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Article: Neoadjuvante Radiochemotherapie für Mundhöhlenkarzinome-INVERT. Prospektive, unizentrische, einarmige, Proof-of-Principle-Studie (ARO 2022-4)

von der Grün, J. / Winkelmann, R. / Burck, I.

2022 Volume 37, Issue 4, Page(s) 311

Language	German
Document type	Article
ZDB-ID	1218650-8
ISSN	0947-0255
Database	Current Contents Medicine

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Book ; Thesis: Quantitative Proteomuntersuchung von Remodellierungsprozessen in Mausherzen nach transverser Aortenkonstriktion

Müller-von der Grün, Jens

2017

Author's details	vorgelegt von Jens Müller-von der Grün
Language	German
Size	125 Seiten, Illustrationen, Diagramme, 30 cm
Publishing place	Frankfurt am Main
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2017
HBZ-ID	HT019608734
Database	Catalogue ZB MED Medicine, Health

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2018 E 221	order for loan	Magazin

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Article ; Online: Radiotherapie mit Cetuximab oder Cisplatin beim Plattenepithelkarzinom der Kopf-Hals-Region – was ist zu bevorzugen?

von der Grün, Jens / Balermpas, Panagiotis

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

2019 Volume 196, Issue 2, Page(s) 197–199

Title translation	Radiotherapy with cetuximab or cisplatin for squamous cell carcinoma of the head and neck-what should be preferred?
MeSH term(s)	Carcinoma, Squamous Cell ; Cetuximab ; Cisplatin ; Head and Neck Neoplasms ; Humans ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	Cetuximab (PQX0D8J21J) ; Cisplatin (Q20Q21Q62J)
Language	German
Publishing date	2019-12-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	84983-2
ISSN	1439-099X ; 0179-7158 ; 0039-2073
ISSN (online)	1439-099X
ISSN	0179-7158 ; 0039-2073
DOI	10.1007/s00066-019-01568-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Association between spatial distribution of leukocyte subsets and clinical presentation of head and neck squamous cell carcinoma.

Netzer, Christoph / von Arps-Aubert, Vanessa / Mačinković, Igor / von der Grün, Jens / Küffer, Stefan / Ströbel, Philipp / von Knethen, Andreas / Weigert, Andreas / Beutner, Dirk

Frontiers in immunology

2024 Volume 14, Page(s) 1240394

Abstract: Background: Interactions between tumor cells and cells in the microenvironment contribute to tumor development and metastasis. The spatial arrangement of individual cells in relation to each other influences the likelihood of whether and how these cells ...

Abstract	Background: Interactions between tumor cells and cells in the microenvironment contribute to tumor development and metastasis. The spatial arrangement of individual cells in relation to each other influences the likelihood of whether and how these cells interact with each other. Methods: This study investigated the effect of spatial distribution on the function of leukocyte subsets in the microenvironment of human head and neck squamous cell carcinoma (HNSCC) using multiplex immunohistochemistry (IHC). Leukocyte subsets were further classified based on analysis of two previously published HNSCC single-cell RNA datasets and flow cytometry (FC). Results: IHC revealed distinct distribution patterns of leukocytes differentiated by CD68 and CD163. While CD68hiCD163 Conclusion: The distribution patterns and their distinct interactions via the PD-L1/PD-1 pathway suggest divergent roles of CD68/CD163 subsets in the HNSCC microenvironment. PD-L1/PD-1 interactions appear to occur primarily between specific cell types close to the tumor site. Whether PD-L1/PD-1 interactions have a positive or negative impact on patient survival appears to depend on both the spatial localization and the entity of the interacting cells. Co-expression of other markers, particularly CD80 and CD206, supports the hypothesis that CD68/CD163 IHC subsets have distinct functions. These results highlight the association between spatial leukocyte distribution patterns and the clinical presentation of HNSCC.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor ; T-Lymphocytes/metabolism ; Head and Neck Neoplasms ; RNA ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; RNA (63231-63-0)
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1240394
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MRI-based radiomics for predicting histology in malignant salivary gland tumors: methodology and "proof of principle".

Khodabakhshi, Zahra / Motisi, Laura / Bink, Andrea / Broglie, Martina A / Rupp, Niels J / Fleischmann, Maximilian / von der Grün, Jens / Guckenberger, Matthias / Tanadini-Lang, Stephanie / Balermpas, Panagiotis

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9945

Abstract: Defining the exact histological features of salivary gland malignancies before treatment remains an unsolved problem that compromises the ability to tailor further therapeutic steps individually. Radiomics, a new methodology to extract quantitative ... ...

