain is significantly impaired in AF patients with a spherical LA, though this relation was not independent from LA volume.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Retrospective Studies ; Predictive Value of Tests ; Heart Atria ; Atrial Appendage ; Atrial Remodeling ; Catheter Ablation/methods
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-023-02866-2
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    Zs.A 2104: Show issues Location:
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  2. Article ; Online: Left atrial strain is associated with arrhythmia recurrence after atrial fibrillation ablation: Cardiac magnetic resonance rapid strain vs. feature tracking strain.

    Hopman, Luuk H G A / Mulder, Mark J / van der Laan, Anja M / Bhagirath, Pranav / Demirkiran, Ahmet / von Bartheld, Martin B / Kemme, Michiel J B / van Rossum, Albert C / Allaart, Cornelis P / Götte, Marco J W

    International journal of cardiology

    2023  Volume 378, Page(s) 23–31

    Abstract: Purpose: The present study assesses different left atrial (LA) strain approaches in relation to atrial fibrillation (AF) recurrence after ablation and compares LA feature tracking (FT) strain to novel rapid LA strain approaches in AF patients.: ... ...

    Abstract Purpose: The present study assesses different left atrial (LA) strain approaches in relation to atrial fibrillation (AF) recurrence after ablation and compares LA feature tracking (FT) strain to novel rapid LA strain approaches in AF patients.
    Methods: This retrospective single-center study comprised of 110 prospectively recruited AF patients who underwent cardiac magnetic resonance (CMR) imaging in sinus rhythm prior to their first pulmonary vein isolation ablation. LA rapid strain (long axis strain and atrioventricular (AV)-junction strain), LA FT strain, and LA volumes were derived from 2-chamber and 4-chamber cine images. AF recurrence was followed up for 12 months using either 12‑lead ECGs or rhythm Holter monitoring.
    Results: Arrhythmia recurrence was observed in 39 patients (36%) after the 90-day blanking period, occurring at a median of 181 (122-286) days. LA long axis strain, AV-junction strain, and FT strain were all more impaired in patients with AF recurrence compared to patients without AF recurrence (long axis strain: P < 0.01; AV-junction strain: P < 0.001; FT strain: P < 0.01, respectively). Area under the curve (AUC) values for LA remodeling parameters in association with AF recurrence were 0.68 for long axis strain, 0.68 for AV-junction strain, 0.66 for FT strain, 0.66 for LA volume index. Phasic FT LA strain demonstrated that contractile strain had the highest AUC (0.70).
    Conclusion: Both LA rapid strain and LA FT strain are associated with arrhythmia recurrence after ablation in AF patients. LA rapid strain can be a convenient and reproducible alternative for LA FT strain to assess LA function in clinical practice.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Atrial Fibrillation/pathology ; Retrospective Studies ; Predictive Value of Tests ; Heart Atria ; Magnetic Resonance Spectroscopy ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Recurrence
    Language English
    Publishing date 2023-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.02.019
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  3. Article ; Online: Atrial Ablation Lesion Evaluation by Cardiac Magnetic Resonance: Review of Imaging Strategies and Histological Correlations.

    Hopman, Luuk H G A / van Pouderoijen, Nikki / Mulder, Mark J / van der Laan, Anja M / Bhagirath, Pranav / Nazarian, Saman / Niessen, Hans W M / Ferrari, Victor A / Allaart, Cornelis P / Götte, Marco J W

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 12, Page(s) 2665–2679

    Abstract: Cardiac magnetic resonance (CMR) imaging is a valuable noninvasive tool for evaluating tissue response following catheter ablation of atrial tissue. This review provides an overview of the contemporary CMR strategies to visualize atrial ablation lesions ... ...

