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  1. Book ; Thesis: Immunmodulatorische Effekte des Histon-Deacetylasen-Inhibitors LBH589 auf die Interaktionen von Lymphozyten und Hodgkin Lymphom-Zelllinien

    Klein, Jan Martin / Pogge von Strandmann, Elke / Schweiger, Michal-Ruth

    2020  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von Jan Martin Klein ; 1. Gutachterin: Professorin Dr. rer. nat. E. Pogge von Standmann, 2. Gutachterin: Universitätsprofessorin Dr. med. Dr. rer. nat. M.-R. Schweiger ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I, Hämatologie und Onkologie
    Subject code 610
    Language German ; English
    Size 84 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2019
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT020431597
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2020 D 307 order for loan Magazin

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  2. Book ; Thesis: The acetyltransferases CBP/p300 regulate the expression of NKG2D ligands on tumor cells

    Çetintaş, Ayşe / Pogge von Strandmann, Elke / Schweiger, Manfred

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von: Ayşe Çetintaş ; 1. Berichterstatterin: Professorin Dr. rer. nat. E. Pogge von Strandmann, 2. Berichterstatterin: Universitätsprofessorin Dr. med. Dr. rer. nat. M.-R. Schweiger ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language English
    Size 46 Blätter, Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2018
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT019925848
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 8 order for loan Magazin

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  3. Book ; Online ; Thesis: The acetyltransferases CBP/p300 regulate the expression of NKG2D ligands on tumor cells

    Çetintaş, Ayşe / Pogge von Strandmann, Elke / Schweiger, Manfred

    2018  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgelegt von: Ayşe Çetintaş ; 1. Berichterstatterin: Professorin Dr. rer. nat. E. Pogge von Strandmann, 2. Berichterstatterin: Universitätsprofessorin Dr. med. Dr. rer. nat. M.-R. Schweiger ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language English
    Size 1 Online-Ressource (44 Seiten), Illustrationen
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2018
    Note Zusammenfassung in deutscher und englischer Sprache ; Open Access
    HBZ-ID HT019894461
    DOI 10.4126/FRL01-006411508
    Database Repository for Life Sciences

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  4. Book ; Online ; Thesis: Funktionelle Analyse der Ceramid Synthasen und ihre Rolle in der Immunoseneszenz

    Nordbeck, Johanna / Pogge von Strandmann, Elke / Krönke, Martin

    2013  

    Institution Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
    Author's details vorgelegt von Johanna Nordbeck ; 1. Berichterstatter: Universitätsprofessor Dr. med. M. Krönke, 2. Berichterstatterin: Frau Professor Dr. rer. nat. E. Pogge von Strandmann ; aus dem Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln
    Subject code 610
    Language German
    Size 40 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2013
    HBZ-ID HT018118219
    DOI 10.4126/38m-005447187
    Database Repository for Life Sciences

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  5. Book ; Thesis: Funktionelle Analyse der Ceramid Synthasen und ihre Rolle in der Immunoseneszenz

    Nordbeck, Johanna / Krönke, Martin / Pogge von Strandmann, Elke

    2013  

    Institution Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
    Author's details vorgelegt von Johanna Nordbeck ; 1. Berichterstatter: Universitätsprofessor Dr. med. M. Krönke, 2. Berichterstatterin: Frau Professor Dr. rer. nat. E. Pogge von Strandmann ; aus dem Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln
    Subject code 610
    Language German
    Size 40 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2013
    HBZ-ID HT018208408
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 D 164 order for loan Magazin

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  6. Article ; Online: KLF4-mediated upregulation of the NKG2D ligand MICA in acute myeloid leukemia: a novel therapeutic target identified by enChIP.

    Alkhayer, Reem / Ponath, Viviane / Frech, Miriam / Adhikary, Till / Graumann, Johannes / Neubauer, Andreas / von Strandmann, Elke Pogge

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 94

    Abstract: The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of NKG2D ligands ( ...

    Abstract The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of NKG2D ligands (NKG2D-L), including MICA. The absence of NKG2D-L on AML cells is moreover associated with leukemia stem cell characteristics. The NKG2D/NKG2D-L system thus qualifies as an interesting and promising therapeutic target.Here we aimed to identify transcription factors susceptible to pharmacological stimulation resulting in the expression of the NKG2D-L MICA in AML cells to restore anti-tumor activity. Using a CRISPR-based engineered ChIP (enChIP) assay for the MICA promoter region and readout by mass spectrometry-based proteomics, we identified the transcription factor krüppel-like factor 4 (KLF4) as associated with the promoter. We demonstrated that the MICA promoter comprises functional binding sites for KLF4 and genetic as well as pharmacological gain- and loss-of-function experiments revealed inducible MICA expression to be mediated by KLF4.Furthermore, induction in AML cells was achieved with the small compound APTO253, a KLF4 activator, which also inhibits MYC expression and causes DNA damage. This induction in turn yielded increased expression and cell surface presentation of MICA, thus rendering AML cells more susceptible to NK cell-mediated killing. These data unravel a novel link between APTO253 and the innate anti-tumor immune response providing a rationale for targeting AML cells via APTO253-dependent KFL4/MICA induction to allow elimination by endogenous or transplanted NK and T cells in vivo. Video Abstract.
    MeSH term(s) Humans ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Up-Regulation ; Ligands ; Kruppel-Like Factor 4 ; Histocompatibility Antigens Class I/genetics ; Leukemia, Myeloid, Acute/metabolism ; Cell Line, Tumor
    Chemical Substances NK Cell Lectin-Like Receptor Subfamily K ; Ligands ; Kruppel-Like Factor 4 ; Histocompatibility Antigens Class I
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01118-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of local human microbiota on the allergic diseases: Organ-organ interaction.