Abstract	Defining the exact histological features of salivary gland malignancies before treatment remains an unsolved problem that compromises the ability to tailor further therapeutic steps individually. Radiomics, a new methodology to extract quantitative information from medical images, could contribute to characterizing the individual cancer phenotype already before treatment in a fast and non-invasive way. Consequently, the standardization and implementation of radiomic analysis in the clinical routine work to predict histology of salivary gland cancer (SGC) could also provide improvements in clinical decision-making. In this study, we aimed to investigate the potential of radiomic features as imaging biomarker to distinguish between high grade and low-grade salivary gland malignancies. We have also investigated the effect of image and feature level harmonization on the performance of radiomic models. For this study, our dual center cohort consisted of 126 patients, with histologically proven SGC, who underwent curative-intent treatment in two tertiary oncology centers. We extracted and analyzed the radiomics features of 120 pre-therapeutic MRI images with gadolinium (T1 sequences), and correlated those with the definitive post-operative histology. In our study the best radiomic model achieved average AUC of 0.66 and balanced accuracy of 0.63. According to the results, there is significant difference between the performance of models based on MRI intensity normalized images + harmonized features and other models (p value < 0.05) which indicates that in case of dealing with heterogeneous dataset, applying the harmonization methods is beneficial. Among radiomic features minimum intensity from first order, and gray level-variance from texture category were frequently selected during multivariate analysis which indicate the potential of these features as being used as imaging biomarker. The present bicentric study presents for the first time the feasibility of implementing MR-based, handcrafted radiomics, based on T1 contrast-enhanced sequences and the ComBat harmonization method in an effort to predict the formal grading of salivary gland carcinoma with satisfactory performance.
MeSH term(s)	Humans ; Salivary Gland Neoplasms/diagnostic imaging ; Salivary Gland Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Female ; Male ; Middle Aged ; Aged ; Adult ; Aged, 80 and over ; Image Processing, Computer-Assisted/methods ; Radiomics
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60200-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Management of anal cancer patients - a pattern of care analysis in German-speaking countries.

Martin, Daniel / von der Grün, Jens / Rödel, Claus / Fokas, Emmanouil

Radiation oncology (London, England)

2020 Volume 15, Issue 1, Page(s) 122

Abstract: Background: Radiotherapy dose and target volume prescriptions for anal squamous cell carcinoma (ASCC) vary considerably in daily practice and guidelines, including those from NCCN, UK, Australasian, and ESMO. We conducted a pattern-of-care survey to ... ...

Abstract	Background: Radiotherapy dose and target volume prescriptions for anal squamous cell carcinoma (ASCC) vary considerably in daily practice and guidelines, including those from NCCN, UK, Australasian, and ESMO. We conducted a pattern-of-care survey to assess the patient management in German speaking countries. Methods: We developed an anonymous questionnaire comprising 18 questions on diagnosis and treatment of ASCC. The survey was sent to 361 DEGRO-associated institutions, including 41 university hospitals, 118 non-university institutions, and 202 private practices. Results: We received a total of 101 (28%) surveys, including 20 (19.8%) from university, 36 (35.6%) from non-university clinics, and 45 (44.6%) from private practices. A total of 28 (27.8%) institutions reported to treat more than 5 patients with early-stage ASCC and 42 (41.6%) institutions treat more than 5 patients with locoregionally-advanced ASCC per year. Biopsy of suspicious inguinal nodes was advocated in only 12 (11.8%) centers. Screening for human immunodeficiency virus (HIV) is done in 28 (27.7%). Intensity modulated radiotherapy or similar techniques are used in 97%. The elective lymph node dose ranged from 30.6 Gy to 52.8 Gy, whereas 87% prescribed 50.4-55. 8 Gy (range: 30.6 to 59.4 Gy) to the involved lymph nodes. The dose to gross disease of cT1 or cT2 ASCC ranged from 50 to ≥60 Gy. For cT3 or cT4 tumors the target dose ranged from 54 Gy to more than 60 Gy, with 76 (75.2%) institutions prescribing 59.4 Gy. The preferred concurrent chemotherapy regimen was 5-FU/Mitomycin C, whereas 6 (6%) prescribed Capecitabine/Mitomycin C. HIV-positive patients are treated with full-dose CRT in 87 (86.1%) institutions. First assessment for clinical response is reported to be performed at 4-6 weeks after completion of CRT in 2 (2%) institutions, at 6-8 weeks in 20 (19.8%), and 79 (78%) institutions wait up to 5 months. Conclusions: We observed marked differences in radiotherapy doses and treatment technique in patients with ASCC, and also variable approaches for patients with HIV. These data underline the need for an consensus treatment guideline for ASCC.
MeSH term(s)	Anus Neoplasms/radiotherapy ; Carcinoma, Squamous Cell/radiotherapy ; Chemoradiotherapy ; HIV Infections/diagnosis ; Humans ; Radiotherapy Dosage
Language	English
Publishing date	2020-05-25
Publishing country	England
Document type	Journal Article
ISSN	1748-717X
ISSN (online)	1748-717X
DOI	10.1186/s13014-020-01539-x
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Article: Sarcopenia Is Associated With Hematologic Toxicity During Chemoradiotherapy in Patients With Anal Carcinoma.