    Abstract Cardiac magnetic resonance (CMR) imaging is a valuable noninvasive tool for evaluating tissue response following catheter ablation of atrial tissue. This review provides an overview of the contemporary CMR strategies to visualize atrial ablation lesions in both the acute and chronic postablation stages, focusing on their strengths and limitations. Moreover, the accuracy of CMR imaging in comparison to atrial lesion histology is discussed. T2-weighted CMR imaging is sensitive to edema and tends to overestimate lesion size in the acute stage after ablation. Noncontrast agent-enhanced T1-weighted CMR imaging has the potential to provide more accurate assessment of lesions in the acute stage but may not be as effective in the chronic stage. Late gadolinium enhancement imaging can be used to detect chronic atrial scarring, which may inform repeat ablation strategies. Moreover, novel imaging strategies are being developed, but their efficacy in characterizing atrial lesions is yet to be determined. Overall, CMR imaging has the potential to provide virtual histology that aids in evaluating the efficacy and safety of catheter ablation and monitoring of postprocedural myocardial changes. However, technical factors, scanning during arrhythmia, and transmurality assessment pose challenges. Therefore, further research is needed to develop CMR strategies to visualize the ablation lesion maturation process more effectively.
    MeSH term(s) Humans ; Contrast Media ; Gadolinium ; Magnetic Resonance Imaging/methods ; Catheter Ablation/adverse effects ; Magnetic Resonance Spectroscopy
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.08.013
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  4. Article ; Online: Right atrial function and fibrosis in relation to successful atrial fibrillation ablation.

    Hopman, Luuk H G A / Visch, Julia E / Bhagirath, Pranav / van der Laan, Anja M / Mulder, Mark J / Razeghi, Orod / Kemme, Michiel J B / Niederer, Steven A / Allaart, Cornelis P / Götte, Marco J W

    European heart journal. Cardiovascular Imaging

    2021  Volume 24, Issue 3, Page(s) 336–345

    Abstract: Aims: Bi-atrial remodelling in patients with atrial fibrillation (AF) is rarely assessed and data on the presence of right atrial (RA) fibrosis, the relationship between RA and left atrial (LA) fibrosis, and possible association of RA remodelling with ... ...

    Abstract Aims: Bi-atrial remodelling in patients with atrial fibrillation (AF) is rarely assessed and data on the presence of right atrial (RA) fibrosis, the relationship between RA and left atrial (LA) fibrosis, and possible association of RA remodelling with AF recurrence after ablation in patients with AF is limited.
    Methods and results: A total of 110 patients with AF undergoing initial pulmonary vein isolation (PVI) were included in the present study. All patients were in sinus rhythm during cardiac magnetic resonance (CMR) imaging performed prior to ablation. LA and RA volumes and function (volumetric and feature tracking strain) were derived from cine CMR images. The extent of LA and RA fibrosis was assessed from 3D late gadolinium enhancement images. AF recurrence was followed up for 12 months after PVI using either 12-lead electrocardiograms or Holter monitoring. Arrhythmia recurrence was observed in 39 patients (36%) after the 90-day blanking period, occurring at a median of 181 (interquartile range: 122-286) days. RA remodelling parameters were not significantly different between patients with and without AF recurrence after ablation, whereas LA remodelling parameters were different (volume, emptying fraction, and strain indices). LA fibrosis had a strong correlation with RA fibrosis (r = 0.88, P < 0.001). Both LA and RA fibrosis were not different between patients with and without AF recurrence.
    Conclusions: This study shows that RA remodelling parameters were not predictive of AF recurrence after AF ablation. Bi-atrial fibrotic remodelling is present in patients with AF and moreover, the amount of LA fibrosis had a strong correlation with the amount of RA fibrosis.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Atrial Fibrillation/pathology ; Contrast Media ; Atrial Function, Right ; Gadolinium ; Heart Atria ; Fibrosis ; Catheter Ablation/methods ; Recurrence ; Treatment Outcome
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2021-11-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeac152
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    Zs.A 5614: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Impaired left atrial reservoir and conduit strain in patients with atrial fibrillation and extensive left atrial fibrosis.

