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  1. Article ; Online: 60/m nach SARS-CoV-2-Infektion mit „PICS“ : Vorbereitungskurs Anästhesiologische Intensivmedizin: Fall 2.

    von Loeffelholz, C / Schwarze, A

    Die Anaesthesiologie

    2022  Volume 71, Issue Suppl 1, Page(s) 8–12

    Title translation 60/m-SARS-CoV-2 infection with PICS : Preparation course anesthesiological intensive care medicine: case 2.
    MeSH term(s) COVID-19 ; Critical Care ; Humans ; Intensive Care Units ; Medicine ; SARS-CoV-2
    Language German
    Publishing date 2022-06-23
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-6866
    ISSN (online) 2731-6866
    DOI 10.1007/s00101-022-01143-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lebensbedrohliche euglykämische Ketoacidose unter Therapie mit Empagliflozin beim kardiochirurgischen Patienten: seltener Einzelfall oder zukünftig ein häufiges Problem?

    Wachter, H / von Loeffelholz, C / Thomas-Rüddel, D O / Bargenda, S / Birkenfeld, A L / Bauer, M / Ehler, J

    Die Anaesthesiologie

    2024  

    Title translation Life-threatening euglycemic ketoacidosis under treatment with empagliflozin in cardiac surgery patients: rare isolated case or a frequent problem in the future?
    Language German
    Publishing date 2024-04-18
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-6866
    ISSN (online) 2731-6866
    DOI 10.1007/s00101-024-01406-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tight versus liberal blood-glucose control in the intensive care unit: special considerations for patients with diabetes.

    von Loeffelholz, Christian / Birkenfeld, Andreas L

    The lancet. Diabetes & endocrinology

    2023  Volume 12, Issue 4, Page(s) 277–284

    Abstract: Stress hyperglycaemia, hypoglycaemia, and diabetes are common in critically ill patients and related to clinical endpoints. To avoid complications related to hypoglycaemia and hyperglycaemia, it is recommended to start insulin therapy for the majority of ...

    Abstract Stress hyperglycaemia, hypoglycaemia, and diabetes are common in critically ill patients and related to clinical endpoints. To avoid complications related to hypoglycaemia and hyperglycaemia, it is recommended to start insulin therapy for the majority of critically ill patients with persistent blood glucose concentrations higher than 10·0 mmol/L (>180 mg/dL), targeting a range of 7·8-10·0 mmol/L (140-180 mg/dL). However, management and evidence-based targets for blood glucose control are under debate, particularly for patients with diabetes. Recent randomised controlled clinical trials now challenge current recommendations. In this Personal View, we aim to highlight these developments and the important differences between critically ill patients with and without diabetes, taking into account the considerable heterogeneity in this patient group. We critically discuss evidence from prospective randomised controlled trials and observational studies on the safety and efficacy of glycaemic control, specifically in the context of patients with diabetes in intensive care units.
    MeSH term(s) Humans ; Blood Glucose ; Hypoglycemic Agents/therapeutic use ; Glycemic Control ; Critical Illness/therapy ; Prospective Studies ; Diabetes Mellitus/drug therapy ; Insulin/therapeutic use ; Hypoglycemia/chemically induced ; Hypoglycemia/prevention & control ; Hyperglycemia/prevention & control ; Hyperglycemia/drug therapy ; Intensive Care Units
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(24)00058-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mehr als „nur“ ein provozierter Anfall bei bekannter Epilepsie unklarer Ätiologie.

    Roth, J / von Loeffelholz, C / Eckhardt, N / Klingner, C / Sandhaus, T

    Medizinische Klinik, Intensivmedizin und Notfallmedizin

    2022  Volume 117, Issue 7, Page(s) 571–574

    Title translation More than "just" a provoked seizure in association with a known history of epilepsy.
    MeSH term(s) Epilepsy/complications ; Humans ; Seizures/complications ; Seizures/therapy
    Language German
    Publishing date 2022-06-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2636018-4
    ISSN 2193-6226 ; 1435-1420 ; 0723-5003 ; 2193-6218 ; 0175-3851
    ISSN (online) 2193-6226 ; 1435-1420
    ISSN 0723-5003 ; 2193-6218 ; 0175-3851
    DOI 10.1007/s00063-022-00936-2
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  5. Article: Hypoxia in A Patient with Anti-p200 Pemphigoid under Combined Dapsone and Pantoprazole Treatment.