Martin, Daniel / von der Grün, Jens / Rödel, Claus / Fokas, Emmanouil

Frontiers in oncology

2020 Volume 10, Page(s) 1576

Abstract: Purpose: Sarcopenia, defined as a loss of muscle mass and quality, has been associated with impaired oncological outcome and treatment toxicities in several malignancies. However, its role in anal squamous cell carcinoma (ASCC) remains less well ... ...

Abstract	Purpose: Sarcopenia, defined as a loss of muscle mass and quality, has been associated with impaired oncological outcome and treatment toxicities in several malignancies. However, its role in anal squamous cell carcinoma (ASCC) remains less well explored. Methods/materials: Planning CT scans were used to measure cross-sectional skeletal muscle area (SMA) to calculate the skeletal muscle index (SMI). The association of sarcopenia with clinical and treatment-related parameters, and toxicity was assessed in 114 patients with ASCC that underwent standard 5-Fluorouracil/Mitomycin C chemoradiotherapy (CRT). The prognostic impact of sarcopenia on local relapse-free survival (LRFS), disease-free survival (DFS), and overall survival was examined using a Cox regression analysis. Results: 29 (25.4%) patients had sarcopenia. Patients with sarcopenia had lower baseline hemoglobin levels ( Conclusion: This is the largest study to assess the impact of sarcopenia on toxicity and oncological outcome in patients with ASCC. Increased clinician awareness of higher hematological toxicity risk is needed for sarcopenic patients with ASCC undergoing CRT to facilitate closer monitoring of side effects and earlier introduction of supportive measures. Further prospective studies are needed to elucidate the prognostic role and impact of sarcopenia on CRT-related toxicity in ASCC.
Language	English
Publishing date	2020-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.01576
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Article ; Online: Tumor-associated immune cell infiltrate density in penile squamous cell carcinomas.

Hladek, Luca / Bankov, Katrin / von der Grün, Jens / Filmann, Natalie / Demes, Melanie / Vallo, Stefan / Wild, Peter J / Winkelmann, Ria

Virchows Archiv : an international journal of pathology

2022 Volume 480, Issue 6, Page(s) 1159–1169

Abstract: Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with ...

Abstract	Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapted to the individual patient. Fifty-five therapy naïve squamous cell carcinomas, age range between 41 and 85 years with known clinicopathological data, were investigated with the use of tissue microarrays (TMA) regarding the tumor-associated immune cell infiltrate density (ICID). Slides were stained with antibodies against CD3, CD8 and CD20. An image analysis software was applied for evaluation. Data were correlated with clinicopathological characteristics and overall survival. There was a significant increase of ICID in squamous cell carcinomas of the penis in relation to tumor adjacent physiological tissue. Higher CD3-positive ICID was significantly associated with lower tumor stage in our cohort. The ICID was not associated with overall survival. Our data sharpens the view on tumor-associated immune cell infiltrate in penile squamous cell carcinomas with an unbiased digital and automated cell count. Further investigations on the immune cell infiltrate and its prognostic and possible therapeutic impact are needed.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/pathology ; Cell Count ; Europe ; Humans ; Male ; Middle Aged ; Penile Neoplasms/pathology ; Tumor Microenvironment
Language	English
Publishing date	2022-01-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-022-03271-1
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Article ; Online: The routine use of LCD-Array hybridisation technique for HPV subtyping in the diagnosis of penile carcinoma compared to other methods.