    Hopman, Luuk H G A / Mulder, Mark J / van der Laan, Anja M / Demirkiran, Ahmet / Bhagirath, Pranav / van Rossum, Albert C / Allaart, Cornelis P / Götte, Marco J W

    Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

    2021  Volume 23, Issue 1, Page(s) 131

    Abstract: Background: Atrial fibrillation (AF) is associated with profound structural and functional changes in the atria. In the present study, we investigated the association between left atrial (LA) phasic function and the extent of LA fibrosis using advanced ... ...

    Abstract Background: Atrial fibrillation (AF) is associated with profound structural and functional changes in the atria. In the present study, we investigated the association between left atrial (LA) phasic function and the extent of LA fibrosis using advanced cardiovascular magnetic resonance (CMR) imaging techniques, including 3-dimensional (3D) late gadolinium enhancement (LGE) and feature tracking.
    Methods: Patients with paroxysmal and persistent AF (n = 105) underwent CMR in sinus rhythm. LA global reservoir strain, conduit strain and contractile strain were derived from cine CMR images using CMR feature tracking. The extent of LA fibrosis was assessed from 3D LGE images. Healthy subjects underwent CMR and served as controls (n = 19).
    Results: Significantly lower LA reservoir strain, conduit strain and contractile strain were found in AF patients, as compared to healthy controls (- 15.9 ± 3.8% vs. - 21.1 ± 3.6% P < 0.001, - 8.7 ± 2.7% vs. - 12.6 ± 2.5% P < 0.001 and - 7.2 ± 2.3% vs. - 8.6 ± 2.2% P = 0.02, respectively). Patients with a high degree of LA fibrosis (dichotomized by the median value) had lower reservoir strain and conduit strain compared to patients with a low degree of LA fibrosis (- 15.0 ± 3.9% vs. - 16.9 ± 3.3%, P = 0.02 and - 7.9 ± 2.7% vs. - 9.5 ± 2.6%, P = 0.01, respectively). In contrast, no difference was found for LA contractile strain (- 7.1 ± 2.4% vs. - 7.4 ± 2.3%, P = 0.55).
    Conclusions: Impaired LA reservoir and conduit strain are present in AF patients with extensive atrial fibrosis. Future studies are needed to examine the biologic nature of this association and possible therapeutic implications.
    MeSH term(s) Atrial Fibrillation/diagnostic imaging ; Contrast Media ; Fibrosis ; Gadolinium ; Humans ; Predictive Value of Tests
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2021-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1458034-2
    ISSN 1532-429X ; 1097-6647
    ISSN (online) 1532-429X
    ISSN 1097-6647
    DOI 10.1186/s12968-021-00820-6
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    Zs.A 5045: Show issues Location:
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  6. Article ; Online: Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair.

    DeBerge, Matthew / Lantz, Connor / Dehn, Shirley / Sullivan, David P / van der Laan, Anja M / Niessen, Hans W M / Flanagan, Margaret E / Brat, Daniel J / Feinstein, Matthew J / Kaushal, Sunjay / Wilsbacher, Lisa D / Thorp, Edward B

    The Journal of experimental medicine

    2021  Volume 218, Issue 9

    Abstract: Hypoxia-inducible factors (HIFs) are activated in parenchymal cells in response to low oxygen and as such have been proposed as therapeutic targets during hypoxic insult, including myocardial infarction (MI). HIFs are also activated within macrophages, ... ...