    Lang, Sebastian / Sänger, Philipp Wilhelm / Kocina, Sandra / von Loeffelholz, Christian

    Biomedicines

    2022  Volume 10, Issue 11

    Abstract: A 70-year-old male patient was admitted to our dermatology outpatient clinic with newly developed personality changes and signs of hypoxemia. His anti-p200 Pemphigoid was treated with Dapsone for a few weeks. Due to generalized tonic-clonic seizure with ... ...

    Abstract A 70-year-old male patient was admitted to our dermatology outpatient clinic with newly developed personality changes and signs of hypoxemia. His anti-p200 Pemphigoid was treated with Dapsone for a few weeks. Due to generalized tonic-clonic seizure with a subsequent Glasgow Coma Scale of 5 points and a peripheral oxygen saturation not exceeding 88% under conditions of high-flow nasal cannula, he was intubated by the emergency team and transferred to the intensive care unit. Comprehensive tests were performed, but Dapsone-induced methemoglobinemia remained the exclusive explanation for the observed scenario, although arterial MetHb analysis showed a peak value of only 6%. The patient recovered shortly after repeated infusions of Methylene blue and Ascorbate, and cessation of Dapsone. We provide an overview of the pathophysiology, diagnostic procedures, and possible explanations for this case of Dapsone-induced methaemoglobinaemia. In conclusion, our case report provides evidence that even mild chronic methemglobinemia can induce severe clinical symptoms.
    Language English
    Publishing date 2022-11-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10112837
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  6. Article ; Online: A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies.

    von Loeffelholz, Christian / Coldewey, Sina M / Birkenfeld, Andreas L

    Cells

    2021  Volume 10, Issue 7

    Abstract: 5'AMP-activated protein kinase (AMPK) is known as metabolic sensor in mammalian cells that becomes activated by an increasing adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio. The heterotrimeric AMPK protein comprises three subunits, each ...

    Abstract 5'AMP-activated protein kinase (AMPK) is known as metabolic sensor in mammalian cells that becomes activated by an increasing adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio. The heterotrimeric AMPK protein comprises three subunits, each of which has multiple phosphorylation sites, playing an important role in the regulation of essential molecular pathways. By phosphorylation of downstream proteins and modulation of gene transcription AMPK functions as a master switch of energy homeostasis in tissues with high metabolic turnover, such as the liver, skeletal muscle, and adipose tissue. Regulation of AMPK under conditions of chronic caloric oversupply emerged as substantial research target to get deeper insight into the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Evidence supporting the role of AMPK in NAFLD is mainly derived from preclinical cell culture and animal studies. Dysbalanced de novo lipogenesis has been identified as one of the key processes in NAFLD pathogenesis. Thus, the scope of this review is to provide an integrative overview of evidence, in particular from clinical studies and human samples, on the role of AMPK in the regulation of primarily de novo lipogenesis in human NAFLD.
    MeSH term(s) AMP-Activated Protein Kinases/chemistry ; AMP-Activated Protein Kinases/metabolism ; Humans ; Insulin/metabolism ; Lipogenesis ; Models, Biological ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Signal Transduction
    Chemical Substances Insulin ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10071822
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  7. Article ; Online: Die atrioösophageale Fistel nach Pulmonalvenenisolation – eine interdisziplinäre Herausforderung.

    Neumann, Caroline / von Loeffelholz, Christian / Färber, Gloria / Lange, Kathleen / Bauer, Michael

    Die Anaesthesiologie

    2023  Volume 72, Issue 9, Page(s) 643–646

    Title translation Atrioesophageal fistula after pulmonary vein isolation-An interdisciplinary challenge.
    MeSH term(s) Humans ; Pulmonary Veins/surgery ; Fistula/diagnosis ; Atrial Fibrillation/surgery
    Language German
    Publishing date 2023-07-25
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-6866
    ISSN (online) 2731-6866
    DOI 10.1007/s00101-023-01316-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Predictive Value of Serial Model of End-Stage Liver Disease Score Determination in Patients with Postcardiotomy Extracorporeal Membrane Oxygenation.

