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  1. Article ; Online: The "Hygiene Hypothesis" and the Lessons Learnt From Farm Studies.

    von Mutius, Erika

    Frontiers in immunology

    2021  Volume 12, Page(s) 635522

    Language English
    Publishing date 2021-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.635522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [No title information]

    von Mutius, Erika

    Drug research

    2020  Volume 70, Issue S 01, Page(s) S16

    Title translation Bedeutung von Mikrobiomen in Darm und Atemwegen für Therapien.
    Language German
    Publishing date 2020-11-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1119-2740
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    Uf I Zs.151: Show issues Location:
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  3. Article ; Online: The Microbiome in Clinical Allergy and Immunology: Emerging Role as Friend and Foe.

    Banzon, Tina M / von Mutius, Erika / Phipatanakul, Wanda

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 9, Page(s) 2252–2253

    MeSH term(s) Humans ; Hypersensitivity ; Microbiota
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Editorial
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.06.024
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    Zs.A 7086: Show issues Location:
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  4. Article ; Online: Effect of Farming on Asthma.

    Pechlivanis, Sonali / von Mutius, Erika

    Acta medica academica

    2020  Volume 49, Issue 2, Page(s) 144–155

    Abstract: In this review, we discuss an immunobiology model of farm exposure towards the protective effect of asthma. Unraveling the protective effect of farming exposure could help develop novel strategies to prevent asthma. Asthma is a chronic airway ... ...

    Abstract In this review, we discuss an immunobiology model of farm exposure towards the protective effect of asthma. Unraveling the protective effect of farming exposure could help develop novel strategies to prevent asthma. Asthma is a chronic airway inflammation that causes coughing, wheezing, chest tightness or shortness of breath. The reasons for the increase in the prevalence of asthma worldwide is still unclear but has been hypothesized to be attributable to westernization/urbanization of rural regions thus resulting in the loss of rural farming environmental. In this review we discuss the effect of the environmental factors, specifically farming, on the risk of asthma in children. Here, we will summarize the main findings of 27 studies related to 11 different cohorts. Several studies have shown preventive effect of traditional farming on the prevalence and incidence of asthma in childhood. Furthermore, consumption of unpasteurized cow's milk, exposure to farm animals as well as fodder have been shown to have a protective effect on asthma. The precise mechanism of the protective effect is still unclear. There are assumptions, that maternal/childhood exposures to farm animals result in higher microbial exposures through which the protective effect might be mediated. Also, consumption of unpasteurized milk (when consumed during pregnancy by mother or early childhood by children) can modulate cytokine production patterns which could be responsible for the observed protective effect. CONCLUSION: This review provides evidence of the protective effect of farming environment i.e., exposure to farm animals, their fodder as well as consumption of unpasteurized cow's milk suggesting that novel strategies could be developed to prevent asthma.
    MeSH term(s) Agriculture ; Animal Feed ; Animals ; Animals, Domestic ; Asthma/epidemiology ; Asthma/immunology ; Child ; Cytokines/immunology ; Environmental Exposure ; Farms ; Humans ; Milk/immunology ; Pasteurization ; Protective Factors
    Chemical Substances Cytokines
    Language English
    Publishing date 2020-11-12
    Publishing country Bosnia and Herzegovina
    Document type Journal Article ; Review
    ZDB-ID 2558604-X
    ISSN 1840-2879 ; 1840-1848
    ISSN (online) 1840-2879
    ISSN 1840-1848
    DOI 10.5644/ama2006-124.293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intimate Crosstalk in Lower Airways at the Beginning of Life.

    von Mutius, Erika

    Cell host & microbe

    2018  Volume 24, Issue 6, Page(s) 758–759

    Abstract: The early life formation of the immunological and microbial environment of the human lower airways remains unknown. In this issue of Cell Host & Microbe, Pattaroni et al. (2018) shed light on this critical period, which is important for maturation or ... ...

    Abstract The early life formation of the immunological and microbial environment of the human lower airways remains unknown. In this issue of Cell Host & Microbe, Pattaroni et al. (2018) shed light on this critical period, which is important for maturation or dysregulation of the microbiome and immune responses and disease development.
    MeSH term(s) Beginning of Human Life ; Humans ; Microbiota ; Respiratory System
    Language English
    Publishing date 2018-12-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2018.11.014
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    Zs.A 6578: Show issues Location:
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  6. Article ; Online: Childhood origins of COPD.

    von Mutius, Erika

    The Lancet. Respiratory medicine

    2018  Volume 6, Issue 7, Page(s) 482–483

    MeSH term(s) Child ; Child, Preschool ; Forced Expiratory Volume ; Humans ; Pulmonary Disease, Chronic Obstructive ; Retrospective Studies
    Language English
    Publishing date 2018-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(18)30141-3
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    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Biodiversity: The new kid on the block?