    Abstract Hypoxia-inducible factors (HIFs) are activated in parenchymal cells in response to low oxygen and as such have been proposed as therapeutic targets during hypoxic insult, including myocardial infarction (MI). HIFs are also activated within macrophages, which orchestrate the tissue repair response. Although isoform-specific therapeutics are in development for cardiac ischemic injury, surprisingly, the unique role of myeloid HIFs, and particularly HIF-2α, is unknown. Using a murine model of myocardial infarction and mice with conditional genetic loss and gain of function, we uncovered unique proinflammatory roles for myeloid cell expression of HIF-1α and HIF-2α during MI. We found that HIF-2α suppressed anti-inflammatory macrophage mitochondrial metabolism, while HIF-1α promoted cleavage of cardioprotective MerTK through glycolytic reprogramming of macrophages. Unexpectedly, combinatorial loss of both myeloid HIF-1α and HIF-2α was catastrophic and led to macrophage necroptosis, impaired fibrogenesis, and cardiac rupture. These findings support a strategy for selective inhibition of macrophage HIF isoforms and promotion of anti-inflammatory mitochondrial metabolism during ischemic tissue repair.
    MeSH term(s) Aged ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cardiomyopathies/physiopathology ; Disease Models, Animal ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Myeloid Cells/metabolism ; Myeloid Cells/pathology ; Myocardial Infarction/physiopathology ; Myocardial Ischemia/physiopathology ; Myocarditis/metabolism ; Myocarditis/pathology ; Mice
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; HIF1A protein, human ; Hif1a protein, mouse ; Hypoxia-Inducible Factor 1, alpha Subunit ; endothelial PAS domain-containing protein 1 (1B37H0967P)
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20200667
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  7. Article ; Online: Republished: healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response.

    van der Laan, Anja M / Nahrendorf, Matthias / Piek, Jan J

    Postgraduate medical journal

    2013  Volume 89, Issue 1047, Page(s) 52–58

    Language English
    Publishing date 2013-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2012-301623rep
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  8. Article ; Online: What is the best heparin to treat sepsis with?

    van Roessel, Stijn / van der Laan, Anja M / de Pont, Anne-Cornélie J M

    Critical care medicine

    2015  Volume 43, Issue 6, Page(s) e212–3

    MeSH term(s) Anticoagulants/therapeutic use ; Disseminated Intravascular Coagulation/drug therapy ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Sepsis/drug therapy
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight ; Heparin (9005-49-6)
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000000916
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  9. Article ; Online: Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction.

    Zhang, Shuang / Paccalet, Alexandre / Rohde, David / Cremer, Sebastian / Hulsmans, Maarten / Lee, I-Hsiu / Mentkowski, Kyle / Grune, Jana / Schloss, Maximilian J / Honold, Lisa / Iwamoto, Yoshiko / Zheng, Yi / Bredella, Miriam A / Buckless, Colleen / Ghoshhajra, Brian / Thondapu, Vikas / van der Laan, Anja M / Piek, Jan J / Niessen, Hans W M /
    Pallante, Fabio / Carnevale, Raimondo / Perrotta, Sara / Carnevale, Daniela / Iborra-Egea, Oriol / Muñoz-Guijosa, Christian / Galvez-Monton, Carolina / Bayes-Genis, Antoni / Vidoudez, Charles / Trauger, Sunia A / Scadden, David / Swirski, Filip K / Moskowitz, Michael A / Naxerova, Kamila / Nahrendorf, Matthias

    Nature cardiovascular research

    2023  Volume 2, Issue 12, Page(s) 1277–1290

    Abstract: After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Since the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell ... ...

    Abstract After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Since the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell homeostasis, metabolic cues may influence emergency myelopoiesis. Here, we show in humans and female mice that hematopoietic progenitor cells increase fatty acid metabolism after MI. Blockade of fatty acid oxidation by deleting carnitine palmitoyltransferase (
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ISSN 2731-0590
    ISSN (online) 2731-0590
    DOI 10.1038/s44161-023-00388-7
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  10. Article ; Online: Healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response.

    van der Laan, Anja M / Nahrendorf, Matthias / Piek, Jan J

    Heart (British Cardiac Society)

    2012  Volume 98, Issue 18, Page(s) 1384–1390

    MeSH term(s) Blood Cells/immunology ; Forecasting ; Humans ; Immunity, Cellular/physiology ; Immunity, Innate/immunology ; Macrophages/immunology ; Mast Cells/immunology ; Myocardial Infarction/immunology ; Myocardial Infarction/therapy ; Stem Cells/immunology ; Ventricular Remodeling/immunology ; Wound Healing/immunology
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2012-301623
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