    Sommerfeld, Oliver / Neumann, Caroline / Pfeifer, Marcel-Dominic / Faerber, Gloria / Kirov, Hristo / von Loeffelholz, Christian / Doenst, Torsten / Sponholz, Christoph

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: 1) ...

    Abstract (1)
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13071856
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  9. Article: The Role of Physical Activity in Nonalcoholic and Metabolic Dysfunction Associated Fatty Liver Disease.

    von Loeffelholz, Christian / Roth, Johannes / Coldewey, Sina M / Birkenfeld, Andreas L

    Biomedicines

    2021  Volume 9, Issue 12

    Abstract: Sedentary behavior constitutes a pandemic health threat contributing to the pathophysiology of obesity and type 2 diabetes (T2D). Sedentarism is further associated with liver disease and particularly with nonalcoholic/metabolic dysfunction associated ... ...

    Abstract Sedentary behavior constitutes a pandemic health threat contributing to the pathophysiology of obesity and type 2 diabetes (T2D). Sedentarism is further associated with liver disease and particularly with nonalcoholic/metabolic dysfunction associated fatty liver disease (NAFLD/MAFLD). Insulin resistance (IR) represents an early pathophysiologic key element of NAFLD/MAFLD, prediabetes and T2D. Current treatment guidelines recommend regular physical activity. There is evidence, that physical exercise has impact on a variety of molecular pathways, such as AMP-activated protein kinase and insulin signaling as well as glucose transporter 4 translocation, modulating insulin action, cellular substrate flow and in particular ectopic lipid and glycogen storage in a positive manner. Therefore, physical exercise can lead to substantial clinical benefit in persons with diabetes and/or NAFLD/MAFLD. However, experience from long term observational studies shows that the patients' motivation to exercise regularly appears to be a major limitation. Strategies to integrate everyday physical activity (i.e., nonexercise activity thermogenesis) in lifestyle treatment schedules might be a promising approach. This review aggregates evidence on the impact of regular physical activity on selected molecular mechanisms as well as clinical outcomes of patients suffering from IR and NAFLD/MAFLD.
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9121853
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  10. Article ; Online: Extracorporeal albumin dialysis in critically ill patients with liver failure: Comparison of four different devices-A retrospective analysis.

    Sommerfeld, Oliver / Neumann, Caroline / Becker, Jan / von Loeffelholz, Christian / Roth, Johannes / Kortgen, Andreas / Bauer, Michael / Sponholz, Christoph

    The International journal of artificial organs

    2023  Volume 46, Issue 8-9, Page(s) 481–491

    Abstract: Background: Besides standard medical therapy and critical care monitoring, extracorporeal liver support may provide a therapeutic option in patients with liver failure. However, little is known about detoxification capabilities, efficacy, and efficiency ...

    Abstract Background: Besides standard medical therapy and critical care monitoring, extracorporeal liver support may provide a therapeutic option in patients with liver failure. However, little is known about detoxification capabilities, efficacy, and efficiency among different devices.
    Methods: Retrospective single-center analysis of patients treated with extracorporeal albumin dialysis. Generalized Estimating Equations with robust variance estimator were used to account for repeated measurements of several cycles and devices per patient.
    Results: Between 2015 and 2021
    Conclusions: From this clinical perspective ADVOS and OPAL may provide higher reduction capabilities of liver solutes (i.e. bilirubin and ammonia) in comparison to MARS and SPAD. However, further prospective studies comparing the effectiveness of the devices to support liver impairment (i.e. bile acid clearance or albumin binding capacity) as well as markers of renal recovery are warranted.
    MeSH term(s) Humans ; Ammonia ; Critical Illness ; Prospective Studies ; Retrospective Studies ; Renal Dialysis ; Liver Failure ; Albumins ; Bilirubin
    Chemical Substances Ammonia (7664-41-7) ; Albumins ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2023-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80456-3
    ISSN 1724-6040 ; 0391-3988
    ISSN (online) 1724-6040
    ISSN 0391-3988
    DOI 10.1177/03913988231191952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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