    von Mutius, Erika

    The Journal of allergy and clinical immunology

    2018  Volume 141, Issue 4, Page(s) 1215–1216

    MeSH term(s) Allergens ; Asthma ; Biodiversity ; Child ; Humans
    Chemical Substances Allergens
    Language English
    Publishing date 2018-02-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.01.036
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    Uh III Zs.92: Show issues Location:
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  8. Article: Bedeutung von Mikrobiomen in Darm und Atemwegen für Therapien

    von Mutius, Erika

    Drug Research

    2020  Volume 70, Issue S 01, Page(s) S16–S16

    Language German
    Publishing date 2020-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1119-2740
    Database Thieme publisher's database

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    Uf I Zs.151: Show issues Location:
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  9. Article ; Online: Protection against allergies: Microbes, immunity, and the farming effect.

    Deckers, Julie / Marsland, Benjamin J / von Mutius, Erika

    European journal of immunology

    2021  Volume 51, Issue 10, Page(s) 2387–2398

    Abstract: The prevalence of asthma and other allergic diseases has rapidly increased in "Westernized" countries over recent decades. This rapid increase suggests the involvement of environmental factors, behavioral changes or lifestyle, rather than genetic drift. ... ...

    Abstract The prevalence of asthma and other allergic diseases has rapidly increased in "Westernized" countries over recent decades. This rapid increase suggests the involvement of environmental factors, behavioral changes or lifestyle, rather than genetic drift. It has become increasingly clear that the microbiome plays a key role in educating the host immune system and, thus, regulation of disease susceptibility. This review will focus on recent advances uncovering immunological and microbial mechanisms that protect against allergies, in particular, within the context of a farming environment. A whole body of epidemiological data disclosed the nature of the protective exposures in a farm. Current evidence points toward an important role of the host microbiome in setting an immunological equilibrium that determines progression toward, or protection against allergic diseases. Conclusive mechanistic insights on how microbial exposures prevent from developing allergic diseases in humans are still lacking but findings from experimental models reveal plausible immunological mechanisms. Gathering further knowledge on these mechanisms and confirming their relevance in humans is of great importance to develop preventive strategies for children at risk of developing allergies.
    MeSH term(s) Adaptive Immunity ; Age Factors ; Agriculture ; Animals ; Disease Management ; Disease Susceptibility/immunology ; Environmental Exposure ; Host-Pathogen Interactions/immunology ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/etiology ; Hypersensitivity/prevention & control ; Hypersensitivity/therapy ; Immunity, Innate ; Microbiota/immunology
    Language English
    Publishing date 2021-09-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202048938
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    Zs.A 489: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 85: Show issues

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  10. Article: Effective Ways to Prevent Allergic Diseases: Where Do We Stand?

    Landgraf-Rauf, Katja / von Mutius, Erika

    Handbook of experimental pharmacology

    2021  Volume 268, Page(s) 437–448

    Abstract: Since allergic diseases are of great public health relevance, effective primary prevention strategies are urgently needed. This chapter gives an overview of existing primary prevention programs on environmental exposures and dietary strategies based on ... ...

    Abstract Since allergic diseases are of great public health relevance, effective primary prevention strategies are urgently needed. This chapter gives an overview of existing primary prevention programs on environmental exposures and dietary strategies based on epidemiological studies which have defined risk- and protective factors for the development of allergic diseases.The allergy protective effect mediated by growing up on a traditional farm environment is well studied. But the exact underlying mechanisms have still not been fully clarified and have not yet led to concrete prevention strategies. The beneficial effect of avoiding cigarette smoke exposure, indoor moisture and molds in pregnancy and childhood on the development of asthma is well documented. Whereas the avoidance of house dust mite exposure is not recommended to prevent eczema or allergy. Dietary supplementation with vitamins, pre- and probiotics in pregnant woman and their offspring is not harmful but evidence for the prevention of allergic diseases is still lacking. Fish oil consumption was shown to be asthma protective. The early introduction of peanuts and egg protein to prevent peanut and egg allergy in children with atopic dermatitis is promising. Further studies are needed to increase the overall evidence in allergy prevention. Most studies lack methodological standards such as randomization and blinding. More evidence is in demand on the potential beneficial impact of multifaceted interventional studies. The future of allergy prevention strategies might be based on individual risk assessment. Therefore, research in the immunological and molecular basis of allergic diseases needs to be promoted.
    MeSH term(s) Asthma ; Child ; Dermatitis, Atopic ; Diet ; Eczema ; Female ; Humans ; Hypersensitivity/prevention & control ; Infant ; Pregnancy
    Language English
    Publishing date 2021-06-30
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_497
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