Winkelmann, Ria / Bankov, Katrin / von der Grün, Jens / Cinatl, Jindrich / Wild, Peter J / Vallo, Stefan / Demes, Melanie

BMC urology

2022 Volume 22, Issue 1, Page(s) 10

Abstract: Background: Routine human papillomavirus (HPV) testing is performed in cervival cancer and is required for classification of some head and neck cancers. In penile cancer a statement on HPV association of the carcinoma is required. In most cases p16 ... ...

Abstract	Background: Routine human papillomavirus (HPV) testing is performed in cervival cancer and is required for classification of some head and neck cancers. In penile cancer a statement on HPV association of the carcinoma is required. In most cases p16 immunohistochemistry as a surrogate marker is applied in this setting. Since differing clinical outcomes for HPV positive and HPV negative tumors are described we await HPV testing to be requested more frequently by clinicians, also in the context of HPV vaccination, where other HPV subtypes are expected to emerge. Method: Therefore, a cohort of archived, formalin-fixed paraffin embedded (FFPE) penile neoplasias was stained for p16 and thereafter tested for HPV infection status via PCR based methods. Additionally to Sanger sequencing, we chose LCD-Array technique (HPV 3.5 LCD-Array Kit, Chipron; LCD-Array) for the detection of HPV in our probes expecting a less time consuming and sensitive HPV test for our probes. Results: We found that LCD-Array is a sensitive and feasible method for HPV testing in routine diagnostics applicable to FFPE material in our cohort. Our cohort of penile carcinomas and carcinomas in situ was associated with HPV infection in 61% of cases. We detected no significant association between HPV infection status and histomorphological tumor characteristics as well as overall survival. Conclusions: We showed usability of molecular HPV testing on a cohort of archived penile carcinomas. To the best of our knowledge, this is the first study investigating LCD-Array technique on a cohort of penile neoplasias.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Papillomaviridae/classification ; Papillomavirus Infections/complications ; Penile Neoplasms/diagnosis ; Penile Neoplasms/virology ; Virology/methods
Language	English
Publishing date	2022-01-29
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-022-00962-4
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Article ; Online: Enabling ultra-high dose rate electron beams at a clinical linear accelerator for isocentric treatments.

Dal Bello, Riccardo / von der Grün, Jens / Fabiano, Silvia / Rudolf, Thomas / Saltybaeva, Natalia / Stark, Luisa S / Ahmed, Md / Bathula, Manohar / Kucuker Dogan, Serpil / McNeur, Joshua / Guckenberger, Matthias / Tanadini-Lang, Stephanie

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2023 Volume 187, Page(s) 109822

Abstract: Background and purpose: Radiotherapy delivery with ultra-high dose rates (UHDR) has consistently produced normal tissue sparing while maintaining efficacy for tumour control in preclinical studies, known as the FLASH effect. Modified clinical electron ... ...

Abstract	Background and purpose: Radiotherapy delivery with ultra-high dose rates (UHDR) has consistently produced normal tissue sparing while maintaining efficacy for tumour control in preclinical studies, known as the FLASH effect. Modified clinical electron linacs have been used for pre-clinical studies at reduced source-surface distance (SSD) and novel intra-operative devices are becoming available. In this context, we modified a clinical linac to deliver 16 MeV UHDR electron beams with an isocentric setup. Materials and methods: The first Varian TrueBeam (SN 1001) was clinically operative between 2009-2022, it was then decommissioned and converted into a research platform. The 18 MeV electron beam was converted into the experimental 16 MeV UHDR. Modifications were performed by Varian and included a software patch, thinner scattering foil and beam tuning. The dose rate, beam characteristics and reproducibility were measured with electron applicators at SSD = 100 cm. Results: The dose per pulse at isocenter was up to 1.28 Gy/pulse, corresponding to average and instantaneous dose rates up to 256 Gy/s and 3⋅10 Conclusions: We report on the first technical conversion of a Varian TrueBeam to produce 16 MeV UHDR electron beams. This research platform will allow isocenter experiments and deliveries with conventional setups up to field sizes of 10x10 cm
MeSH term(s)	Humans ; Radiotherapy Dosage ; Electrons ; Reproducibility of Results ; Particle Accelerators ; Radiometry
Language	English
Publishing date	2023-07-27
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2023.109822
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