    Alashkar Alhamwe, Bilal / López, Juan-Felipe / Zhernov, Yury / von Strandmann, Elke Pogge / Karaulov, Alexander / Kolahian, Saeed / Geßner, Reinhard / Renz, Harald

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 6, Page(s) e13976

    Abstract: The homogeneous impact of local dysbiosis on the development of allergic diseases in the same organ has been thoroughly studied. However, much less is known about the heterogeneous influence of dysbiosis within one organ on allergic diseases in other ... ...

    Abstract The homogeneous impact of local dysbiosis on the development of allergic diseases in the same organ has been thoroughly studied. However, much less is known about the heterogeneous influence of dysbiosis within one organ on allergic diseases in other organs. A comprehensive analysis of the current scientific literature revealed that most of the relevant publications focus on only three organs: gut, airways, and skin. Moreover, the interactions appear to be mainly unidirectional, that is, dysbiotic conditions of the gut being associated with allergic diseases of the airways and the skin. Similar to homogeneous interactions, early life appears to be not only a crucial period for the formation of the microbiota in one organ but also for the later development of allergic diseases in other organs. In particular, we were able to identify a number of specific bacterial and fungal species/genera in the intestine that were repeatedly associated in the literature with either increased or decreased allergic diseases of the skin, like atopic dermatitis, or the airways, like allergic rhinitis and asthma. The reported studies indicate that in addition to the composition of the microbiome, also the relative abundance of certain microbial species and the overall diversity are associated with allergic diseases of the corresponding organs. As anticipated for human association studies, the underlying mechanisms of the organ-organ crosstalk could not be clearly resolved yet. Thus, further work, in particular experimental animal studies are required to elucidate the mechanisms linking dysbiotic conditions of one organ to allergic diseases in other organs.
    MeSH term(s) Animals ; Humans ; Dysbiosis ; Asthma ; Microbiota ; Dermatitis, Atopic ; Rhinitis, Allergic
    Language English
    Publishing date 2023-06-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3096: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Online ; Thesis: Aktivierung von natürlichen Killerzellen in einem Kolonkarzinom-Mausmodell

    Madlener, Marie Elisabeth / Pogge von Strandmann, Elke / Sterner-Kock, Anja

    in-vivo Aktivität des Immunliganden ULBP2-antiCEA

    2012  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgeelgt von Marie Elisabeth Madlener ; 1. Berichterstatterin: Frau Professor Dr. rer. nat. E. Pogge von Strandmann, 2. Berichterstatterin: Frau Professor Dr. med. vet. A. Sterner-Kock, PhD ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language German
    Size XI, 79 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2012
    HBZ-ID HT017475407
    DOI 10.4126/38m-004766898
    Database Repository for Life Sciences

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  9. Book ; Thesis: Aktivierung von natürlichen Killerzellen in einem Kolonkarzinom-Mausmodell

    Madlener, Marie Elisabeth / Pogge von Strandmann, Elke / Sterner-Kock, Anja

    in-vivo Aktivität des Immunliganden ULBP2-antiCEA

    2012  

    Institution Universitätsklinikum Köln / Klinik I für Innere Medizin
    Author's details vorgeelgt von Marie Elisabeth Madlener ; 1. Berichterstatterin: Frau Professor Dr. rer. nat. E. Pogge von Strandmann, 2. Berichterstatterin: Frau Professor Dr. med. vet. A. Sterner-Kock, PhD ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin I Hämatologie und Onkologie
    Subject code 610
    Language German
    Size XI, 79 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2012
    HBZ-ID HT017501124
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 D 11 order for loan Magazin

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  10. Article ; Online: Molecular Determinants for RNA Release into Extracellular Vesicles.

    Mosbach, Marie-Luise / Pfafenrot, Christina / von Strandmann, Elke Pogge / Bindereif, Albrecht / Preußer, Christian

    Cells

    2021  Volume 10, Issue 10

    Abstract: Extracellular vesicles (EVs) are important for intercellular communication and act as vehicles for biological material, such as various classes of coding and non-coding RNAs, a few of which were shown to selectively target into vesicles. However, protein ...

    Abstract Extracellular vesicles (EVs) are important for intercellular communication and act as vehicles for biological material, such as various classes of coding and non-coding RNAs, a few of which were shown to selectively target into vesicles. However, protein factors, mechanisms, and sequence elements contributing to this specificity remain largely elusive. Here, we use a reporter system that results in different types of modified transcripts to decipher the specificity determinants of RNAs released into EVs. First, we found that small RNAs are more efficiently packaged into EVs than large ones, and second, we determined absolute quantities for several endogenous RNA transcripts in EVs (U6 snRNA, U1 snRNA, Y1 RNA, and GAPDH mRNA). We show that RNA polymerase III (pol III) transcripts are more efficiently secreted into EVs compared to pol II-derived transcripts. Surprisingly, our quantitative analysis revealed no RNA accumulation in the vesicles relative to the total cellular levels, based on both overexpressed reporter transcripts and endogenous RNAs. RNA appears to be EV-associated only at low copy numbers, ranging between 0.02 and 1 molecule per EV. This RNA association may reflect internal EV encapsulation or a less tightly bound state at the vesicle surface.
    MeSH term(s) Cell Line ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/ultrastructure ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/genetics ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)/metabolism ; Humans ; Poly A/metabolism ; Polyadenylation ; RNA Caps/metabolism ; RNA Polymerase III/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Nuclear/metabolism
    Chemical Substances RNA Caps ; RNA, Messenger ; RNA, Small Nuclear ; U1 small nuclear RNA ; U6 small nuclear RNA ; Poly A (24937-83-5) ; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) (EC 1.2.1.12) ; RNA Polymerase III (EC 2.7.7.6)
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10102674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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