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  1. AU="von Creytz, Isabel"
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Artikel: Rescue and characterization of the first West African Marburg virus 2021 from Guinea.

von Creytz, Isabel / Gerresheim, Gesche K / Lier, Clemens / Schneider, Jana / Schauflinger, Martin / Benz, Marcel / Kämper, Lennart / Rohde, Cornelius / Eickmann, Markus / Biedenkopf, Nadine

Heliyon

2023  Band 9, Heft 9, Seite(n) e19613

Abstract: Marburg virus (MARV) is a causative agent of a severe hemorrhagic fever with high fatality rates endemic in central Africa. Current outbreaks of MARV in Equatorial Guinea and Tanzania underline the relevance of MARV as a public health emergency pathogen. ...

Abstract Marburg virus (MARV) is a causative agent of a severe hemorrhagic fever with high fatality rates endemic in central Africa. Current outbreaks of MARV in Equatorial Guinea and Tanzania underline the relevance of MARV as a public health emergency pathogen. In 2021, the first known human MARV case was confirmed in Guinea, West Africa. Since no infectious virus could be isolated from that fatal case in 2021, we generated recombinant (rec) MARV Guinea by reverse genetics in order to study and characterize this new MARV, which occurred in West Africa for the first time, in terms of its growth properties, detection by antibodies, and therapeutic potential compared to known MARV strains. Our results showed a solid viral replication of recMARV Guinea in human, bat, and monkey cell lines in comparison to other known MARV strains. We further demonstrated that replication of recMARV Guinea in cells can be inhibited by the nucleoside analogue remdesivir. Taken together, we could successfully reconstitute
Sprache Englisch
Erscheinungsdatum 2023-08-29
Erscheinungsland England
Dokumenttyp Journal Article
ZDB-ID 2835763-2
ISSN 2405-8440
ISSN 2405-8440
DOI 10.1016/j.heliyon.2023.e19613
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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